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Fusion gene ID: 43268 |
FusionGeneSummary for ZNF398_TPK1 |
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Fusion gene information | Fusion gene name: ZNF398_TPK1 | Fusion gene ID: 43268 | Hgene | Tgene | Gene symbol | ZNF398 | TPK1 | Gene ID | 57541 | 27010 |
Gene name | zinc finger protein 398 | thiamin pyrophosphokinase 1 | |
Synonyms | P51|P71|ZER6 | HTPK1|PP20|THMD5 | |
Cytomap | 7q36.1 | 7q35 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 398zinc finger DNA binding protein ZER6zinc finger DNA binding protein p52/p71zinc finger-estrogen receptor interaction, clone 6 | thiamin pyrophosphokinase 1placental protein 20thiamine diphosphokinasethiamine kinase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8TD17 | Q9H3S4 | |
Ensembl transtripts involved in fusion gene | ENST00000426851, ENST00000485111, ENST00000420008, ENST00000475153, ENST00000483892, ENST00000491174, ENST00000540950, ENST00000335901, | ENST00000360057, ENST00000538212, ENST00000549981, ENST00000378099, ENST00000547966, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 3 X 2=12 |
# samples | 3 | 2 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF398 [Title/Abstract] AND TPK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-X6-A7WC-01A | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
TCGA | LD | SARC | TCGA-X6-A7WC-01A | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000426851 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000426851 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000426851 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000426851 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000426851 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-3CDS | ENST00000485111 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000485111 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000485111 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000485111 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000485111 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
5UTR-3CDS | ENST00000420008 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
5UTR-intron | ENST00000420008 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
5UTR-intron | ENST00000420008 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
5UTR-intron | ENST00000420008 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
5UTR-intron | ENST00000420008 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
Frame-shift | ENST00000475153 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
5CDS-intron | ENST00000475153 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
5CDS-intron | ENST00000475153 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
5CDS-intron | ENST00000475153 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
5CDS-intron | ENST00000475153 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-3CDS | ENST00000483892 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000483892 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000483892 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000483892 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000483892 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-3CDS | ENST00000491174 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000491174 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000491174 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000491174 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000491174 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-3CDS | ENST00000540950 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000540950 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000540950 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000540950 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000540950 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-3CDS | ENST00000335901 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000335901 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000335901 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000335901 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-intron | ENST00000335901 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144463044 | - |
intron-5UTR | ENST00000426851 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000426851 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000426851 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-5UTR | ENST00000426851 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000426851 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-5UTR | ENST00000485111 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000485111 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000485111 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-5UTR | ENST00000485111 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000485111 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
5UTR-5UTR | ENST00000420008 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
5UTR-intron | ENST00000420008 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
5UTR-intron | ENST00000420008 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
5UTR-5UTR | ENST00000420008 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
5UTR-intron | ENST00000420008 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
5CDS-5UTR | ENST00000475153 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
5CDS-intron | ENST00000475153 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
5CDS-intron | ENST00000475153 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
5CDS-5UTR | ENST00000475153 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
5CDS-intron | ENST00000475153 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-5UTR | ENST00000483892 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000483892 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000483892 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-5UTR | ENST00000483892 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000483892 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-5UTR | ENST00000491174 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000491174 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000491174 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-5UTR | ENST00000491174 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000491174 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-5UTR | ENST00000540950 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000540950 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000540950 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-5UTR | ENST00000540950 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000540950 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-5UTR | ENST00000335901 | ENST00000360057 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000335901 | ENST00000538212 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000335901 | ENST00000549981 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-5UTR | ENST00000335901 | ENST00000378099 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
intron-intron | ENST00000335901 | ENST00000547966 | ZNF398 | chr7 | 148844858 | + | TPK1 | chr7 | 144532711 | - |
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FusionProtFeatures for ZNF398_TPK1 |
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Hgene | Tgene |
ZNF398 | TPK1 |
Function as a transcriptional activator. | Catalyzes the phosphorylation of thiamine to thiaminepyrophosphate. Can also catalyze the phosphorylation ofpyrithiamine to pyrithiamine pyrophosphate.{ECO:0000269|PubMed:11342111}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF398_TPK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF398_TPK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF398 | ESR1, DGCR6, NDE1, CLK2, MFAP1, ELMO1, OPTN, C1orf109, MAGOHB, GPATCH2L, PLEKHF2, CIB3, LOC155060, ZNF282, ZNF212, ZNF746, EFEMP1, ZNF783, LRP4, ZNF777, HIST2H2AB, SMARCB1 | TPK1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF398_TPK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | TPK1 | Q9H3S4 | DB00152 | Thiamine | Thiamin pyrophosphokinase 1 | small molecule | approved|investigational|nutraceutical|vet_approved |
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RelatedDiseases for ZNF398_TPK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TPK1 | C3280866 | THIAMINE METABOLISM DYSFUNCTION SYNDROME 5 (EPISODIC ENCEPHALOPATHY TYPE) | 1 | ORPHANET;UNIPROT |