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Fusion gene ID: 43061 |
FusionGeneSummary for ZNF197_OSBPL10 |
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Fusion gene information | Fusion gene name: ZNF197_OSBPL10 | Fusion gene ID: 43061 | Hgene | Tgene | Gene symbol | ZNF197 | OSBPL10 | Gene ID | 10168 | 114884 |
Gene name | zinc finger protein 197 | oxysterol binding protein like 10 | |
Synonyms | D3S1363E|P18|VHLaK|ZKSCAN9|ZNF166|ZNF20|ZSCAN41 | ORP10|OSBP9 | |
Cytomap | 3p21.31 | 3p23 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 197VHL-associated KRAB-A domain-containing proteinpVHL-associated KRAB domain-containing proteinzinc finger protein 166zinc finger protein 20zinc finger protein with KRAB and SCAN domains 9 | oxysterol-binding protein-related protein 10ORP-10OSBP-related protein 10 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O14709 | Q9BXB5 | |
Ensembl transtripts involved in fusion gene | ENST00000383744, ENST00000344387, ENST00000383745, ENST00000396058, | ENST00000396556, ENST00000438237, ENST00000467647, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 3 X 4=72 |
# samples | 3 | 5 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/72*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF197 [Title/Abstract] AND OSBPL10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | MESO | TCGA-XT-AASU-01A | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000383744 | ENST00000396556 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
intron-intron | ENST00000383744 | ENST00000438237 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
intron-intron | ENST00000383744 | ENST00000467647 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
intron-intron | ENST00000344387 | ENST00000396556 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
intron-intron | ENST00000344387 | ENST00000438237 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
intron-intron | ENST00000344387 | ENST00000467647 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
intron-intron | ENST00000383745 | ENST00000396556 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
intron-intron | ENST00000383745 | ENST00000438237 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
intron-intron | ENST00000383745 | ENST00000467647 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
intron-intron | ENST00000396058 | ENST00000396556 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
intron-intron | ENST00000396058 | ENST00000438237 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
intron-intron | ENST00000396058 | ENST00000467647 | ZNF197 | chr3 | 44627705 | + | OSBPL10 | chr3 | 32088095 | - |
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FusionProtFeatures for ZNF197_OSBPL10 |
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Hgene | Tgene |
ZNF197 | OSBPL10 |
May be involved in transcriptional regulation. | Probable lipid transporter involved in lipidcountertransport between the endoplasmic reticulum and the plasmamembrane. Its ability to bind phosphatidylserine, suggests that itspecifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P(PubMed:23934110) (Probable). Plays a role in negative regulationof lipid biosynthesis (PubMed:19554302). Negatively regulates APOBsecretion from hepatocytes (PubMed:19554302, PubMed:22906437).Binds cholesterol and acidic phospholipids (PubMed:22906437). Alsobinds 25-hydroxycholesterol (PubMed:17428193). Bindsphosphatidylserine (PubMed:23934110).{ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302,ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110,ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF197_OSBPL10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF197_OSBPL10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF197 | VHL, HIF1A, TRIM28, DISC1, NDEL1, ZSCAN32, ZNF397, ZSCAN20, HSPB1, CCDC136, ZNF232, ZNF483 | OSBPL10 | AP2B1, ALDOA, BBS1, GBAS, MMP2, CUL1, CLINT1, KEAP1, SAP18, SRRM2, WRNIP1, CLPB, USP11, OSBPL9, ZC3H18, PGAM5, IKBKG, VAPB, VAPA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF197_OSBPL10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF197_OSBPL10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |