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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42962

FusionGeneSummary for ZMYM6_ACOX3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMYM6_ACOX3
Fusion gene ID: 42962
HgeneTgene
Gene symbol

ZMYM6

ACOX3

Gene ID

9204

8310

Gene namezinc finger MYM-type containing 6acyl-CoA oxidase 3, pristanoyl
SynonymsBuster2|MYM|ZBED7|ZNF198L4|ZNF258-
Cytomap

1p34.3

4p16.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger MYM-type protein 6transposon-derived Buster2 transposase-like proteinzinc finger protein 258zinc finger, BED-type containing 7zinc finger, MYM-type 6peroxisomal acyl-coenzyme A oxidase 3BRCACoxacyl-Coenzyme A oxidase 3, pristanoylbranched-chain acyl-CoA oxidasepristanoyl-CoA oxidase
Modification date2018052220180523
UniProtAcc

O95789

O15254

Ensembl transtripts involved in fusion geneENST00000487874, ENST00000373340, 
ENST00000493328, ENST00000357182, 
ENST00000317538, ENST00000373333, 
ENST00000356406, ENST00000413009, 
ENST00000503233, ENST00000515797, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: ZMYM6 [Title/Abstract] AND ACOX3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A3IS-01AZMYM6chr1

35496148

-ACOX3chr4

8375355

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000487874ENST00000356406ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-intronENST00000487874ENST00000413009ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-intronENST00000487874ENST00000503233ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-5UTRENST00000487874ENST00000515797ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
Frame-shiftENST00000373340ENST00000356406ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-intronENST00000373340ENST00000413009ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-intronENST00000373340ENST00000503233ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-5UTRENST00000373340ENST00000515797ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5UTR-3CDSENST00000493328ENST00000356406ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5UTR-intronENST00000493328ENST00000413009ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5UTR-intronENST00000493328ENST00000503233ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5UTR-5UTRENST00000493328ENST00000515797ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
Frame-shiftENST00000357182ENST00000356406ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-intronENST00000357182ENST00000413009ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-intronENST00000357182ENST00000503233ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-5UTRENST00000357182ENST00000515797ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
Frame-shiftENST00000317538ENST00000356406ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-intronENST00000317538ENST00000413009ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-intronENST00000317538ENST00000503233ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-5UTRENST00000317538ENST00000515797ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
Frame-shiftENST00000373333ENST00000356406ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-intronENST00000373333ENST00000413009ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-intronENST00000373333ENST00000503233ZMYM6chr1

35496148

-ACOX3chr4

8375355

-
5CDS-5UTRENST00000373333ENST00000515797ZMYM6chr1

35496148

-ACOX3chr4

8375355

-

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FusionProtFeatures for ZMYM6_ACOX3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZMYM6

O95789

ACOX3

O15254

Oxidizes the CoA-esters of 2-methyl-branched fattyacids. {ECO:0000250, ECO:0000269|PubMed:9271077}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZMYM6_ACOX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZMYM6_ACOX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZMYM6KLHL13, UCHL3, CTDSP2, RFPL4B, FHL3, HDAC7, FHL5, QPRT, TIMP2, ZNF707, LTBR, PLEKHO2, CRTAC1, GRB2, LSP1, TUFM, CCDC89, OPTN, ZNF232, LMO2, DEF8, HAVCR2, LZTS2, EMILIN1, CDA, ZNF263, FAM60A, ZNF18, TRAF1, ACOT12, TPGS2, LMNAACOX3PEX5, SMURF2, TMEM150A, FKBP6, MICU2, YTHDF1, HERC3, CENPH, HAUS7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZMYM6_ACOX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZMYM6_ACOX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource