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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 43230

FusionGeneSummary for ZNF341_CBFA2T2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF341_CBFA2T2
Fusion gene ID: 43230
HgeneTgene
Gene symbol

ZNF341

CBFA2T2

Gene ID

84905

9139

Gene namezinc finger protein 341CBFA2/RUNX1 translocation partner 2
Synonyms-EHT|MTGR1|ZMYND3|p85
Cytomap

20q11.22

20q11.21-q11.22

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 341protein CBFA2T2ETO homolog on chromosome 20ETO homologous on chromosome 20MTG8-like proteinMTG8-related protein 1core-binding factor, runt domain, alpha subunit 2; translocated to, 2myeloid translocation gene-related protein 1myeloid translocation-
Modification date2018052320180523
UniProtAcc

Q9BYN7

O43439

Ensembl transtripts involved in fusion geneENST00000375200, ENST00000342427, 
ENST00000342704, ENST00000375279, 
ENST00000344201, ENST00000397798, 
ENST00000346541, ENST00000397800, 
ENST00000492345, ENST00000359606, 
ENST00000491618, ENST00000543126, 
Fusion gene scores* DoF score3 X 5 X 4=6011 X 10 X 8=880
# samples 515
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/880*10)=-2.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF341 [Title/Abstract] AND CBFA2T2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCBFA2T2

GO:0010976

positive regulation of neuron projection development

19026687

TgeneCBFA2T2

GO:0045892

negative regulation of transcription, DNA-templated

23251453


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-86-7953-01AZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375200ENST00000342704ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
Frame-shiftENST00000375200ENST00000375279ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000375200ENST00000344201ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000375200ENST00000397798ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000375200ENST00000346541ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000375200ENST00000397800ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000375200ENST00000492345ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000375200ENST00000359606ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000375200ENST00000491618ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000375200ENST00000543126ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
In-frameENST00000342427ENST00000342704ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
Frame-shiftENST00000342427ENST00000375279ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000342427ENST00000344201ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000342427ENST00000397798ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000342427ENST00000346541ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000342427ENST00000397800ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000342427ENST00000492345ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000342427ENST00000359606ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000342427ENST00000491618ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000342427ENST00000543126ZNF341chr20

32358098

+CBFA2T2chr20

32232153

+

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FusionProtFeatures for ZNF341_CBFA2T2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF341

Q9BYN7

CBFA2T2

O43439

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015143_186533848Compositional biasNote=Pro-rich
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015143_186540855Compositional biasNote=Pro-rich
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015322_344533848Zinc fingerC2H2-type 2
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015350_372533848Zinc fingerC2H2-type 3
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015445_467533848Zinc fingerC2H2-type 4
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015473_497533848Zinc fingerC2H2-type 5
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015503_525533848Zinc fingerC2H2-type 6
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+101553_76533848Zinc fingerC2H2-type 1%3B atypical
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015322_344540855Zinc fingerC2H2-type 2
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015350_372540855Zinc fingerC2H2-type 3
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015445_467540855Zinc fingerC2H2-type 4
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015473_497540855Zinc fingerC2H2-type 5
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015503_525540855Zinc fingerC2H2-type 6
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+101553_76540855Zinc fingerC2H2-type 1%3B atypical
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000344201+06451_491-123264Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397798+07451_491-208264Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000344201+0633_97-123264Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397798+0733_97-208264Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000344201+06113_208-123264DomainTAFH
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397798+07113_208-208264DomainTAFH
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000344201+06331_377-123264RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000344201+06435_484-123264RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397798+07331_377-208264RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397798+07435_484-208264RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000342704+911517_553496596Zinc fingerMYND-type
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000344201+06517_553-123264Zinc fingerMYND-type
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000346541+1012517_553505605Zinc fingerMYND-type
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000359606+911517_553515615Zinc fingerMYND-type
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000375279+1012517_553505605Zinc fingerMYND-type
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397798+07517_553-208264Zinc fingerMYND-type
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397800+911517_553476576Zinc fingerMYND-type
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000492345+1113517_553476576Zinc fingerMYND-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015540_564533848Zinc fingerC2H2-type 7
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015566_588533848Zinc fingerC2H2-type 8
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015594_616533848Zinc fingerC2H2-type 9
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015622_644533848Zinc fingerC2H2-type 10
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015650_677533848Zinc fingerC2H2-type 11
HgeneZNF341chr20:32358098chr20:32232153ENST00000342427+1015683_705533848Zinc fingerC2H2-type 12
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015540_564540855Zinc fingerC2H2-type 7
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015566_588540855Zinc fingerC2H2-type 8
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015594_616540855Zinc fingerC2H2-type 9
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015622_644540855Zinc fingerC2H2-type 10
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015650_677540855Zinc fingerC2H2-type 11
HgeneZNF341chr20:32358098chr20:32232153ENST00000375200+1015683_705540855Zinc fingerC2H2-type 12
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000342704+911451_491496596Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000346541+1012451_491505605Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000359606+911451_491515615Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000375279+1012451_491505605Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397800+911451_491476576Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000492345+1113451_491476576Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000342704+91133_97496596Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000346541+101233_97505605Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000359606+91133_97515615Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000375279+101233_97505605Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397800+91133_97476576Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000492345+111333_97476576Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000342704+911113_208496596DomainTAFH
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000346541+1012113_208505605DomainTAFH
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000359606+911113_208515615DomainTAFH
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000375279+1012113_208505605DomainTAFH
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397800+911113_208476576DomainTAFH
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000492345+1113113_208476576DomainTAFH
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000342704+911331_377496596RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000342704+911435_484496596RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000346541+1012331_377505605RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000346541+1012435_484505605RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000359606+911331_377515615RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000359606+911435_484515615RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000375279+1012331_377505605RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000375279+1012435_484505605RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397800+911331_377476576RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397800+911435_484476576RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000492345+1113331_377476576RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000492345+1113435_484476576RegionNervy homology region 3 (NHR3)


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FusionGeneSequence for ZNF341_CBFA2T2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF341_ENST00000375200_chr20_32358098_+_CBFA2T2_ENST00000342704_chr20_32232153_+_640aa
MAQAIFEALEGMDNQTVLAVQSLLDGQGAVPDPTGQSVNAPPAIQPLDDEDVFLCGKCKKQFNSLPAFMTHKREQCQGNAPALATVSLAT
NSIYPPSAAPTAVQQAPTPANRQISTYITVPPSPLIQTLVQGNILVSDDVLMSAMSAFTSLDQPMPQGPPPVQSSLNMHSVPSYLTQPPP
PPPPPPPLPPPPPPQPPPPPPQSLGPPGRPNPGGNGVVEVYSAAAPLAGSGTVEIQALGMQPYPPLEVPNQCVEPPVYPTPTVYSPGKQG
FKPKGPNPAAPMTSATGGTVATFDSPATLKTRRAKGARGLPEAAGKPKAQKLKCSYCDKSFTKNFDLQQHIRSHTGEKPFQCIACGRAFA
QKSNVKKHMQTHKVWPPGHSGGTVSRNSVTVQVMALNPSRQEDEESTGLGQPLPGAPQPQALSTAGEEEGDKPESKQVVLIDSSYLCQFC
PSKFSTYFQLKSHMTQHKNEQVYKCVVKSCAQTFPKLDTFLEHIKSHQEELSYRCHLCGKDFPSLYDLGVHQYSHSLLPQHSPKKDNAVY
KTAGTVAAKPARHAVAAISRDTVALSASTRTGSGTTASVVRTCMARAPTARAGRCFLXAGAPLPGPPTAACPAQPSTRPRQPHRVPQHLL

>In-frame_ZNF341_ENST00000342427_chr20_32358098_+_CBFA2T2_ENST00000342704_chr20_32232153_+_633aa
MAQAIFEALEGMDNQTVLAVQSLLDGQGAVPDPTGQSVNAPPAIQPLDDEDVFLCGKCKKQFNSLPAFMTHKREQCQGNAPALATVSLAT
NSIYPPSAAPTAVQQAPTPANRQISTYITVPPSPLIQTLVQGNILVSDDVLMSAMSAFTSLDQPMPQGPPPVQSSLNMHSVPSYLTQPPP
PPPPPPPLPPPPPPQPPPPPPQSLGPPGRPNPGGNGVVEVYSAAAPLAGSGTVEIQALGMQPYPPLEVPNQCVEPPVYPTPTVYSPGKQG
FKPKGPNPAAPMTSATGGTVATFDSPATLKTRRAKAAGKPKAQKLKCSYCDKSFTKNFDLQQHIRSHTGEKPFQCIACGRAFAQKSNVKK
HMQTHKVWPPGHSGGTVSRNSVTVQVMALNPSRQEDEESTGLGQPLPGAPQPQALSTAGEEEGDKPESKQVVLIDSSYLCQFCPSKFSTY
FQLKSHMTQHKNEQVYKCVVKSCAQTFPKLDTFLEHIKSHQEELSYRCHLCGKDFPSLYDLGVHQYSHSLLPQHSPKKDNAVYKTAGTVA
AKPARHAVAAISRDTVALSASTRTGSGTTASVVRTCMARAPTARAGRCFLXAGAPLPGPPTAACPAQPSTRPRQPHRVPQHLLLXQLSTP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF341_ENST00000375200_chr20_32358098_+_CBFA2T2_ENST00000342704_chr20_32232153_+_1922nt
ATGGCGCAGGCGATCTTTGAGGCCCTGGAGGGAATGGACAATCAGACCGTTCTGGCTGTCCAGTCATTATTGGATGGCCAAGGAGCAGTC
CCTGATCCGACAGGCCAGAGTGTCAATGCGCCCCCTGCTATCCAGCCATTGGATGACGAGGATGTATTTCTCTGCGGGAAGTGTAAGAAG
CAATTCAACTCGCTGCCAGCGTTTATGACCCACAAGCGGGAACAGTGCCAGGGGAATGCCCCCGCCCTGGCCACAGTCTCACTGGCCACC
AACAGCATCTACCCACCTTCGGCAGCACCCACAGCGGTCCAGCAGGCCCCAACTCCTGCCAATCGCCAGATCTCCACATACATCACAGTG
CCCCCGTCCCCACTGATCCAGACCCTGGTGCAGGGGAACATCTTGGTGAGCGATGATGTGCTCATGTCTGCCATGTCAGCCTTCACATCC
CTGGACCAGCCCATGCCCCAGGGCCCCCCACCTGTGCAGAGCAGCCTGAACATGCATTCCGTGCCCAGCTACCTCACCCAGCCTCCACCT
CCTCCTCCACCTCCTCCACCACTGCCCCCACCGCCACCACCTCAGCCTCCACCACCTCCACCCCAGAGCCTGGGCCCCCCTGGGCGTCCC
AACCCTGGTGGGAACGGTGTGGTGGAGGTGTACAGTGCTGCTGCGCCCCTGGCTGGGAGTGGAACGGTGGAGATCCAGGCACTGGGGATG
CAGCCCTACCCACCCCTAGAGGTGCCAAACCAGTGTGTGGAGCCTCCAGTATATCCCACCCCCACAGTGTACAGCCCTGGCAAACAGGGA
TTCAAACCCAAAGGACCAAACCCCGCCGCCCCCATGACCAGCGCCACCGGGGGCACGGTGGCCACCTTTGACTCTCCAGCAACGCTGAAG
ACCCGACGAGCTAAAGGTGCCAGGGGACTCCCGGAAGCTGCAGGGAAGCCAAAGGCTCAGAAACTCAAGTGCTCATACTGTGACAAGTCA
TTCACCAAAAACTTTGACCTGCAGCAGCACATCCGAAGCCACACCGGTGAGAAGCCCTTCCAGTGCATTGCATGTGGCCGTGCCTTTGCC
CAGAAGTCTAATGTTAAGAAACACATGCAGACCCACAAGGTGTGGCCTCCAGGACACAGTGGTGGCACCGTGTCTCGAAACTCTGTGACC
GTACAGGTCATGGCCCTGAACCCCAGCAGGCAGGAGGACGAGGAAAGCACAGGGTTGGGCCAGCCCCTGCCGGGTGCGCCACAGCCCCAG
GCCTTGTCCACAGCTGGTGAGGAAGAGGGGGACAAGCCGGAGTCCAAGCAGGTGGTCCTCATCGACAGCTCCTACCTGTGCCAATTCTGC
CCCAGCAAATTCAGCACCTACTTCCAGCTCAAGTCTCACATGACCCAGCATAAGAATGAGCAGGTGTACAAGTGTGTGGTCAAAAGCTGT
GCCCAGACGTTCCCAAAGCTCGACACATTTCTGGAGCACATCAAGAGCCACCAGGAGGAGCTGAGCTACCGCTGCCACCTCTGCGGCAAG
GACTTCCCCTCGCTGTACGACCTGGGCGTGCACCAGTACTCCCACAGCCTCCTGCCACAGCACAGCCCCAAGAAGGACAATGCCGTCTAC
AAAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGG
ACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGG
GCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTT

>In-frame_ZNF341_ENST00000342427_chr20_32358098_+_CBFA2T2_ENST00000342704_chr20_32232153_+_1901nt
ATGGCGCAGGCGATCTTTGAGGCCCTGGAGGGAATGGACAATCAGACCGTTCTGGCTGTCCAGTCATTATTGGATGGCCAAGGAGCAGTC
CCTGATCCGACAGGCCAGAGTGTCAATGCGCCCCCTGCTATCCAGCCATTGGATGACGAGGATGTATTTCTCTGCGGGAAGTGTAAGAAG
CAATTCAACTCGCTGCCAGCGTTTATGACCCACAAGCGGGAACAGTGCCAGGGGAATGCCCCCGCCCTGGCCACAGTCTCACTGGCCACC
AACAGCATCTACCCACCTTCGGCAGCACCCACAGCGGTCCAGCAGGCCCCAACTCCTGCCAATCGCCAGATCTCCACATACATCACAGTG
CCCCCGTCCCCACTGATCCAGACCCTGGTGCAGGGGAACATCTTGGTGAGCGATGATGTGCTCATGTCTGCCATGTCAGCCTTCACATCC
CTGGACCAGCCCATGCCCCAGGGCCCCCCACCTGTGCAGAGCAGCCTGAACATGCATTCCGTGCCCAGCTACCTCACCCAGCCTCCACCT
CCTCCTCCACCTCCTCCACCACTGCCCCCACCGCCACCACCTCAGCCTCCACCACCTCCACCCCAGAGCCTGGGCCCCCCTGGGCGTCCC
AACCCTGGTGGGAACGGTGTGGTGGAGGTGTACAGTGCTGCTGCGCCCCTGGCTGGGAGTGGAACGGTGGAGATCCAGGCACTGGGGATG
CAGCCCTACCCACCCCTAGAGGTGCCAAACCAGTGTGTGGAGCCTCCAGTATATCCCACCCCCACAGTGTACAGCCCTGGCAAACAGGGA
TTCAAACCCAAAGGACCAAACCCCGCCGCCCCCATGACCAGCGCCACCGGGGGCACGGTGGCCACCTTTGACTCTCCAGCAACGCTGAAG
ACCCGACGAGCTAAAGCTGCAGGGAAGCCAAAGGCTCAGAAACTCAAGTGCTCATACTGTGACAAGTCATTCACCAAAAACTTTGACCTG
CAGCAGCACATCCGAAGCCACACCGGTGAGAAGCCCTTCCAGTGCATTGCATGTGGCCGTGCCTTTGCCCAGAAGTCTAATGTTAAGAAA
CACATGCAGACCCACAAGGTGTGGCCTCCAGGACACAGTGGTGGCACCGTGTCTCGAAACTCTGTGACCGTACAGGTCATGGCCCTGAAC
CCCAGCAGGCAGGAGGACGAGGAAAGCACAGGGTTGGGCCAGCCCCTGCCGGGTGCGCCACAGCCCCAGGCCTTGTCCACAGCTGGTGAG
GAAGAGGGGGACAAGCCGGAGTCCAAGCAGGTGGTCCTCATCGACAGCTCCTACCTGTGCCAATTCTGCCCCAGCAAATTCAGCACCTAC
TTCCAGCTCAAGTCTCACATGACCCAGCATAAGAATGAGCAGGTGTACAAGTGTGTGGTCAAAAGCTGTGCCCAGACGTTCCCAAAGCTC
GACACATTTCTGGAGCACATCAAGAGCCACCAGGAGGAGCTGAGCTACCGCTGCCACCTCTGCGGCAAGGACTTCCCCTCGCTGTACGAC
CTGGGCGTGCACCAGTACTCCCACAGCCTCCTGCCACAGCACAGCCCCAAGAAGGACAATGCCGTCTACAAAACTGCTGGAACTGTGGCC
GCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCC
TCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCG
ACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF341_ENST00000375200_chr20_32358098_+_CBFA2T2_ENST00000342704_chr20_32232153_+_3182nt
ACGTGCTGTGGGAATGGGGGATTCTGTGTCAGAGCTGGGGGGTCGGGTCCGGTGAGATGGGGATGCGGATTTAGATAATAGGGATGGGAA
GTTCCGCGTGTGCGGCGGATATAAGGTCGGTGTAGACTTGGTCGTTCAAGTGAGGCGGGGTCCACACTCGGTGGCCCGGTGACTGGGTTA
TCGAGTGGAGCCAGGGCAGCCCAGAGATGCTGGGGTCCCGCGAGCCTAGGTTGGGTTTCCAGGGCTGGGGGCTCGGCGGCGGCTCCTGGG
CGCCCCCTGGCGGCCCCGACTCAACCGCCACGGCTCCCACAATGCTCGCGTAGCCGGGCTTCGGTTCCTGTGGCGGCGACGGCGGCGGCT
CCAAGATGGCGCAGGCGATCTTTGAGGCCCTGGAGGGAATGGACAATCAGACCGTTCTGGCTGTCCAGTCATTATTGGATGGCCAAGGAG
CAGTCCCTGATCCGACAGGCCAGAGTGTCAATGCGCCCCCTGCTATCCAGCCATTGGATGACGAGGATGTATTTCTCTGCGGGAAGTGTA
AGAAGCAATTCAACTCGCTGCCAGCGTTTATGACCCACAAGCGGGAACAGTGCCAGGGGAATGCCCCCGCCCTGGCCACAGTCTCACTGG
CCACCAACAGCATCTACCCACCTTCGGCAGCACCCACAGCGGTCCAGCAGGCCCCAACTCCTGCCAATCGCCAGATCTCCACATACATCA
CAGTGCCCCCGTCCCCACTGATCCAGACCCTGGTGCAGGGGAACATCTTGGTGAGCGATGATGTGCTCATGTCTGCCATGTCAGCCTTCA
CATCCCTGGACCAGCCCATGCCCCAGGGCCCCCCACCTGTGCAGAGCAGCCTGAACATGCATTCCGTGCCCAGCTACCTCACCCAGCCTC
CACCTCCTCCTCCACCTCCTCCACCACTGCCCCCACCGCCACCACCTCAGCCTCCACCACCTCCACCCCAGAGCCTGGGCCCCCCTGGGC
GTCCCAACCCTGGTGGGAACGGTGTGGTGGAGGTGTACAGTGCTGCTGCGCCCCTGGCTGGGAGTGGAACGGTGGAGATCCAGGCACTGG
GGATGCAGCCCTACCCACCCCTAGAGGTGCCAAACCAGTGTGTGGAGCCTCCAGTATATCCCACCCCCACAGTGTACAGCCCTGGCAAAC
AGGGATTCAAACCCAAAGGACCAAACCCCGCCGCCCCCATGACCAGCGCCACCGGGGGCACGGTGGCCACCTTTGACTCTCCAGCAACGC
TGAAGACCCGACGAGCTAAAGGTGCCAGGGGACTCCCGGAAGCTGCAGGGAAGCCAAAGGCTCAGAAACTCAAGTGCTCATACTGTGACA
AGTCATTCACCAAAAACTTTGACCTGCAGCAGCACATCCGAAGCCACACCGGTGAGAAGCCCTTCCAGTGCATTGCATGTGGCCGTGCCT
TTGCCCAGAAGTCTAATGTTAAGAAACACATGCAGACCCACAAGGTGTGGCCTCCAGGACACAGTGGTGGCACCGTGTCTCGAAACTCTG
TGACCGTACAGGTCATGGCCCTGAACCCCAGCAGGCAGGAGGACGAGGAAAGCACAGGGTTGGGCCAGCCCCTGCCGGGTGCGCCACAGC
CCCAGGCCTTGTCCACAGCTGGTGAGGAAGAGGGGGACAAGCCGGAGTCCAAGCAGGTGGTCCTCATCGACAGCTCCTACCTGTGCCAAT
TCTGCCCCAGCAAATTCAGCACCTACTTCCAGCTCAAGTCTCACATGACCCAGCATAAGAATGAGCAGGTGTACAAGTGTGTGGTCAAAA
GCTGTGCCCAGACGTTCCCAAAGCTCGACACATTTCTGGAGCACATCAAGAGCCACCAGGAGGAGCTGAGCTACCGCTGCCACCTCTGCG
GCAAGGACTTCCCCTCGCTGTACGACCTGGGCGTGCACCAGTACTCCCACAGCCTCCTGCCACAGCACAGCCCCAAGAAGGACAATGCCG
TCTACAAAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCA
CAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGG
CAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACC
TGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGC
TGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAA
TAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTC
CATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCC
TTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGA
GCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGC
AACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAA
AAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTA
CTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAG
GCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAA

>In-frame_ZNF341_ENST00000342427_chr20_32358098_+_CBFA2T2_ENST00000342704_chr20_32232153_+_3161nt
ACGTGCTGTGGGAATGGGGGATTCTGTGTCAGAGCTGGGGGGTCGGGTCCGGTGAGATGGGGATGCGGATTTAGATAATAGGGATGGGAA
GTTCCGCGTGTGCGGCGGATATAAGGTCGGTGTAGACTTGGTCGTTCAAGTGAGGCGGGGTCCACACTCGGTGGCCCGGTGACTGGGTTA
TCGAGTGGAGCCAGGGCAGCCCAGAGATGCTGGGGTCCCGCGAGCCTAGGTTGGGTTTCCAGGGCTGGGGGCTCGGCGGCGGCTCCTGGG
CGCCCCCTGGCGGCCCCGACTCAACCGCCACGGCTCCCACAATGCTCGCGTAGCCGGGCTTCGGTTCCTGTGGCGGCGACGGCGGCGGCT
CCAAGATGGCGCAGGCGATCTTTGAGGCCCTGGAGGGAATGGACAATCAGACCGTTCTGGCTGTCCAGTCATTATTGGATGGCCAAGGAG
CAGTCCCTGATCCGACAGGCCAGAGTGTCAATGCGCCCCCTGCTATCCAGCCATTGGATGACGAGGATGTATTTCTCTGCGGGAAGTGTA
AGAAGCAATTCAACTCGCTGCCAGCGTTTATGACCCACAAGCGGGAACAGTGCCAGGGGAATGCCCCCGCCCTGGCCACAGTCTCACTGG
CCACCAACAGCATCTACCCACCTTCGGCAGCACCCACAGCGGTCCAGCAGGCCCCAACTCCTGCCAATCGCCAGATCTCCACATACATCA
CAGTGCCCCCGTCCCCACTGATCCAGACCCTGGTGCAGGGGAACATCTTGGTGAGCGATGATGTGCTCATGTCTGCCATGTCAGCCTTCA
CATCCCTGGACCAGCCCATGCCCCAGGGCCCCCCACCTGTGCAGAGCAGCCTGAACATGCATTCCGTGCCCAGCTACCTCACCCAGCCTC
CACCTCCTCCTCCACCTCCTCCACCACTGCCCCCACCGCCACCACCTCAGCCTCCACCACCTCCACCCCAGAGCCTGGGCCCCCCTGGGC
GTCCCAACCCTGGTGGGAACGGTGTGGTGGAGGTGTACAGTGCTGCTGCGCCCCTGGCTGGGAGTGGAACGGTGGAGATCCAGGCACTGG
GGATGCAGCCCTACCCACCCCTAGAGGTGCCAAACCAGTGTGTGGAGCCTCCAGTATATCCCACCCCCACAGTGTACAGCCCTGGCAAAC
AGGGATTCAAACCCAAAGGACCAAACCCCGCCGCCCCCATGACCAGCGCCACCGGGGGCACGGTGGCCACCTTTGACTCTCCAGCAACGC
TGAAGACCCGACGAGCTAAAGCTGCAGGGAAGCCAAAGGCTCAGAAACTCAAGTGCTCATACTGTGACAAGTCATTCACCAAAAACTTTG
ACCTGCAGCAGCACATCCGAAGCCACACCGGTGAGAAGCCCTTCCAGTGCATTGCATGTGGCCGTGCCTTTGCCCAGAAGTCTAATGTTA
AGAAACACATGCAGACCCACAAGGTGTGGCCTCCAGGACACAGTGGTGGCACCGTGTCTCGAAACTCTGTGACCGTACAGGTCATGGCCC
TGAACCCCAGCAGGCAGGAGGACGAGGAAAGCACAGGGTTGGGCCAGCCCCTGCCGGGTGCGCCACAGCCCCAGGCCTTGTCCACAGCTG
GTGAGGAAGAGGGGGACAAGCCGGAGTCCAAGCAGGTGGTCCTCATCGACAGCTCCTACCTGTGCCAATTCTGCCCCAGCAAATTCAGCA
CCTACTTCCAGCTCAAGTCTCACATGACCCAGCATAAGAATGAGCAGGTGTACAAGTGTGTGGTCAAAAGCTGTGCCCAGACGTTCCCAA
AGCTCGACACATTTCTGGAGCACATCAAGAGCCACCAGGAGGAGCTGAGCTACCGCTGCCACCTCTGCGGCAAGGACTTCCCCTCGCTGT
ACGACCTGGGCGTGCACCAGTACTCCCACAGCCTCCTGCCACAGCACAGCCCCAAGAAGGACAATGCCGTCTACAAAACTGCTGGAACTG
TGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCA
CCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTC
CGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGA
CACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAAC
CCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTG
TGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTC
CTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAA
TGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAA
TAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTC
TTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAA
CATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTT
TTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGT
TTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTAT


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FusionGenePPI for ZNF341_CBFA2T2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF341ARNT2, CSTF2, MAGEB4, WDYHV1, KLHL38, CENPP, ZDHHC17CBFA2T2WDYHV1, MDFI, RUNX1T1, CBFA2T3, TAL1, RUNX1, GTF2E1, ID3, NEUROG1, TAL2, FBXL19, PRDM14, SIN3A, NCOR1, HDAC3, ATN1, ATXN1L, RERE, APP, LBP, TCP1, CBFA2T2, PDP1, NOTCH3, PRDM6, TCF4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000344201+06107_215-123264PRDM14
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397798+07107_215-208264PRDM14


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000342704+911107_215496596PRDM14
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000346541+1012107_215505605PRDM14
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000359606+911107_215515615PRDM14
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000375279+1012107_215505605PRDM14
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000397800+911107_215476576PRDM14
TgeneCBFA2T2chr20:32358098chr20:32232153ENST00000492345+1113107_215476576PRDM14


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF341_CBFA2T2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF341_CBFA2T2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource