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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43268

FusionGeneSummary for ZNF398_TPK1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF398_TPK1
Fusion gene ID: 43268
HgeneTgene
Gene symbol

ZNF398

TPK1

Gene ID

57541

27010

Gene namezinc finger protein 398thiamin pyrophosphokinase 1
SynonymsP51|P71|ZER6HTPK1|PP20|THMD5
Cytomap

7q36.1

7q35

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 398zinc finger DNA binding protein ZER6zinc finger DNA binding protein p52/p71zinc finger-estrogen receptor interaction, clone 6thiamin pyrophosphokinase 1placental protein 20thiamine diphosphokinasethiamine kinase
Modification date2018052320180523
UniProtAcc

Q8TD17

Q9H3S4

Ensembl transtripts involved in fusion geneENST00000426851, ENST00000485111, 
ENST00000420008, ENST00000475153, 
ENST00000483892, ENST00000491174, 
ENST00000540950, ENST00000335901, 
ENST00000360057, ENST00000538212, 
ENST00000549981, ENST00000378099, 
ENST00000547966, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 3 X 2=12
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF398 [Title/Abstract] AND TPK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-X6-A7WC-01AZNF398chr7

148844858

+TPK1chr7

144463044

-
TCGALDSARCTCGA-X6-A7WC-01AZNF398chr7

148844858

+TPK1chr7

144532711

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000426851ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000426851ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000426851ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000426851ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000426851ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-3CDSENST00000485111ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000485111ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000485111ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000485111ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000485111ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144463044

-
5UTR-3CDSENST00000420008ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144463044

-
5UTR-intronENST00000420008ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144463044

-
5UTR-intronENST00000420008ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144463044

-
5UTR-intronENST00000420008ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144463044

-
5UTR-intronENST00000420008ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144463044

-
Frame-shiftENST00000475153ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144463044

-
5CDS-intronENST00000475153ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144463044

-
5CDS-intronENST00000475153ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144463044

-
5CDS-intronENST00000475153ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144463044

-
5CDS-intronENST00000475153ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-3CDSENST00000483892ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000483892ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000483892ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000483892ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000483892ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-3CDSENST00000491174ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000491174ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000491174ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000491174ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000491174ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-3CDSENST00000540950ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000540950ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000540950ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000540950ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000540950ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-3CDSENST00000335901ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000335901ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000335901ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000335901ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-intronENST00000335901ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144463044

-
intron-5UTRENST00000426851ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000426851ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000426851ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-5UTRENST00000426851ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000426851ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-5UTRENST00000485111ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000485111ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000485111ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-5UTRENST00000485111ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000485111ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144532711

-
5UTR-5UTRENST00000420008ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144532711

-
5UTR-intronENST00000420008ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144532711

-
5UTR-intronENST00000420008ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144532711

-
5UTR-5UTRENST00000420008ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144532711

-
5UTR-intronENST00000420008ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144532711

-
5CDS-5UTRENST00000475153ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144532711

-
5CDS-intronENST00000475153ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144532711

-
5CDS-intronENST00000475153ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144532711

-
5CDS-5UTRENST00000475153ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144532711

-
5CDS-intronENST00000475153ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-5UTRENST00000483892ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000483892ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000483892ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-5UTRENST00000483892ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000483892ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-5UTRENST00000491174ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000491174ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000491174ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-5UTRENST00000491174ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000491174ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-5UTRENST00000540950ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000540950ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000540950ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-5UTRENST00000540950ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000540950ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-5UTRENST00000335901ENST00000360057ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000335901ENST00000538212ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000335901ENST00000549981ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-5UTRENST00000335901ENST00000378099ZNF398chr7

148844858

+TPK1chr7

144532711

-
intron-intronENST00000335901ENST00000547966ZNF398chr7

148844858

+TPK1chr7

144532711

-

Top

FusionProtFeatures for ZNF398_TPK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF398

Q8TD17

TPK1

Q9H3S4

Function as a transcriptional activator. Catalyzes the phosphorylation of thiamine to thiaminepyrophosphate. Can also catalyze the phosphorylation ofpyrithiamine to pyrithiamine pyrophosphate.{ECO:0000269|PubMed:11342111}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF398_TPK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF398_TPK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF398ESR1, DGCR6, NDE1, CLK2, MFAP1, ELMO1, OPTN, C1orf109, MAGOHB, GPATCH2L, PLEKHF2, CIB3, LOC155060, ZNF282, ZNF212, ZNF746, EFEMP1, ZNF783, LRP4, ZNF777, HIST2H2AB, SMARCB1TPK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZNF398_TPK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTPK1Q9H3S4DB00152ThiamineThiamin pyrophosphokinase 1small moleculeapproved|investigational|nutraceutical|vet_approved

Top

RelatedDiseases for ZNF398_TPK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTPK1C3280866THIAMINE METABOLISM DYSFUNCTION SYNDROME 5 (EPISODIC ENCEPHALOPATHY TYPE)1ORPHANET;UNIPROT