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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43112

FusionGeneSummary for ZNF236_DTNA

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF236_DTNA
Fusion gene ID: 43112
HgeneTgene
Gene symbol

ZNF236

DTNA

Gene ID

7776

1837

Gene namezinc finger protein 236dystrobrevin alpha
SynonymsZNF236A|ZNF236BD18S892E|DRP3|DTN|DTN-A|LVNC1
Cytomap

18q23

18q12.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 236regulated by glucosedystrobrevin alphadystrophin-related protein 3
Modification date2018051920180522
UniProtAcc

Q9UL36

Q9Y4J8

Ensembl transtripts involved in fusion geneENST00000320610, ENST00000253159, 
ENST00000583095, 		ENST00000283365, 
ENST00000596745, ENST00000315456, 
ENST00000598334, ENST00000554864, 
ENST00000399121, ENST00000595022, 
ENST00000269190, ENST00000399097, 
ENST00000598774, ENST00000598142, 
ENST00000348997, ENST00000597599, 
ENST00000269191, ENST00000444659, 
ENST00000399113, ENST00000601125, 
ENST00000269192, ENST00000591182, 
ENST00000597674, ENST00000556414, 
ENST00000599844, ENST00000590831, 
ENST00000592449, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 4 X 2=32
# samples 54
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF236 [Title/Abstract] AND DTNA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A0TV-01AZNF236chr18

74640062

+DTNAchr18

32093479

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000320610ENST00000283365ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000596745ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000315456ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000598334ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000554864ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000399121ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000595022ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000269190ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000399097ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000598774ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000598142ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000348997ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000597599ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000269191ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000444659ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000399113ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000601125ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000269192ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000591182ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000597674ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000556414ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000599844ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000590831ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000320610ENST00000592449ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000283365ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000596745ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000315456ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000598334ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000554864ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000399121ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000595022ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000269190ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000399097ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000598774ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000598142ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000348997ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000597599ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000269191ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000444659ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000399113ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000601125ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000269192ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000591182ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000597674ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000556414ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000599844ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000590831ZNF236chr18

74640062

+DTNAchr18

32093479

+
5CDS-intronENST00000253159ENST00000592449ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000283365ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000596745ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000315456ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000598334ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000554864ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000399121ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000595022ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000269190ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000399097ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000598774ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000598142ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000348997ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000597599ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000269191ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000444659ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000399113ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000601125ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000269192ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000591182ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000597674ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000556414ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000599844ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000590831ZNF236chr18

74640062

+DTNAchr18

32093479

+
intron-intronENST00000583095ENST00000592449ZNF236chr18

74640062

+DTNAchr18

32093479

+

Top

FusionProtFeatures for ZNF236_DTNA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF236

Q9UL36

DTNA

Q9Y4J8

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZNF236_DTNA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZNF236_DTNA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF236DTNADMD, KCNJ12, SYNM, UTRN, SNTA1, MARK2, GFI1B, SEC24C, NUP62, MYO1E, PSEN1, SEC23A, MLC1, TJP1, ACTB, ADRA1D, FYCO1, CCDC101, DTNBP1, NMT1, POTEI, SAR1A, SPZ1, DRP2, STAT3, CTDSPL, SNTG2, HMG20A, COG6, FAM167A, RAB30, TENC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZNF236_DTNA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZNF236_DTNA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDTNAC1858725NONCOMPACTION OF LEFT VENTRICULAR MYOCARDIUM, FAMILIAL ISOLATED, AUTOSOMAL DOMINANT 11CTD_human;UNIPROT