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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43015

FusionGeneSummary for ZNF141_NUP98

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF141_NUP98
Fusion gene ID: 43015
HgeneTgene
Gene symbol

ZNF141

NUP98

Gene ID

7700

4928

Gene namezinc finger protein 141nucleoporin 98
SynonymsD4S90|pHZ-44ADIR2|NUP196|NUP96
Cytomap

4p16.3

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 141zinc finger protein 141 (clone pHZ-44)nuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 98kDnucleoporin 98kDa
Modification date2018040320180523
UniProtAcc

Q15928

P52948

Ensembl transtripts involved in fusion geneENST00000512994, ENST00000505939, 
ENST00000240499, ENST00000579770, 
ENST00000324932, ENST00000359171, 
ENST00000355260, ENST00000397004, 
ENST00000397007, ENST00000488828, 
Fusion gene scores* DoF score2 X 2 X 1=49 X 9 X 5=405
# samples 211
** MAII scorelog2(2/4*10)=2.32192809488736log2(11/405*10)=-1.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF141 [Title/Abstract] AND NUP98 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA817816ZNF141chr4

337645

+NUP98chr11

3756511

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000512994ENST00000324932ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000512994ENST00000359171ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000512994ENST00000355260ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000512994ENST00000397004ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000512994ENST00000397007ZNF141chr4

337645

+NUP98chr11

3756511

-
5CDS-intronENST00000512994ENST00000488828ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000505939ENST00000324932ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000505939ENST00000359171ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000505939ENST00000355260ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000505939ENST00000397004ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000505939ENST00000397007ZNF141chr4

337645

+NUP98chr11

3756511

-
5CDS-intronENST00000505939ENST00000488828ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000240499ENST00000324932ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000240499ENST00000359171ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000240499ENST00000355260ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000240499ENST00000397004ZNF141chr4

337645

+NUP98chr11

3756511

-
In-frameENST00000240499ENST00000397007ZNF141chr4

337645

+NUP98chr11

3756511

-
5CDS-intronENST00000240499ENST00000488828ZNF141chr4

337645

+NUP98chr11

3756511

-
intron-3CDSENST00000579770ENST00000324932ZNF141chr4

337645

+NUP98chr11

3756511

-
intron-3CDSENST00000579770ENST00000359171ZNF141chr4

337645

+NUP98chr11

3756511

-
intron-3CDSENST00000579770ENST00000355260ZNF141chr4

337645

+NUP98chr11

3756511

-
intron-3CDSENST00000579770ENST00000397004ZNF141chr4

337645

+NUP98chr11

3756511

-
intron-3CDSENST00000579770ENST00000397007ZNF141chr4

337645

+NUP98chr11

3756511

-
intron-intronENST00000579770ENST00000488828ZNF141chr4

337645

+NUP98chr11

3756511

-

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FusionProtFeatures for ZNF141_NUP98


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF141

Q15928

NUP98

P52948

May be involved in transcriptional regulation as arepressor. Plays a role in limb development.{ECO:0000269|PubMed:23160277}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNUP98chr4:337645chr11:3756511ENST00000324932-0337_480-1411801Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr4:337645chr11:3756511ENST00000324932-033890_894-1411801Compositional biasNote=Poly-Glu
TgeneNUP98chr4:337645chr11:3756511ENST00000355260-0327_480-291727Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr4:337645chr11:3756511ENST00000355260-032890_894-291727Compositional biasNote=Poly-Glu
TgeneNUP98chr4:337645chr11:3756511ENST00000397004-0207_480-57921Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr4:337645chr11:3756511ENST00000397004-020890_894-57921Compositional biasNote=Poly-Glu
TgeneNUP98chr4:337645chr11:3756511ENST00000397007-0207_480-59938Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr4:337645chr11:3756511ENST00000397007-020890_894-59938Compositional biasNote=Poly-Glu
TgeneNUP98chr4:337645chr11:3756511ENST00000324932-033738_880-1411801DomainPeptidase S59
TgeneNUP98chr4:337645chr11:3756511ENST00000355260-032738_880-291727DomainPeptidase S59
TgeneNUP98chr4:337645chr11:3756511ENST00000397004-020738_880-57921DomainPeptidase S59
TgeneNUP98chr4:337645chr11:3756511ENST00000397007-020738_880-59938DomainPeptidase S59
TgeneNUP98chr4:337645chr11:3756511ENST00000324932-0331_156-1411801RegionNote=FG repeats 1
TgeneNUP98chr4:337645chr11:3756511ENST00000324932-033214_480-1411801RegionNote=FG repeats 2
TgeneNUP98chr4:337645chr11:3756511ENST00000355260-0321_156-291727RegionNote=FG repeats 1
TgeneNUP98chr4:337645chr11:3756511ENST00000355260-032214_480-291727RegionNote=FG repeats 2
TgeneNUP98chr4:337645chr11:3756511ENST00000397004-0201_156-57921RegionNote=FG repeats 1
TgeneNUP98chr4:337645chr11:3756511ENST00000397004-020214_480-57921RegionNote=FG repeats 2
TgeneNUP98chr4:337645chr11:3756511ENST00000397007-0201_156-59938RegionNote=FG repeats 1
TgeneNUP98chr4:337645chr11:3756511ENST00000397007-020214_480-59938RegionNote=FG repeats 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF141_NUP98


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0aa

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt

>In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt


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FusionGenePPI for ZNF141_NUP98


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF141_NUP98


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF141_NUP98


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNF141C3808889POLYDACTYLY, POSTAXIAL, TYPE A61UNIPROT
TgeneNUP98C0023467Leukemia, Myelocytic, Acute1CTD_human