	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 43274

FusionGeneSummary for ZNF404_DMKN

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF404_DMKN
	Fusion gene ID: 43274
		Hgene	Tgene
	Gene symbol	ZNF404	DMKN
	Gene ID	342908	93099
	Gene name	zinc finger protein 404	dermokine
	Synonyms	-	UNQ729\|ZD52F10
	Cytomap	19q13.31	19q13.12
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 404	dermokineepidermis-specific secreted protein SK30/SK89
	Modification date	20180523	20180523
	UniProtAcc	Q494X3	Q6E0U4
	Ensembl transtripts involved in fusion gene	ENST00000587539, ENST00000324394, ENST00000588094,	ENST00000408915, ENST00000402589, ENST00000339686, ENST00000436012, ENST00000414866, ENST00000480502, ENST00000467637, ENST00000429837, ENST00000419602, ENST00000462126, ENST00000443640, ENST00000472252, ENST00000492341, ENST00000602781, ENST00000474928, ENST00000488892, ENST00000461300, ENST00000447113, ENST00000392206, ENST00000440396, ENST00000458071, ENST00000418261, ENST00000424570, ENST00000451297,
Fusion gene scores	* DoF score	2 X 2 X 2=8	3 X 3 X 3=27
	# samples	2	3
	** MAII score	log2(2/8*10)=1.32192809488736	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ZNF404 [Title/Abstract] AND DMKN [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	SARC	TCGA-FX-A76Y-01A	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000587539	ENST00000408915	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000402589	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000339686	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000436012	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000414866	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000480502	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000467637	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000429837	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000419602	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000462126	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000443640	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000472252	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000492341	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000602781	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000474928	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000488892	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000461300	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000447113	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000392206	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000440396	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000458071	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000418261	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000424570	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5CDS-intron	ENST00000587539	ENST00000451297	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000408915	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000402589	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000339686	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000436012	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000414866	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000480502	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000467637	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000429837	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000419602	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000462126	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000443640	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000472252	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000492341	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000602781	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000474928	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000488892	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000461300	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000447113	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000392206	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000440396	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000458071	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000418261	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000424570	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
intron-intron	ENST00000324394	ENST00000451297	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000408915	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000402589	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000339686	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000436012	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000414866	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000480502	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000467637	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000429837	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000419602	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000462126	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000443640	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000472252	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000492341	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000602781	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000474928	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000488892	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000461300	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000447113	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000392206	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000440396	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000458071	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000418261	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000424570	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-
5UTR-intron	ENST00000588094	ENST00000451297	ZNF404	chr19	44388108	-	DMKN	chr19	35997087	-

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FusionProtFeatures for ZNF404_DMKN

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF404 Q494X3	DMKN Q6E0U4
May be involved in transcriptional regulation.{ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ZNF404_DMKN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF404_DMKN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
ZNF404	MEOX2	DMKN	ELAVL1, APP, RBM24, FOXD4, ZSCAN12, FCF1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ZNF404_DMKN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZNF404_DMKN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 43274

FusionGeneSummary for ZNF404_DMKN

FusionProtFeatures for ZNF404_DMKN

FusionGeneSequence for ZNF404_DMKN

FusionGenePPI for ZNF404_DMKN

RelatedDrugs for ZNF404_DMKN

RelatedDiseases for ZNF404_DMKN