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Fusion gene ID: 43131 |
FusionGeneSummary for ZNF254_ETFB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF254_ETFB | Fusion gene ID: 43131 | Hgene | Tgene | Gene symbol | ZNF254 | ETFB | Gene ID | 9534 | 2109 |
| Gene name | zinc finger protein 254 | electron transfer flavoprotein subunit beta | |
| Synonyms | BMZF-5|HD-ZNF1|ZNF539|ZNF91L | FP585|MADD | |
| Cytomap | 19p12 | 19q13.41 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 254CTD-2017D11.1bone marrow zinc finger 5hematopoietic cell-derived zinc finger protein 1zinc finger protein 539 | electron transfer flavoprotein subunit betabeta-ETFelectron transfer flavoprotein beta subunitelectron transfer flavoprotein, beta polypeptideelectron-transferring-flavoprotein, beta polypeptide | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | O75437 | P38117 | |
| Ensembl transtripts involved in fusion gene | ENST00000342944, ENST00000339642, ENST00000357002, | ENST00000354232, ENST00000309244, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 1 X 2=4 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: ZNF254 [Title/Abstract] AND ETFB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ETFB | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase | 25416781 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-19-A6J5-01A | ZNF254 | chr19 | 24270139 | + | ETFB | chr19 | 51857562 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000342944 | ENST00000354232 | ZNF254 | chr19 | 24270139 | + | ETFB | chr19 | 51857562 | - |
| intron-3CDS | ENST00000342944 | ENST00000309244 | ZNF254 | chr19 | 24270139 | + | ETFB | chr19 | 51857562 | - |
| In-frame | ENST00000339642 | ENST00000354232 | ZNF254 | chr19 | 24270139 | + | ETFB | chr19 | 51857562 | - |
| In-frame | ENST00000339642 | ENST00000309244 | ZNF254 | chr19 | 24270139 | + | ETFB | chr19 | 51857562 | - |
| In-frame | ENST00000357002 | ENST00000354232 | ZNF254 | chr19 | 24270139 | + | ETFB | chr19 | 51857562 | - |
| In-frame | ENST00000357002 | ENST00000309244 | ZNF254 | chr19 | 24270139 | + | ETFB | chr19 | 51857562 | - |
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FusionProtFeatures for ZNF254_ETFB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF254 | ETFB |
| May be involved in transcriptional regulation. | Heterodimeric electron transfer flavoprotein thataccepts electrons from several mitochondrial dehydrogenases,including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosinedehydrogenase (PubMed:25416781, PubMed:15159392, PubMed:15975918).It transfers the electrons to the main mitochondrial respiratorychain via ETF-ubiquinone oxidoreductase (Probable). Required fornormal mitochondrial fatty acid oxidation and normal amino acidmetabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMPmolecule that probably has a purely structural role(PubMed:8962055, PubMed:15159392, PubMed:15975918).{ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:15159392,ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:25416781,ECO:0000269|PubMed:7912128, ECO:0000269|PubMed:8962055,ECO:0000303|PubMed:17941859, ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF254_ETFB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZNF254_ENST00000339642_chr19_24270139_+_ETFB_ENST00000354232_chr19_51857562_-_10aa >In-frame_ZNF254_ENST00000339642_chr19_24270139_+_ETFB_ENST00000309244_chr19_51857562_-_247aa MPGPPRSLEMIRVKPDRTGVVTDGVKHSMNPFCEIAVEEAVRLKEKKLVKEVIAVSCGPAQCQETIRTALAMGADRGIHVEVPPAEAERL GPLQVARVLAKLAEKEKVDLVLLGKQAIDDDCNQTGQMTAGFLDWPQGTFASQVTLEGDKLKVEREIDGGLETLRLKLPAVVTADLRLNE >In-frame_ZNF254_ENST00000357002_chr19_24270139_+_ETFB_ENST00000354232_chr19_51857562_-_10aa >In-frame_ZNF254_ENST00000357002_chr19_24270139_+_ETFB_ENST00000309244_chr19_51857562_-_247aa MPGPPRSLEMIRVKPDRTGVVTDGVKHSMNPFCEIAVEEAVRLKEKKLVKEVIAVSCGPAQCQETIRTALAMGADRGIHVEVPPAEAERL GPLQVARVLAKLAEKEKVDLVLLGKQAIDDDCNQTGQMTAGFLDWPQGTFASQVTLEGDKLKVEREIDGGLETLRLKLPAVVTADLRLNE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZNF254_ENST00000339642_chr19_24270139_+_ETFB_ENST00000354232_chr19_51857562_-_30nt >In-frame_ZNF254_ENST00000339642_chr19_24270139_+_ETFB_ENST00000309244_chr19_51857562_-_741nt ATGCCAGGACCCCCTAGAAGCCTAGAAATGATCCGAGTGAAGCCTGACAGGACCGGTGTGGTCACGGATGGTGTGAAGCACTCCATGAAC CCCTTCTGTGAGATCGCGGTGGAGGAGGCTGTGCGGCTCAAGGAGAAGAAGCTGGTGAAGGAGGTCATCGCCGTCAGCTGTGGGCCTGCA CAGTGCCAGGAGACGATTCGTACCGCCCTGGCCATGGGTGCAGACCGAGGTATCCACGTGGAGGTGCCCCCAGCAGAAGCAGAACGCTTG GGTCCCCTGCAGGTGGCTCGGGTCCTGGCCAAGCTGGCAGAGAAGGAGAAGGTGGACCTGGTGCTGCTGGGCAAACAGGCCATCGATGAT GACTGTAACCAGACAGGGCAGATGACAGCTGGATTTCTTGACTGGCCACAGGGCACATTCGCCTCCCAGGTGACGCTGGAGGGGGACAAG TTGAAAGTGGAGCGGGAGATCGATGGGGGCCTGGAGACCCTGCGCCTGAAGCTGCCAGCTGTGGTGACAGCTGACCTGAGGCTCAACGAG CCCCGCTACGCCACGCTGCCCAACATCATGAAAGCCAAGAAGAAGAAGATCGAGGTGATCAAGCCTGGGGACCTGGGTGTGGACCTGACC TCCAAGCTCTCTGTGATCAGTGTGGAGGACCCGCCCCAGCGCACGGCCGGCGTCAAGGTGGAGACCACTGAGGACCTGGTGGCCAAGCTG >In-frame_ZNF254_ENST00000357002_chr19_24270139_+_ETFB_ENST00000354232_chr19_51857562_-_30nt >In-frame_ZNF254_ENST00000357002_chr19_24270139_+_ETFB_ENST00000309244_chr19_51857562_-_741nt ATGCCAGGACCCCCTAGAAGCCTAGAAATGATCCGAGTGAAGCCTGACAGGACCGGTGTGGTCACGGATGGTGTGAAGCACTCCATGAAC CCCTTCTGTGAGATCGCGGTGGAGGAGGCTGTGCGGCTCAAGGAGAAGAAGCTGGTGAAGGAGGTCATCGCCGTCAGCTGTGGGCCTGCA CAGTGCCAGGAGACGATTCGTACCGCCCTGGCCATGGGTGCAGACCGAGGTATCCACGTGGAGGTGCCCCCAGCAGAAGCAGAACGCTTG GGTCCCCTGCAGGTGGCTCGGGTCCTGGCCAAGCTGGCAGAGAAGGAGAAGGTGGACCTGGTGCTGCTGGGCAAACAGGCCATCGATGAT GACTGTAACCAGACAGGGCAGATGACAGCTGGATTTCTTGACTGGCCACAGGGCACATTCGCCTCCCAGGTGACGCTGGAGGGGGACAAG TTGAAAGTGGAGCGGGAGATCGATGGGGGCCTGGAGACCCTGCGCCTGAAGCTGCCAGCTGTGGTGACAGCTGACCTGAGGCTCAACGAG CCCCGCTACGCCACGCTGCCCAACATCATGAAAGCCAAGAAGAAGAAGATCGAGGTGATCAAGCCTGGGGACCTGGGTGTGGACCTGACC TCCAAGCTCTCTGTGATCAGTGTGGAGGACCCGCCCCAGCGCACGGCCGGCGTCAAGGTGGAGACCACTGAGGACCTGGTGGCCAAGCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZNF254_ENST00000339642_chr19_24270139_+_ETFB_ENST00000354232_chr19_51857562_-_3546nt GGGGCCTTTGTCTCTCGCTGTCGCCGGAGTCCCAGGTCTGTCTTCACTGCTCTGTGTCCTCTGCTCCTAGAGGCCCAGCCTCTGTGGCGC TGTTACCAGCAGGTATTGGAGATCCACAGCTAAGATGCCAGGACCCCCTAGAAGCCTAGAAATGGCGAGAGCCCATCTAAAAAAAAAAAA AAAAGAAATTAGAAACAGGGTCTTTGCAGATGTGATTAAATTAAGCATCTTGAGATGGGGGCATTATCCTGGATTATTTAGGTGGGCCCT GAATGCCATCTCAAGAGTCCTTATAAGAGAGAGACAGAGGGAGACTAGACACGCAGAGAGAGGAGAAGGCCACGTGAAGACAGAGCTGAG GATGCTGGCATTGAAGATAAAGCGATGCAGCCACAAGCCAGGGAGTGTCAGCAGAAGCTGGAGGAGGCAAGAAACGTGTTCCTCCCGGGG CCTGCAGACCCCTTGGTCTCACCCTGGTGACACTGACTTTGGACTTCTGGCCTCCAGAGCTGTAAGATTCTAAGCCACCAAATATATGGT GATTTGTTACGGCAGCCGAGAGAAACTAATAGGAGAGTGGTTAGTGGTTCACGCTACACCCTGGTCTACACCGGAAGCCTCTCTCCCTGG CACATGATGGTGTCCCCAGGATCCAGCTCAGAGCCAGGCACACAGTGGGGCCCAGGAGAGACAAAAATGATGTGCAGAAGCAAATGGGTG GGGTTTGCCACCCACCTCCCTTACCTCCCTTGTCTGTTTAGCAAAGAGGTCTTTCATGCTGGTGTTTTCCAAATTAGGTTGTGACCATGT GTGATCATGACATCCAGGCAGAGGGCTGGCATTTTTCCGAAAAAGGGTAGAAAATGTCAGAGTATGGTGTGTGTGTAGGCAGGGTCAGTA TTGGTCACTGACCCTTACACTGCAGTGGCATTTGTGAAATAGGTCAGGGTCACTGGTCACGTTGTCTAAGGTGTTATCCGAGCTCGTTTC ACAACCAAGAGAATTAAAGAGCATAGACCACCCAAAAGGTGAGGTTGGAGCGAAAGTTTAATAAGCAAAAGAAGAAAGCTCTCCACAGAG GAGAGGGAAGCCCAAGCGGGTTGCCATTTTTACAGTTGATTCCAAAAGCTTTTTTTTTAAAAAATTATTTATTTATTTATTTTTTATTAT TATACTTTAAGTTTTAGGATACATGTGCACAACGTACAGGTTTGTTACATGTGTTTATATGTGCCATGTTGGTGTGCTGCACCCAGTAAC TCGTCCTTTAGCATTAGGTATATCTCCTAATGCTATCCCTCCCCCCTCCCCCCACCCCACGACAGTCCCCGGTGTGTGATGTTCCCCTTC CTGTGTCCATGTGTTCTCATTGTTCAATTCCCACCTATGAGTGAGAACATGCGTTGTTTGGTTTTCTGTCCTTGCGATAGTTTGCTGAGA ATGATGGTTTCCAGCTTCATCCATGTCCCTACAAAGGACATGAACTCATCATTGTTTATGGCTGCATAGTATTCCATGGTGTATATGTGC CACATTTTCTTAATCCAGTCTATCATTGTTGGACATTTGGGTTGGTTCCAAGTCTTTACTATTGTGAATAGTGCCGCAATAAACATATGT GTGCATGTGTCTTTATAGCAGCATGATTTATAATCCTTTGGGTATATACCCAGTAATAGGATGGCTGGGTCAAATGGTATTTCTAGTTCT AGATCCCTGAGGAATCACCACACCGACTTCCACAATGGTTGAACTAGTTTACAGTCCCACCAACAGTGTAAAAGTGTTCCTTTTTCTCCA CATCCTCTCCAGCACCTGTTCTTTCCTGACTTTTTAATGATCGCCGTTCTAACTGGTGTGAGACGGTATCTCATTGTGATTTTGATTTGC ATTTCTCTGATGGCCAGTGATGATGAGCATTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCTATTCATATCCT TCGCCCACTTTTTGATGGGGTTGTTTGTTTTTTTCTTGTACATTTGTTTGAGTTCATTGTAGATTCTGGATATTAGCCATTTGTCAGATG AGTAGGCTGCAAAAATTTTCTCCCATTCTGTAGGTTGCCTGTTCACTCTGATGGTTAAACTAAAGAGCTTCTGCACAGCAAAAGACACCA AAAGCTTTTATAAGAAACTCCTTTCATCTCTGTAGCTGTTTGAGTATCTTATCTGTAAAGCTATCTGCATAACTCTCCGTTATCTATGTA GTTGTGGGTACGTCTTTAGGCAAGCACAAAGCTCCGCTTCTCTTGTTTCTGTAACCGTGGGTTTGTTTTAGGTAAGCTCCGCCCCTCCCC GTGCAAGTTCCCACAGAGACCACCATGTACGTGCCTGAAAAGGGGAGGGAACTTTTCCTGGGAGCCTGTCAGTCACGCAAAGAACAAAAG GCTTCTGTGCTGGGCAGCTTGAGTTTTCCCCAGGCTGCTCTATTGTTGCCTGTAGCTGTGATTTTTCAGGCAGGCTGCTCCTCTGAGGAC CACCCTTAACTGTCTACCTAACTGGTTTTTCCTTTTCTTCTCCTCATTTGTATTTATGTATCAGTGTATTATGTATTTATATACACTTGG AGATACAGTAAAATGTACCTCTCACTGTGGGTTACCATAAATACTGTAAATTTGAGAAACACTCTTTCAGGCCTGAGAGGAGCAGTGACA ACAGTAGGGATGATCAAGTCAGATGTCCCTGGTACCCAGGAATGGCTGGATGAGAGAAGGAGACAGGGTGACCTGCCCCTGCCTACAAAC TCTAACCCAGTTCTGTCCCTGGAGCTGTGTGACCCCGGACAAGGCCCTGCCCCTTTCCAGGCTGTCGTTGTCCTCATCCAGCCTGGGAGA GGGTTGGCGCTGAGGCCCCCACCTTCTTGCCTGTTTCCTCCTGACCCCACCCCTTCCCCTCCTGCTGGGCAGATCCGAGTGAAGCCTGAC AGGACCGGTGTGGTCACGGATGGTGTGAAGCACTCCATGAACCCCTTCTGTGAGATCGCGGTGGAGGAGGCTGTGCGGCTCAAGGAGAAG AAGCTGGTGAAGGAGGTCATCGCCGTCAGCTGTGGGCCTGCACAGTGCCAGGAGACGATTCGTACCGCCCTGGCCATGGGTGCAGACCGA GGTATCCACGTGGAGGTGCCCCCAGCAGAAGCAGAACGCTTGGGTCCCCTGCAGGTGGCTCGGGTCCTGGCCAAGCTGGCAGAGAAGGAG AAGGTGGACCTGGTGCTGCTGGGCAAACAGGCCATCGATGATGACTGTAACCAGACAGGGCAGATGACAGCTGGATTTCTTGACTGGCCA CAGGGCACATTCGCCTCCCAGGTGACGCTGGAGGGGGACAAGTTGAAAGTGGAGCGGGAGATCGATGGGGGCCTGGAGACCCTGCGCCTG AAGCTGCCAGCTGTGGTGACAGCTGACCTGAGGCTCAACGAGCCCCGCTACGCCACGCTGCCCAACATCATGAAATCCTAAGTAATGCAC >In-frame_ZNF254_ENST00000339642_chr19_24270139_+_ETFB_ENST00000309244_chr19_51857562_-_905nt GGGGCCTTTGTCTCTCGCTGTCGCCGGAGTCCCAGGTCTGTCTTCACTGCTCTGTGTCCTCTGCTCCTAGAGGCCCAGCCTCTGTGGCGC TGTTACCAGCAGGTATTGGAGATCCACAGCTAAGATGCCAGGACCCCCTAGAAGCCTAGAAATGATCCGAGTGAAGCCTGACAGGACCGG TGTGGTCACGGATGGTGTGAAGCACTCCATGAACCCCTTCTGTGAGATCGCGGTGGAGGAGGCTGTGCGGCTCAAGGAGAAGAAGCTGGT GAAGGAGGTCATCGCCGTCAGCTGTGGGCCTGCACAGTGCCAGGAGACGATTCGTACCGCCCTGGCCATGGGTGCAGACCGAGGTATCCA CGTGGAGGTGCCCCCAGCAGAAGCAGAACGCTTGGGTCCCCTGCAGGTGGCTCGGGTCCTGGCCAAGCTGGCAGAGAAGGAGAAGGTGGA CCTGGTGCTGCTGGGCAAACAGGCCATCGATGATGACTGTAACCAGACAGGGCAGATGACAGCTGGATTTCTTGACTGGCCACAGGGCAC ATTCGCCTCCCAGGTGACGCTGGAGGGGGACAAGTTGAAAGTGGAGCGGGAGATCGATGGGGGCCTGGAGACCCTGCGCCTGAAGCTGCC AGCTGTGGTGACAGCTGACCTGAGGCTCAACGAGCCCCGCTACGCCACGCTGCCCAACATCATGAAAGCCAAGAAGAAGAAGATCGAGGT GATCAAGCCTGGGGACCTGGGTGTGGACCTGACCTCCAAGCTCTCTGTGATCAGTGTGGAGGACCCGCCCCAGCGCACGGCCGGCGTCAA GGTGGAGACCACTGAGGACCTGGTGGCCAAGCTGAAGGAGATTGGGCGGATTTGAGCCCCTCCCAGAGATGGCAATAAAACTGACTCTCA >In-frame_ZNF254_ENST00000357002_chr19_24270139_+_ETFB_ENST00000354232_chr19_51857562_-_3694nt GTCTCTCGCTGTCGCCGGAGTCCCAGGTCTGTCTTCACTGCTCTGTGTCCTCTGCTCCTAGAGGCCCAGCCTCTGTGGCGCTGTTACCAG CAGGTATTGGAGATCCACAGCTAAGATGCCAGGACCCCCTAGAAGCCTAGAAATGGCGAGAGCCCATCTAAAAAAAAAAAAAAAAGAAAT TAGAAACAGGGTCTTTGCAGATGTGATTAAATTAAGCATCTTGAGATGGGGGCATTATCCTGGATTATTTAGGTGGGCCCTGAATGCCAT CTCAAGAGTCCTTATAAGAGAGAGACAGAGGGAGACTAGACACGCAGAGAGAGGAGAAGGCCACGTGAAGACAGAGCTGAGGATGCTGGC ATTGAAGATAAAGCGATGCAGCCACAAGCCAGGGAGTGTCAGCAGAAGCTGGAGGAGGCAAGAAACGTGTTCCTCCCGGGGCCTGCAGAC CCCTTGGTCTCACCCTGGTGACACTGACTTTGGACTTCTGGCCTCCAGAGCTGTAAGATTCTAAGCCACCAAATATATGGTGATTTGTTA CGGCAGCCGAGAGAAACTAATAGGAGAGTGGTTAGTGGTTCACGCTACACCCTGGTCTACACCGGAAGCCTCTCTCCCTGGCACATGATG GTGTCCCCAGGATCCAGCTCAGAGCCAGGCACACAGTGGGGCCCAGGAGAGACAAAAATGATGTGCAGAAGCAAATGGGTGGGGTTTGCC ACCCACCTCCCTTACCTCCCTTGTCTGTTTAGCAAAGAGGTCTTTCATGCTGGTGTTTTCCAAATTAGGTTGTGACCATGTGTGATCATG ACATCCAGGCAGAGGGCTGGCATTTTTCCGAAAAAGGGTAGAAAATGTCAGAGTATGGTGTGTGTGTAGGCAGGGTCAGTATTGGTCACT GACCCTTACACTGCAGTGGCATTTGTGAAATAGGTCAGGGTCACTGGTCACGTTGTCTAAGGTGTTATCCGAGCTCGTTTCACAACCAAG AGAATTAAAGAGCATAGACCACCCAAAAGGTGAGGTTGGAGCGAAAGTTTAATAAGCAAAAGAAGAAAGCTCTCCACAGAGGAGAGGGAA GCCCAAGCGGGTTGCCATTTTTACAGTTGATTCCAAAAGCTTTTTTTTTAAAAAATTATTTATTTATTTATTTTTTATTATTATACTTTA AGTTTTAGGATACATGTGCACAACGTACAGGTTTGTTACATGTGTTTATATGTGCCATGTTGGTGTGCTGCACCCAGTAACTCGTCCTTT AGCATTAGGTATATCTCCTAATGCTATCCCTCCCCCCTCCCCCCACCCCACGACAGTCCCCGGTGTGTGATGTTCCCCTTCCTGTGTCCA TGTGTTCTCATTGTTCAATTCCCACCTATGAGTGAGAACATGCGTTGTTTGGTTTTCTGTCCTTGCGATAGTTTGCTGAGAATGATGGTT TCCAGCTTCATCCATGTCCCTACAAAGGACATGAACTCATCATTGTTTATGGCTGCATAGTATTCCATGGTGTATATGTGCCACATTTTC TTAATCCAGTCTATCATTGTTGGACATTTGGGTTGGTTCCAAGTCTTTACTATTGTGAATAGTGCCGCAATAAACATATGTGTGCATGTG TCTTTATAGCAGCATGATTTATAATCCTTTGGGTATATACCCAGTAATAGGATGGCTGGGTCAAATGGTATTTCTAGTTCTAGATCCCTG AGGAATCACCACACCGACTTCCACAATGGTTGAACTAGTTTACAGTCCCACCAACAGTGTAAAAGTGTTCCTTTTTCTCCACATCCTCTC CAGCACCTGTTCTTTCCTGACTTTTTAATGATCGCCGTTCTAACTGGTGTGAGACGGTATCTCATTGTGATTTTGATTTGCATTTCTCTG ATGGCCAGTGATGATGAGCATTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCTATTCATATCCTTCGCCCACT TTTTGATGGGGTTGTTTGTTTTTTTCTTGTACATTTGTTTGAGTTCATTGTAGATTCTGGATATTAGCCATTTGTCAGATGAGTAGGCTG CAAAAATTTTCTCCCATTCTGTAGGTTGCCTGTTCACTCTGATGGTTAAACTAAAGAGCTTCTGCACAGCAAAAGACACCAAAAGCTTTT ATAAGAAACTCCTTTCATCTCTGTAGCTGTTTGAGTATCTTATCTGTAAAGCTATCTGCATAACTCTCCGTTATCTATGTAGTTGTGGGT ACGTCTTTAGGCAAGCACAAAGCTCCGCTTCTCTTGTTTCTGTAACCGTGGGTTTGTTTTAGGTAAGCTCCGCCCCTCCCCGTGCAAGTT CCCACAGAGACCACCATGTACGTGCCTGAAAAGGGGAGGGAACTTTTCCTGGGAGCCTGTCAGTCACGCAAAGAACAAAAGGCTTCTGTG CTGGGCAGCTTGAGTTTTCCCCAGGCTGCTCTATTGTTGCCTGTAGCTGTGATTTTTCAGGCAGGCTGCTCCTCTGAGGACCACCCTTAA CTGTCTACCTAACTGGTTTTTCCTTTTCTTCTCCTCATTTGTATTTATGTATCAGTGTATTATGTATTTATATACACTTGGAGATACAGT AAAATGTACCTCTCACTGTGGGTTACCATAAATACTGTAAATTTGAGAAACACTCTTTCAGGCCTGAGAGGAGCAGTGACAACAGTAGGG ATGATCAAGTCAGATGTCCCTGGTACCCAGGAATGGCTGGATGAGAGAAGGAGACAGGGTGACCTGCCCCTGCCTACAAACTCTAACCCA GTTCTGTCCCTGGAGCTGTGTGACCCCGGACAAGGCCCTGCCCCTTTCCAGGCTGTCGTTGTCCTCATCCAGCCTGGGAGAGGGTTGGCG CTGAGGCCCCCACCTTCTTGCCTGTTTCCTCCTGACCCCACCCCTTCCCCTCCTGCTGGGCAGATCCGAGTGAAGCCTGACAGGACCGGT GTGGTCACGGATGGTGTGAAGCACTCCATGAACCCCTTCTGTGAGATCGCGGTGGAGGAGGCTGTGCGGCTCAAGGAGAAGAAGCTGGTG AAGGAGGTCATCGCCGTCAGCTGTGGGCCTGCACAGTGCCAGGAGACGATTCGTACCGCCCTGGCCATGGGTGCAGACCGAGGTATCCAC GTGGAGGTGCCCCCAGCAGAAGCAGAACGCTTGGGTCCCCTGCAGGTGGCTCGGGTCCTGGCCAAGCTGGCAGAGAAGGAGAAGGTGGAC CTGGTGCTGCTGGGCAAACAGGCCATCGATGATGACTGTAACCAGACAGGGCAGATGACAGCTGGATTTCTTGACTGGCCACAGGGCACA TTCGCCTCCCAGGTGACGCTGGAGGGGGACAAGTTGAAAGTGGAGCGGGAGATCGATGGGGGCCTGGAGACCCTGCGCCTGAAGCTGCCA GCTGTGGTGACAGCTGACCTGAGGCTCAACGAGCCCCGCTACGCCACGCTGCCCAACATCATGAAAGCCAAGAAGAAGAAGATCGAGGTG ATCAAGCCTGGGGACCTGGGTGTGGACCTGACCTCCAAGCTCTCTGTGATCAGTGTGGAGGACCCGCCCCAGCGCACGGCCGGCGTCAAG GTGGAGACCACTGAGGACCTGGTGGCCAAGCTGAAGGAGATTGGGCGGATTTGAGCCCCTCCCAGAGATGGCAATAAAACTGACTCTCAA >In-frame_ZNF254_ENST00000357002_chr19_24270139_+_ETFB_ENST00000309244_chr19_51857562_-_896nt GTCTCTCGCTGTCGCCGGAGTCCCAGGTCTGTCTTCACTGCTCTGTGTCCTCTGCTCCTAGAGGCCCAGCCTCTGTGGCGCTGTTACCAG CAGGTATTGGAGATCCACAGCTAAGATGCCAGGACCCCCTAGAAGCCTAGAAATGATCCGAGTGAAGCCTGACAGGACCGGTGTGGTCAC GGATGGTGTGAAGCACTCCATGAACCCCTTCTGTGAGATCGCGGTGGAGGAGGCTGTGCGGCTCAAGGAGAAGAAGCTGGTGAAGGAGGT CATCGCCGTCAGCTGTGGGCCTGCACAGTGCCAGGAGACGATTCGTACCGCCCTGGCCATGGGTGCAGACCGAGGTATCCACGTGGAGGT GCCCCCAGCAGAAGCAGAACGCTTGGGTCCCCTGCAGGTGGCTCGGGTCCTGGCCAAGCTGGCAGAGAAGGAGAAGGTGGACCTGGTGCT GCTGGGCAAACAGGCCATCGATGATGACTGTAACCAGACAGGGCAGATGACAGCTGGATTTCTTGACTGGCCACAGGGCACATTCGCCTC CCAGGTGACGCTGGAGGGGGACAAGTTGAAAGTGGAGCGGGAGATCGATGGGGGCCTGGAGACCCTGCGCCTGAAGCTGCCAGCTGTGGT GACAGCTGACCTGAGGCTCAACGAGCCCCGCTACGCCACGCTGCCCAACATCATGAAAGCCAAGAAGAAGAAGATCGAGGTGATCAAGCC TGGGGACCTGGGTGTGGACCTGACCTCCAAGCTCTCTGTGATCAGTGTGGAGGACCCGCCCCAGCGCACGGCCGGCGTCAAGGTGGAGAC |
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FusionGenePPI for ZNF254_ETFB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF254 | TRIM44, TRIM28, ZNF479, CYP24A1, TRIM24 | ETFB | APP, ETFA, DLD, IRF2BPL, ADRB2, STAU1, CUL7, CAPG, GRHPR, HADH, RABGGTA, GPX4, PITPNB, NTRK1, DYNLT1, XPO1, LRPPRC, ATP6AP2, ATL3, GOLT1B, LYRM5, IVD, EYA2, GMCL1, AKAP11, PRKACB, NDUFAB1, CASC5, DSN1, PLCH1, PRKAR1B, DLST, SOD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF254_ETFB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF254_ETFB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ETFB | C0268596 | Multiple Acyl Coenzyme A Dehydrogenase Deficiency | 2 | CTD_human;UNIPROT |
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