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Fusion gene ID: 43084 |
FusionGeneSummary for ZNF212_PDE3B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF212_PDE3B | Fusion gene ID: 43084 | Hgene | Tgene | Gene symbol | ZNF212 | PDE3B | Gene ID | 7988 | 5140 |
| Gene name | zinc finger protein 212 | phosphodiesterase 3B | |
| Synonyms | C2H2-150|ZNF182|ZNFC150 | HcGIP1|cGIPDE1 | |
| Cytomap | 7q36.1 | 11p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 212Zinc finger protein C2H2-150 | cGMP-inhibited 3',5'-cyclic phosphodiesterase BCGI-PDE BCGIP1cyclic GMP-inhibited phosphodiesterase Bcyclic nucleotide phosphodiesterasephosphodiesterase 3B, cGMP-inhibited | |
| Modification date | 20180522 | 20180525 | |
| UniProtAcc | Q9UDV6 | Q13370 | |
| Ensembl transtripts involved in fusion gene | ENST00000335870, | ENST00000282096, ENST00000455098, ENST00000534317, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF212 [Title/Abstract] AND PDE3B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-WE-A8ZM-06A | ZNF212 | chr7 | 148947898 | + | PDE3B | chr11 | 14839729 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000335870 | ENST00000282096 | ZNF212 | chr7 | 148947898 | + | PDE3B | chr11 | 14839729 | + |
| In-frame | ENST00000335870 | ENST00000455098 | ZNF212 | chr7 | 148947898 | + | PDE3B | chr11 | 14839729 | + |
| 5CDS-intron | ENST00000335870 | ENST00000534317 | ZNF212 | chr7 | 148947898 | + | PDE3B | chr11 | 14839729 | + |
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FusionProtFeatures for ZNF212_PDE3B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF212 | PDE3B |
| May be involved in transcriptional regulation. | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are keyregulators of many important physiological processes. May play arole in fat metabolism. Regulates cAMP binding of RAPGEF3. Throughsimultaneous binding to RAPGEF3 and PIK3R6 assembles a signalingcomplex in which the PI3K gamma complex is activated by RAPGEF3and which is involved in angiogenesis.{ECO:0000269|PubMed:15147193, ECO:0000269|PubMed:21393242}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PDE3B | chr7:148947898 | chr11:14839729 | ENST00000282096 | + | 4 | 16 | 1077_1080 | 507 | 1113 | Compositional bias | Note=Poly-Glu |
| Tgene | >PDE3B | chr7:148947898 | chr11:14839729 | ENST00000282096 | + | 4 | 16 | 651_1079 | 507 | 1113 | Domain | PDEase |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZNF212 | chr7:148947898 | chr11:14839729 | ENST00000335870 | + | 3 | 5 | 141_219 | 180 | 496 | Domain | KRAB |
| Hgene | >ZNF212 | chr7:148947898 | chr11:14839729 | ENST00000335870 | + | 3 | 5 | 316_338 | 180 | 496 | Zinc finger | C2H2-type 1 |
| Hgene | >ZNF212 | chr7:148947898 | chr11:14839729 | ENST00000335870 | + | 3 | 5 | 369_391 | 180 | 496 | Zinc finger | C2H2-type 2 |
| Hgene | >ZNF212 | chr7:148947898 | chr11:14839729 | ENST00000335870 | + | 3 | 5 | 427_449 | 180 | 496 | Zinc finger | C2H2-type 3 |
| Hgene | >ZNF212 | chr7:148947898 | chr11:14839729 | ENST00000335870 | + | 3 | 5 | 455_477 | 180 | 496 | Zinc finger | C2H2-type 4 |
| Tgene | PDE3B | chr7:148947898 | chr11:14839729 | ENST00000282096 | + | 4 | 16 | 117_137 | 507 | 1113 | Transmembrane | Helical |
| Tgene | PDE3B | chr7:148947898 | chr11:14839729 | ENST00000282096 | + | 4 | 16 | 152_172 | 507 | 1113 | Transmembrane | Helical |
| Tgene | PDE3B | chr7:148947898 | chr11:14839729 | ENST00000282096 | + | 4 | 16 | 192_212 | 507 | 1113 | Transmembrane | Helical |
| Tgene | PDE3B | chr7:148947898 | chr11:14839729 | ENST00000282096 | + | 4 | 16 | 220_240 | 507 | 1113 | Transmembrane | Helical |
| Tgene | PDE3B | chr7:148947898 | chr11:14839729 | ENST00000282096 | + | 4 | 16 | 247_267 | 507 | 1113 | Transmembrane | Helical |
| Tgene | PDE3B | chr7:148947898 | chr11:14839729 | ENST00000282096 | + | 4 | 16 | 88_108 | 507 | 1113 | Transmembrane | Helical |
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FusionGeneSequence for ZNF212_PDE3B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZNF212_ENST00000335870_chr7_148947898_+_PDE3B_ENST00000282096_chr11_14839729_+_786aa MAESAPARHRRKRRSTPLTSSTLPSQATEKSSYFQTTEISLWTVVAAIQAVEKKMESQAARLQSLEGRTGTAEKKLADCEKMAVEFGNQL EGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKVSRSLENDGVCFTEQEWENLEDWQKELYRNVMESNYETLVSL SVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDC CSGKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEK MGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDG RINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPE YNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVN EFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPK >In-frame_ZNF212_ENST00000335870_chr7_148947898_+_PDE3B_ENST00000455098_chr11_14839729_+_786aa MAESAPARHRRKRRSTPLTSSTLPSQATEKSSYFQTTEISLWTVVAAIQAVEKKMESQAARLQSLEGRTGTAEKKLADCEKMAVEFGNQL EGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKVSRSLENDGVCFTEQEWENLEDWQKELYRNVMESNYETLVSL SVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDC CSGKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEK MGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDG RINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPE YNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVN EFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZNF212_ENST00000335870_chr7_148947898_+_PDE3B_ENST00000282096_chr11_14839729_+_2358nt ATGGCGGAGTCGGCGCCTGCTCGGCACAGGAGAAAACGACGCTCCACACCTTTAACTTCTTCCACACTTCCTTCACAAGCAACAGAGAAA AGCTCCTATTTTCAGACCACCGAGATTTCACTCTGGACGGTGGTGGCCGCTATTCAGGCTGTGGAGAAGAAGATGGAGTCCCAGGCTGCC CGGCTACAGAGCCTGGAGGGGCGCACGGGGACAGCCGAGAAGAAGCTGGCTGACTGCGAGAAGATGGCCGTGGAGTTCGGGAACCAGCTG GAGGGCAAGTGGGCCGTGCTGGGGACCCTGCTGCAGGAGTATGGGCTACTGCAGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAAC AGGAACTTCTGGATCCTGCGGCTGCCCCCGGGCAGCAAGGGGGAGGCCCCCAAGGTGTCCAGGTCACTGGAGAATGATGGCGTCTGTTTC ACCGAGCAGGAATGGGAGAATCTGGAGGATTGGCAGAAGGAGCTCTACAGAAACGTGATGGAGAGTAACTATGAGACACTGGTCTCTCTG AGTGTTTTGTCCAGTCTGAGTCCTGTGAATTCTTCCAACCATGGACCAGTGTCTACTGGCTCTCTAACTAATCGATCACCCATAGAATTT CCTGATACTGCTGATTTTCTTAATAAGCCAAGCGTTATCTTGCAGAGATCTCTGGGCAATGCACCTAATACTCCAGATTTTTATCAGCAA CTTAGAAATTCTGATAGCAATCTGTGTAACAGCTGTGGACATCAAATGCTGAAATATGTTTCAACATCTGAATCAGATGGTACAGATTGC TGCAGTGGAAAATCAGGTGAAGAAGAAAACATTTTCTCGAAAGAATCATTCAAACTTATGGAAACTCAACAAGAAGAGGAAACAGAGAAG AAAGACAGCAGAAAATTATTTCAGGAAGGTGATAAGTGGCTAACAGAAGAGGCACAGAGTGAACAGCAAACAAATATTGAACAGGAAGTA TCACTGGACCTGATTTTAGTAGAAGAGTATGACTCATTAATAGAAAAGATGAGCAACTGGAATTTTCCAATTTTTGAACTTGTAGAAAAG ATGGGAGAGAAATCAGGAAGGATTCTCAGTCAGGTTATGTATACCTTATTTCAAGACACTGGTTTATTGGAAATATTTAAAATTCCCACT CAACAATTTATGAACTATTTTCGTGCATTAGAAAATGGCTATCGAGACATTCCTTATCACAATCGTATACATGCCACAGATGTGCTACAT GCAGTTTGGTATCTGACAACACGGCCAGTTCCTGGCTTACAGCAGATCCACAATGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGT AGAATTAACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCT GCATTAGAATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAAT GCCCCTCAGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAA TACAACTTCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAG CATTTTGATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTG GTATGCCAGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAAT GAATTTTATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTC CAAGAATCTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAA GAGGATAATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAA CCACCAAGAAGGAAAAGCAGACGGCGAATATTTTGTCAGCTAATGCACCACCTCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAG GAAGAAGAAAAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGATGAGATTCAGGTAATTGAAGAG >In-frame_ZNF212_ENST00000335870_chr7_148947898_+_PDE3B_ENST00000455098_chr11_14839729_+_2358nt ATGGCGGAGTCGGCGCCTGCTCGGCACAGGAGAAAACGACGCTCCACACCTTTAACTTCTTCCACACTTCCTTCACAAGCAACAGAGAAA AGCTCCTATTTTCAGACCACCGAGATTTCACTCTGGACGGTGGTGGCCGCTATTCAGGCTGTGGAGAAGAAGATGGAGTCCCAGGCTGCC CGGCTACAGAGCCTGGAGGGGCGCACGGGGACAGCCGAGAAGAAGCTGGCTGACTGCGAGAAGATGGCCGTGGAGTTCGGGAACCAGCTG GAGGGCAAGTGGGCCGTGCTGGGGACCCTGCTGCAGGAGTATGGGCTACTGCAGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAAC AGGAACTTCTGGATCCTGCGGCTGCCCCCGGGCAGCAAGGGGGAGGCCCCCAAGGTGTCCAGGTCACTGGAGAATGATGGCGTCTGTTTC ACCGAGCAGGAATGGGAGAATCTGGAGGATTGGCAGAAGGAGCTCTACAGAAACGTGATGGAGAGTAACTATGAGACACTGGTCTCTCTG AGTGTTTTGTCCAGTCTGAGTCCTGTGAATTCTTCCAACCATGGACCAGTGTCTACTGGCTCTCTAACTAATCGATCACCCATAGAATTT CCTGATACTGCTGATTTTCTTAATAAGCCAAGCGTTATCTTGCAGAGATCTCTGGGCAATGCACCTAATACTCCAGATTTTTATCAGCAA CTTAGAAATTCTGATAGCAATCTGTGTAACAGCTGTGGACATCAAATGCTGAAATATGTTTCAACATCTGAATCAGATGGTACAGATTGC TGCAGTGGAAAATCAGGTGAAGAAGAAAACATTTTCTCGAAAGAATCATTCAAACTTATGGAAACTCAACAAGAAGAGGAAACAGAGAAG AAAGACAGCAGAAAATTATTTCAGGAAGGTGATAAGTGGCTAACAGAAGAGGCACAGAGTGAACAGCAAACAAATATTGAACAGGAAGTA TCACTGGACCTGATTTTAGTAGAAGAGTATGACTCATTAATAGAAAAGATGAGCAACTGGAATTTTCCAATTTTTGAACTTGTAGAAAAG ATGGGAGAGAAATCAGGAAGGATTCTCAGTCAGGTTATGTATACCTTATTTCAAGACACTGGTTTATTGGAAATATTTAAAATTCCCACT CAACAATTTATGAACTATTTTCGTGCATTAGAAAATGGCTATCGAGACATTCCTTATCACAATCGTATACATGCCACAGATGTGCTACAT GCAGTTTGGTATCTGACAACACGGCCAGTTCCTGGCTTACAGCAGATCCACAATGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGT AGAATTAACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCT GCATTAGAATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAAT GCCCCTCAGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAA TACAACTTCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAG CATTTTGATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTG GTATGCCAGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAAT GAATTTTATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTC CAAGAATCTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAA GAGGATAATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAA CCACCAAGAAGGAAAAGCAGACGGCGAATATTTTGTCAGCTAATGCACCACCTCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAG GAAGAAGAAAAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGATGAGATTCAGGTAATTGAAGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZNF212_ENST00000335870_chr7_148947898_+_PDE3B_ENST00000282096_chr11_14839729_+_3630nt AGAATGCACCTGGCATCAACACGGCGGCGGCGGCGGCGGCTTCCAACAGGCTCTGGGGCGCCGAGCGGACAGGAACGCAGCACGGGGGCT CCGAGGCGGGGTCTGGGTGTTGAGGGGCGACTGGAGCCATGGCGGAGTCGGCGCCTGCTCGGCACAGGAGAAAACGACGCTCCACACCTT TAACTTCTTCCACACTTCCTTCACAAGCAACAGAGAAAAGCTCCTATTTTCAGACCACCGAGATTTCACTCTGGACGGTGGTGGCCGCTA TTCAGGCTGTGGAGAAGAAGATGGAGTCCCAGGCTGCCCGGCTACAGAGCCTGGAGGGGCGCACGGGGACAGCCGAGAAGAAGCTGGCTG ACTGCGAGAAGATGGCCGTGGAGTTCGGGAACCAGCTGGAGGGCAAGTGGGCCGTGCTGGGGACCCTGCTGCAGGAGTATGGGCTACTGC AGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCCTGCGGCTGCCCCCGGGCAGCAAGGGGGAGGCCCCCA AGGTGTCCAGGTCACTGGAGAATGATGGCGTCTGTTTCACCGAGCAGGAATGGGAGAATCTGGAGGATTGGCAGAAGGAGCTCTACAGAA ACGTGATGGAGAGTAACTATGAGACACTGGTCTCTCTGAGTGTTTTGTCCAGTCTGAGTCCTGTGAATTCTTCCAACCATGGACCAGTGT CTACTGGCTCTCTAACTAATCGATCACCCATAGAATTTCCTGATACTGCTGATTTTCTTAATAAGCCAAGCGTTATCTTGCAGAGATCTC TGGGCAATGCACCTAATACTCCAGATTTTTATCAGCAACTTAGAAATTCTGATAGCAATCTGTGTAACAGCTGTGGACATCAAATGCTGA AATATGTTTCAACATCTGAATCAGATGGTACAGATTGCTGCAGTGGAAAATCAGGTGAAGAAGAAAACATTTTCTCGAAAGAATCATTCA AACTTATGGAAACTCAACAAGAAGAGGAAACAGAGAAGAAAGACAGCAGAAAATTATTTCAGGAAGGTGATAAGTGGCTAACAGAAGAGG CACAGAGTGAACAGCAAACAAATATTGAACAGGAAGTATCACTGGACCTGATTTTAGTAGAAGAGTATGACTCATTAATAGAAAAGATGA GCAACTGGAATTTTCCAATTTTTGAACTTGTAGAAAAGATGGGAGAGAAATCAGGAAGGATTCTCAGTCAGGTTATGTATACCTTATTTC AAGACACTGGTTTATTGGAAATATTTAAAATTCCCACTCAACAATTTATGAACTATTTTCGTGCATTAGAAAATGGCTATCGAGACATTC CTTATCACAATCGTATACATGCCACAGATGTGCTACATGCAGTTTGGTATCTGACAACACGGCCAGTTCCTGGCTTACAGCAGATCCACA ATGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATTAACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATC CTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATTAGAATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATC ACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCTCAGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATG CTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAACTTCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTT TAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTTGATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTA ATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATGCCAGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTC GAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTTTATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTC CATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGAATCTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATG CTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGATAATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATA CAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAACCACCAAGAAGGAAAAGCAGACGGCGAATATTTTGTCAGCTAATGCACCACC TCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAGGAAGAAGAAAAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCT CCTTACCTCAAGCAGATGAGATTCAGGTAATTGAAGAGGCAGATGAAGAGGAATAGCGACAGTTTGAGTAAAAGAAAAGTCATATTGAAG AAGCCCAGAGGGTTGTGCCCAGGGGCAGAAATCATTGCCTAGTGTTCACCGGCTGACTCTCAACTGACCATTCCCATGTGGACAGGCCTT AATACTGTGAGAGGATCCTTGCTCTGCTGGCAGTTTCCCACTCCTATGCACTTTCACAGGAACTAGAAAACTATTCTTAAACCAAAAATA CCATCCGTGTTGACCCATGTTGCAGAGCCCTTACTTAAATCCTTCACTGGTGTATGAATACTTTGTCATAATGCTGCTTTGCTGGGTAGT GAGCTCTTATTTTTCACTGGGGGTCAGCTATAACTAAAAACTCAAGTGACATATTTCAGTTACCAAAGTGGCCAGGAACTTTTTGCTTTT ATGAAAATAGATTCATATTGTATTTCCCAGTGTGTCTTTTATGTCTTTGAATGTTTTGGAGAAAAGTCTATGCCTGTCTAAAAATGAATC CAGTGTTGCCTTTCTGAGGGATTTCTGCTCAATGCAATACACTGTTCAGTGCTATTCTCCCAGCTAGGTTTATCCATGAAGGACTGAGTG ACCTTTGTTGTATTTAACAAAATCCAGGTGCATCAATTTCTGATGCTTTTTACTATTGTGTATTATCTACTATGTGTGTTTTATTTCTGC TGAGAGTATTCAGGTTTGCCATGGACATCAGAAGTTTGAATTCCAGTCTTATCTTATGTTCCATGGCTGAATTTTAAAGCTGTTTAGGTT TAACAATGAAGGGATTTATTCTTTAGTCAAAATTGTTGTTTTTACTCTAGCTCAGGATTCGTATTTTTAAAGATTTAGTTAATATGAACA CAGCACAGATTTGTTAGAAGAAAAAAAATTTGCTGTAATACCAAAACTAACCTCATCAAAGATACAGAAAAAAAGAAATATAGTGAGCCC TAAAGGACACATACATTGAATAAATAATTGGAACATGTGGTTATCTTTAGATCCACATCTTAGCTGTCATTTGTTCACTCTAAAACTGAT GTTCATCTTTCTGTTAATTTCCCTCTGCCTAAAGACTACATGACAGAAATGACCTATCACTACTTATTATTTCTGAAGCCTAACTGCAAG >In-frame_ZNF212_ENST00000335870_chr7_148947898_+_PDE3B_ENST00000455098_chr11_14839729_+_2720nt AGAATGCACCTGGCATCAACACGGCGGCGGCGGCGGCGGCTTCCAACAGGCTCTGGGGCGCCGAGCGGACAGGAACGCAGCACGGGGGCT CCGAGGCGGGGTCTGGGTGTTGAGGGGCGACTGGAGCCATGGCGGAGTCGGCGCCTGCTCGGCACAGGAGAAAACGACGCTCCACACCTT TAACTTCTTCCACACTTCCTTCACAAGCAACAGAGAAAAGCTCCTATTTTCAGACCACCGAGATTTCACTCTGGACGGTGGTGGCCGCTA TTCAGGCTGTGGAGAAGAAGATGGAGTCCCAGGCTGCCCGGCTACAGAGCCTGGAGGGGCGCACGGGGACAGCCGAGAAGAAGCTGGCTG ACTGCGAGAAGATGGCCGTGGAGTTCGGGAACCAGCTGGAGGGCAAGTGGGCCGTGCTGGGGACCCTGCTGCAGGAGTATGGGCTACTGC AGAGGCGGCTGGAGAACGTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCCTGCGGCTGCCCCCGGGCAGCAAGGGGGAGGCCCCCA AGGTGTCCAGGTCACTGGAGAATGATGGCGTCTGTTTCACCGAGCAGGAATGGGAGAATCTGGAGGATTGGCAGAAGGAGCTCTACAGAA ACGTGATGGAGAGTAACTATGAGACACTGGTCTCTCTGAGTGTTTTGTCCAGTCTGAGTCCTGTGAATTCTTCCAACCATGGACCAGTGT CTACTGGCTCTCTAACTAATCGATCACCCATAGAATTTCCTGATACTGCTGATTTTCTTAATAAGCCAAGCGTTATCTTGCAGAGATCTC TGGGCAATGCACCTAATACTCCAGATTTTTATCAGCAACTTAGAAATTCTGATAGCAATCTGTGTAACAGCTGTGGACATCAAATGCTGA AATATGTTTCAACATCTGAATCAGATGGTACAGATTGCTGCAGTGGAAAATCAGGTGAAGAAGAAAACATTTTCTCGAAAGAATCATTCA AACTTATGGAAACTCAACAAGAAGAGGAAACAGAGAAGAAAGACAGCAGAAAATTATTTCAGGAAGGTGATAAGTGGCTAACAGAAGAGG CACAGAGTGAACAGCAAACAAATATTGAACAGGAAGTATCACTGGACCTGATTTTAGTAGAAGAGTATGACTCATTAATAGAAAAGATGA GCAACTGGAATTTTCCAATTTTTGAACTTGTAGAAAAGATGGGAGAGAAATCAGGAAGGATTCTCAGTCAGGTTATGTATACCTTATTTC AAGACACTGGTTTATTGGAAATATTTAAAATTCCCACTCAACAATTTATGAACTATTTTCGTGCATTAGAAAATGGCTATCGAGACATTC CTTATCACAATCGTATACATGCCACAGATGTGCTACATGCAGTTTGGTATCTGACAACACGGCCAGTTCCTGGCTTACAGCAGATCCACA ATGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATTAACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATC CTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATTAGAATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATC ACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCTCAGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATG CTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAACTTCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTT TAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTTGATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTA ATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATGCCAGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTC GAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTTTATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTC CATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGAATCTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATG CTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGATAATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATA CAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAACCACCAAGAAGGAAAAGCAGACGGCGAATATTTTGTCAGCTAATGCACCACC TCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAGGAAGAAGAAAAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCT CCTTACCTCAAGCAGATGAGATTCAGGTAATTGAAGAGGCAGATGAAGAGGAATAGCGACAGTTTGAGTAAAAGAAAAGTCATATTGAAG AAGCCCAGAGGGTTGTGCCCAGGGGCAGAAATCATTGCCTAGTGTTCACCGGCTGACTCTCAACTGACCATTCCCATGTGGACAGGCCTT AATACTGTGAGAGGATCCTTGCTCTGCTGGCAGTTTCCCACTCCTATGCACTTTCACAGGAACTAGAAAACTATTCTTAAACCAAAAATA |
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FusionGenePPI for ZNF212_PDE3B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF212 | ZZZ3, PPARGC1B, ATF4, ATF3, CREB3L2, CSK, DPF2, DUSP6, FHL2, GNL1, HBP1, SAP30BP, NFKBIA, NKX2-3, PTP4A1, RND1, ZNF212, ZNF3, ZNF331, ZNF408, SUV39H2, SF3A3, FAM90A1, LOC155060, ZNF746, ADO, ZNF398, ZNF282, ERP44, EPDR1, ZNF777, DIS3 | PDE3B | ANKRA2, YWHAQ, SRPRB, SLC8A3, TMEM59, TEX264, IL9R, GNAI1, SLC39A4, FAM189A2, EVA1C, CHRNA9, LRRTM2, TEX28, ZNRF4, LRRTM1, PCDHAC2, HLA-DRB1, IL17RC, KCNS3, FAM189B, KCNC4, TMPRSS3, CD79B, LRRC8B, RNF170, PDGFRB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | PDE3B | chr7:148947898 | chr11:14839729 | ENST00000282096 | + | 4 | 16 | 436_460 | 507 | 1113 | PIK3R6 |
| Tgene | PDE3B | chr7:148947898 | chr11:14839729 | ENST00000282096 | + | 4 | 16 | 1_25 | 507 | 1113 | RAPGEF3 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF212_PDE3B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF212_PDE3B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PDE3B | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
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