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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43056

FusionGeneSummary for ZNF185_B2M

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF185_B2M
Fusion gene ID: 43056
HgeneTgene
Gene symbol

ZNF185

B2M

Gene ID

7739

567

Gene namezinc finger protein 185 with LIM domainbeta-2-microglobulin
SynonymsSCELLIMD43
Cytomap

Xq28

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 185P1-Asciellin likezinc finger protein 185 (LIM domain)beta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobin
Modification date2018051920180523
UniProtAcc

O15231

P61769

Ensembl transtripts involved in fusion geneENST00000535861, ENST00000318504, 
ENST00000539731, ENST00000324823, 
ENST00000449285, ENST00000370268, 
ENST00000370270, ENST00000318529, 
ENST00000454925, 		ENST00000558401, 
ENST00000559916, ENST00000544417, 
ENST00000559220, 
Fusion gene scores* DoF score1 X 1 X 1=114 X 19 X 3=798
# samples 123
** MAII scorelog2(1/1*10)=3.32192809488736log2(23/798*10)=-1.79475488527797
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF185 [Title/Abstract] AND B2M [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneB2M

GO:0002726

positive regulation of T cell cytokine production

24643698

TgeneB2M

GO:1900121

negative regulation of receptor binding

9465039


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW997596ZNF185chrX

152141128

+B2Mchr15

45010424

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000535861ENST00000558401ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000535861ENST00000559916ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000535861ENST00000544417ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000535861ENST00000559220ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-3UTRENST00000318504ENST00000558401ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000318504ENST00000559916ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000318504ENST00000544417ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000318504ENST00000559220ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-3UTRENST00000539731ENST00000558401ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000539731ENST00000559916ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000539731ENST00000544417ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000539731ENST00000559220ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-3UTRENST00000324823ENST00000558401ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000324823ENST00000559916ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000324823ENST00000544417ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000324823ENST00000559220ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-3UTRENST00000449285ENST00000558401ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000449285ENST00000559916ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000449285ENST00000544417ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000449285ENST00000559220ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-3UTRENST00000370268ENST00000558401ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000370268ENST00000559916ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000370268ENST00000544417ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000370268ENST00000559220ZNF185chrX

152141128

+B2Mchr15

45010424

-
intron-3UTRENST00000370270ENST00000558401ZNF185chrX

152141128

+B2Mchr15

45010424

-
intron-intronENST00000370270ENST00000559916ZNF185chrX

152141128

+B2Mchr15

45010424

-
intron-intronENST00000370270ENST00000544417ZNF185chrX

152141128

+B2Mchr15

45010424

-
intron-intronENST00000370270ENST00000559220ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-3UTRENST00000318529ENST00000558401ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000318529ENST00000559916ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000318529ENST00000544417ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000318529ENST00000559220ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-3UTRENST00000454925ENST00000558401ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000454925ENST00000559916ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000454925ENST00000544417ZNF185chrX

152141128

+B2Mchr15

45010424

-
3UTR-intronENST00000454925ENST00000559220ZNF185chrX

152141128

+B2Mchr15

45010424

-

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FusionProtFeatures for ZNF185_B2M


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF185

O15231

B2M

P61769

Component of the class I major histocompatibilitycomplex (MHC). Involved in the presentation of peptide antigens tothe immune system. Exogenously applied M.tuberculosis EsxA orEsxA-EsxB (or EsxA expressed in host) binds B2M and decreases itsexport to the cell surface (total protein levels do not change),probably leading to defects in class I antigen presentation(PubMed:25356553). {ECO:0000269|PubMed:25356553}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF185_B2M


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF185_B2M


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF185_B2M


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneB2MP61769DB00254DoxycyclineBeta-2-microglobulinsmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for ZNF185_B2M


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneB2MC0022658Kidney Diseases3CTD_human;HPO
TgeneB2MC2609414Acute kidney injury2CTD_human
TgeneB2MC0004364Autoimmune Diseases1CTD_human
TgeneB2MC0018799Heart Diseases1CTD_human
TgeneB2MC0020455Hypergammaglobulinemia1CTD_human
TgeneB2MC0033578Prostatic Neoplasms1CTD_human
TgeneB2MC0036341Schizophrenia1PSYGENET
TgeneB2MC0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneB2MC0079774Peripheral T-Cell Lymphoma1CTD_human
TgeneB2MC0268389Amyloidosis, familial visceral1UNIPROT
TgeneB2MC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneB2MC1855796Hypoproteinemia, Hypercatabolic1CTD_human;UNIPROT