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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43016

FusionGeneSummary for ZNF141_ZNF254

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF141_ZNF254
Fusion gene ID: 43016
HgeneTgene
Gene symbol

ZNF141

ZNF254

Gene ID

7700

9534

Gene namezinc finger protein 141zinc finger protein 254
SynonymsD4S90|pHZ-44BMZF-5|HD-ZNF1|ZNF539|ZNF91L
Cytomap

4p16.3

19p12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 141zinc finger protein 141 (clone pHZ-44)zinc finger protein 254CTD-2017D11.1bone marrow zinc finger 5hematopoietic cell-derived zinc finger protein 1zinc finger protein 539
Modification date2018040320180522
UniProtAcc

Q15928

O75437

Ensembl transtripts involved in fusion geneENST00000512994, ENST00000505939, 
ENST00000240499, ENST00000579770, 
ENST00000342944, ENST00000339642, 
ENST00000357002, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 2=8
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: ZNF141 [Title/Abstract] AND ZNF254 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG403577ZNF141chr4

369712

-ZNF254chr19

24311986

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000512994ENST00000342944ZNF141chr4

369712

-ZNF254chr19

24311986

+
intron-intronENST00000512994ENST00000339642ZNF141chr4

369712

-ZNF254chr19

24311986

+
intron-3UTRENST00000512994ENST00000357002ZNF141chr4

369712

-ZNF254chr19

24311986

+
intron-3UTRENST00000505939ENST00000342944ZNF141chr4

369712

-ZNF254chr19

24311986

+
intron-intronENST00000505939ENST00000339642ZNF141chr4

369712

-ZNF254chr19

24311986

+
intron-3UTRENST00000505939ENST00000357002ZNF141chr4

369712

-ZNF254chr19

24311986

+
intron-3UTRENST00000240499ENST00000342944ZNF141chr4

369712

-ZNF254chr19

24311986

+
intron-intronENST00000240499ENST00000339642ZNF141chr4

369712

-ZNF254chr19

24311986

+
intron-3UTRENST00000240499ENST00000357002ZNF141chr4

369712

-ZNF254chr19

24311986

+
intron-3UTRENST00000579770ENST00000342944ZNF141chr4

369712

-ZNF254chr19

24311986

+
intron-intronENST00000579770ENST00000339642ZNF141chr4

369712

-ZNF254chr19

24311986

+
intron-3UTRENST00000579770ENST00000357002ZNF141chr4

369712

-ZNF254chr19

24311986

+

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FusionProtFeatures for ZNF141_ZNF254


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF141

Q15928

ZNF254

O75437

May be involved in transcriptional regulation as arepressor. Plays a role in limb development.{ECO:0000269|PubMed:23160277}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF141_ZNF254


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF141_ZNF254


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF141_ZNF254


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF141_ZNF254


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNF141C3808889POLYDACTYLY, POSTAXIAL, TYPE A61UNIPROT