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Fusion gene ID: 42986 |
FusionGeneSummary for ZNF100_XPO1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF100_XPO1 | Fusion gene ID: 42986 | Hgene | Tgene | Gene symbol | ZNF100 | XPO1 | Gene ID | 163227 | 7514 |
| Gene name | zinc finger protein 100 | exportin 1 | |
| Synonyms | - | CRM1|emb|exp1 | |
| Cytomap | 19p12 | 2p15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 100zinc finger protein 100 (Y1) | exportin-1chromosome region maintenance 1 homologchromosome region maintenance 1 protein homologexportin 1 (CRM1 homolog, yeast)exportin-1 (required for chromosome region maintenance) | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IYN0 | O14980 | |
| Ensembl transtripts involved in fusion gene | ENST00000358296, ENST00000305570, ENST00000596452, | ENST00000401558, ENST00000404992, ENST00000406957, ENST00000481214, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 5 X 1=10 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/10*10)=2.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF100 [Title/Abstract] AND XPO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | XPO1 | GO:0006611 | protein export from nucleus | 22250199 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB158037 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000358296 | ENST00000401558 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| intron-intron | ENST00000358296 | ENST00000404992 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| intron-intron | ENST00000358296 | ENST00000406957 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| intron-intron | ENST00000358296 | ENST00000481214 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| intron-5UTR | ENST00000305570 | ENST00000401558 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| intron-intron | ENST00000305570 | ENST00000404992 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| intron-intron | ENST00000305570 | ENST00000406957 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| intron-intron | ENST00000305570 | ENST00000481214 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| intron-5UTR | ENST00000596452 | ENST00000401558 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| intron-intron | ENST00000596452 | ENST00000404992 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| intron-intron | ENST00000596452 | ENST00000406957 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
| intron-intron | ENST00000596452 | ENST00000481214 | ZNF100 | chr19 | 21913286 | - | XPO1 | chr2 | 61764896 | - |
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FusionProtFeatures for ZNF100_XPO1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF100 | XPO1 |
| May be involved in transcriptional regulation. | Mediates the nuclear export of cellular proteins(cargos) bearing a leucine-rich nuclear export signal (NES) and ofRNAs. In the nucleus, in association with RANBP3, bindscooperatively to the NES on its target protein and to the GTPaseRAN in its active GTP-bound form (Ran-GTP). Docking of thiscomplex to the nuclear pore complex (NPC) is mediated throughbinding to nucleoporins. Upon transit of a nuclear export complexinto the cytoplasm, disassembling of the complex and hydrolysis ofRan-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively)cause release of the cargo from the export receptor. Thedirectionality of nuclear export is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. Involved in U3 snoRNA transportfrom Cajal bodies to nucleoli. Binds to late precursor U3 snoRNAbearing a TMG cap. {ECO:0000269|PubMed:15574332,ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922,ECO:0000269|PubMed:9323133}. (Microbial infection) Mediates the export of unsplicedor incompletely spliced RNAs out of the nucleus from differentviruses including HIV-1, HTLV-1 and influenza A. Interacts with,and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rexproteins. Involved in HTLV-1 Rex multimerization.{ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF100_XPO1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF100_XPO1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF100_XPO1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF100_XPO1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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