FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 43135

FusionGeneSummary for ZNF257_TRHDE

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF257_TRHDE
Fusion gene ID: 43135
HgeneTgene
Gene symbol

ZNF257

TRHDE

Gene ID

113835

29953

Gene namezinc finger protein 257thyrotropin releasing hormone degrading enzyme
SynonymsBMZF-4|BMZF4PAP-II|PGPEP2|TRH-DE
Cytomap

19p12

12q21.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 257bone marrow zinc finger 4thyrotropin-releasing hormone-degrading ectoenzymeTRH-degrading ectoenzymeTRH-specific aminopeptidasepyroglutamyl aminopeptidase IIpyroglutamyl-peptidase IIthyroliberinase
Modification date2018051920180523
UniProtAcc

Q9Y2Q1

Q9UKU6

Ensembl transtripts involved in fusion geneENST00000594947, ENST00000596471, 
ENST00000600162, 
ENST00000261180, 
ENST00000549138, 
Fusion gene scores* DoF score2 X 1 X 2=414 X 6 X 5=420
# samples 213
** MAII scorelog2(2/4*10)=2.32192809488736log2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF257 [Title/Abstract] AND TRHDE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AC-A7VB-01AZNF257chr19

22235437

+TRHDEchr12

72863538

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000594947ENST00000261180ZNF257chr19

22235437

+TRHDEchr12

72863538

+
5CDS-intronENST00000594947ENST00000549138ZNF257chr19

22235437

+TRHDEchr12

72863538

+
3UTR-3CDSENST00000596471ENST00000261180ZNF257chr19

22235437

+TRHDEchr12

72863538

+
3UTR-intronENST00000596471ENST00000549138ZNF257chr19

22235437

+TRHDEchr12

72863538

+
Frame-shiftENST00000600162ENST00000261180ZNF257chr19

22235437

+TRHDEchr12

72863538

+
5CDS-intronENST00000600162ENST00000549138ZNF257chr19

22235437

+TRHDEchr12

72863538

+

Top

FusionProtFeatures for ZNF257_TRHDE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF257

Q9Y2Q1

TRHDE

Q9UKU6

May be involved in transcriptional regulation. Specific inactivation of TRH after its release.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZNF257_TRHDE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZNF257_TRHDE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF257HIST1H3ATRHDEAKT1, EGFR, MUL1, TSPAN3, DNAJB9, LEMD3, EMILIN2, MANEA, FKBP14, KIRREL, CANX, TMTC3, MESDC2, MAN1A2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZNF257_TRHDE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZNF257_TRHDE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource