	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 43144

FusionGeneSummary for ZNF266_MECOM

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF266_MECOM
	Fusion gene ID: 43144
		Hgene	Tgene
	Gene symbol	ZNF266	MECOM
	Gene ID	10781	2122
	Gene name	zinc finger protein 266	MDS1 and EVI1 complex locus
	Synonyms	HZF1	AML1-EVI-1\|EVI1\|KMT8E\|MDS1\|MDS1-EVI1\|PRDM3\|RUSAT2
	Cytomap	19p13.2	3q26.2
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 266zinc finger protein 1zinc finger protein HZF1	MDS1 and EVI1 complex locus proteinMDS1 and EVI1 complex locus protein EVI1AML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein 1onc
	Modification date	20180523	20180522
	UniProtAcc	Q14584	Q03112
	Ensembl transtripts involved in fusion gene	ENST00000361151, ENST00000361451, ENST00000588933, ENST00000588221, ENST00000592904, ENST00000590306, ENST00000592292, ENST00000588013,	ENST00000264674, ENST00000392736, ENST00000464456, ENST00000472280, ENST00000494292, ENST00000468789, ENST00000460814, ENST00000433243, ENST00000485957,
Fusion gene scores	* DoF score	4 X 5 X 3=60	8 X 7 X 6=336
	# samples	4	10
	** MAII score	log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/336*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF266 [Title/Abstract] AND MECOM [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MECOM	GO:0045892	negative regulation of transcription, DNA-templated	10856240\|11568182
Tgene	MECOM	GO:0045893	positive regulation of transcription, DNA-templated	11568182\|19767769
Tgene	MECOM	GO:0051726	regulation of cell cycle	11568182

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF917110	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000361151	ENST00000264674	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361151	ENST00000392736	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361151	ENST00000464456	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361151	ENST00000472280	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361151	ENST00000494292	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361151	ENST00000468789	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361151	ENST00000460814	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361151	ENST00000433243	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361151	ENST00000485957	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361451	ENST00000264674	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361451	ENST00000392736	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361451	ENST00000464456	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361451	ENST00000472280	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361451	ENST00000494292	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361451	ENST00000468789	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361451	ENST00000460814	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361451	ENST00000433243	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000361451	ENST00000485957	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588933	ENST00000264674	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588933	ENST00000392736	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588933	ENST00000464456	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588933	ENST00000472280	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588933	ENST00000494292	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588933	ENST00000468789	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588933	ENST00000460814	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588933	ENST00000433243	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588933	ENST00000485957	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588221	ENST00000264674	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588221	ENST00000392736	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588221	ENST00000464456	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588221	ENST00000472280	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588221	ENST00000494292	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588221	ENST00000468789	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588221	ENST00000460814	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588221	ENST00000433243	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588221	ENST00000485957	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592904	ENST00000264674	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592904	ENST00000392736	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592904	ENST00000464456	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592904	ENST00000472280	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592904	ENST00000494292	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592904	ENST00000468789	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592904	ENST00000460814	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592904	ENST00000433243	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592904	ENST00000485957	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000590306	ENST00000264674	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000590306	ENST00000392736	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000590306	ENST00000464456	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000590306	ENST00000472280	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000590306	ENST00000494292	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000590306	ENST00000468789	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000590306	ENST00000460814	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000590306	ENST00000433243	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000590306	ENST00000485957	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592292	ENST00000264674	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592292	ENST00000392736	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592292	ENST00000464456	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592292	ENST00000472280	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592292	ENST00000494292	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592292	ENST00000468789	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592292	ENST00000460814	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592292	ENST00000433243	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000592292	ENST00000485957	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588013	ENST00000264674	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588013	ENST00000392736	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588013	ENST00000464456	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588013	ENST00000472280	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588013	ENST00000494292	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588013	ENST00000468789	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588013	ENST00000460814	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588013	ENST00000433243	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+
intron-intron	ENST00000588013	ENST00000485957	ZNF266	chr19	9524224	-	MECOM	chr3	169326285	+

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FusionProtFeatures for ZNF266_MECOM

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF266 Q14584	MECOM Q03112
May be involved in transcriptional regulation.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ZNF266_MECOM

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF266_MECOM

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ZNF266_MECOM

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZNF266_MECOM

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	MECOM	C0009375	Colonic Neoplasms	1	CTD_human
Tgene	MECOM	C0023448	Lymphoid leukemia	1	CTD_human
Tgene	MECOM	C0023470	Myeloid Leukemia	1	CTD_human
Tgene	MECOM	C0027439	Nasopharyngeal Neoplasms	1	CTD_human
Tgene	MECOM	C0919267	ovarian neoplasm	1	CTD_human
Tgene	MECOM	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	MECOM	C4225221	RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 2	1	UNIPROT

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Fusion gene ID: 43144

FusionGeneSummary for ZNF266_MECOM

FusionProtFeatures for ZNF266_MECOM

FusionGeneSequence for ZNF266_MECOM

FusionGenePPI for ZNF266_MECOM

RelatedDrugs for ZNF266_MECOM

RelatedDiseases for ZNF266_MECOM