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Fusion gene ID: 43115 |
FusionGeneSummary for ZNF236_ZNF627 |
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Fusion gene information | Fusion gene name: ZNF236_ZNF627 | Fusion gene ID: 43115 | Hgene | Tgene | Gene symbol | ZNF236 | ZNF627 | Gene ID | 7776 | 199692 |
Gene name | zinc finger protein 236 | zinc finger protein 627 | |
Synonyms | ZNF236A|ZNF236B | - | |
Cytomap | 18q23 | 19p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 236regulated by glucose | zinc finger protein 627 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9UL36 | Q7L945 | |
Ensembl transtripts involved in fusion gene | ENST00000320610, ENST00000253159, ENST00000583095, | ENST00000588651, ENST00000361113, ENST00000588174, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 3 X 2 X 3=18 |
# samples | 5 | 4 | |
** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF236 [Title/Abstract] AND ZNF627 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CN-4725-01A | ZNF236 | chr18 | 74593468 | + | ZNF627 | chr19 | 11725342 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000320610 | ENST00000588651 | ZNF236 | chr18 | 74593468 | + | ZNF627 | chr19 | 11725342 | + |
5CDS-intron | ENST00000320610 | ENST00000361113 | ZNF236 | chr18 | 74593468 | + | ZNF627 | chr19 | 11725342 | + |
5CDS-intron | ENST00000320610 | ENST00000588174 | ZNF236 | chr18 | 74593468 | + | ZNF627 | chr19 | 11725342 | + |
5CDS-intron | ENST00000253159 | ENST00000588651 | ZNF236 | chr18 | 74593468 | + | ZNF627 | chr19 | 11725342 | + |
5CDS-intron | ENST00000253159 | ENST00000361113 | ZNF236 | chr18 | 74593468 | + | ZNF627 | chr19 | 11725342 | + |
5CDS-intron | ENST00000253159 | ENST00000588174 | ZNF236 | chr18 | 74593468 | + | ZNF627 | chr19 | 11725342 | + |
intron-intron | ENST00000583095 | ENST00000588651 | ZNF236 | chr18 | 74593468 | + | ZNF627 | chr19 | 11725342 | + |
intron-intron | ENST00000583095 | ENST00000361113 | ZNF236 | chr18 | 74593468 | + | ZNF627 | chr19 | 11725342 | + |
intron-intron | ENST00000583095 | ENST00000588174 | ZNF236 | chr18 | 74593468 | + | ZNF627 | chr19 | 11725342 | + |
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FusionProtFeatures for ZNF236_ZNF627 |
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Hgene | Tgene |
ZNF236 | ZNF627 |
May be involved in transcriptional regulation. | May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF236_ZNF627 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF236_ZNF627 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF236 | ZNF627 | CCNDBP1, PPP1R16B, VWCE, EFEMP1, NELL2, DLK1, GPR156 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF236_ZNF627 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF236_ZNF627 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |