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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43007

FusionGeneSummary for ZNF133_MS4A4A

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF133_MS4A4A
Fusion gene ID: 43007
HgeneTgene
Gene symbol

ZNF133

MS4A4A

Gene ID

7692

51338

Gene namezinc finger protein 133membrane spanning 4-domains A4A
SynonymsZNF150|pHZ-13|pHZ-664SPAN1|CD20-L1|CD20L1|HDCME31P|MS4A4|MS4A7
Cytomap

20p11.23

11q12.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 133zinc finger protein 133 (clone pHZ-13)zinc finger protein 150 (pHZ-66)membrane-spanning 4-domains subfamily A member 4ACD20 antigen-like 1Fc epsilon receptor beta subunit homologfour-span transmembrane protein 1membrane-spanning 4-domains, subfamily A, member 4
Modification date2018052320180429
UniProtAcc

P52736

Q96JQ5

Ensembl transtripts involved in fusion geneENST00000377671, ENST00000396026, 
ENST00000402618, ENST00000401790, 
ENST00000538547, ENST00000535822, 
ENST00000316358, ENST00000462170, 
ENST00000532114, ENST00000337908, 
ENST00000355131, ENST00000395016, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 2 X 4=32
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF133 [Title/Abstract] AND MS4A4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-S9-A89V-01AZNF133chr20

18269248

+MS4A4Achr11

60059698

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000377671ENST00000532114ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-3CDSENST00000377671ENST00000337908ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000377671ENST00000355131ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000377671ENST00000395016ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-3CDSENST00000396026ENST00000532114ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-3CDSENST00000396026ENST00000337908ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000396026ENST00000355131ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000396026ENST00000395016ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-3CDSENST00000402618ENST00000532114ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-3CDSENST00000402618ENST00000337908ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000402618ENST00000355131ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000402618ENST00000395016ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-3CDSENST00000401790ENST00000532114ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-3CDSENST00000401790ENST00000337908ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000401790ENST00000355131ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000401790ENST00000395016ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-3CDSENST00000538547ENST00000532114ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-3CDSENST00000538547ENST00000337908ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000538547ENST00000355131ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000538547ENST00000395016ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-3CDSENST00000535822ENST00000532114ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-3CDSENST00000535822ENST00000337908ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000535822ENST00000355131ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
5UTR-5UTRENST00000535822ENST00000395016ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
intron-3CDSENST00000316358ENST00000532114ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
intron-3CDSENST00000316358ENST00000337908ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
intron-5UTRENST00000316358ENST00000355131ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
intron-5UTRENST00000316358ENST00000395016ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
intron-3CDSENST00000462170ENST00000532114ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
intron-3CDSENST00000462170ENST00000337908ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
intron-5UTRENST00000462170ENST00000355131ZNF133chr20

18269248

+MS4A4Achr11

60059698

+
intron-5UTRENST00000462170ENST00000395016ZNF133chr20

18269248

+MS4A4Achr11

60059698

+

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FusionProtFeatures for ZNF133_MS4A4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF133

P52736

MS4A4A

Q96JQ5

May be involved in signal transduction as a component ofa multimeric receptor complex.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF133_MS4A4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF133_MS4A4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF133ILK, PDPK1, MAPK6, TRIM28, FOS, MDM2, KRTAP10-7, MRS2, RPS27A, SAV1, STK3, TRIM24, MRPS7, STK4, DAP3, CLPP, MRPS2, FTL, MRPS23, TPD52MS4A4A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF133_MS4A4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF133_MS4A4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMS4A4AC0002395Alzheimer's Disease1CTD_human
TgeneMS4A4AC3495559Juvenile arthritis1CTD_human