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Fusion gene ID: 4324 |
FusionGeneSummary for BPHL_MFSD9 |
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Fusion gene information | Fusion gene name: BPHL_MFSD9 | Fusion gene ID: 4324 | Hgene | Tgene | Gene symbol | BPHL | MFSD9 | Gene ID | 670 | 84804 |
Gene name | biphenyl hydrolase like | major facilitator superfamily domain containing 9 | |
Synonyms | BPH-RP|MCNAA|VACVASE | - | |
Cytomap | 6p25.2 | 2q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | valacyclovir hydrolasebiphenyl hydrolase-like (serine hydrolase)biphenyl hydrolase-related proteinbreast epithelial mucin-associated antigenvalacyclovirase | major facilitator superfamily domain-containing protein 9 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q86WA6 | Q8NBP5 | |
Ensembl transtripts involved in fusion gene | ENST00000434640, ENST00000380368, ENST00000380375, ENST00000380379, ENST00000464040, | ENST00000496253, ENST00000258436, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/18*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: BPHL [Title/Abstract] AND MFSD9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW082286 | BPHL | chr6 | 3152995 | - | MFSD9 | chr2 | 103334117 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000434640 | ENST00000496253 | BPHL | chr6 | 3152995 | - | MFSD9 | chr2 | 103334117 | + |
intron-3UTR | ENST00000434640 | ENST00000258436 | BPHL | chr6 | 3152995 | - | MFSD9 | chr2 | 103334117 | + |
3UTR-intron | ENST00000380368 | ENST00000496253 | BPHL | chr6 | 3152995 | - | MFSD9 | chr2 | 103334117 | + |
3UTR-3UTR | ENST00000380368 | ENST00000258436 | BPHL | chr6 | 3152995 | - | MFSD9 | chr2 | 103334117 | + |
3UTR-intron | ENST00000380375 | ENST00000496253 | BPHL | chr6 | 3152995 | - | MFSD9 | chr2 | 103334117 | + |
3UTR-3UTR | ENST00000380375 | ENST00000258436 | BPHL | chr6 | 3152995 | - | MFSD9 | chr2 | 103334117 | + |
3UTR-intron | ENST00000380379 | ENST00000496253 | BPHL | chr6 | 3152995 | - | MFSD9 | chr2 | 103334117 | + |
3UTR-3UTR | ENST00000380379 | ENST00000258436 | BPHL | chr6 | 3152995 | - | MFSD9 | chr2 | 103334117 | + |
3UTR-intron | ENST00000464040 | ENST00000496253 | BPHL | chr6 | 3152995 | - | MFSD9 | chr2 | 103334117 | + |
3UTR-3UTR | ENST00000464040 | ENST00000258436 | BPHL | chr6 | 3152995 | - | MFSD9 | chr2 | 103334117 | + |
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FusionProtFeatures for BPHL_MFSD9 |
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Hgene | Tgene |
BPHL | MFSD9 |
Serine hydrolase that catalyzes the hydrolyticactivation of amino acid ester prodrugs of nucleoside analogs suchas valacyclovir and valganciclovir. Activates valacyclovir toacyclovir. May play a role in detoxification processes. It is aspecific alpha-amino acid ester hydrolase that prefers small,hydrophobic, and aromatic side chains and does not have astringent requirement for the leaving group other than preferringa primary alcohol. {ECO:0000269|PubMed:18256025}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BPHL_MFSD9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BPHL_MFSD9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BPHL_MFSD9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BPHL_MFSD9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |