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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43034

FusionGeneSummary for ZNF14_RGL3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF14_RGL3
Fusion gene ID: 43034
HgeneTgene
Gene symbol

ZNF14

RGL3

Gene ID

7561

57139

Gene namezinc finger protein 14ral guanine nucleotide dissociation stimulator like 3
SynonymsGIOT-4|KOX6-
Cytomap

19p13.11

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 14gonadotropin inducible transcription repressor-4gonadotropin-inducible ovary transcription repressor 4zinc finger protein 14 (KOX 6)zinc finger protein KOX6ral guanine nucleotide dissociation stimulator-like 3RalGEF-like protein 3, mouse homologralGDS-like 3
Modification date2018040320180329
UniProtAcc

P17017

Q3MIN7

Ensembl transtripts involved in fusion geneENST00000344099, ENST00000380456, 
ENST00000568628, ENST00000393423, 
Fusion gene scores* DoF score3 X 2 X 3=183 X 3 X 4=36
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF14 [Title/Abstract] AND RGL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A295-01AZNF14chr19

19843765

-RGL3chr19

11513382

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344099ENST00000380456ZNF14chr19

19843765

-RGL3chr19

11513382

-
5CDS-intronENST00000344099ENST00000568628ZNF14chr19

19843765

-RGL3chr19

11513382

-
5CDS-intronENST00000344099ENST00000393423ZNF14chr19

19843765

-RGL3chr19

11513382

-

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FusionProtFeatures for ZNF14_RGL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF14

P17017

RGL3

Q3MIN7

May be involved in transcriptional regulation. Guanine nucleotide exchange factor (GEF) for Ral-A.Potential effector of GTPase HRas and Ras-related protein M-Ras.Negatively regulates Elk-1-dependent gene induction downstream ofHRas and MEKK1 (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRGL3chr19:19843765chr19:11513382ENST00000380456-819537_607395711Compositional biasNote=Pro-rich
TgeneRGL3chr19:19843765chr19:11513382ENST00000393423-819537_607395717Compositional biasNote=Pro-rich
TgeneRGL3chr19:19843765chr19:11513382ENST00000380456-819613_700395711DomainRas-associating
TgeneRGL3chr19:19843765chr19:11513382ENST00000393423-819613_700395717DomainRas-associating

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-144_761643DomainKRAB
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14103_1251643Zinc fingerC2H2-type 1
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14141_1631643Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14169_1911643Zinc fingerC2H2-type 3
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14197_2171643Zinc fingerC2H2-type 4%3B atypical
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14223_2451643Zinc fingerC2H2-type 5
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14251_2731643Zinc fingerC2H2-type 6
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14279_3011643Zinc fingerC2H2-type 7
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14307_3291643Zinc fingerC2H2-type 8
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14335_3571643Zinc fingerC2H2-type 9
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14363_3851643Zinc fingerC2H2-type 10
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14391_4131643Zinc fingerC2H2-type 11
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14419_4411643Zinc fingerC2H2-type 12
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14447_4691643Zinc fingerC2H2-type 13
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14475_4971643Zinc fingerC2H2-type 14
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14503_5251643Zinc fingerC2H2-type 15
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14531_5531643Zinc fingerC2H2-type 16
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14559_5811643Zinc fingerC2H2-type 17
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14587_6091643Zinc fingerC2H2-type 18
HgeneZNF14chr19:19843765chr19:11513382ENST00000344099-14615_6371643Zinc fingerC2H2-type 19
TgeneRGL3chr19:19843765chr19:11513382ENST00000380456-819231_234395711Compositional biasNote=Poly-Glu
TgeneRGL3chr19:19843765chr19:11513382ENST00000393423-819231_234395717Compositional biasNote=Poly-Glu
TgeneRGL3chr19:19843765chr19:11513382ENST00000380456-819247_505395711DomainRas-GEF
TgeneRGL3chr19:19843765chr19:11513382ENST00000380456-81965_200395711DomainN-terminal Ras-GEF
TgeneRGL3chr19:19843765chr19:11513382ENST00000393423-819247_505395717DomainRas-GEF
TgeneRGL3chr19:19843765chr19:11513382ENST00000393423-81965_200395717DomainN-terminal Ras-GEF


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FusionGeneSequence for ZNF14_RGL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF14_ENST00000344099_chr19_19843765_-_RGL3_ENST00000380456_chr19_11513382_-_317aa
MEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAAL
HAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASP
GPQGPSTKLPLSLDLPSPRPFALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF14_ENST00000344099_chr19_19843765_-_RGL3_ENST00000380456_chr19_11513382_-_951nt
ATGGAGGAGGCCACTGAGGGATCCCAAGAAGAGGACAACACCCCAGGCAGCCTGCCCTCAAAACCACCCCCAGGCCCTGTCCCCTACCTT
GGCACCTTCCTTACGGACCTGGTTATGCTGGACACAGCCCTGCCGGATATGTTGGAGGGGGATCTCATTAACTTTGAGAAGAGGAGGAAG
GAGTGGGAGATCCTGGCCCGCATCCAGCAGCTGCAGAGGCGCTGTCAGAGCTACACCCTGAGCCCCCACCCGCCCATCCTGGCTGCCCTG
CATGCCCAGAACCAGCTCACCGAGGAGCAGAGCTACCGGCTCTCCCGGGTCATTGAGCCACCAGCTGCCTCCTGCCCCAGCTCCCCACGC
ATCCGACGGCGGATCAGCCTCACCAAGCGTCTCAGTGCGAAGCTTGCCCGAGAGAAAAGCTCATCACCTAGTGGGAGTCCCGGGGACCCC
TCATCCCCCACCTCCAGTGTGTCCCCAGGGTCACCCCCCTCAAGTCCTAGAAGCAGAGATGCTCCTGCTGGCAGTCCCCCGGCCTCTCCA
GGGCCCCAGGGCCCCAGCACCAAGCTGCCCCTGAGCCTGGACCTGCCCAGCCCCCGGCCCTTCGCTTTGCCTCTGGGCAGCCCTCGAATC
CCCCTCCCGGCGCAGCAGAGCTCGGAGGCCCGTGTCATCCGCGTCAGCATCGACAATGACCACGGGAACCTGTATCGAAGCATCTTGCTG
ACCAGTCAGGACAAAGCCCCCAGCGTGGTCCGGCGAGCCTTGCAGAAGCACAATGTGCCCCAGCCCTGGGCCTGTGACTATCAGCTCTTT
CAAGTCCTTCCTGGGGACCGGGTGCTCCTGATTCCTGACAATGCCAACGTCTTCTATGCCATGAGTCCAGTCGCCCCCAGAGACTTCATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF14_ENST00000344099_chr19_19843765_-_RGL3_ENST00000380456_chr19_11513382_-_1435nt
ATTCCTGGCCCATGGGAAGATTGCGTTTCACCTGCTCCTGAAGGCCGAAGGTGGCTCTAGCGCATCCTTTGTCGCGCCGTGACCTGCAGG
TACTGACAGATCCGTAGGGAGGACACCGTGACTTCCCGGACGCTGGGAAATGGAGGAGGCCACTGAGGGATCCCAAGAAGAGGACAACAC
CCCAGGCAGCCTGCCCTCAAAACCACCCCCAGGCCCTGTCCCCTACCTTGGCACCTTCCTTACGGACCTGGTTATGCTGGACACAGCCCT
GCCGGATATGTTGGAGGGGGATCTCATTAACTTTGAGAAGAGGAGGAAGGAGTGGGAGATCCTGGCCCGCATCCAGCAGCTGCAGAGGCG
CTGTCAGAGCTACACCCTGAGCCCCCACCCGCCCATCCTGGCTGCCCTGCATGCCCAGAACCAGCTCACCGAGGAGCAGAGCTACCGGCT
CTCCCGGGTCATTGAGCCACCAGCTGCCTCCTGCCCCAGCTCCCCACGCATCCGACGGCGGATCAGCCTCACCAAGCGTCTCAGTGCGAA
GCTTGCCCGAGAGAAAAGCTCATCACCTAGTGGGAGTCCCGGGGACCCCTCATCCCCCACCTCCAGTGTGTCCCCAGGGTCACCCCCCTC
AAGTCCTAGAAGCAGAGATGCTCCTGCTGGCAGTCCCCCGGCCTCTCCAGGGCCCCAGGGCCCCAGCACCAAGCTGCCCCTGAGCCTGGA
CCTGCCCAGCCCCCGGCCCTTCGCTTTGCCTCTGGGCAGCCCTCGAATCCCCCTCCCGGCGCAGCAGAGCTCGGAGGCCCGTGTCATCCG
CGTCAGCATCGACAATGACCACGGGAACCTGTATCGAAGCATCTTGCTGACCAGTCAGGACAAAGCCCCCAGCGTGGTCCGGCGAGCCTT
GCAGAAGCACAATGTGCCCCAGCCCTGGGCCTGTGACTATCAGCTCTTTCAAGTCCTTCCTGGGGACCGGGTGCTCCTGATTCCTGACAA
TGCCAACGTCTTCTATGCCATGAGTCCAGTCGCCCCCAGAGACTTCATGCTGCGGCGGAAAGAGGGGACCCGGAACACTCTGTCTGTCTC
CCCAAGCTGAGGCAGCCCTGTCCTCTCCACAAGACACAAGTCCCACAGGCAAGCTTGCGACTCTTCTCCTGGAAAGCTGCCATCCCCCAG
TAGAGGCCACTGTGCTGTGTATCCCAGGACCACCACCCAACTGTAGCCCATTGGACCCCATCTCTTTTTCTGACTCTGTTGGTACTAGAT
CCATATTCCAAAGACATCAGCCCATGGGTGGCTGGTGGAGAGCTCAATCCCATAAATGTAGAAAGAGGTGGGGCATGGATACGTCAAATC


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FusionGenePPI for ZNF14_RGL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF14RGL3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRGL3chr19:19843765chr19:11513382ENST00000380456-819612_707395711HRAS%2C MRAS and RIT1
TgeneRGL3chr19:19843765chr19:11513382ENST00000393423-819612_707395717HRAS%2C MRAS and RIT1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF14_RGL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF14_RGL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource