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Fusion gene ID: 4293 |
FusionGeneSummary for BOLA2_CNNM2 |
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Fusion gene information | Fusion gene name: BOLA2_CNNM2 | Fusion gene ID: 4293 | Hgene | Tgene | Gene symbol | BOLA2 | CNNM2 | Gene ID | 654483 | 54805 |
Gene name | bolA family member 2B | cyclin and CBS domain divalent metal cation transport mediator 2 | |
Synonyms | BOLA2 | ACDP2|HOMG6|HOMGSMR | |
Cytomap | 16p11.2 | 10q24.32 | |
Type of gene | protein-coding | protein-coding | |
Description | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | metal transporter CNNM2ancient conserved domain-containing protein 2cyclin M2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9H3K6 | Q9H8M5 | |
Ensembl transtripts involved in fusion gene | ENST00000330978, | ENST00000369878, ENST00000433628, ENST00000369875, ENST00000475511, | |
Fusion gene scores | * DoF score | 24 X 31 X 3=2232 | 3 X 3 X 2=18 |
# samples | 31 | 3 | |
** MAII score | log2(31/2232*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: BOLA2 [Title/Abstract] AND CNNM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
Hgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG988047 | BOLA2 | chr16 | 30005413 | + | CNNM2 | chr10 | 104828464 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000330978 | ENST00000369878 | BOLA2 | chr16 | 30005413 | + | CNNM2 | chr10 | 104828464 | - |
intron-3CDS | ENST00000330978 | ENST00000433628 | BOLA2 | chr16 | 30005413 | + | CNNM2 | chr10 | 104828464 | - |
intron-intron | ENST00000330978 | ENST00000369875 | BOLA2 | chr16 | 30005413 | + | CNNM2 | chr10 | 104828464 | - |
intron-3UTR | ENST00000330978 | ENST00000475511 | BOLA2 | chr16 | 30005413 | + | CNNM2 | chr10 | 104828464 | - |
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FusionProtFeatures for BOLA2_CNNM2 |
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Hgene | Tgene |
BOLA2 | CNNM2 |
Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}. | Divalent metal cation transporter. Mediates transport ofdivalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) >Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).{ECO:0000250|UniProtKB:Q3TWN3}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BOLA2_CNNM2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BOLA2_CNNM2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BOLA2_CNNM2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BOLA2_CNNM2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CNNM2 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | CNNM2 | C0003811 | Cardiac Arrhythmia | 1 | CTD_human |
Tgene | CNNM2 | C0022658 | Kidney Diseases | 1 | CTD_human |
Tgene | CNNM2 | C0036572 | Seizures | 1 | CTD_human;HPO |
Tgene | CNNM2 | C0039621 | Tetany | 1 | CTD_human |
Tgene | CNNM2 | C3151295 | HYPOMAGNESEMIA 6, RENAL | 1 | UNIPROT |
Tgene | CNNM2 | C4225333 | HYPOMAGNESEMIA, SEIZURES, AND MENTAL RETARDATION | 1 | UNIPROT |