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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43115

FusionGeneSummary for ZNF236_ZNF627

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF236_ZNF627
Fusion gene ID: 43115
HgeneTgene
Gene symbol

ZNF236

ZNF627

Gene ID

7776

199692

Gene namezinc finger protein 236zinc finger protein 627
SynonymsZNF236A|ZNF236B-
Cytomap

18q23

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 236regulated by glucosezinc finger protein 627
Modification date2018051920180519
UniProtAcc

Q9UL36

Q7L945

Ensembl transtripts involved in fusion geneENST00000320610, ENST00000253159, 
ENST00000583095, 
ENST00000588651, 
ENST00000361113, ENST00000588174, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 2 X 3=18
# samples 54
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF236 [Title/Abstract] AND ZNF627 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CN-4725-01AZNF236chr18

74593468

+ZNF627chr19

11725342

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000320610ENST00000588651ZNF236chr18

74593468

+ZNF627chr19

11725342

+
5CDS-intronENST00000320610ENST00000361113ZNF236chr18

74593468

+ZNF627chr19

11725342

+
5CDS-intronENST00000320610ENST00000588174ZNF236chr18

74593468

+ZNF627chr19

11725342

+
5CDS-intronENST00000253159ENST00000588651ZNF236chr18

74593468

+ZNF627chr19

11725342

+
5CDS-intronENST00000253159ENST00000361113ZNF236chr18

74593468

+ZNF627chr19

11725342

+
5CDS-intronENST00000253159ENST00000588174ZNF236chr18

74593468

+ZNF627chr19

11725342

+
intron-intronENST00000583095ENST00000588651ZNF236chr18

74593468

+ZNF627chr19

11725342

+
intron-intronENST00000583095ENST00000361113ZNF236chr18

74593468

+ZNF627chr19

11725342

+
intron-intronENST00000583095ENST00000588174ZNF236chr18

74593468

+ZNF627chr19

11725342

+

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FusionProtFeatures for ZNF236_ZNF627


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF236

Q9UL36

ZNF627

Q7L945

May be involved in transcriptional regulation. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF236_ZNF627


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF236_ZNF627


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF236ZNF627CCNDBP1, PPP1R16B, VWCE, EFEMP1, NELL2, DLK1, GPR156


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF236_ZNF627


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF236_ZNF627


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource