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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43017

FusionGeneSummary for ZNF142_POLR1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF142_POLR1B
Fusion gene ID: 43017
HgeneTgene
Gene symbol

ZNF142

POLR1B

Gene ID

7701

84172

Gene namezinc finger protein 142RNA polymerase I subunit B
SynonymspHZ-49RPA135|RPA2|Rpo1-2
Cytomap

2q35

2q14.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 142HA4654zinc finger protein 142 (clone pHZ-49)DNA-directed RNA polymerase I subunit RPA2DNA-directed RNA polymerase I 135 kDa polypeptideDNA-directed RNA polymerase I 135kDa polypeptideRNA polymerase I subunit 2polymerase (RNA) I polypeptide B, 128kDapolymerase (RNA) I subunit B
Modification date2018052320180523
UniProtAcc

P52746

Q9H9Y6

Ensembl transtripts involved in fusion geneENST00000449707, ENST00000411696, 
ENST00000263331, ENST00000541869, 
ENST00000409894, ENST00000537335, 
ENST00000417433, ENST00000498054, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 3 X 2=12
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF142 [Title/Abstract] AND POLR1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-A7NN-01AZNF142chr2

219523703

-POLR1Bchr2

113306844

+
TCGALDPRADTCGA-EJ-A7NN-01AZNF142chr2

219523703

-POLR1Bchr2

113308443

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000449707ENST00000263331ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-3CDSENST00000449707ENST00000541869ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-3CDSENST00000449707ENST00000409894ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-intronENST00000449707ENST00000537335ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-intronENST00000449707ENST00000417433ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-intronENST00000449707ENST00000498054ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-3CDSENST00000411696ENST00000263331ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-3CDSENST00000411696ENST00000541869ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-3CDSENST00000411696ENST00000409894ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-intronENST00000411696ENST00000537335ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-intronENST00000411696ENST00000417433ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-intronENST00000411696ENST00000498054ZNF142chr2

219523703

-POLR1Bchr2

113306844

+
5UTR-3CDSENST00000449707ENST00000263331ZNF142chr2

219523703

-POLR1Bchr2

113308443

+
5UTR-3CDSENST00000449707ENST00000541869ZNF142chr2

219523703

-POLR1Bchr2

113308443

+
5UTR-3CDSENST00000449707ENST00000409894ZNF142chr2

219523703

-POLR1Bchr2

113308443

+
5UTR-5UTRENST00000449707ENST00000537335ZNF142chr2

219523703

-POLR1Bchr2

113308443

+
5UTR-5UTRENST00000449707ENST00000417433ZNF142chr2

219523703

-POLR1Bchr2

113308443

+
5UTR-intronENST00000449707ENST00000498054ZNF142chr2

219523703

-POLR1Bchr2

113308443

+
5UTR-3CDSENST00000411696ENST00000263331ZNF142chr2

219523703

-POLR1Bchr2

113308443

+
5UTR-3CDSENST00000411696ENST00000541869ZNF142chr2

219523703

-POLR1Bchr2

113308443

+
5UTR-3CDSENST00000411696ENST00000409894ZNF142chr2

219523703

-POLR1Bchr2

113308443

+
5UTR-5UTRENST00000411696ENST00000537335ZNF142chr2

219523703

-POLR1Bchr2

113308443

+
5UTR-5UTRENST00000411696ENST00000417433ZNF142chr2

219523703

-POLR1Bchr2

113308443

+
5UTR-intronENST00000411696ENST00000498054ZNF142chr2

219523703

-POLR1Bchr2

113308443

+

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FusionProtFeatures for ZNF142_POLR1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF142

P52746

POLR1B

Q9H9Y6

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF142_POLR1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF142_POLR1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF142MAPK14, CHMP5, NXF1, MUS81, PTTG1, MCM2, CACNG5, RPL30POLR1BTAF1D, USP11, POLR1A, LZTR1, ARRB2, CAND1, POLR1D, CD3EAP, POLR1C, TSR1, DHX8, NOP56, ERBB2, ACTB, ACTA1, RRN3, MED20, HDAC6, AKT2, CCND1, RPL37, ZNF207, LDB1, GIT2, RPA3, RPA2, RPA1, ABCE1, GPN3, TWISTNB, SKAP1, LOC554223, GFOD1, EEFSEC, EIF2S3, DDX18, POLR2B, POLR3A, POLR3B, POLR2E, POLR2H, POLR2I, POLR2L, RPL11, RPL30, RPL9, RPS5, TBL3, WDR36, NTRK1, MYO1C, POLR2F, NOLC1, TCOF1, PTPN21, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF142_POLR1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF142_POLR1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource