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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42992

FusionGeneSummary for ZNF106_TNPO1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF106_TNPO1
Fusion gene ID: 42992
HgeneTgene
Gene symbol

ZNF106

TNPO1

Gene ID

64397

3842

Gene namezinc finger protein 106transportin 1
SynonymsSH3BP3|ZFP106|ZNF474IPO2|KPNB2|MIP|MIP1|TRN
Cytomap

15q15.1

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 106SH3-domain binding protein 3zinc finger protein 474transportin-1M9 region interaction proteinimportin 2importin beta 2karyopherin (importin) beta 2karyopherin beta-2
Modification date2018052320180523
UniProtAcc

Q9H2Y7

Q92973

Ensembl transtripts involved in fusion geneENST00000263805, ENST00000565380, 
ENST00000565611, ENST00000565660, 
ENST00000337273, ENST00000454282, 
ENST00000447967, ENST00000523768, 
ENST00000513944, ENST00000506351, 
Fusion gene scores* DoF score6 X 7 X 3=1263 X 3 X 3=27
# samples 95
** MAII scorelog2(9/126*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/27*10)=0.888968687611256
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF106 [Title/Abstract] AND TNPO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE701928ZNF106chr15

42707674

-TNPO1chr5

72185092

+
ChiTaRS3.1BQ338378ZNF106chr15

42707674

-TNPO1chr5

72185092

+
ChiTaRS3.1BQ338569ZNF106chr15

42707674

-TNPO1chr5

72185092

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000263805ENST00000337273ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000263805ENST00000454282ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000263805ENST00000447967ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000263805ENST00000523768ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000263805ENST00000513944ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000263805ENST00000506351ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565380ENST00000337273ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565380ENST00000454282ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565380ENST00000447967ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565380ENST00000523768ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565380ENST00000513944ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565380ENST00000506351ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565611ENST00000337273ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565611ENST00000454282ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565611ENST00000447967ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565611ENST00000523768ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565611ENST00000513944ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565611ENST00000506351ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565660ENST00000337273ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565660ENST00000454282ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565660ENST00000447967ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565660ENST00000523768ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565660ENST00000513944ZNF106chr15

42707674

-TNPO1chr5

72185092

+
intron-intronENST00000565660ENST00000506351ZNF106chr15

42707674

-TNPO1chr5

72185092

+

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FusionProtFeatures for ZNF106_TNPO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF106

Q9H2Y7

TNPO1

Q92973

Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates (PubMed:24753571). Is thought to mediatedocking of the importin/substrate complex to the nuclear porecomplex (NPC) through binding to nucleoporin and the complex issubsequently translocated through the pore by an energy requiring,Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region ofthe heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2and mediates their nuclear import. Appears also to be involved inhnRNP A1/A2 nuclear export. Mediates the nuclear import ofribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-likeimport receptor binding (BIB) domain of RPL23A. In vitro, mediatesnuclear import of H2A, H2B, H3 and H4 histones, and SRP19 (Bysimilarity). Mediates nuclear import of ADAR/ADAR1 isoform 1 andisoform 5 in a RanGTP-dependent manner (PubMed:19124606,PubMed:24753571). {ECO:0000250|UniProtKB:Q8BFY9,ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606,ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:8986607,ECO:0000269|PubMed:9687515}. (Microbial infection) In case of HIV-1 infection, bindsand mediates the nuclear import of HIV-1 Rev.{ECO:0000269|PubMed:16704975}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF106_TNPO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF106_TNPO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF106_TNPO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF106_TNPO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource