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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43043

FusionGeneSummary for ZNF16_PLEKHA4

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF16_PLEKHA4
Fusion gene ID: 43043
HgeneTgene
Gene symbol

ZNF16

PLEKHA4

Gene ID

7564

57664

Gene namezinc finger protein 16pleckstrin homology domain containing A4
SynonymsHZF1|KOX9PEPP1
Cytomap

8q24.3

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 16zinc finger protein KOX9zinc finger protein Kruppel type 9pleckstrin homology domain-containing family A member 4PH domain-containing family A member 4phosphoinositol 3-phosphate-binding PH domain protein 1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
Modification date2018052220180519
UniProtAcc

P17020

Q9H4M7

Ensembl transtripts involved in fusion geneENST00000276816, ENST00000394909, 
ENST00000355496, ENST00000263265, 
ENST00000596713, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 3=36
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF16 [Title/Abstract] AND PLEKHA4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF16

GO:0008284

positive regulation of cell proliferation

21874239

HgeneZNF16

GO:0033674

positive regulation of kinase activity

21874239

HgeneZNF16

GO:0043066

negative regulation of apoptotic process

21874239

HgeneZNF16

GO:0072707

cellular response to sodium dodecyl sulfate

21874239

HgeneZNF16

GO:1901989

positive regulation of cell cycle phase transition

21874239


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A8BJ-01AZNF16chr8

146171397

-PLEKHA4chr19

49355583

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000276816ENST00000355496ZNF16chr8

146171397

-PLEKHA4chr19

49355583

-
In-frameENST00000276816ENST00000263265ZNF16chr8

146171397

-PLEKHA4chr19

49355583

-
5CDS-intronENST00000276816ENST00000596713ZNF16chr8

146171397

-PLEKHA4chr19

49355583

-
Frame-shiftENST00000394909ENST00000355496ZNF16chr8

146171397

-PLEKHA4chr19

49355583

-
Frame-shiftENST00000394909ENST00000263265ZNF16chr8

146171397

-PLEKHA4chr19

49355583

-
5CDS-intronENST00000394909ENST00000596713ZNF16chr8

146171397

-PLEKHA4chr19

49355583

-

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FusionProtFeatures for ZNF16_PLEKHA4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF16

P17020

PLEKHA4

Q9H4M7

Acts as a transcriptional activator. Promotes cellproliferation by facilitating the cell cycle phase transition fromthe S to G2/M phase. Involved in both the hemin- and phorbolmyristate acetate (PMA)-induced erythroid and megakaryocyticdifferentiation, respectively. Plays also a role as an inhibitorof cell apoptosis. {ECO:0000269|PubMed:16628192,ECO:0000269|PubMed:19763908, ECO:0000269|PubMed:21874239}. Binds specifically to phosphatidylinositol 3-phosphate(PtdIns3P), but not to other phosphoinositides.{ECO:0000269|PubMed:11001876}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34268_39365683RegionNote=Required for nuclear localization
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34341_37365683RegionNote=Required for nuclear localization
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34473_50365683RegionNote=Required for nuclear localization
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-3462_21065683RegionNote=Necessary for transcription activation
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23268_39365683RegionNote=Required for nuclear localization
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23341_37365683RegionNote=Required for nuclear localization
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23473_50365683RegionNote=Required for nuclear localization
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-2362_21065683RegionNote=Necessary for transcription activation
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34209_23165683Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34237_25965683Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34265_28765683Zinc fingerC2H2-type 3
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34293_31565683Zinc fingerC2H2-type 4
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34321_34365683Zinc fingerC2H2-type 5
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34349_37165683Zinc fingerC2H2-type 6
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34377_39965683Zinc fingerC2H2-type 7
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34405_42765683Zinc fingerC2H2-type 8
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34433_45565683Zinc fingerC2H2-type 9
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34461_48365683Zinc fingerC2H2-type 10
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34489_51165683Zinc fingerC2H2-type 11
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34517_53965683Zinc fingerC2H2-type 12
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34545_56765683Zinc fingerC2H2-type 13
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34573_59565683Zinc fingerC2H2-type 14
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34601_62365683Zinc fingerC2H2-type 15
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34629_65165683Zinc fingerC2H2-type 16
HgeneZNF16chr8:146171397chr19:49355583ENST00000276816-34657_67965683Zinc fingerC2H2-type 17
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23209_23165683Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23237_25965683Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23265_28765683Zinc fingerC2H2-type 3
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23293_31565683Zinc fingerC2H2-type 4
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23321_34365683Zinc fingerC2H2-type 5
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23349_37165683Zinc fingerC2H2-type 6
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23377_39965683Zinc fingerC2H2-type 7
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23405_42765683Zinc fingerC2H2-type 8
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23433_45565683Zinc fingerC2H2-type 9
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23461_48365683Zinc fingerC2H2-type 10
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23489_51165683Zinc fingerC2H2-type 11
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23517_53965683Zinc fingerC2H2-type 12
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23545_56765683Zinc fingerC2H2-type 13
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23573_59565683Zinc fingerC2H2-type 14
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23601_62365683Zinc fingerC2H2-type 15
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23629_65165683Zinc fingerC2H2-type 16
HgeneZNF16chr8:146171397chr19:49355583ENST00000394909-23657_67965683Zinc fingerC2H2-type 17
TgenePLEKHA4chr8:146171397chr19:49355583ENST00000263265-1120162_353442780Compositional biasNote=Pro-rich
TgenePLEKHA4chr8:146171397chr19:49355583ENST00000355496-1017162_353417619Compositional biasNote=Pro-rich
TgenePLEKHA4chr8:146171397chr19:49355583ENST00000263265-112054_153442780DomainPH
TgenePLEKHA4chr8:146171397chr19:49355583ENST00000355496-101754_153417619DomainPH


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FusionGeneSequence for ZNF16_PLEKHA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF16_ENST00000276816_chr8_146171397_-_PLEKHA4_ENST00000355496_chr19_49355583_-_232aa
MPSLRTRREEAEMELSVPGPSPWTPAAQARVRDAPAVTHPGSAACGTPCCSDTELEAICPHYQQPGAREGLGHVQWPGAGAGHLKRDAGV
PAAPWFSPGQSVCSAAAVDGGRHAGRSGWPPETAPTHXAXLPISRAPGRGVLREGEPARVLGTELPXVPRDXLGAASWRRQRPRQPSLRS

>In-frame_ZNF16_ENST00000276816_chr8_146171397_-_PLEKHA4_ENST00000263265_chr19_49355583_-_403aa
MPSLRTRREEAEMELSVPGPSPWTPAAQARVRDAPAVTHPGSAACGTPCCSDTELEAICPHYQQPGAREGLGHVQWPGAGAGHLKRDAGV
PAAPWFSPGQSVCSAAAVDGGRHAGRSGWPPETAPTHXAXLPISRAPGRGVLREGEPARVLGTELPXVPRDXLGAASWRRQRPRQPSLRS
WVSEGLPGFQPXGSPPPFPTARNQGPGGPAPDECPGAAGADAQKPGMWTALPSPDLPPASHPGKDTVPSQTPAXRGAKACRRTLGSPEMA
QKLWVLEXSKEHHPLLADFRRSPGAGSQPLPSPGYXGVAVAQNDDRWKFGLPGRPSSRCAAASFGPHAPGDPSPQISPGGXFGFHGVLSP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF16_ENST00000276816_chr8_146171397_-_PLEKHA4_ENST00000355496_chr19_49355583_-_697nt
ATGCCCAGCCTCAGAACTCGCCGTGAGGAGGCAGAGATGGAGCTCTCAGTTCCAGGACCATCCCCCTGGACCCCTGCAGCCCAGGCCCGT
GTGAGAGATGCTCCTGCTGTGACCCACCCTGGATCTGCAGCCTGTGGTACCCCCTGCTGTAGTGATACTGAGCTGGAAGCCATCTGCCCT
CACTATCAGCAGCCAGGAGCGAGAGAGGGTTTGGGACACGTACAGTGGCCTGGAGCAGGAGCTGGGCACCTTAAGAGAGACGCTGGAGTA
CCTGCTGCACCTTGGTTCTCCCCAGGACAGAGTGTCTGCTCAGCAGCAGCTGTGGATGGTGGAAGACACGCTGGCAGGTCTGGGTGGCCC
CCAGAAACCGCCCCCACACACTGAGCCTGACTCCCCATCTCCCGTGCTCCAGGGCGAGGAGTCCTCAGAGAGGGAGAGCCTGCCAGAGTC
CTTGGAACTGAGCTCCCCTAGGTCCCCCGAGACTGACTGGGGGCGGCCTCCTGGAGGCGACAAAGACCTCGCCAGCCCTCACTTAGGTCT
TGGGTCTCCGAGGGTCTCCCGGGCTTCCAGCCCTGAGGGTCGCCACCTCCCTTCCCCACAGCTAGGAACCAAGTCCAAGGAACACCACCC

>In-frame_ZNF16_ENST00000276816_chr8_146171397_-_PLEKHA4_ENST00000263265_chr19_49355583_-_1210nt
ATGCCCAGCCTCAGAACTCGCCGTGAGGAGGCAGAGATGGAGCTCTCAGTTCCAGGACCATCCCCCTGGACCCCTGCAGCCCAGGCCCGT
GTGAGAGATGCTCCTGCTGTGACCCACCCTGGATCTGCAGCCTGTGGTACCCCCTGCTGTAGTGATACTGAGCTGGAAGCCATCTGCCCT
CACTATCAGCAGCCAGGAGCGAGAGAGGGTTTGGGACACGTACAGTGGCCTGGAGCAGGAGCTGGGCACCTTAAGAGAGACGCTGGAGTA
CCTGCTGCACCTTGGTTCTCCCCAGGACAGAGTGTCTGCTCAGCAGCAGCTGTGGATGGTGGAAGACACGCTGGCAGGTCTGGGTGGCCC
CCAGAAACCGCCCCCACACACTGAGCCTGACTCCCCATCTCCCGTGCTCCAGGGCGAGGAGTCCTCAGAGAGGGAGAGCCTGCCAGAGTC
CTTGGAACTGAGCTCCCCTAGGTCCCCCGAGACTGACTGGGGGCGGCCTCCTGGAGGCGACAAAGACCTCGCCAGCCCTCACTTAGGTCT
TGGGTCTCCGAGGGTCTCCCGGGCTTCCAGCCCTGAGGGTCGCCACCTCCCTTCCCCACAGCTAGGAACCAAGGCCCCGGTGGCCCGGCC
CCGGATGAGTGCCCAGGAGCAGCTGGAGCGGATGCGCAGAAACCAGGAATGTGGACGGCCCTTCCCTCGCCCGACCTCCCCCCGGCTTCT
CACCCTGGGAAGGACACTGTCCCCAGCCAGACGCCAGCCTGACGTGGAGCAAAGGCCTGTCGTAGGACACTCGGGAGCCCAGAAATGGCT
CAGAAGCTCTGGGTCCTGGAGTAGTCCAAGGAACACCACCCCTTACTTGCCGACTTCCGAAGGTCACCGGGAGCGGGTTCTCAGCCTCTC
CCAAGCCCTGGCTACTGAGGCGTCGCAGTGGCACAGAATGATGACAGGTGGAAATTTGGACTCCCAGGGAGACCCTCTTCCCGGTGTGCC
GCTGCCTCCTTCGGACCCCACGCGCCAGGAGACCCCTCCCCCCAGATCTCCCCCGGTGGCTAATTCGGGTTCCACGGGGTTCTCTCGCCG
AGGGAGTGGGCGTGGAGGAGGTCCCACCCCCTGGGGGCCCGCGTGGGATGCCGGGATCGCCCCTCCGGTCCTGCCACAAGACGAGGGGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF16_ENST00000276816_chr8_146171397_-_PLEKHA4_ENST00000355496_chr19_49355583_-_1368nt
AATTCGGGGCGGGACTTCCGGGGGTCAGCCGGCGTTGGCTGAGACGTCTTCGTGCCACGGTGCTGCCTCCTTTCCAAGCGCGACCCGTTG
AGATCCCCTTGACCACACCCTCATTCTCAGCTGGTGCTCATGAAGGACAGAAGAGTCAATGTCAGTACAATGTGAGTGAAGGGCTGAGGT
CCTTGTCATGCCCAGCCTCAGAACTCGCCGTGAGGAGGCAGAGATGGAGCTCTCAGTTCCAGGACCATCCCCCTGGACCCCTGCAGCCCA
GGCCCGTGTGAGAGATGCTCCTGCTGTGACCCACCCTGGATCTGCAGCCTGTGGTACCCCCTGCTGTAGTGATACTGAGCTGGAAGCCAT
CTGCCCTCACTATCAGCAGCCAGGAGCGAGAGAGGGTTTGGGACACGTACAGTGGCCTGGAGCAGGAGCTGGGCACCTTAAGAGAGACGC
TGGAGTACCTGCTGCACCTTGGTTCTCCCCAGGACAGAGTGTCTGCTCAGCAGCAGCTGTGGATGGTGGAAGACACGCTGGCAGGTCTGG
GTGGCCCCCAGAAACCGCCCCCACACACTGAGCCTGACTCCCCATCTCCCGTGCTCCAGGGCGAGGAGTCCTCAGAGAGGGAGAGCCTGC
CAGAGTCCTTGGAACTGAGCTCCCCTAGGTCCCCCGAGACTGACTGGGGGCGGCCTCCTGGAGGCGACAAAGACCTCGCCAGCCCTCACT
TAGGTCTTGGGTCTCCGAGGGTCTCCCGGGCTTCCAGCCCTGAGGGTCGCCACCTCCCTTCCCCACAGCTAGGAACCAAGTCCAAGGAAC
ACCACCCCTTACTTGCCGACTTCCGAAGGTCACCGGGAGCGGGTTCTCAGCCTCTCCCAAGCCCTGGCTACTGAGGCGTCGCAGTGGCAC
AGAATGATGACAGGTGGAAATTTGGACTCCCAGGGAGACCCTCTTCCCGGTGTGCCGCTGCCTCCTTCGGACCCCACGCGCCAGGAGACC
CCTCCCCCCAGATCTCCCCCGGTGGCTAATTCGGGTTCCACGGGGTTCTCTCGCCGAGGGAGTGGGCGTGGAGGAGGTCCCACCCCCTGG
GGGCCCGCGTGGGATGCCGGGATCGCCCCTCCGGTCCTGCCACAAGACGAGGGGGCATGGCCTCTGCGAGTCACTCTGCTACAATCCAGC
TTCTAATCCGCCCAAAAGCGGCAGCCAATCGGAGCGCGAGGACGTGGTCTGGAGGTACCGCCGGAGATCTGGGACCACTCAGGGCATCAG
GGGGCGTGGTCTGGTCCCCATTGCGGGCCCGGGAGGGGAATGGTTTCTATGGCCAAAGTTTGGTTTTCTCAACACTGTCTAAATTTGGAT

>In-frame_ZNF16_ENST00000276816_chr8_146171397_-_PLEKHA4_ENST00000263265_chr19_49355583_-_1589nt
AATTCGGGGCGGGACTTCCGGGGGTCAGCCGGCGTTGGCTGAGACGTCTTCGTGCCACGGTGCTGCCTCCTTTCCAAGCGCGACCCGTTG
AGATCCCCTTGACCACACCCTCATTCTCAGCTGGTGCTCATGAAGGACAGAAGAGTCAATGTCAGTACAATGTGAGTGAAGGGCTGAGGT
CCTTGTCATGCCCAGCCTCAGAACTCGCCGTGAGGAGGCAGAGATGGAGCTCTCAGTTCCAGGACCATCCCCCTGGACCCCTGCAGCCCA
GGCCCGTGTGAGAGATGCTCCTGCTGTGACCCACCCTGGATCTGCAGCCTGTGGTACCCCCTGCTGTAGTGATACTGAGCTGGAAGCCAT
CTGCCCTCACTATCAGCAGCCAGGAGCGAGAGAGGGTTTGGGACACGTACAGTGGCCTGGAGCAGGAGCTGGGCACCTTAAGAGAGACGC
TGGAGTACCTGCTGCACCTTGGTTCTCCCCAGGACAGAGTGTCTGCTCAGCAGCAGCTGTGGATGGTGGAAGACACGCTGGCAGGTCTGG
GTGGCCCCCAGAAACCGCCCCCACACACTGAGCCTGACTCCCCATCTCCCGTGCTCCAGGGCGAGGAGTCCTCAGAGAGGGAGAGCCTGC
CAGAGTCCTTGGAACTGAGCTCCCCTAGGTCCCCCGAGACTGACTGGGGGCGGCCTCCTGGAGGCGACAAAGACCTCGCCAGCCCTCACT
TAGGTCTTGGGTCTCCGAGGGTCTCCCGGGCTTCCAGCCCTGAGGGTCGCCACCTCCCTTCCCCACAGCTAGGAACCAAGGCCCCGGTGG
CCCGGCCCCGGATGAGTGCCCAGGAGCAGCTGGAGCGGATGCGCAGAAACCAGGAATGTGGACGGCCCTTCCCTCGCCCGACCTCCCCCC
GGCTTCTCACCCTGGGAAGGACACTGTCCCCAGCCAGACGCCAGCCTGACGTGGAGCAAAGGCCTGTCGTAGGACACTCGGGAGCCCAGA
AATGGCTCAGAAGCTCTGGGTCCTGGAGTAGTCCAAGGAACACCACCCCTTACTTGCCGACTTCCGAAGGTCACCGGGAGCGGGTTCTCA
GCCTCTCCCAAGCCCTGGCTACTGAGGCGTCGCAGTGGCACAGAATGATGACAGGTGGAAATTTGGACTCCCAGGGAGACCCTCTTCCCG
GTGTGCCGCTGCCTCCTTCGGACCCCACGCGCCAGGAGACCCCTCCCCCCAGATCTCCCCCGGTGGCTAATTCGGGTTCCACGGGGTTCT
CTCGCCGAGGGAGTGGGCGTGGAGGAGGTCCCACCCCCTGGGGGCCCGCGTGGGATGCCGGGATCGCCCCTCCGGTCCTGCCACAAGACG
AGGGGGCATGGCCTCTGCGAGTCACTCTGCTACAATCCAGCTTCTAATCCGCCCAAAAGCGGCAGCCAATCGGAGCGCGAGGACGTGGTC
TGGAGGTACCGCCGGAGATCTGGGACCACTCAGGGCATCAGGGGGCGTGGTCTGGTCCCCATTGCGGGCCCGGGAGGGGAATGGTTTCTA


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FusionGenePPI for ZNF16_PLEKHA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF16GORAB, ZNF101, HIST1H1E, PPAN, GLTSCR2PLEKHA4EEF1G, KAT5, LRIF1, SETDB1, CCNG1, PRKAA1, ABL1, PTPN11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF16_PLEKHA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF16_PLEKHA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource