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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43047

FusionGeneSummary for ZNF177_DAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF177_DAB1
Fusion gene ID: 43047
HgeneTgene
Gene symbol

ZNF177

DAB1

Gene ID

7730

115209

Gene namezinc finger protein 177OMA1 zinc metallopeptidase
SynonymsPIGX2010001O09Rik|DAB1|MPRP-1|MPRP1|YKR087C|ZMPOMA1|peptidase
Cytomap

19p13.2

1p32.2-p32.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 177metalloendopeptidase OMA1, mitochondrialOMA1 homolog, zinc metallopeptidaseOMA1 zinc metallopeptidase homologmetalloprotease-related protein 1overlapping activity with M-AAA proteaseoverlapping with the m-AAA protease 1 homologzinc metallopeptidase
Modification date2018052320180519
UniProtAcc

Q13360

O75553

Ensembl transtripts involved in fusion geneENST00000446085, ENST00000541595, 
ENST00000602738, ENST00000605471, 
ENST00000602856, ENST00000343499, 
ENST00000589262, ENST00000434737, 
ENST00000590616, 		ENST00000485760, 
ENST00000371236, ENST00000371234, 
ENST00000420954, ENST00000439789, 
ENST00000414851, ENST00000371231, 
ENST00000371230, 
Fusion gene scores* DoF score3 X 2 X 2=1210 X 7 X 7=490
# samples 310
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/490*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF177 [Title/Abstract] AND DAB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AJ-A3NF-01AZNF177chr19

9475624

+DAB1chr1

57611102

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000446085ENST00000485760ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000446085ENST00000371236ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000446085ENST00000371234ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000446085ENST00000420954ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000446085ENST00000439789ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000446085ENST00000414851ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000446085ENST00000371231ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000446085ENST00000371230ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000541595ENST00000485760ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000541595ENST00000371236ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000541595ENST00000371234ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000541595ENST00000420954ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000541595ENST00000439789ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000541595ENST00000414851ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000541595ENST00000371231ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000541595ENST00000371230ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602738ENST00000485760ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602738ENST00000371236ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602738ENST00000371234ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602738ENST00000420954ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602738ENST00000439789ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602738ENST00000414851ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602738ENST00000371231ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602738ENST00000371230ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000605471ENST00000485760ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000605471ENST00000371236ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000605471ENST00000371234ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000605471ENST00000420954ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000605471ENST00000439789ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000605471ENST00000414851ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000605471ENST00000371231ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000605471ENST00000371230ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602856ENST00000485760ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602856ENST00000371236ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602856ENST00000371234ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602856ENST00000420954ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602856ENST00000439789ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602856ENST00000414851ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602856ENST00000371231ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000602856ENST00000371230ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000343499ENST00000485760ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000343499ENST00000371236ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000343499ENST00000371234ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000343499ENST00000420954ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000343499ENST00000439789ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000343499ENST00000414851ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000343499ENST00000371231ZNF177chr19

9475624

+DAB1chr1

57611102

-
5UTR-5UTRENST00000343499ENST00000371230ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000589262ENST00000485760ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000589262ENST00000371236ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000589262ENST00000371234ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000589262ENST00000420954ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000589262ENST00000439789ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000589262ENST00000414851ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000589262ENST00000371231ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000589262ENST00000371230ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000434737ENST00000485760ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000434737ENST00000371236ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000434737ENST00000371234ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000434737ENST00000420954ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000434737ENST00000439789ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000434737ENST00000414851ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000434737ENST00000371231ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000434737ENST00000371230ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000590616ENST00000485760ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000590616ENST00000371236ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000590616ENST00000371234ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000590616ENST00000420954ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000590616ENST00000439789ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000590616ENST00000414851ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000590616ENST00000371231ZNF177chr19

9475624

+DAB1chr1

57611102

-
intron-5UTRENST00000590616ENST00000371230ZNF177chr19

9475624

+DAB1chr1

57611102

-

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FusionProtFeatures for ZNF177_DAB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF177

Q13360

DAB1

O75553

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF177_DAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF177_DAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF177SLC37A3, ARHGAP21, RHOUDAB1APLP1, SIAH1, LRP2, LRP1, LDLR, VLDLR, LRP8, MYO6, APP, APLP2, CDK5, SH3KBP1, SOCS1, SOCS3, ERBB2, ERBB3, INPP5D, RBFOX1, CDK6, MBNL1, ROR2, PIN1, SNRPB, TCEA2, HYAL3, BHLHE40, PPIG, MAGED1, DAZAP2, SERF2, SIRPB1, ARID5A, CLASRP, POGZ, FAM168A, RBFOX2, ZBTB32, VENTX, TOLLIP, USP53, ZCCHC10, WDYHV1, STRBP, MBNL3, SMAP2, HMBOX1, FAM103A1, RHOXF2, LNX1, ZC3H10, C1orf94, NAF1, HNRNPLL, ZNF488, PRR20A, CIART, TMTC3, TCEANC, LGALS9B, KRTAP8-1, KRTAP19-5, KRTAP19-7, LGALS9C, SOCS6, SOCS7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF177_DAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF177_DAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNF177C0038356Stomach Neoplasms1CTD_human
TgeneDAB1C0004352Autistic Disorder1CTD_human