![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 4294 |
FusionGeneSummary for BOLA2_CORO1A |
![]() |
Fusion gene information | Fusion gene name: BOLA2_CORO1A | Fusion gene ID: 4294 | Hgene | Tgene | Gene symbol | BOLA2 | CORO1A | Gene ID | 654483 | 11151 |
Gene name | bolA family member 2B | coronin 1A | |
Synonyms | BOLA2 | CLABP|CLIPINA|HCORO1|IMD8|TACO|p57 | |
Cytomap | 16p11.2 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | coronin-1Aclipin-Acoronin, actin binding protein, 1Acoronin-1coronin-like protein Acoronin-like protein p57tryptophan aspartate-containing coat protein | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9H3K6 | P31146 | |
Ensembl transtripts involved in fusion gene | ENST00000330978, | ENST00000219150, ENST00000566619, ENST00000570045, ENST00000565497, | |
Fusion gene scores | * DoF score | 24 X 31 X 3=2232 | 2 X 2 X 2=8 |
# samples | 31 | 2 | |
** MAII score | log2(31/2232*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: BOLA2 [Title/Abstract] AND CORO1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
Hgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
Tgene | CORO1A | GO:0050918 | positive chemotaxis | 17442961 |
Tgene | CORO1A | GO:0051126 | negative regulation of actin nucleation | 17442961 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-EA-A5ZE-01A | BOLA2 | chr16 | 29465338 | - | CORO1A | chr16 | 30196529 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000330978 | ENST00000219150 | BOLA2 | chr16 | 29465338 | - | CORO1A | chr16 | 30196529 | + |
5CDS-3UTR | ENST00000330978 | ENST00000566619 | BOLA2 | chr16 | 29465338 | - | CORO1A | chr16 | 30196529 | + |
5CDS-5UTR | ENST00000330978 | ENST00000570045 | BOLA2 | chr16 | 29465338 | - | CORO1A | chr16 | 30196529 | + |
5CDS-5UTR | ENST00000330978 | ENST00000565497 | BOLA2 | chr16 | 29465338 | - | CORO1A | chr16 | 30196529 | + |
Top |
FusionProtFeatures for BOLA2_CORO1A |
![]() |
Hgene | Tgene |
BOLA2 | CORO1A |
Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}. | May be a crucial component of the cytoskeleton of highlymotile cells, functioning both in the invagination of large piecesof plasma membrane, as well as in forming protrusions of theplasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane preventsfusion between phagosomes and lysosomes.{ECO:0000269|PubMed:10338208}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for BOLA2_CORO1A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for BOLA2_CORO1A |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BOLA2 | ARRB2, CUL3, CUL2, MAGOH, EIF4A3, VCAM1, IQCB1, ITGA4, PAN2, NPM1, HIST1H3E, MCM2, CRBN, CDK1, COQ2, COX15, DLD, DLST, PARK7, SOAT1, VDAC1 | CORO1A | DKK1, UBE2G2, FMNL1, STAT3, MAGOH, TAB1, POLR1C, FHL3, LMO2, SMAD3, SMARCD1, GIT2, POT1, SPATA20, YTHDC1, GOLGA2, FSD2, POC1A, SLC25A41, IFT57, POC1B, CORO6, CORO1B, BICD2, IFT172, VARS, RABGAP1L, RABGAP1, IFT20, TRAF7, TJAP1, IFT80, FAM208A, CEP44, CORO2A, ACTR2, ACTR3, ASPDH, NHP2L1, U2AF2, CORO1C, NELL2, TMCC2, COX4I1, MRPL12, RASSF8, TMEM205, FOXA3, DNAJC1, DDX24 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for BOLA2_CORO1A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for BOLA2_CORO1A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CORO1A | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | CORO1A | C0041296 | Tuberculosis | 1 | CTD_human |
Tgene | CORO1A | C3809383 | IMMUNODEFICIENCY 8 | 1 | ORPHANET;UNIPROT |