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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43238

FusionGeneSummary for ZNF345_PTPRH

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF345_PTPRH
Fusion gene ID: 43238
HgeneTgene
Gene symbol

ZNF345

PTPRH

Gene ID

25850

5794

Gene namezinc finger protein 345protein tyrosine phosphatase, receptor type H
SynonymsHZF10R-PTP-H|SAP1
Cytomap

19q13.12

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 345zinc finger protein HZF10receptor-type tyrosine-protein phosphatase Hstomach cancer-associated protein tyrosine phosphatase 1transmembrane-type protein-tyrosine phosphatase type H
Modification date2018052320180519
UniProtAcc

Q14585

Q9HD43

Ensembl transtripts involved in fusion geneENST00000589046, ENST00000420450, 
ENST00000526123, ENST00000432005, 
ENST00000529555, 		ENST00000263434, 
ENST00000376350, ENST00000588559, 
Fusion gene scores* DoF score5 X 3 X 3=453 X 2 X 2=12
# samples 42
** MAII scorelog2(4/45*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF345 [Title/Abstract] AND PTPRH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-TM-A84B-01AZNF345chr19

37342806

+PTPRHchr19

55699536

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000589046ENST00000263434ZNF345chr19

37342806

+PTPRHchr19

55699536

-
5UTR-3CDSENST00000589046ENST00000376350ZNF345chr19

37342806

+PTPRHchr19

55699536

-
5UTR-intronENST00000589046ENST00000588559ZNF345chr19

37342806

+PTPRHchr19

55699536

-
5UTR-3CDSENST00000420450ENST00000263434ZNF345chr19

37342806

+PTPRHchr19

55699536

-
5UTR-3CDSENST00000420450ENST00000376350ZNF345chr19

37342806

+PTPRHchr19

55699536

-
5UTR-intronENST00000420450ENST00000588559ZNF345chr19

37342806

+PTPRHchr19

55699536

-
5UTR-3CDSENST00000526123ENST00000263434ZNF345chr19

37342806

+PTPRHchr19

55699536

-
5UTR-3CDSENST00000526123ENST00000376350ZNF345chr19

37342806

+PTPRHchr19

55699536

-
5UTR-intronENST00000526123ENST00000588559ZNF345chr19

37342806

+PTPRHchr19

55699536

-
3UTR-3CDSENST00000432005ENST00000263434ZNF345chr19

37342806

+PTPRHchr19

55699536

-
3UTR-3CDSENST00000432005ENST00000376350ZNF345chr19

37342806

+PTPRHchr19

55699536

-
3UTR-intronENST00000432005ENST00000588559ZNF345chr19

37342806

+PTPRHchr19

55699536

-
5UTR-3CDSENST00000529555ENST00000263434ZNF345chr19

37342806

+PTPRHchr19

55699536

-
5UTR-3CDSENST00000529555ENST00000376350ZNF345chr19

37342806

+PTPRHchr19

55699536

-
5UTR-intronENST00000529555ENST00000588559ZNF345chr19

37342806

+PTPRHchr19

55699536

-

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FusionProtFeatures for ZNF345_PTPRH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF345

Q14585

PTPRH

Q9HD43

May be involved in transcriptional regulation. Protein phosphatase that may contribute to contactinhibition of cell growth and motility by mediating thedephosphorylation of focal adhesion-associated substrates and thusnegatively regulating integrin-promoted signaling processes.Induces apoptotic cell death by at least two distinct mechanisms:inhibition of cell survival signaling mediated by PI 3-kinase,Akt, and ILK and activation of a caspase-dependent proapoptoticpathway. Inhibits the basal activity of LCK and its activation inresponse to TCR stimulation and TCR-induced activation of MAPkinase and surface expression of CD69. Inhibits TCR-inducedtyrosine phosphorylation of LAT and ZAP70. Inhibits both basalactivity of DOK1 and its CD2-induced tyrosine phosphorylation.Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC.Reduces migratory activity of activity of Jurkat cells. Reducestyrosine phosphorylation of CEACAM20 and thereby contributes tosuppress the intestinal immune response CEACAM20 (By similarity).{ECO:0000250|UniProtKB:E9Q0N2, ECO:0000269|PubMed:11278335,ECO:0000269|PubMed:12101188, ECO:0000269|PubMed:12837766,ECO:0000269|PubMed:15850787}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF345_PTPRH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF345_PTPRH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF345PTPRHBCAR1, PXN, GHR, MLH1, DHPS, KRTAP10-8, KRTAP10-3, EGFR, ERBB3, ERBB4, ERBB2, LRP6, EXOC3, RAB11FIP5, C1orf226, RALGAPA1, ARL13B, NBEA, NOS1AP, RAB11FIP1, RALGAPB, RICTOR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF345_PTPRH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF345_PTPRH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource