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Fusion gene ID: 43036 |
FusionGeneSummary for ZNF154_KIR2DL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF154_KIR2DL1 | Fusion gene ID: 43036 | Hgene | Tgene | Gene symbol | ZNF154 | KIR2DL1 | Gene ID | 7710 | 3802 |
| Gene name | zinc finger protein 154 | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 | |
| Synonyms | pHZ-92 | CD158A|KIR-K64|KIR221|KIR2DL3|NKAT|NKAT-1|NKAT1|p58.1 | |
| Cytomap | 19q13.43 | 19q13.42 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 154 | killer cell immunoglobulin-like receptor 2DL1CD158 antigen-like family member AKIR2DL proteinKIR2DL1/3DL2MHC class I NK cell receptorkiller cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1killer inhibitory receptor 2-2-1natu | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13106 | P43626 | |
| Ensembl transtripts involved in fusion gene | ENST00000512439, ENST00000426889, | ENST00000336077, ENST00000291633, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ZNF154 [Title/Abstract] AND KIR2DL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KIR2DL1 | GO:0002769 | natural killer cell inhibitory signaling pathway | 18604210 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A1-A0SQ-01A | ZNF154 | chr19 | 58216221 | - | KIR2DL1 | chr19 | 55284785 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000512439 | ENST00000336077 | ZNF154 | chr19 | 58216221 | - | KIR2DL1 | chr19 | 55284785 | + |
| Frame-shift | ENST00000512439 | ENST00000291633 | ZNF154 | chr19 | 58216221 | - | KIR2DL1 | chr19 | 55284785 | + |
| In-frame | ENST00000426889 | ENST00000336077 | ZNF154 | chr19 | 58216221 | - | KIR2DL1 | chr19 | 55284785 | + |
| In-frame | ENST00000426889 | ENST00000291633 | ZNF154 | chr19 | 58216221 | - | KIR2DL1 | chr19 | 55284785 | + |
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FusionProtFeatures for ZNF154_KIR2DL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF154 | KIR2DL1 |
| May be involved in transcriptional regulation. | Receptor on natural killer (NK) cells for some HLA-Calleles such as w4 and w6. Inhibits the activity of NK cells thuspreventing cell lysis. {ECO:0000269|PubMed:18604210}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF154_KIR2DL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZNF154_ENST00000426889_chr19_58216221_-_KIR2DL1_ENST00000336077_chr19_55284785_+_379aa MAAATLRTPTQGTVTFEDVAVHFSWEEWGLLDEAQRCLYRDVMLENLALLTSLGVHRKPSLLAHPGRLVKSEETVILQCWSDVMFEHFLL HREGMFNDTLRLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKPSLSAQLGPTVLAGENVTLSCS SRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGN PRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDPQEVTYTQLNHCVFTQRKITRPSQRPKTPPTDII >In-frame_ZNF154_ENST00000426889_chr19_58216221_-_KIR2DL1_ENST00000291633_chr19_55284785_+_405aa MAAATLRTPTQGTVTFEDVAVHFSWEEWGLLDEAQRCLYRDVMLENLALLTSLGVHRKPSLLAHPGRLVKSEETVILQCWSDVMFEHFLL HREGMFNDTLRLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKPSLSAQLGPTVLAGENVTLSCS SRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTER MFHHVGQACLKLPTSSDPTVSACQSNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDPQEVTYTQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZNF154_ENST00000426889_chr19_58216221_-_KIR2DL1_ENST00000336077_chr19_55284785_+_1137nt ATGGCAGCGGCCACTCTGAGGACGCCAACTCAGGGCACTGTGACCTTTGAAGATGTGGCCGTACACTTCTCCTGGGAGGAATGGGGTCTC CTTGATGAGGCTCAAAGATGCCTGTACCGTGATGTGATGCTGGAGAACTTGGCTCTTTTAACCTCTCTAGGAGTCCACAGAAAACCTTCC CTCCTGGCCCACCCAGGTCGCCTGGTGAAATCAGAAGAGACAGTCATCCTGCAGTGTTGGTCAGATGTCATGTTTGAACACTTCCTTCTG CACAGAGAGGGGATGTTTAACGACACTTTGCGCCTCATTGGAGAACACCATGATGGGGTCTCCAAGGCCAACTTCTCCATCAGTCGCATG ACGCAAGACCTGGCAGGGACCTACAGATGCTACGGTTCTGTTACTCACTCCCCCTATCAGGTGTCAGCTCCCAGTGACCCTCTGGACATC GTGATCATAGGTCTATATGAGAAACCTTCTCTCTCAGCCCAGCTGGGCCCCACGGTTCTGGCAGGAGAGAATGTGACCTTGTCCTGCAGC TCCCGGAGCTCCTATGACATGTACCATCTATCCAGGGAAGGGGAGGCCCATGAACGTAGGCTCCCTGCAGGGCCCAAGGTCAACGGAACA TTCCAGGCTGACTTTCCTCTGGGCCCTGCCACCCACGGAGGGACCTACAGATGCTTCGGCTCTTTCCATGACTCTCCATACGAGTGGTCA AAGTCAAGTGACCCACTGCTTGTTTCTGTCACAGGAAACCCTTCAAATAGTTGGCCTTCACCCACTGAACCAAGCTCCAAAACCGGTAAC CCCCGACACCTGCACATTCTGATTGGGACCTCAGTGGTCATCATCCTCTTCATCCTCCTCTTCTTTCTCCTTCATCGCTGGTGCTCCAAC AAAAAAAATGCTGCGGTAATGGACCAAGAGTCTGCAGGAAACAGAACAGCGAATAGCGAGGACTCTGATGAACAAGACCCTCAGGAGGTG ACATACACACAGTTGAATCACTGCGTTTTCACACAGAGAAAAATCACTCGCCCTTCTCAGAGGCCCAAGACACCCCCAACAGATATCATC >In-frame_ZNF154_ENST00000426889_chr19_58216221_-_KIR2DL1_ENST00000291633_chr19_55284785_+_1215nt ATGGCAGCGGCCACTCTGAGGACGCCAACTCAGGGCACTGTGACCTTTGAAGATGTGGCCGTACACTTCTCCTGGGAGGAATGGGGTCTC CTTGATGAGGCTCAAAGATGCCTGTACCGTGATGTGATGCTGGAGAACTTGGCTCTTTTAACCTCTCTAGGAGTCCACAGAAAACCTTCC CTCCTGGCCCACCCAGGTCGCCTGGTGAAATCAGAAGAGACAGTCATCCTGCAGTGTTGGTCAGATGTCATGTTTGAACACTTCCTTCTG CACAGAGAGGGGATGTTTAACGACACTTTGCGCCTCATTGGAGAACACCATGATGGGGTCTCCAAGGCCAACTTCTCCATCAGTCGCATG ACGCAAGACCTGGCAGGGACCTACAGATGCTACGGTTCTGTTACTCACTCCCCCTATCAGGTGTCAGCTCCCAGTGACCCTCTGGACATC GTGATCATAGGTCTATATGAGAAACCTTCTCTCTCAGCCCAGCTGGGCCCCACGGTTCTGGCAGGAGAGAATGTGACCTTGTCCTGCAGC TCCCGGAGCTCCTATGACATGTACCATCTATCCAGGGAAGGGGAGGCCCATGAACGTAGGCTCCCTGCAGGGCCCAAGGTCAACGGAACA TTCCAGGCTGACTTTCCTCTGGGCCCTGCCACCCACGGAGGGACCTACAGATGCTTCGGCTCTTTCCATGACTCTCCATACGAGTGGTCA AAGTCAAGTGACCCACTGCTTGTTTCTGTCACAGGAAACCCTTCAAATAGTTGGCCTTCACCCACTGAACCAAGCTCCAAAACCGAGAGG ATGTTTCACCACGTTGGCCAAGCTTGTCTGAAACTCCCAACCTCAAGTGATCCGACCGTCTCAGCATGCCAAAGTAACCCCCGACACCTG CACATTCTGATTGGGACCTCAGTGGTCATCATCCTCTTCATCCTCCTCTTCTTTCTCCTTCATCGCTGGTGCTCCAACAAAAAAAATGCT GCGGTAATGGACCAAGAGTCTGCAGGAAACAGAACAGCGAATAGCGAGGACTCTGATGAACAAGACCCTCAGGAGGTGACATACACACAG TTGAATCACTGCGTTTTCACACAGAGAAAAATCACTCGCCCTTCTCAGAGGCCCAAGACACCCCCAACAGATATCATCGTGTACACGGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZNF154_ENST00000426889_chr19_58216221_-_KIR2DL1_ENST00000336077_chr19_55284785_+_1886nt CCTCTTCGTGGCGGCCATTTTAGCTTCTCTGAGGTGTGTTCACCGGATCAGAGATAGCAGAGCGCCGAGTTGGGGCCACGAAGGCGTGAG GGGAGTCGTCGTCCCTCCTGCACGAAAGCGTCTAAGCCTTGGCGACGCCGCCCTGGGGGACCCACGTCAGGCCTGGGATAGGGACCGCTG TCCCCGGGTCCCTACCAATGTCGCCCGTCGCTCCCGGCCCAGCTCTACCCGCAGAGTCTGATGGCAGCGGCCACTCTGAGGACGCCAACT CAGGGCACTGTGACCTTTGAAGATGTGGCCGTACACTTCTCCTGGGAGGAATGGGGTCTCCTTGATGAGGCTCAAAGATGCCTGTACCGT GATGTGATGCTGGAGAACTTGGCTCTTTTAACCTCTCTAGGAGTCCACAGAAAACCTTCCCTCCTGGCCCACCCAGGTCGCCTGGTGAAA TCAGAAGAGACAGTCATCCTGCAGTGTTGGTCAGATGTCATGTTTGAACACTTCCTTCTGCACAGAGAGGGGATGTTTAACGACACTTTG CGCCTCATTGGAGAACACCATGATGGGGTCTCCAAGGCCAACTTCTCCATCAGTCGCATGACGCAAGACCTGGCAGGGACCTACAGATGC TACGGTTCTGTTACTCACTCCCCCTATCAGGTGTCAGCTCCCAGTGACCCTCTGGACATCGTGATCATAGGTCTATATGAGAAACCTTCT CTCTCAGCCCAGCTGGGCCCCACGGTTCTGGCAGGAGAGAATGTGACCTTGTCCTGCAGCTCCCGGAGCTCCTATGACATGTACCATCTA TCCAGGGAAGGGGAGGCCCATGAACGTAGGCTCCCTGCAGGGCCCAAGGTCAACGGAACATTCCAGGCTGACTTTCCTCTGGGCCCTGCC ACCCACGGAGGGACCTACAGATGCTTCGGCTCTTTCCATGACTCTCCATACGAGTGGTCAAAGTCAAGTGACCCACTGCTTGTTTCTGTC ACAGGAAACCCTTCAAATAGTTGGCCTTCACCCACTGAACCAAGCTCCAAAACCGGTAACCCCCGACACCTGCACATTCTGATTGGGACC TCAGTGGTCATCATCCTCTTCATCCTCCTCTTCTTTCTCCTTCATCGCTGGTGCTCCAACAAAAAAAATGCTGCGGTAATGGACCAAGAG TCTGCAGGAAACAGAACAGCGAATAGCGAGGACTCTGATGAACAAGACCCTCAGGAGGTGACATACACACAGTTGAATCACTGCGTTTTC ACACAGAGAAAAATCACTCGCCCTTCTCAGAGGCCCAAGACACCCCCAACAGATATCATCGTGTACACGGAACTTCCAAATGCTGAGTCC AGATCCAAAGTTGTCTCCTGCCCATGAGCACCACAGTCAGGCCTTGAGGGCGTCTTCTAGGGAGACAACAGCCCTGTCTCAAAACCGGGT TGCCAGCTCCCATGTACCAGCAGCTGGAATCTGAAGGCGTGAGTCTGCATCTTAGGGCATCGATCTTCCTCACACCACAAATCTGAATGT GCCTCTCTCTTGCTTACAAATGTCTAAGGTCCCCACTGCCTGCTGGAGAAAAAACACACTCCTTTGCTTAACCCACAGTTCTCCATTTCA CTTGACCCCTGCCCACCTCTCCAACCTAACTGGCTTACTTCCTAGTCTACTTGAGGCTGCAATCACACTGAGGAACTCACAATTCCAAAC ATACAAGAGGCTCCCTCTTAACGCAGCACTTAGACACGTGTTGTTCCACCTTCCCTCATGCTGTTCCACCTCCCCTCAGACTAGCTTTCA >In-frame_ZNF154_ENST00000426889_chr19_58216221_-_KIR2DL1_ENST00000291633_chr19_55284785_+_1507nt CCTCTTCGTGGCGGCCATTTTAGCTTCTCTGAGGTGTGTTCACCGGATCAGAGATAGCAGAGCGCCGAGTTGGGGCCACGAAGGCGTGAG GGGAGTCGTCGTCCCTCCTGCACGAAAGCGTCTAAGCCTTGGCGACGCCGCCCTGGGGGACCCACGTCAGGCCTGGGATAGGGACCGCTG TCCCCGGGTCCCTACCAATGTCGCCCGTCGCTCCCGGCCCAGCTCTACCCGCAGAGTCTGATGGCAGCGGCCACTCTGAGGACGCCAACT CAGGGCACTGTGACCTTTGAAGATGTGGCCGTACACTTCTCCTGGGAGGAATGGGGTCTCCTTGATGAGGCTCAAAGATGCCTGTACCGT GATGTGATGCTGGAGAACTTGGCTCTTTTAACCTCTCTAGGAGTCCACAGAAAACCTTCCCTCCTGGCCCACCCAGGTCGCCTGGTGAAA TCAGAAGAGACAGTCATCCTGCAGTGTTGGTCAGATGTCATGTTTGAACACTTCCTTCTGCACAGAGAGGGGATGTTTAACGACACTTTG CGCCTCATTGGAGAACACCATGATGGGGTCTCCAAGGCCAACTTCTCCATCAGTCGCATGACGCAAGACCTGGCAGGGACCTACAGATGC TACGGTTCTGTTACTCACTCCCCCTATCAGGTGTCAGCTCCCAGTGACCCTCTGGACATCGTGATCATAGGTCTATATGAGAAACCTTCT CTCTCAGCCCAGCTGGGCCCCACGGTTCTGGCAGGAGAGAATGTGACCTTGTCCTGCAGCTCCCGGAGCTCCTATGACATGTACCATCTA TCCAGGGAAGGGGAGGCCCATGAACGTAGGCTCCCTGCAGGGCCCAAGGTCAACGGAACATTCCAGGCTGACTTTCCTCTGGGCCCTGCC ACCCACGGAGGGACCTACAGATGCTTCGGCTCTTTCCATGACTCTCCATACGAGTGGTCAAAGTCAAGTGACCCACTGCTTGTTTCTGTC ACAGGAAACCCTTCAAATAGTTGGCCTTCACCCACTGAACCAAGCTCCAAAACCGAGAGGATGTTTCACCACGTTGGCCAAGCTTGTCTG AAACTCCCAACCTCAAGTGATCCGACCGTCTCAGCATGCCAAAGTAACCCCCGACACCTGCACATTCTGATTGGGACCTCAGTGGTCATC ATCCTCTTCATCCTCCTCTTCTTTCTCCTTCATCGCTGGTGCTCCAACAAAAAAAATGCTGCGGTAATGGACCAAGAGTCTGCAGGAAAC AGAACAGCGAATAGCGAGGACTCTGATGAACAAGACCCTCAGGAGGTGACATACACACAGTTGAATCACTGCGTTTTCACACAGAGAAAA ATCACTCGCCCTTCTCAGAGGCCCAAGACACCCCCAACAGATATCATCGTGTACACGGAACTTCCAAATGCTGAGTCCAGATCCAAAGTT |
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FusionGenePPI for ZNF154_KIR2DL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF154 | KIR2DL1 | HLA-C |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF154_KIR2DL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF154_KIR2DL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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