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Fusion gene ID: 43072 |
FusionGeneSummary for ZNF207_LRRC37B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF207_LRRC37B | Fusion gene ID: 43072 | Hgene | Tgene | Gene symbol | ZNF207 | LRRC37B | Gene ID | 7756 | 114659 |
| Gene name | zinc finger protein 207 | leucine rich repeat containing 37B | |
| Synonyms | BuGZ|hBuGZ | LRRC37 | |
| Cytomap | 17q11.2 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | BUB3-interacting and GLEBS motif-containing protein ZNF207 | leucine-rich repeat-containing protein 37BC66 SLIT-like testicular protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43670 | Q96QE4 | |
| Ensembl transtripts involved in fusion gene | ENST00000394670, ENST00000321233, ENST00000394673, ENST00000341711, ENST00000342555, ENST00000577908, ENST00000584416, | ENST00000543378, ENST00000327564, ENST00000394713, ENST00000584368, ENST00000341671, ENST00000581786, | |
| Fusion gene scores | * DoF score | 10 X 12 X 8=960 | 6 X 6 X 6=216 |
| # samples | 13 | 6 | |
| ** MAII score | log2(13/960*10)=-2.88452278258006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZNF207 [Title/Abstract] AND LRRC37B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZNF207 | GO:0090307 | mitotic spindle assembly | 26388440 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-FR-A7U8-06A | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000394670 | ENST00000543378 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000394670 | ENST00000327564 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000394670 | ENST00000394713 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000394670 | ENST00000584368 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000394670 | ENST00000341671 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-intron | ENST00000394670 | ENST00000581786 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000321233 | ENST00000543378 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000321233 | ENST00000327564 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000321233 | ENST00000394713 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000321233 | ENST00000584368 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000321233 | ENST00000341671 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-intron | ENST00000321233 | ENST00000581786 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000394673 | ENST00000543378 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000394673 | ENST00000327564 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000394673 | ENST00000394713 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000394673 | ENST00000584368 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000394673 | ENST00000341671 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-intron | ENST00000394673 | ENST00000581786 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000341711 | ENST00000543378 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000341711 | ENST00000327564 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000341711 | ENST00000394713 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000341711 | ENST00000584368 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000341711 | ENST00000341671 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-intron | ENST00000341711 | ENST00000581786 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000342555 | ENST00000543378 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000342555 | ENST00000327564 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000342555 | ENST00000394713 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000342555 | ENST00000584368 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-3CDS | ENST00000342555 | ENST00000341671 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| 3UTR-intron | ENST00000342555 | ENST00000581786 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-3CDS | ENST00000577908 | ENST00000543378 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-3CDS | ENST00000577908 | ENST00000327564 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-3CDS | ENST00000577908 | ENST00000394713 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-3CDS | ENST00000577908 | ENST00000584368 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-3CDS | ENST00000577908 | ENST00000341671 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-intron | ENST00000577908 | ENST00000581786 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-3CDS | ENST00000584416 | ENST00000543378 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-3CDS | ENST00000584416 | ENST00000327564 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-3CDS | ENST00000584416 | ENST00000394713 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-3CDS | ENST00000584416 | ENST00000584368 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-3CDS | ENST00000584416 | ENST00000341671 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
| intron-intron | ENST00000584416 | ENST00000581786 | ZNF207 | chr17 | 30696801 | + | LRRC37B | chr17 | 30376121 | + |
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FusionProtFeatures for ZNF207_LRRC37B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF207 | LRRC37B |
| Kinetochore- and microtubule-binding protein that playsa key role in spindle assembly (PubMed:24462186, PubMed:24462187,PubMed:26388440). ZNF207/BuGZ is mainly composed of disorderedlow-complexity regions and undergoes phase transition orcoacervation to form temperature-dependent liquid droplets.Coacervation promotes microtubule bundling and concentratestubulin, promoting microtubule polymerization and assembly ofspindle and spindle matrix by concentrating its building blocks(PubMed:26388440). Also acts as a regulator of mitotic chromosomealignment by mediating the stability and kinetochore loading ofBUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3is protected are unclear: according to a first report, ZNF207/BuGZmay act by blocking ubiquitination and proteasomal degradation ofBUB3 (PubMed:24462186). According to another report, thestabilization is independent of the proteasome (PubMed:24462187).{ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187,ECO:0000269|PubMed:26388440}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF207_LRRC37B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF207_LRRC37B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF207 | USP7, ERBB3, SF3A2, BUB3, ZC3H14, TXNDC5, HNRNPUL1, WDR77, HNRNPM, MAP2K2, POLR1B, HECW2, WBP4, SHMT2, MOV10, NXF1, ABCE1, NTRK1, EWSR1, RNPS1, UBR5, KPNB1, HSPH1, ZNF207, PUF60, SRSF11, DPY30, S100A9, SETD1A, CS, PA2G4, TRAP1, SND1, ANXA5, SNRPB2, EIF5B, GPI, IDH2, PDIA3, UBE2N | LRRC37B | ELAVL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF207_LRRC37B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF207_LRRC37B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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