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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43264

FusionGeneSummary for ZNF395_SLC25A44

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF395_SLC25A44
Fusion gene ID: 43264
HgeneTgene
Gene symbol

ZNF395

SLC25A44

Gene ID

55893

9673

Gene namezinc finger protein 395solute carrier family 25 member 44
SynonymsHDBP-2|HDBP2|HDRF-2|PBF|PRF-1|PRF1|Si-1-8-14-
Cytomap

8p21.1

1q22

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 395HD gene regulatory region-binding protein 2HD-regulating factor 2Huntington's disease gene regulatory region-binding protein 2huntington disease gene regulatory region-binding protein 2papillomavirus regulatory factor 1papillosolute carrier family 25 member 44
Modification date2018051920180522
UniProtAcc

Q9H8N7

Q96H78

Ensembl transtripts involved in fusion geneENST00000344423, ENST00000523202, 
ENST00000523095, ENST00000519730, 
ENST00000359511, ENST00000423538, 
ENST00000469537, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 3=27
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF395 [Title/Abstract] AND SLC25A44 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7744-01AZNF395chr8

28243521

-SLC25A44chr1

156177677

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000344423ENST00000359511ZNF395chr8

28243521

-SLC25A44chr1

156177677

+
intron-3CDSENST00000344423ENST00000423538ZNF395chr8

28243521

-SLC25A44chr1

156177677

+
intron-3UTRENST00000344423ENST00000469537ZNF395chr8

28243521

-SLC25A44chr1

156177677

+
intron-3CDSENST00000523202ENST00000359511ZNF395chr8

28243521

-SLC25A44chr1

156177677

+
intron-3CDSENST00000523202ENST00000423538ZNF395chr8

28243521

-SLC25A44chr1

156177677

+
intron-3UTRENST00000523202ENST00000469537ZNF395chr8

28243521

-SLC25A44chr1

156177677

+
5UTR-3CDSENST00000523095ENST00000359511ZNF395chr8

28243521

-SLC25A44chr1

156177677

+
5UTR-3CDSENST00000523095ENST00000423538ZNF395chr8

28243521

-SLC25A44chr1

156177677

+
5UTR-3UTRENST00000523095ENST00000469537ZNF395chr8

28243521

-SLC25A44chr1

156177677

+
intron-3CDSENST00000519730ENST00000359511ZNF395chr8

28243521

-SLC25A44chr1

156177677

+
intron-3CDSENST00000519730ENST00000423538ZNF395chr8

28243521

-SLC25A44chr1

156177677

+
intron-3UTRENST00000519730ENST00000469537ZNF395chr8

28243521

-SLC25A44chr1

156177677

+

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FusionProtFeatures for ZNF395_SLC25A44


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF395

Q9H8N7

SLC25A44

Q96H78


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF395_SLC25A44


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF395_SLC25A44


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF395SAP30, HDAC1, ELAVL1, WASL, FBXW11, BTRCSLC25A44ELAVL1, JUP, NME2P1, IMPDH2, LASP1, IMPDH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF395_SLC25A44


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF395_SLC25A44


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource