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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43104

FusionGeneSummary for ZNF229_ZFP28

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF229_ZFP28
Fusion gene ID: 43104
HgeneTgene
Gene symbol

ZNF229

ZFP28

Gene ID

7772

140612

Gene namezinc finger protein 229ZFP28 zinc finger protein
Synonyms-mkr5
Cytomap

19q13.31

19q13.43

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 229zinc finger protein 28 homologkrueppel-like zinc finger factor X6zfp-28zinc finger factor X6
Modification date2018040320180522
UniProtAcc

Q9UJW7

Q8NHY6

Ensembl transtripts involved in fusion geneENST00000591289, ENST00000291187, 
ENST00000588931, 		ENST00000301318, 
ENST00000591844, ENST00000594386, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 1=4
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/4*10)=2.32192809488736
Context

PubMed: ZNF229 [Title/Abstract] AND ZFP28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CR749659ZNF229chr19

44951700

-ZFP28chr19

57065050

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000591289ENST00000301318ZNF229chr19

44951700

-ZFP28chr19

57065050

+
5UTR-intronENST00000591289ENST00000591844ZNF229chr19

44951700

-ZFP28chr19

57065050

+
5UTR-intronENST00000591289ENST00000594386ZNF229chr19

44951700

-ZFP28chr19

57065050

+
5UTR-3CDSENST00000291187ENST00000301318ZNF229chr19

44951700

-ZFP28chr19

57065050

+
5UTR-intronENST00000291187ENST00000591844ZNF229chr19

44951700

-ZFP28chr19

57065050

+
5UTR-intronENST00000291187ENST00000594386ZNF229chr19

44951700

-ZFP28chr19

57065050

+
5UTR-3CDSENST00000588931ENST00000301318ZNF229chr19

44951700

-ZFP28chr19

57065050

+
5UTR-intronENST00000588931ENST00000591844ZNF229chr19

44951700

-ZFP28chr19

57065050

+
5UTR-intronENST00000588931ENST00000594386ZNF229chr19

44951700

-ZFP28chr19

57065050

+

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FusionProtFeatures for ZNF229_ZFP28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF229

Q9UJW7

ZFP28

Q8NHY6

May be involved in transcriptional regulation. May be involved in transcriptional regulation. May havea role in embryonic development.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF229_ZFP28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF229_ZFP28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF229ZFP28PPP2CB, HMOX2, PRKRA, C8orf33, KDM1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF229_ZFP28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF229_ZFP28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource