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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43134

FusionGeneSummary for ZNF257_ARIH2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF257_ARIH2
Fusion gene ID: 43134
HgeneTgene
Gene symbol

ZNF257

ARIH2

Gene ID

113835

10425

Gene namezinc finger protein 257ariadne RBR E3 ubiquitin protein ligase 2
SynonymsBMZF-4|BMZF4ARI2|TRIAD1
Cytomap

19p12

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 257bone marrow zinc finger 4E3 ubiquitin-protein ligase ARIH2RING-type E3 ubiquitin transferase ARIH2all-trans retinoic acid inducible RING fingerariadne homolog 2protein ariadne-2 homolog
Modification date2018051920180523
UniProtAcc

Q9Y2Q1

O95376

Ensembl transtripts involved in fusion geneENST00000594947, ENST00000596471, 
ENST00000600162, 
ENST00000356401, 
ENST00000449376, ENST00000490095, 
Fusion gene scores* DoF score2 X 1 X 2=49 X 10 X 4=360
# samples 211
** MAII scorelog2(2/4*10)=2.32192809488736log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF257 [Title/Abstract] AND ARIH2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARIH2

GO:0000209

protein polyubiquitination

16118314|19340006

TgeneARIH2

GO:0006511

ubiquitin-dependent protein catabolic process

16118314

TgeneARIH2

GO:0016567

protein ubiquitination

24076655

TgeneARIH2

GO:0048588

developmental cell growth

19340006

TgeneARIH2

GO:0070534

protein K63-linked ubiquitination

19340006

TgeneARIH2

GO:0070936

protein K48-linked ubiquitination

16118314|19340006

TgeneARIH2

GO:0071425

hematopoietic stem cell proliferation

16118314|19340006


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-D7-6527-01AZNF257chr19

22235437

+ARIH2chr3

49016915

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000594947ENST00000356401ZNF257chr19

22235437

+ARIH2chr3

49016915

+
Frame-shiftENST00000594947ENST00000449376ZNF257chr19

22235437

+ARIH2chr3

49016915

+
5CDS-3UTRENST00000594947ENST00000490095ZNF257chr19

22235437

+ARIH2chr3

49016915

+
3UTR-3CDSENST00000596471ENST00000356401ZNF257chr19

22235437

+ARIH2chr3

49016915

+
3UTR-3CDSENST00000596471ENST00000449376ZNF257chr19

22235437

+ARIH2chr3

49016915

+
3UTR-3UTRENST00000596471ENST00000490095ZNF257chr19

22235437

+ARIH2chr3

49016915

+
Frame-shiftENST00000600162ENST00000356401ZNF257chr19

22235437

+ARIH2chr3

49016915

+
Frame-shiftENST00000600162ENST00000449376ZNF257chr19

22235437

+ARIH2chr3

49016915

+
5CDS-3UTRENST00000600162ENST00000490095ZNF257chr19

22235437

+ARIH2chr3

49016915

+

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FusionProtFeatures for ZNF257_ARIH2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF257

Q9Y2Q1

ARIH2

O95376

May be involved in transcriptional regulation. E3 ubiquitin-protein ligase, which catalyzesubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546,PubMed:19340006, PubMed:24076655). Acts as an atypical E3ubiquitin-protein ligase by working together with cullin-5-RINGubiquitin ligase complex (ECS complex, also named CRL5 complex)and initiating ubiquitination of ECS substrates: associates withECS complex and specifically mediates addition of the firstubiquitin on ECS targets (By similarity). The initial ubiquitin isthen elongated (By similarity). E3 ubiquitin-protein ligaseactivity is activated upon binding to neddylated form of the ECScomplex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546,PubMed:19340006). May play a role in myelopoiesis(PubMed:19340006). {ECO:0000250|UniProtKB:Q9Y4X5,ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546,ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF257_ARIH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF257_ARIH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF257HIST1H3AARIH2UGP2, BUB1, EML4, WDR91, KCNQ2, LOC147791, SGCE, CBR3, ENSA, IL4R, PPP2R1A, SLC1A6, ARAP1, DLST, KAT5, SCAMP2, UTP14A, KIAA1377, PTN, RPL8, TP53, EEF1A1, EEF1G, UBE2L3, GFI1, UBE2L6, UBE2E2, UBE2T, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2V1, UBE2R2, DISC1, PML, UBE2N, UBC, MDM2, NOTCH1, VCP, TRIM27, PHF7, RHEB, CUL5, NEDD8, ARIH2, APEX1, EHD1, PAPSS2, PARP6, PDLIM1, HK2, NUBP1, TWF2, PABPN1, REL, CCDC33, TCEB2, TCEB1, SOCS6, RAB40A, ASB9, ZFP41, NTRK1, BMX, TULP3, WSB2, PYCARD, NLRP3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF257_ARIH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF257_ARIH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource