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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43203

FusionGeneSummary for ZNF321P_ERGIC3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF321P_ERGIC3
Fusion gene ID: 43203
HgeneTgene
Gene symbol

ZNF321P

ERGIC3

Gene ID

399669

51614

Gene namezinc finger protein 321, pseudogeneERGIC and golgi 3
SynonymsZNF321C20orf47|C2orf47|CGI-54|Erv46|NY-BR-84|PRO0989|SDBCAG84|dJ477O4.2
Cytomap

19q13.41

20q11.22

Type of genepseudoprotein-coding
Description-endoplasmic reticulum-Golgi intermediate compartment protein 3endoplasmic reticulum-localized protein ERp43serologically defined breast cancer antigen 84serologically defined breast cancer antigen NY-BR-84
Modification date2018032920180523
UniProtAcc

Q8N8H1

Q9Y282

Ensembl transtripts involved in fusion geneENST00000391777, ENST00000348547, 
ENST00000357394, ENST00000279052, 
ENST00000447986, ENST00000482338, 
Fusion gene scores* DoF score2 X 1 X 2=46 X 6 X 3=108
# samples 28
** MAII scorelog2(2/4*10)=2.32192809488736log2(8/108*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF321P [Title/Abstract] AND ERGIC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A03L-01AZNF321Pchr19

53445794

-ERGIC3chr20

34130072

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000391777ENST00000348547ZNF321Pchr19

53445794

-ERGIC3chr20

34130072

+
intron-3CDSENST00000391777ENST00000357394ZNF321Pchr19

53445794

-ERGIC3chr20

34130072

+
intron-3CDSENST00000391777ENST00000279052ZNF321Pchr19

53445794

-ERGIC3chr20

34130072

+
intron-3CDSENST00000391777ENST00000447986ZNF321Pchr19

53445794

-ERGIC3chr20

34130072

+
intron-intronENST00000391777ENST00000482338ZNF321Pchr19

53445794

-ERGIC3chr20

34130072

+

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FusionProtFeatures for ZNF321P_ERGIC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF321P

Q8N8H1

ERGIC3

Q9Y282

Possible role in transport between endoplasmic reticulumand Golgi. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF321P_ERGIC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF321P_ERGIC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF321PERGIC3ERGIC1, CPSF7, COX16, PXMP2, ATP1A3, TMEM87A, SLC30A9, DNAJC11, FLVCR1, PARL, MFAP3, TMEM192, FAR2, ARV1, CLPTM1, ABCB6, SLC38A10, SLC26A2, EXT1, PSEN2, TMEM246, AGPAT6, STOM, STARD3, VMP1, ERGIC2, ANKRD13D, ANKRD13A, LMBRD2, TMEM184B, SLC25A17, TMEM223, CHPT1, GK, NDC1, PIGU, BDH1, SFXN5, WRB, TMEM186, PAM16, NR2F2, RER1, YIPF3, SLC16A13, SLC25A46, SGPP1, BSCL2, PTPMT1, DOLK, MTFP1, ALG3, TCTN3, COPG1, ZFPL1, SLC22A6, SPPL2B, VAC14, GPR114, SLC25A6, CHRND, C19orf52, SSR1, SLC39A8, TRAPPC5, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF321P_ERGIC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF321P_ERGIC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource