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Fusion gene ID: 43097 |
FusionGeneSummary for ZNF224_CYP2S1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF224_CYP2S1 | Fusion gene ID: 43097 | Hgene | Tgene | Gene symbol | ZNF224 | CYP2S1 | Gene ID | 7767 | 29785 |
| Gene name | zinc finger protein 224 | cytochrome P450 family 2 subfamily S member 1 | |
| Synonyms | BMZF-2|BMZF2|KOX22|ZNF233|ZNF255|ZNF27 | CYPIIS1 | |
| Cytomap | 19q13.31 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 224bone marrow zinc finger 2zinc finger protein 233zinc finger protein 255zinc finger protein 27zinc finger protein KOX22 | cytochrome P450 2S1cytochrome P450, family 2, subfamily S, polypeptide 1cytochrome P540, subfamily IIS, polypeptide 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NZL3 | Q96SQ9 | |
| Ensembl transtripts involved in fusion gene | ENST00000336976, ENST00000586978, | ENST00000310054, ENST00000542619, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF224 [Title/Abstract] AND CYP2S1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZNF224 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12527367 |
| Hgene | ZNF224 | GO:0045892 | negative regulation of transcription, DNA-templated | 20587513 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A8BU-01A | ZNF224 | chr19 | 44602041 | + | CYP2S1 | chr19 | 41711863 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000336976 | ENST00000310054 | ZNF224 | chr19 | 44602041 | + | CYP2S1 | chr19 | 41711863 | + |
| In-frame | ENST00000336976 | ENST00000542619 | ZNF224 | chr19 | 44602041 | + | CYP2S1 | chr19 | 41711863 | + |
| intron-3CDS | ENST00000586978 | ENST00000310054 | ZNF224 | chr19 | 44602041 | + | CYP2S1 | chr19 | 41711863 | + |
| intron-3CDS | ENST00000586978 | ENST00000542619 | ZNF224 | chr19 | 44602041 | + | CYP2S1 | chr19 | 41711863 | + |
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FusionProtFeatures for ZNF224_CYP2S1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF224 | CYP2S1 |
| May be involved in transcriptional regulation as atranscriptional repressor. The DEPDC1A-ZNF224 complex may play acritical role in bladder carcinogenesis by repressing thetranscription of the A20 gene, leading to transport of NF-KBprotein into the nucleus, resulting in suppression of apoptosis ofbladder cancer cells. {ECO:0000269|PubMed:20587513}. | Has a potential importance for extrahepatic xenobioticmetabolism. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 8_78 | 5 | 708 | Domain | KRAB |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 176_198 | 5 | 708 | Zinc finger | C2H2-type 1 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 204_226 | 5 | 708 | Zinc finger | C2H2-type 2 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 232_254 | 5 | 708 | Zinc finger | C2H2-type 3 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 260_282 | 5 | 708 | Zinc finger | C2H2-type 4 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 288_310 | 5 | 708 | Zinc finger | C2H2-type 5 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 316_338 | 5 | 708 | Zinc finger | C2H2-type 6 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 344_366 | 5 | 708 | Zinc finger | C2H2-type 7 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 372_394 | 5 | 708 | Zinc finger | C2H2-type 8 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 400_422 | 5 | 708 | Zinc finger | C2H2-type 9 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 428_450 | 5 | 708 | Zinc finger | C2H2-type 10 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 456_478 | 5 | 708 | Zinc finger | C2H2-type 11 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 484_506 | 5 | 708 | Zinc finger | C2H2-type 12 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 512_534 | 5 | 708 | Zinc finger | C2H2-type 13 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 540_562 | 5 | 708 | Zinc finger | C2H2-type 14%3B degenerate |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 568_590 | 5 | 708 | Zinc finger | C2H2-type 15 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 596_618 | 5 | 708 | Zinc finger | C2H2-type 16 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 652_674 | 5 | 708 | Zinc finger | C2H2-type 17 |
| Hgene | >ZNF224 | chr19:44602041 | chr19:41711863 | ENST00000336976 | + | 3 | 6 | 680_702 | 5 | 708 | Zinc finger | C2H2-type 18 |
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FusionGeneSequence for ZNF224_CYP2S1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZNF224_ENST00000336976_chr19_44602041_+_CYP2S1_ENST00000310054_chr19_41711863_+_122aa MTTFKGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLS >In-frame_ZNF224_ENST00000336976_chr19_44602041_+_CYP2S1_ENST00000542619_chr19_41711863_+_122aa MTTFKGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZNF224_ENST00000336976_chr19_44602041_+_CYP2S1_ENST00000310054_chr19_41711863_+_366nt ATGACCACGTTCAAGGGCACGGAGGTCTTCCCCCTCCTTGGCTCCATCCTGCATGACCCCAACATCTTCAAGCACCCAGAAGAGTTCAAC CCAGACCGTTTCCTGGATGCAGATGGACGGTTCAGGAAGCATGAGGCGTTCCTGCCCTTCTCCTTAGGGAAGCGTGTCTGCCTTGGAGAG GGCCTGGCAAAAGCGGAGCTCTTCCTCTTCTTCACCACCATCCTACAAGCCTTCTCCCTGGAGAGCCCGTGCCCGCCGGACACCCTGAGC CTCAAGCCCACCGTCAGTGGCCTTTTCAACATTCCCCCAGCCTTCCAGCTGCAAGTCCGTCCCACTGACCTTCACTCCACCACGCAGACC >In-frame_ZNF224_ENST00000336976_chr19_44602041_+_CYP2S1_ENST00000542619_chr19_41711863_+_366nt ATGACCACGTTCAAGGGCACGGAGGTCTTCCCCCTCCTTGGCTCCATCCTGCATGACCCCAACATCTTCAAGCACCCAGAAGAGTTCAAC CCAGACCGTTTCCTGGATGCAGATGGACGGTTCAGGAAGCATGAGGCGTTCCTGCCCTTCTCCTTAGGGAAGCGTGTCTGCCTTGGAGAG GGCCTGGCAAAAGCGGAGCTCTTCCTCTTCTTCACCACCATCCTACAAGCCTTCTCCCTGGAGAGCCCGTGCCCGCCGGACACCCTGAGC CTCAAGCCCACCGTCAGTGGCCTTTTCAACATTCCCCCAGCCTTCCAGCTGCAAGTCCGTCCCACTGACCTTCACTCCACCACGCAGACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZNF224_ENST00000336976_chr19_44602041_+_CYP2S1_ENST00000310054_chr19_41711863_+_1671nt GGTTGCTGCAGTTTTTCCGCGATAGTTTGGGGCAGTTCCGCGCGTTGCAGGCCCTTCTGAATTTCCTGGACCTACGCATTGGATCCTCAA AGAACTGCTGAATACCACTAGAAACATACCTGTAACCAGAGACAGCTGATTATAGCTTTCTGCAGCAAGGAAGCCCACGTACCAGGGGCT GTCTTGGCACAATTCTGCTTTCCCAGGAACTGCATCACTCAGGACTCTGCAAGTTTCCAGAAGTAAGAGGGAAAATGACCACGTTCAAGG GCACGGAGGTCTTCCCCCTCCTTGGCTCCATCCTGCATGACCCCAACATCTTCAAGCACCCAGAAGAGTTCAACCCAGACCGTTTCCTGG ATGCAGATGGACGGTTCAGGAAGCATGAGGCGTTCCTGCCCTTCTCCTTAGGGAAGCGTGTCTGCCTTGGAGAGGGCCTGGCAAAAGCGG AGCTCTTCCTCTTCTTCACCACCATCCTACAAGCCTTCTCCCTGGAGAGCCCGTGCCCGCCGGACACCCTGAGCCTCAAGCCCACCGTCA GTGGCCTTTTCAACATTCCCCCAGCCTTCCAGCTGCAAGTCCGTCCCACTGACCTTCACTCCACCACGCAGACCAGATGAAGGAAGGCAA CTTGGAAGTGGTGGGTGCCCAGGACGGTGCCTCCAGCCTCAACAGTGGGCATGGACAGGGTTAATGTCTCCAGAGTGTACACTGCAGGCA GCCACATTTACACGCCTGCAGTTGTTTTCCGGAGTCTGTCCCACGGCCCACACGCTCACTTGACTCATGCTGCTAAGATGCACAACCGCA CACCCATACACAACTACAAGGGCCACAAAGCAACTGCTGGGTTAGCTTTCCACAGACATAAATATAGTCCATCTGCAATCACAAGCACAT AGCCAGGTAACCCACCAACTCCCCTGGATCTGCAGCCCACACGTGGGAGTCTGGCTGTCACCTTCACAAGCCACAGAAACGGCCACACAT GTTCACAGCTCACACGCCCTCTCCATTCATCGAACTTCTCAGTGTCCCTGTCCCTGGTGCCTGGCACAGGGAACAGCATGCCCCCTCCGG GGTCATGCCACCCAGAGACTGTCGCTGTCTATGGCCCCAACTCATGCTCCCTCTCTTGGCTACACCACTCTCCCAGCCTGTGACCACCGA TGTCCACACACCCCCAACCACTTGTCCACACAGCTACCCACGTACGACATCGTCCTGGCTCCCCAGAGTATCTTCCCACTGAGACACGCC GCCCCCACAGAGGCACAGTCCCCAGCCACCTCTGCAACTGCAGCCCTCAGTCACCCCTTTTTAAGCACCCTGATTCTACCAAATGCAAAC ACATCTGGGTCTGCGATTATGCACAGAGACTTTGGACATACGAGGACCCTCAGACCGGAGGAACACCTGCCCAACCCCAACACGTGCTTA TGTAACCACGTGGAAAGCGGCCCCTGCTGCCCCTCCACACACACATACACACTCACTGATCTACAGCCCCTGTTCGGCGTCAGAGTCCCC ACTAGACCCAGTGGAAGGGGTTAGAGACCAAGTAGGGGCCAGTTTCCAATTCACCCTGTCAGGGAGTGAGCCGGATCTGACGTTCCTTGT >In-frame_ZNF224_ENST00000336976_chr19_44602041_+_CYP2S1_ENST00000542619_chr19_41711863_+_1049nt GGTTGCTGCAGTTTTTCCGCGATAGTTTGGGGCAGTTCCGCGCGTTGCAGGCCCTTCTGAATTTCCTGGACCTACGCATTGGATCCTCAA AGAACTGCTGAATACCACTAGAAACATACCTGTAACCAGAGACAGCTGATTATAGCTTTCTGCAGCAAGGAAGCCCACGTACCAGGGGCT GTCTTGGCACAATTCTGCTTTCCCAGGAACTGCATCACTCAGGACTCTGCAAGTTTCCAGAAGTAAGAGGGAAAATGACCACGTTCAAGG GCACGGAGGTCTTCCCCCTCCTTGGCTCCATCCTGCATGACCCCAACATCTTCAAGCACCCAGAAGAGTTCAACCCAGACCGTTTCCTGG ATGCAGATGGACGGTTCAGGAAGCATGAGGCGTTCCTGCCCTTCTCCTTAGGGAAGCGTGTCTGCCTTGGAGAGGGCCTGGCAAAAGCGG AGCTCTTCCTCTTCTTCACCACCATCCTACAAGCCTTCTCCCTGGAGAGCCCGTGCCCGCCGGACACCCTGAGCCTCAAGCCCACCGTCA GTGGCCTTTTCAACATTCCCCCAGCCTTCCAGCTGCAAGTCCGTCCCACTGACCTTCACTCCACCACGCAGACCAGATGAAGGAAGGCAA CTTGGAAGTGGTGGGTGCCCAGGACGGTGCCTCCAGCCTCAACAGTGGGCATGGACAGGGTTAATGTCTCCAGAGTGTACACTGCAGGCA GCCACATTTACACGCCTGCAGTTGTTTTCCGGAGTCTGTCCCACGGCCCACACGCTCACTTGACTCATGCTGCTAAGATGCACAACCGCA CACCCATACACAACTACAAGGGCCACAAAGCAACTGCTGGGTTAGCTTTCCACAGACATAAATATAGTCCATCTGCAATCACAAGCACAT AGCCAGGTAACCCACCAACTCCCCTGGATCTGCAGCCCACACGTGGGAGTCTGGCTGTCACCTTCACAAGCCACAGAAACGGCCACACAT |
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FusionGenePPI for ZNF224_CYP2S1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF224 | PRMT5, TRIM28, MTUS2, MLH1, PTX3, LRP1B, LRP4, SORL1, ZNF813, LRP2, NOTCH3 | CYP2S1 | CDK2, ADAMTSL4, NT5E, KBTBD7, FMN1, VIPR2, CADM4, TPRA1, PRKCA, LAMP2, PCDHA12, PAG1, SRC, HOXB9, NCAM1, HRAS, MPP6, EPHA2, ARVCF, TNFSF8, TXNRD2, RGS19, CSNK1G3, GNA13, MPP2, YES1, MPZL1, EPB41L2, RAP2A, EFNA5, CXADR, GPRIN1, EPB41L3, GAP43, SMPDL3B, GNB4, CDCA3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF224_CYP2S1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF224_CYP2S1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CYP2S1 | C0033860 | Psoriasis | 1 | CTD_human |
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