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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42916

FusionGeneSummary for ZMAT1_ZMAT1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMAT1_ZMAT1
Fusion gene ID: 42916
HgeneTgene
Gene symbol

ZMAT1

ZMAT1

Gene ID

84460

84460

Gene namezinc finger matrin-type 1zinc finger matrin-type 1
Synonyms--
Cytomap

Xq22.1

Xq22.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger matrin-type protein 1zinc finger matrin-type protein 1
Modification date2018051920180519
UniProtAcc

Q5H9K5

Q5H9K5

Ensembl transtripts involved in fusion geneENST00000372782, ENST00000494068, 
ENST00000540921, ENST00000458570, 
ENST00000372782, ENST00000494068, 
ENST00000540921, ENST00000458570, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ZMAT1 [Title/Abstract] AND ZMAT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA313807ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000372782ENST00000372782ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000372782ENST00000494068ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000372782ENST00000540921ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000372782ENST00000458570ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-3CDSENST00000494068ENST00000372782ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000494068ENST00000494068ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000494068ENST00000540921ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000494068ENST00000458570ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-3CDSENST00000540921ENST00000372782ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000540921ENST00000494068ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000540921ENST00000540921ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000540921ENST00000458570ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-3CDSENST00000458570ENST00000372782ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000458570ENST00000494068ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000458570ENST00000540921ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-
intron-5UTRENST00000458570ENST00000458570ZMAT1chrX

101138552

+ZMAT1chrX

101138959

-

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FusionProtFeatures for ZMAT1_ZMAT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZMAT1

Q5H9K5

ZMAT1

Q5H9K5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZMAT1_ZMAT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZMAT1_ZMAT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZMAT1_ZMAT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZMAT1_ZMAT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource