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Fusion gene ID: 43015 |
FusionGeneSummary for ZNF141_NUP98 |
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Fusion gene information | Fusion gene name: ZNF141_NUP98 | Fusion gene ID: 43015 | Hgene | Tgene | Gene symbol | ZNF141 | NUP98 | Gene ID | 7700 | 4928 |
Gene name | zinc finger protein 141 | nucleoporin 98 | |
Synonyms | D4S90|pHZ-44 | ADIR2|NUP196|NUP96 | |
Cytomap | 4p16.3 | 11p15.4 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 141zinc finger protein 141 (clone pHZ-44) | nuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 98kDnucleoporin 98kDa | |
Modification date | 20180403 | 20180523 | |
UniProtAcc | Q15928 | P52948 | |
Ensembl transtripts involved in fusion gene | ENST00000512994, ENST00000505939, ENST00000240499, ENST00000579770, | ENST00000324932, ENST00000359171, ENST00000355260, ENST00000397004, ENST00000397007, ENST00000488828, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 9 X 9 X 5=405 |
# samples | 2 | 11 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(11/405*10)=-1.88041838424733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF141 [Title/Abstract] AND NUP98 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA817816 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000512994 | ENST00000324932 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000512994 | ENST00000359171 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000512994 | ENST00000355260 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000512994 | ENST00000397004 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000512994 | ENST00000397007 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
5CDS-intron | ENST00000512994 | ENST00000488828 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000505939 | ENST00000324932 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000505939 | ENST00000359171 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000505939 | ENST00000355260 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000505939 | ENST00000397004 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000505939 | ENST00000397007 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
5CDS-intron | ENST00000505939 | ENST00000488828 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000240499 | ENST00000324932 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000240499 | ENST00000359171 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000240499 | ENST00000355260 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000240499 | ENST00000397004 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
In-frame | ENST00000240499 | ENST00000397007 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
5CDS-intron | ENST00000240499 | ENST00000488828 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
intron-3CDS | ENST00000579770 | ENST00000324932 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
intron-3CDS | ENST00000579770 | ENST00000359171 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
intron-3CDS | ENST00000579770 | ENST00000355260 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
intron-3CDS | ENST00000579770 | ENST00000397004 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
intron-3CDS | ENST00000579770 | ENST00000397007 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
intron-intron | ENST00000579770 | ENST00000488828 | ZNF141 | chr4 | 337645 | + | NUP98 | chr11 | 3756511 | - |
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FusionProtFeatures for ZNF141_NUP98 |
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Hgene | Tgene |
ZNF141 | NUP98 |
May be involved in transcriptional regulation as arepressor. Plays a role in limb development.{ECO:0000269|PubMed:23160277}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000324932 | - | 0 | 33 | 7_480 | -141 | 1801 | Compositional bias | Note=Gly/Thr-rich |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000324932 | - | 0 | 33 | 890_894 | -141 | 1801 | Compositional bias | Note=Poly-Glu |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000355260 | - | 0 | 32 | 7_480 | -29 | 1727 | Compositional bias | Note=Gly/Thr-rich |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000355260 | - | 0 | 32 | 890_894 | -29 | 1727 | Compositional bias | Note=Poly-Glu |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000397004 | - | 0 | 20 | 7_480 | -57 | 921 | Compositional bias | Note=Gly/Thr-rich |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000397004 | - | 0 | 20 | 890_894 | -57 | 921 | Compositional bias | Note=Poly-Glu |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000397007 | - | 0 | 20 | 7_480 | -59 | 938 | Compositional bias | Note=Gly/Thr-rich |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000397007 | - | 0 | 20 | 890_894 | -59 | 938 | Compositional bias | Note=Poly-Glu |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000324932 | - | 0 | 33 | 738_880 | -141 | 1801 | Domain | Peptidase S59 |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000355260 | - | 0 | 32 | 738_880 | -29 | 1727 | Domain | Peptidase S59 |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000397004 | - | 0 | 20 | 738_880 | -57 | 921 | Domain | Peptidase S59 |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000397007 | - | 0 | 20 | 738_880 | -59 | 938 | Domain | Peptidase S59 |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000324932 | - | 0 | 33 | 1_156 | -141 | 1801 | Region | Note=FG repeats 1 |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000324932 | - | 0 | 33 | 214_480 | -141 | 1801 | Region | Note=FG repeats 2 |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000355260 | - | 0 | 32 | 1_156 | -29 | 1727 | Region | Note=FG repeats 1 |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000355260 | - | 0 | 32 | 214_480 | -29 | 1727 | Region | Note=FG repeats 2 |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000397004 | - | 0 | 20 | 1_156 | -57 | 921 | Region | Note=FG repeats 1 |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000397004 | - | 0 | 20 | 214_480 | -57 | 921 | Region | Note=FG repeats 2 |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000397007 | - | 0 | 20 | 1_156 | -59 | 938 | Region | Note=FG repeats 1 |
Tgene | >NUP98 | chr4:337645 | chr11:3756511 | ENST00000397007 | - | 0 | 20 | 214_480 | -59 | 938 | Region | Note=FG repeats 2 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF141_NUP98 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0aa >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000512994_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000505939_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000324932_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000359171_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000355260_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397004_chr11_3756511_-_0nt >In-frame_ZNF141_ENST00000240499_chr4_337645_+_NUP98_ENST00000397007_chr11_3756511_-_0nt |
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FusionGenePPI for ZNF141_NUP98 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF141_NUP98 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF141_NUP98 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZNF141 | C3808889 | POLYDACTYLY, POSTAXIAL, TYPE A6 | 1 | UNIPROT |
Tgene | NUP98 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |