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Fusion gene ID: 43133 |
FusionGeneSummary for ZNF254_TTBK1 |
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Fusion gene information | Fusion gene name: ZNF254_TTBK1 | Fusion gene ID: 43133 | Hgene | Tgene | Gene symbol | ZNF254 | TTBK1 | Gene ID | 9534 | 84630 |
Gene name | zinc finger protein 254 | tau tubulin kinase 1 | |
Synonyms | BMZF-5|HD-ZNF1|ZNF539|ZNF91L | BDTK | |
Cytomap | 19p12 | 6p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 254CTD-2017D11.1bone marrow zinc finger 5hematopoietic cell-derived zinc finger protein 1zinc finger protein 539 | tau-tubulin kinase 1brain-derived tau kinase | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | O75437 | Q5TCY1 | |
Ensembl transtripts involved in fusion gene | ENST00000342944, ENST00000339642, ENST00000357002, | ENST00000259750, ENST00000304139, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 3=27 |
# samples | 3 | 3 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF254 [Title/Abstract] AND TTBK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TTBK1 | GO:0018105 | peptidyl-serine phosphorylation | 16923168 |
Tgene | TTBK1 | GO:0018107 | peptidyl-threonine phosphorylation | 16923168 |
Tgene | TTBK1 | GO:0018108 | peptidyl-tyrosine phosphorylation | 16923168 |
Tgene | TTBK1 | GO:0032273 | positive regulation of protein polymerization | 16923168 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-44-7671-01A | ZNF254 | chr19 | 24289445 | + | TTBK1 | chr6 | 43250465 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000342944 | ENST00000259750 | ZNF254 | chr19 | 24289445 | + | TTBK1 | chr6 | 43250465 | + |
intron-intron | ENST00000342944 | ENST00000304139 | ZNF254 | chr19 | 24289445 | + | TTBK1 | chr6 | 43250465 | + |
Frame-shift | ENST00000339642 | ENST00000259750 | ZNF254 | chr19 | 24289445 | + | TTBK1 | chr6 | 43250465 | + |
5CDS-intron | ENST00000339642 | ENST00000304139 | ZNF254 | chr19 | 24289445 | + | TTBK1 | chr6 | 43250465 | + |
Frame-shift | ENST00000357002 | ENST00000259750 | ZNF254 | chr19 | 24289445 | + | TTBK1 | chr6 | 43250465 | + |
5CDS-intron | ENST00000357002 | ENST00000304139 | ZNF254 | chr19 | 24289445 | + | TTBK1 | chr6 | 43250465 | + |
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FusionProtFeatures for ZNF254_TTBK1 |
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Hgene | Tgene |
ZNF254 | TTBK1 |
May be involved in transcriptional regulation. | Serine/threonine kinase which is able to phosphorylateTAU on serine, threonine and tyrosine residues. Inducesaggregation of TAU. {ECO:0000269|PubMed:16923168}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF254_TTBK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF254_TTBK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF254 | TRIM44, TRIM28, ZNF479, CYP24A1, TRIM24 | TTBK1 | TTBK2, NUP205, GABARAPL2, HEATR1, MAGI2, DLST |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF254_TTBK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF254_TTBK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |