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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 42914

FusionGeneSummary for ZKSCAN5_SMO

check button Fusion gene summary
Fusion gene informationFusion gene name: ZKSCAN5_SMO
Fusion gene ID: 42914
HgeneTgene
Gene symbol

ZKSCAN5

SMO

Gene ID

23660

54498

Gene namezinc finger with KRAB and SCAN domains 5spermine oxidase
SynonymsZFP-95|ZFP95|ZNF914|ZSCAN37C20orf16|PAO|PAO-1|PAO1|PAOH|PAOH1|SMO
Cytomap

7q22.1

20p13

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein with KRAB and SCAN domains 5zinc finger protein 95 homologzinc finger protein homologous to Zfp95 in mousespermine oxidaseflavin containing amine oxidaseflavin-containing spermine oxidasepolyamine oxidase 1putative cyclin G1 interacting protein
Modification date2018052220180523
UniProtAcc

Q9Y2L8

Q99835

Ensembl transtripts involved in fusion geneENST00000326775, ENST00000451158, 
ENST00000394170, 		ENST00000249373, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/8*10)=1.90689059560852
Context

PubMed: ZKSCAN5 [Title/Abstract] AND SMO [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSMO

GO:0006598

polyamine catabolic process

12477380


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A0U4-01AZKSCAN5chr7

99110214

+SMOchr7

128843225

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000326775ENST00000249373ZKSCAN5chr7

99110214

+SMOchr7

128843225

+
In-frameENST00000451158ENST00000249373ZKSCAN5chr7

99110214

+SMOchr7

128843225

+
In-frameENST00000394170ENST00000249373ZKSCAN5chr7

99110214

+SMOchr7

128843225

+

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FusionProtFeatures for ZKSCAN5_SMO


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZKSCAN5

Q9Y2L8

SMO

Q99835

May be involved in transcriptional regulation. G protein-coupled receptor that probably associates withthe patched protein (PTCH) to transduce the hedgehog's proteinssignal. Binding of sonic hedgehog (SHH) to its receptor patched isthought to prevent normal inhibition by patched of smoothened(SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in thecilia (PubMed:19592253). Interacts with DLG5 at the ciliary baseto induce the accumulation of KIF7 and GLI2 at the ciliary tip forGLI2 activation (By similarity). {ECO:0000250|UniProtKB:P56726,ECO:0000269|PubMed:19592253}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+3751_132184840DomainSCAN box
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+3751_132184840DomainSCAN box
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+3751_132184840DomainSCAN box
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012255_262110788Topological domainCytoplasmic
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012284_314110788Topological domainExtracellular
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012336_358110788Topological domainCytoplasmic
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012380_402110788Topological domainExtracellular
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012424_451110788Topological domainCytoplasmic
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012473_524110788Topological domainExtracellular
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012546_787110788Topological domainCytoplasmic
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012234_254110788TransmembraneHelical%3B Name%3D1
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012263_283110788TransmembraneHelical%3B Name%3D2
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012315_335110788TransmembraneHelical%3B Name%3D3
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012359_379110788TransmembraneHelical%3B Name%3D4
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012403_423110788TransmembraneHelical%3B Name%3D5
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012452_472110788TransmembraneHelical%3B Name%3D6
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012525_545110788TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37218_291184840DomainKRAB
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37218_291184840DomainKRAB
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37218_291184840DomainKRAB
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37346_368184840Zinc fingerC2H2-type 1
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37374_396184840Zinc fingerC2H2-type 2
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37402_424184840Zinc fingerC2H2-type 3
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37430_452184840Zinc fingerC2H2-type 4
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37549_571184840Zinc fingerC2H2-type 5
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37577_599184840Zinc fingerC2H2-type 6
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37605_627184840Zinc fingerC2H2-type 7
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37633_655184840Zinc fingerC2H2-type 8
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37661_683184840Zinc fingerC2H2-type 9
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37717_739184840Zinc fingerC2H2-type 10
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37745_763184840Zinc fingerC2H2-type 11%3B atypical
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37773_795184840Zinc fingerC2H2-type 12
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000326775+37801_823184840Zinc fingerC2H2-type 13
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37346_368184840Zinc fingerC2H2-type 1
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37374_396184840Zinc fingerC2H2-type 2
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37402_424184840Zinc fingerC2H2-type 3
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37430_452184840Zinc fingerC2H2-type 4
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37549_571184840Zinc fingerC2H2-type 5
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37577_599184840Zinc fingerC2H2-type 6
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37605_627184840Zinc fingerC2H2-type 7
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37633_655184840Zinc fingerC2H2-type 8
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37661_683184840Zinc fingerC2H2-type 9
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37717_739184840Zinc fingerC2H2-type 10
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37745_763184840Zinc fingerC2H2-type 11%3B atypical
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37773_795184840Zinc fingerC2H2-type 12
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000394170+37801_823184840Zinc fingerC2H2-type 13
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37346_368184840Zinc fingerC2H2-type 1
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37374_396184840Zinc fingerC2H2-type 2
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37402_424184840Zinc fingerC2H2-type 3
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37430_452184840Zinc fingerC2H2-type 4
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37549_571184840Zinc fingerC2H2-type 5
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37577_599184840Zinc fingerC2H2-type 6
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37605_627184840Zinc fingerC2H2-type 7
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37633_655184840Zinc fingerC2H2-type 8
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37661_683184840Zinc fingerC2H2-type 9
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37717_739184840Zinc fingerC2H2-type 10
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37745_763184840Zinc fingerC2H2-type 11%3B atypical
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37773_795184840Zinc fingerC2H2-type 12
HgeneZKSCAN5chr7:99110214chr7:128843225ENST00000451158+37801_823184840Zinc fingerC2H2-type 13
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+01265_181110788DomainFZ
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+01228_233110788Topological domainExtracellular


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FusionGeneSequence for ZKSCAN5_SMO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZKSCAN5_ENST00000326775_chr7_99110214_+_SMO_ENST00000249373_chr7_128843225_+_862aa
MIMTESREVIDLDPPAETSQEQEDLFIVKVEEEDCTWMQEYNPPTFETFYQRFRHFQYHEASGPREALSQLRVLCCEWLRPELHTKEQIL
ELLVLEQFLTILPEEFQPWVREHHPESGEEAVAVIENIQRELEERRQQIVACPDVLPRKMATPGAVQESCSPHPLTVDTQPEQAPQKPRL
LEENGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVP
LVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFM
DGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAIL
AVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLIT
FSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQS
DDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPV
PPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNP

>In-frame_ZKSCAN5_ENST00000451158_chr7_99110214_+_SMO_ENST00000249373_chr7_128843225_+_862aa
MIMTESREVIDLDPPAETSQEQEDLFIVKVEEEDCTWMQEYNPPTFETFYQRFRHFQYHEASGPREALSQLRVLCCEWLRPELHTKEQIL
ELLVLEQFLTILPEEFQPWVREHHPESGEEAVAVIENIQRELEERRQQIVACPDVLPRKMATPGAVQESCSPHPLTVDTQPEQAPQKPRL
LEENGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVP
LVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFM
DGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAIL
AVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLIT
FSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQS
DDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPV
PPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNP

>In-frame_ZKSCAN5_ENST00000394170_chr7_99110214_+_SMO_ENST00000249373_chr7_128843225_+_862aa
MIMTESREVIDLDPPAETSQEQEDLFIVKVEEEDCTWMQEYNPPTFETFYQRFRHFQYHEASGPREALSQLRVLCCEWLRPELHTKEQIL
ELLVLEQFLTILPEEFQPWVREHHPESGEEAVAVIENIQRELEERRQQIVACPDVLPRKMATPGAVQESCSPHPLTVDTQPEQAPQKPRL
LEENGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVP
LVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFM
DGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAIL
AVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLIT
FSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQS
DDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPV
PPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZKSCAN5_ENST00000326775_chr7_99110214_+_SMO_ENST00000249373_chr7_128843225_+_2586nt
ATGATAATGACCGAATCCCGAGAAGTTATAGACTTAGACCCCCCAGCTGAGACTTCCCAGGAGCAGGAAGACCTTTTCATAGTGAAGGTG
GAAGAAGAAGACTGCACCTGGATGCAGGAGTACAACCCGCCAACGTTTGAGACTTTTTACCAGCGCTTCAGGCACTTCCAGTACCATGAG
GCTTCAGGACCCCGGGAGGCTCTCAGCCAACTCCGGGTGCTCTGCTGTGAGTGGCTGAGGCCCGAGCTGCACACGAAGGAGCAGATCCTG
GAGCTGCTGGTGCTGGAGCAGTTCCTGACCATCCTGCCTGAAGAGTTCCAGCCCTGGGTGAGGGAACATCACCCTGAAAGTGGAGAAGAG
GCGGTGGCCGTGATAGAAAATATACAGCGAGAACTTGAGGAACGCAGACAGCAGATTGTTGCCTGCCCTGATGTGCTTCCTCGGAAGATG
GCAACACCTGGAGCAGTGCAGGAGTCCTGCAGCCCCCATCCCCTGACCGTGGACACCCAGCCTGAGCAAGCGCCACAGAAGCCTCGTCTC
CTGGAGGAAAATGGCCTCCGGAATGCCCCCCGCTGCTGGGCAGTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAAT
GACCGGGTGGAGCTGCCCAGCCGTACCCTCTGCCAGGCCACCCGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTGGCCTGACTTC
CTGCGCTGCACTCCTGACCGCTTCCCTGAAGGCTGCACGAATGAGGTGCAGAACATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCC
TTGGTTCGGACAGACAACCCCAAGAGCTGGTACGAGGACGTGGAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCACAGAGGCTGAG
CACCAGGACATGCACAGCTACATCGCGGCCTTCGGGGCCGTCACGGGCCTCTGCACGCTCTTCACCCTGGCCACATTCGTGGCTGACTGG
CGGAACTCGAATCGCTACCCTGCTGTTATTCTCTTCTACGTCAATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATG
GATGGTGCCCGCCGAGAGATCGTCTGCCGTGCAGATGGCACCATGAGGCTTGGGGAGCCCACCTCCAATGAGACTCTGTCCTGCGTCATC
ATCTTTGTCATCGTGTACTACGCCCTGATGGCTGGTGTGGTTTGGTTTGTGGTCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTG
GGCACCACCTACCAGCCTCTCTCGGGCAAGACCTCCTACTTCCACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGGCAATCCTT
GCTGTGGCGCAGGTGGATGGGGACTCTGTGAGTGGGATTTGTTTTGTGGGCTACAAGAACTACCGATACCGTGCGGGCTTCGTGCTGGCC
CCAATCGGCCTGGTGCTCATCGTGGGAGGCTACTTCCTCATCCGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTG
CTGAGTGAGAAGGCTGCCAGCAAGATCAACGAGACCATGCTGCGCCTGGGCATTTTTGGCTTCCTGGCCTTTGGCTTTGTGCTCATTACC
TTCAGCTGCCACTTCTACGACTTCTTCAACCAGGCTGAGTGGGAGCGCAGCTTCCGGGACTATGTGCTATGTCAGGCCAATGTGACCATC
GGGCTGCCCACCAAGCAGCCCATCCCTGACTGTGAGATCAAGAATCGCCCGAGCCTTCTGGTGGAGAAGATCAACCTGTTTGCCATGTTT
GGAACTGGCATCGCCATGAGCACCTGGGTCTGGACCAAGGCCACGCTGCTCATCTGGAGGCGTACCTGGTGCAGGTTGACTGGGCAGAGT
GACGATGAGCCAAAGCGGATCAAGAAGAGCAAGATGATTGCCAAGGCCTTCTCTAAGCGGCACGAGCTCCTGCAGAACCCAGGCCAGGAG
CTGTCCTTCAGCATGCACACTGTGTCCCACGACGGGCCCGTGGCGGGCTTGGCCTTTGACCTCAATGAGCCCTCAGCTGATGTCTCCTCT
GCCTGGGCCCAGCATGTCACCAAGATGGTGGCTCGGAGAGGAGCCATACTGCCCCAGGATATTTCTGTCACCCCTGTGGCAACTCCAGTG
CCCCCAGAGGAACAAGCCAACCTGTGGCTGGTTGAGGCAGAGATCTCCCCAGAGCTGCAGAAGCGCCTGGGCCGGAAGAAGAAGAGGAGG
AAGAGGAAGAAGGAGGTGTGCCCGCTGGCGCCGCCCCCTGAGCTTCACCCCCCTGCCCCTGCCCCCAGTACCATTCCTCGACTGCCTCAG
CTGCCCCGGCAGAAATGCCTGGTGGCTGCAGGTGCCTGGGGAGCTGGGGACTCTTGCCGACAGGGAGCGTGGACCCTGGTCTCCAACCCA
TTCTGCCCAGAGCCCAGTCCCCCTCAGGATCCATTTCTGCCCAGTGCACCGGCCCCCGTGGCATGGGCTCATGGCCGCCGACAGGGCCTG

>In-frame_ZKSCAN5_ENST00000451158_chr7_99110214_+_SMO_ENST00000249373_chr7_128843225_+_2586nt
ATGATAATGACCGAATCCCGAGAAGTTATAGACTTAGACCCCCCAGCTGAGACTTCCCAGGAGCAGGAAGACCTTTTCATAGTGAAGGTG
GAAGAAGAAGACTGCACCTGGATGCAGGAGTACAACCCGCCAACGTTTGAGACTTTTTACCAGCGCTTCAGGCACTTCCAGTACCATGAG
GCTTCAGGACCCCGGGAGGCTCTCAGCCAACTCCGGGTGCTCTGCTGTGAGTGGCTGAGGCCCGAGCTGCACACGAAGGAGCAGATCCTG
GAGCTGCTGGTGCTGGAGCAGTTCCTGACCATCCTGCCTGAAGAGTTCCAGCCCTGGGTGAGGGAACATCACCCTGAAAGTGGAGAAGAG
GCGGTGGCCGTGATAGAAAATATACAGCGAGAACTTGAGGAACGCAGACAGCAGATTGTTGCCTGCCCTGATGTGCTTCCTCGGAAGATG
GCAACACCTGGAGCAGTGCAGGAGTCCTGCAGCCCCCATCCCCTGACCGTGGACACCCAGCCTGAGCAAGCGCCACAGAAGCCTCGTCTC
CTGGAGGAAAATGGCCTCCGGAATGCCCCCCGCTGCTGGGCAGTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAAT
GACCGGGTGGAGCTGCCCAGCCGTACCCTCTGCCAGGCCACCCGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTGGCCTGACTTC
CTGCGCTGCACTCCTGACCGCTTCCCTGAAGGCTGCACGAATGAGGTGCAGAACATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCC
TTGGTTCGGACAGACAACCCCAAGAGCTGGTACGAGGACGTGGAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCACAGAGGCTGAG
CACCAGGACATGCACAGCTACATCGCGGCCTTCGGGGCCGTCACGGGCCTCTGCACGCTCTTCACCCTGGCCACATTCGTGGCTGACTGG
CGGAACTCGAATCGCTACCCTGCTGTTATTCTCTTCTACGTCAATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATG
GATGGTGCCCGCCGAGAGATCGTCTGCCGTGCAGATGGCACCATGAGGCTTGGGGAGCCCACCTCCAATGAGACTCTGTCCTGCGTCATC
ATCTTTGTCATCGTGTACTACGCCCTGATGGCTGGTGTGGTTTGGTTTGTGGTCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTG
GGCACCACCTACCAGCCTCTCTCGGGCAAGACCTCCTACTTCCACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGGCAATCCTT
GCTGTGGCGCAGGTGGATGGGGACTCTGTGAGTGGGATTTGTTTTGTGGGCTACAAGAACTACCGATACCGTGCGGGCTTCGTGCTGGCC
CCAATCGGCCTGGTGCTCATCGTGGGAGGCTACTTCCTCATCCGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTG
CTGAGTGAGAAGGCTGCCAGCAAGATCAACGAGACCATGCTGCGCCTGGGCATTTTTGGCTTCCTGGCCTTTGGCTTTGTGCTCATTACC
TTCAGCTGCCACTTCTACGACTTCTTCAACCAGGCTGAGTGGGAGCGCAGCTTCCGGGACTATGTGCTATGTCAGGCCAATGTGACCATC
GGGCTGCCCACCAAGCAGCCCATCCCTGACTGTGAGATCAAGAATCGCCCGAGCCTTCTGGTGGAGAAGATCAACCTGTTTGCCATGTTT
GGAACTGGCATCGCCATGAGCACCTGGGTCTGGACCAAGGCCACGCTGCTCATCTGGAGGCGTACCTGGTGCAGGTTGACTGGGCAGAGT
GACGATGAGCCAAAGCGGATCAAGAAGAGCAAGATGATTGCCAAGGCCTTCTCTAAGCGGCACGAGCTCCTGCAGAACCCAGGCCAGGAG
CTGTCCTTCAGCATGCACACTGTGTCCCACGACGGGCCCGTGGCGGGCTTGGCCTTTGACCTCAATGAGCCCTCAGCTGATGTCTCCTCT
GCCTGGGCCCAGCATGTCACCAAGATGGTGGCTCGGAGAGGAGCCATACTGCCCCAGGATATTTCTGTCACCCCTGTGGCAACTCCAGTG
CCCCCAGAGGAACAAGCCAACCTGTGGCTGGTTGAGGCAGAGATCTCCCCAGAGCTGCAGAAGCGCCTGGGCCGGAAGAAGAAGAGGAGG
AAGAGGAAGAAGGAGGTGTGCCCGCTGGCGCCGCCCCCTGAGCTTCACCCCCCTGCCCCTGCCCCCAGTACCATTCCTCGACTGCCTCAG
CTGCCCCGGCAGAAATGCCTGGTGGCTGCAGGTGCCTGGGGAGCTGGGGACTCTTGCCGACAGGGAGCGTGGACCCTGGTCTCCAACCCA
TTCTGCCCAGAGCCCAGTCCCCCTCAGGATCCATTTCTGCCCAGTGCACCGGCCCCCGTGGCATGGGCTCATGGCCGCCGACAGGGCCTG

>In-frame_ZKSCAN5_ENST00000394170_chr7_99110214_+_SMO_ENST00000249373_chr7_128843225_+_2586nt
ATGATAATGACCGAATCCCGAGAAGTTATAGACTTAGACCCCCCAGCTGAGACTTCCCAGGAGCAGGAAGACCTTTTCATAGTGAAGGTG
GAAGAAGAAGACTGCACCTGGATGCAGGAGTACAACCCGCCAACGTTTGAGACTTTTTACCAGCGCTTCAGGCACTTCCAGTACCATGAG
GCTTCAGGACCCCGGGAGGCTCTCAGCCAACTCCGGGTGCTCTGCTGTGAGTGGCTGAGGCCCGAGCTGCACACGAAGGAGCAGATCCTG
GAGCTGCTGGTGCTGGAGCAGTTCCTGACCATCCTGCCTGAAGAGTTCCAGCCCTGGGTGAGGGAACATCACCCTGAAAGTGGAGAAGAG
GCGGTGGCCGTGATAGAAAATATACAGCGAGAACTTGAGGAACGCAGACAGCAGATTGTTGCCTGCCCTGATGTGCTTCCTCGGAAGATG
GCAACACCTGGAGCAGTGCAGGAGTCCTGCAGCCCCCATCCCCTGACCGTGGACACCCAGCCTGAGCAAGCGCCACAGAAGCCTCGTCTC
CTGGAGGAAAATGGCCTCCGGAATGCCCCCCGCTGCTGGGCAGTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAAT
GACCGGGTGGAGCTGCCCAGCCGTACCCTCTGCCAGGCCACCCGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTGGCCTGACTTC
CTGCGCTGCACTCCTGACCGCTTCCCTGAAGGCTGCACGAATGAGGTGCAGAACATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCC
TTGGTTCGGACAGACAACCCCAAGAGCTGGTACGAGGACGTGGAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCACAGAGGCTGAG
CACCAGGACATGCACAGCTACATCGCGGCCTTCGGGGCCGTCACGGGCCTCTGCACGCTCTTCACCCTGGCCACATTCGTGGCTGACTGG
CGGAACTCGAATCGCTACCCTGCTGTTATTCTCTTCTACGTCAATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATG
GATGGTGCCCGCCGAGAGATCGTCTGCCGTGCAGATGGCACCATGAGGCTTGGGGAGCCCACCTCCAATGAGACTCTGTCCTGCGTCATC
ATCTTTGTCATCGTGTACTACGCCCTGATGGCTGGTGTGGTTTGGTTTGTGGTCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTG
GGCACCACCTACCAGCCTCTCTCGGGCAAGACCTCCTACTTCCACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGGCAATCCTT
GCTGTGGCGCAGGTGGATGGGGACTCTGTGAGTGGGATTTGTTTTGTGGGCTACAAGAACTACCGATACCGTGCGGGCTTCGTGCTGGCC
CCAATCGGCCTGGTGCTCATCGTGGGAGGCTACTTCCTCATCCGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTG
CTGAGTGAGAAGGCTGCCAGCAAGATCAACGAGACCATGCTGCGCCTGGGCATTTTTGGCTTCCTGGCCTTTGGCTTTGTGCTCATTACC
TTCAGCTGCCACTTCTACGACTTCTTCAACCAGGCTGAGTGGGAGCGCAGCTTCCGGGACTATGTGCTATGTCAGGCCAATGTGACCATC
GGGCTGCCCACCAAGCAGCCCATCCCTGACTGTGAGATCAAGAATCGCCCGAGCCTTCTGGTGGAGAAGATCAACCTGTTTGCCATGTTT
GGAACTGGCATCGCCATGAGCACCTGGGTCTGGACCAAGGCCACGCTGCTCATCTGGAGGCGTACCTGGTGCAGGTTGACTGGGCAGAGT
GACGATGAGCCAAAGCGGATCAAGAAGAGCAAGATGATTGCCAAGGCCTTCTCTAAGCGGCACGAGCTCCTGCAGAACCCAGGCCAGGAG
CTGTCCTTCAGCATGCACACTGTGTCCCACGACGGGCCCGTGGCGGGCTTGGCCTTTGACCTCAATGAGCCCTCAGCTGATGTCTCCTCT
GCCTGGGCCCAGCATGTCACCAAGATGGTGGCTCGGAGAGGAGCCATACTGCCCCAGGATATTTCTGTCACCCCTGTGGCAACTCCAGTG
CCCCCAGAGGAACAAGCCAACCTGTGGCTGGTTGAGGCAGAGATCTCCCCAGAGCTGCAGAAGCGCCTGGGCCGGAAGAAGAAGAGGAGG
AAGAGGAAGAAGGAGGTGTGCCCGCTGGCGCCGCCCCCTGAGCTTCACCCCCCTGCCCCTGCCCCCAGTACCATTCCTCGACTGCCTCAG
CTGCCCCGGCAGAAATGCCTGGTGGCTGCAGGTGCCTGGGGAGCTGGGGACTCTTGCCGACAGGGAGCGTGGACCCTGGTCTCCAACCCA
TTCTGCCCAGAGCCCAGTCCCCCTCAGGATCCATTTCTGCCCAGTGCACCGGCCCCCGTGGCATGGGCTCATGGCCGCCGACAGGGCCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZKSCAN5_ENST00000326775_chr7_99110214_+_SMO_ENST00000249373_chr7_128843225_+_3803nt
GTTCCGGGAACAGCTGGCCCCTGCGACTCGCGGGTGTGACGTTGAAGATGTCGGCCTTCTGAGCCGACTGCGGTGGTCAAGAGTGTAACA
CAGCCAGCCTCGAAGACTTCCCTCTGAGTTGGAATGATAATGACCGAATCCCGAGAAGTTATAGACTTAGACCCCCCAGCTGAGACTTCC
CAGGAGCAGGAAGACCTTTTCATAGTGAAGGTGGAAGAAGAAGACTGCACCTGGATGCAGGAGTACAACCCGCCAACGTTTGAGACTTTT
TACCAGCGCTTCAGGCACTTCCAGTACCATGAGGCTTCAGGACCCCGGGAGGCTCTCAGCCAACTCCGGGTGCTCTGCTGTGAGTGGCTG
AGGCCCGAGCTGCACACGAAGGAGCAGATCCTGGAGCTGCTGGTGCTGGAGCAGTTCCTGACCATCCTGCCTGAAGAGTTCCAGCCCTGG
GTGAGGGAACATCACCCTGAAAGTGGAGAAGAGGCGGTGGCCGTGATAGAAAATATACAGCGAGAACTTGAGGAACGCAGACAGCAGATT
GTTGCCTGCCCTGATGTGCTTCCTCGGAAGATGGCAACACCTGGAGCAGTGCAGGAGTCCTGCAGCCCCCATCCCCTGACCGTGGACACC
CAGCCTGAGCAAGCGCCACAGAAGCCTCGTCTCCTGGAGGAAAATGGCCTCCGGAATGCCCCCCGCTGCTGGGCAGTGATCCAGCCCCTG
CTGTGTGCCGTATACATGCCCAAGTGTGAGAATGACCGGGTGGAGCTGCCCAGCCGTACCCTCTGCCAGGCCACCCGAGGCCCCTGTGCC
ATCGTGGAGAGGGAGCGGGGCTGGCCTGACTTCCTGCGCTGCACTCCTGACCGCTTCCCTGAAGGCTGCACGAATGAGGTGCAGAACATC
AAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCCTTGGTTCGGACAGACAACCCCAAGAGCTGGTACGAGGACGTGGAGGGCTGCGGCATC
CAGTGCCAGAACCCGCTCTTCACAGAGGCTGAGCACCAGGACATGCACAGCTACATCGCGGCCTTCGGGGCCGTCACGGGCCTCTGCACG
CTCTTCACCCTGGCCACATTCGTGGCTGACTGGCGGAACTCGAATCGCTACCCTGCTGTTATTCTCTTCTACGTCAATGCGTGCTTCTTT
GTGGGCAGCATTGGCTGGCTGGCCCAGTTCATGGATGGTGCCCGCCGAGAGATCGTCTGCCGTGCAGATGGCACCATGAGGCTTGGGGAG
CCCACCTCCAATGAGACTCTGTCCTGCGTCATCATCTTTGTCATCGTGTACTACGCCCTGATGGCTGGTGTGGTTTGGTTTGTGGTCCTC
ACCTATGCCTGGCACACTTCCTTCAAAGCCCTGGGCACCACCTACCAGCCTCTCTCGGGCAAGACCTCCTACTTCCACCTGCTCACCTGG
TCACTCCCCTTTGTCCTCACTGTGGCAATCCTTGCTGTGGCGCAGGTGGATGGGGACTCTGTGAGTGGGATTTGTTTTGTGGGCTACAAG
AACTACCGATACCGTGCGGGCTTCGTGCTGGCCCCAATCGGCCTGGTGCTCATCGTGGGAGGCTACTTCCTCATCCGAGGAGTCATGACT
CTGTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAGGCTGCCAGCAAGATCAACGAGACCATGCTGCGCCTGGGCATTTTT
GGCTTCCTGGCCTTTGGCTTTGTGCTCATTACCTTCAGCTGCCACTTCTACGACTTCTTCAACCAGGCTGAGTGGGAGCGCAGCTTCCGG
GACTATGTGCTATGTCAGGCCAATGTGACCATCGGGCTGCCCACCAAGCAGCCCATCCCTGACTGTGAGATCAAGAATCGCCCGAGCCTT
CTGGTGGAGAAGATCAACCTGTTTGCCATGTTTGGAACTGGCATCGCCATGAGCACCTGGGTCTGGACCAAGGCCACGCTGCTCATCTGG
AGGCGTACCTGGTGCAGGTTGACTGGGCAGAGTGACGATGAGCCAAAGCGGATCAAGAAGAGCAAGATGATTGCCAAGGCCTTCTCTAAG
CGGCACGAGCTCCTGCAGAACCCAGGCCAGGAGCTGTCCTTCAGCATGCACACTGTGTCCCACGACGGGCCCGTGGCGGGCTTGGCCTTT
GACCTCAATGAGCCCTCAGCTGATGTCTCCTCTGCCTGGGCCCAGCATGTCACCAAGATGGTGGCTCGGAGAGGAGCCATACTGCCCCAG
GATATTTCTGTCACCCCTGTGGCAACTCCAGTGCCCCCAGAGGAACAAGCCAACCTGTGGCTGGTTGAGGCAGAGATCTCCCCAGAGCTG
CAGAAGCGCCTGGGCCGGAAGAAGAAGAGGAGGAAGAGGAAGAAGGAGGTGTGCCCGCTGGCGCCGCCCCCTGAGCTTCACCCCCCTGCC
CCTGCCCCCAGTACCATTCCTCGACTGCCTCAGCTGCCCCGGCAGAAATGCCTGGTGGCTGCAGGTGCCTGGGGAGCTGGGGACTCTTGC
CGACAGGGAGCGTGGACCCTGGTCTCCAACCCATTCTGCCCAGAGCCCAGTCCCCCTCAGGATCCATTTCTGCCCAGTGCACCGGCCCCC
GTGGCATGGGCTCATGGCCGCCGACAGGGCCTGGGGCCTATTCACTCCCGCACCAACCTGATGGACACAGAACTCATGGATGCAGACTCG
GACTTCTGAGCCTGCAGAGCAGGACCTGGGACAGGAAAGAGAGGAACCAATACCTTCAAGGCTCTTCTTCCTCACCGAGCATGCTTCCCT
AGGATCCCGTCTTCCAGAGAACCTGTGGGCTGACTGCCCTCCGAAGAGAGTTCTGGATGTCTGGCTCAAAGCAGCAGGACTGTGGGAAAG
AGCCTAACATCTCCATGGGGAGGCCTCACCCCAGGGACAGGGCCCTGGAGCTCAGGGTCCTTGTTTCTGCCCTGCCAGCTGCAGCCTGGT
TGGCAGCATCTGCTCCATCGGGGCAGGGGGTATGCAGAGCTTGTGGTGGGGCAGGAACGGTGGAGGCAGAGGTGACAGTTCCCAGAGTGG
GCTTTGGTGGCCAGGGAGGCAGCCTAGCCTATGTCTGGCAGATGAGGGCTGGCTGCCGTTTTCTGGGCTGATGGGTGCCCTTTCCTGGCA
GTCTCAGTCCAAAAGTGTTGACTGTGTCATTAGTCCTTTGTCTAAGTAGGGCCAGGGCACCGTATTCCTCTCCCAGGTGTTTGTGGGGCT
GGAAGGACCTGCTCCCACAGGGGCCATGTCCTCTCTTAATAGGTGGCACTACCCCAAACCCATCTTTTGTTCTCCTATATCCTCCTTCTT
CTGTTCCATTTCAGTTCAGTTTCAGCGGTGCCAACCTCTTTGCGTTTCCTTTTTGTTGATGAGGACCCAGAGCTGCTGCACACACTCACC
TCTAACCCCCTCCCCTCGCTGCTGGGCCCCATCTCCACAGGAGAGACTGGTTCAGCTCTAGGGCCTCAGTCTGGAGTGGGATAGGAGCAG
TGAGTGACAAAGCCTCTGAAAGATGCATCATCTCTTCCTCACACCCATTTAGTGGGGGATGGGTCCTCTAGACTTGAGGGGCTACCCTGG
GAAGCTGCCGTAGCTTCAGCCAGGCAAGAAAGCTTCCTTCAACCTGCATAGCCGGTGGGTGAGGAGATTCCCACCTTCCATAGCCTCCAA
ACATGTTCCCAAGGCCCCACTTTCAAGAATCAGACAGCAGGAAGCCATAGATGCTGGCTGGGTTCCAGGTTATGGGGAGAAGAAATACAG

>In-frame_ZKSCAN5_ENST00000451158_chr7_99110214_+_SMO_ENST00000249373_chr7_128843225_+_3841nt
GACTCGCGGGTGTGACGTTGAAGATGTCGGCCTTCTGAGCCGACTGCGGTGGTCAAGAGGTTGCATGCTACTGAAAGTGTCCTTCAGAAG
ATATTAAAGAGCAGAAAAACAATTGTTTCAGTGTAACACAGCCAGCCTCGAAGACTTCCCTCTGAGTTGGAATGATAATGACCGAATCCC
GAGAAGTTATAGACTTAGACCCCCCAGCTGAGACTTCCCAGGAGCAGGAAGACCTTTTCATAGTGAAGGTGGAAGAAGAAGACTGCACCT
GGATGCAGGAGTACAACCCGCCAACGTTTGAGACTTTTTACCAGCGCTTCAGGCACTTCCAGTACCATGAGGCTTCAGGACCCCGGGAGG
CTCTCAGCCAACTCCGGGTGCTCTGCTGTGAGTGGCTGAGGCCCGAGCTGCACACGAAGGAGCAGATCCTGGAGCTGCTGGTGCTGGAGC
AGTTCCTGACCATCCTGCCTGAAGAGTTCCAGCCCTGGGTGAGGGAACATCACCCTGAAAGTGGAGAAGAGGCGGTGGCCGTGATAGAAA
ATATACAGCGAGAACTTGAGGAACGCAGACAGCAGATTGTTGCCTGCCCTGATGTGCTTCCTCGGAAGATGGCAACACCTGGAGCAGTGC
AGGAGTCCTGCAGCCCCCATCCCCTGACCGTGGACACCCAGCCTGAGCAAGCGCCACAGAAGCCTCGTCTCCTGGAGGAAAATGGCCTCC
GGAATGCCCCCCGCTGCTGGGCAGTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAATGACCGGGTGGAGCTGCCCA
GCCGTACCCTCTGCCAGGCCACCCGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTGGCCTGACTTCCTGCGCTGCACTCCTGACC
GCTTCCCTGAAGGCTGCACGAATGAGGTGCAGAACATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCCTTGGTTCGGACAGACAACC
CCAAGAGCTGGTACGAGGACGTGGAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCACAGAGGCTGAGCACCAGGACATGCACAGCT
ACATCGCGGCCTTCGGGGCCGTCACGGGCCTCTGCACGCTCTTCACCCTGGCCACATTCGTGGCTGACTGGCGGAACTCGAATCGCTACC
CTGCTGTTATTCTCTTCTACGTCAATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATGGATGGTGCCCGCCGAGAGA
TCGTCTGCCGTGCAGATGGCACCATGAGGCTTGGGGAGCCCACCTCCAATGAGACTCTGTCCTGCGTCATCATCTTTGTCATCGTGTACT
ACGCCCTGATGGCTGGTGTGGTTTGGTTTGTGGTCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTGGGCACCACCTACCAGCCTC
TCTCGGGCAAGACCTCCTACTTCCACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGGCAATCCTTGCTGTGGCGCAGGTGGATG
GGGACTCTGTGAGTGGGATTTGTTTTGTGGGCTACAAGAACTACCGATACCGTGCGGGCTTCGTGCTGGCCCCAATCGGCCTGGTGCTCA
TCGTGGGAGGCTACTTCCTCATCCGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAGGCTGCCA
GCAAGATCAACGAGACCATGCTGCGCCTGGGCATTTTTGGCTTCCTGGCCTTTGGCTTTGTGCTCATTACCTTCAGCTGCCACTTCTACG
ACTTCTTCAACCAGGCTGAGTGGGAGCGCAGCTTCCGGGACTATGTGCTATGTCAGGCCAATGTGACCATCGGGCTGCCCACCAAGCAGC
CCATCCCTGACTGTGAGATCAAGAATCGCCCGAGCCTTCTGGTGGAGAAGATCAACCTGTTTGCCATGTTTGGAACTGGCATCGCCATGA
GCACCTGGGTCTGGACCAAGGCCACGCTGCTCATCTGGAGGCGTACCTGGTGCAGGTTGACTGGGCAGAGTGACGATGAGCCAAAGCGGA
TCAAGAAGAGCAAGATGATTGCCAAGGCCTTCTCTAAGCGGCACGAGCTCCTGCAGAACCCAGGCCAGGAGCTGTCCTTCAGCATGCACA
CTGTGTCCCACGACGGGCCCGTGGCGGGCTTGGCCTTTGACCTCAATGAGCCCTCAGCTGATGTCTCCTCTGCCTGGGCCCAGCATGTCA
CCAAGATGGTGGCTCGGAGAGGAGCCATACTGCCCCAGGATATTTCTGTCACCCCTGTGGCAACTCCAGTGCCCCCAGAGGAACAAGCCA
ACCTGTGGCTGGTTGAGGCAGAGATCTCCCCAGAGCTGCAGAAGCGCCTGGGCCGGAAGAAGAAGAGGAGGAAGAGGAAGAAGGAGGTGT
GCCCGCTGGCGCCGCCCCCTGAGCTTCACCCCCCTGCCCCTGCCCCCAGTACCATTCCTCGACTGCCTCAGCTGCCCCGGCAGAAATGCC
TGGTGGCTGCAGGTGCCTGGGGAGCTGGGGACTCTTGCCGACAGGGAGCGTGGACCCTGGTCTCCAACCCATTCTGCCCAGAGCCCAGTC
CCCCTCAGGATCCATTTCTGCCCAGTGCACCGGCCCCCGTGGCATGGGCTCATGGCCGCCGACAGGGCCTGGGGCCTATTCACTCCCGCA
CCAACCTGATGGACACAGAACTCATGGATGCAGACTCGGACTTCTGAGCCTGCAGAGCAGGACCTGGGACAGGAAAGAGAGGAACCAATA
CCTTCAAGGCTCTTCTTCCTCACCGAGCATGCTTCCCTAGGATCCCGTCTTCCAGAGAACCTGTGGGCTGACTGCCCTCCGAAGAGAGTT
CTGGATGTCTGGCTCAAAGCAGCAGGACTGTGGGAAAGAGCCTAACATCTCCATGGGGAGGCCTCACCCCAGGGACAGGGCCCTGGAGCT
CAGGGTCCTTGTTTCTGCCCTGCCAGCTGCAGCCTGGTTGGCAGCATCTGCTCCATCGGGGCAGGGGGTATGCAGAGCTTGTGGTGGGGC
AGGAACGGTGGAGGCAGAGGTGACAGTTCCCAGAGTGGGCTTTGGTGGCCAGGGAGGCAGCCTAGCCTATGTCTGGCAGATGAGGGCTGG
CTGCCGTTTTCTGGGCTGATGGGTGCCCTTTCCTGGCAGTCTCAGTCCAAAAGTGTTGACTGTGTCATTAGTCCTTTGTCTAAGTAGGGC
CAGGGCACCGTATTCCTCTCCCAGGTGTTTGTGGGGCTGGAAGGACCTGCTCCCACAGGGGCCATGTCCTCTCTTAATAGGTGGCACTAC
CCCAAACCCATCTTTTGTTCTCCTATATCCTCCTTCTTCTGTTCCATTTCAGTTCAGTTTCAGCGGTGCCAACCTCTTTGCGTTTCCTTT
TTGTTGATGAGGACCCAGAGCTGCTGCACACACTCACCTCTAACCCCCTCCCCTCGCTGCTGGGCCCCATCTCCACAGGAGAGACTGGTT
CAGCTCTAGGGCCTCAGTCTGGAGTGGGATAGGAGCAGTGAGTGACAAAGCCTCTGAAAGATGCATCATCTCTTCCTCACACCCATTTAG
TGGGGGATGGGTCCTCTAGACTTGAGGGGCTACCCTGGGAAGCTGCCGTAGCTTCAGCCAGGCAAGAAAGCTTCCTTCAACCTGCATAGC
CGGTGGGTGAGGAGATTCCCACCTTCCATAGCCTCCAAACATGTTCCCAAGGCCCCACTTTCAAGAATCAGACAGCAGGAAGCCATAGAT

>In-frame_ZKSCAN5_ENST00000394170_chr7_99110214_+_SMO_ENST00000249373_chr7_128843225_+_3931nt
CTTCCCCGCCCCACGGAAAGGGGAGGAGCTTGGGCTGTTTGAATGGCTTTGGGATGGAGCAGGGGAGAGAGTGGCTCCGTTTGCCTCCCC
GCTTTGGTGATGCTGTGCGAGCGGCTTCGGGGGCCCTGGAGACGTCCGAGTCACTGAGGGTGGGCTGGGACTCGGGGCCCGCGTCCCATC
TCCCCGCCGATTGGTCCGCCCCCCGTGCGAGTGTAACACAGCCAGCCTCGAAGACTTCCCTCTGAGTTGGAATGATAATGACCGAATCCC
GAGAAGTTATAGACTTAGACCCCCCAGCTGAGACTTCCCAGGAGCAGGAAGACCTTTTCATAGTGAAGGTGGAAGAAGAAGACTGCACCT
GGATGCAGGAGTACAACCCGCCAACGTTTGAGACTTTTTACCAGCGCTTCAGGCACTTCCAGTACCATGAGGCTTCAGGACCCCGGGAGG
CTCTCAGCCAACTCCGGGTGCTCTGCTGTGAGTGGCTGAGGCCCGAGCTGCACACGAAGGAGCAGATCCTGGAGCTGCTGGTGCTGGAGC
AGTTCCTGACCATCCTGCCTGAAGAGTTCCAGCCCTGGGTGAGGGAACATCACCCTGAAAGTGGAGAAGAGGCGGTGGCCGTGATAGAAA
ATATACAGCGAGAACTTGAGGAACGCAGACAGCAGATTGTTGCCTGCCCTGATGTGCTTCCTCGGAAGATGGCAACACCTGGAGCAGTGC
AGGAGTCCTGCAGCCCCCATCCCCTGACCGTGGACACCCAGCCTGAGCAAGCGCCACAGAAGCCTCGTCTCCTGGAGGAAAATGGCCTCC
GGAATGCCCCCCGCTGCTGGGCAGTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAATGACCGGGTGGAGCTGCCCA
GCCGTACCCTCTGCCAGGCCACCCGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTGGCCTGACTTCCTGCGCTGCACTCCTGACC
GCTTCCCTGAAGGCTGCACGAATGAGGTGCAGAACATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCCTTGGTTCGGACAGACAACC
CCAAGAGCTGGTACGAGGACGTGGAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCACAGAGGCTGAGCACCAGGACATGCACAGCT
ACATCGCGGCCTTCGGGGCCGTCACGGGCCTCTGCACGCTCTTCACCCTGGCCACATTCGTGGCTGACTGGCGGAACTCGAATCGCTACC
CTGCTGTTATTCTCTTCTACGTCAATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATGGATGGTGCCCGCCGAGAGA
TCGTCTGCCGTGCAGATGGCACCATGAGGCTTGGGGAGCCCACCTCCAATGAGACTCTGTCCTGCGTCATCATCTTTGTCATCGTGTACT
ACGCCCTGATGGCTGGTGTGGTTTGGTTTGTGGTCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTGGGCACCACCTACCAGCCTC
TCTCGGGCAAGACCTCCTACTTCCACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGGCAATCCTTGCTGTGGCGCAGGTGGATG
GGGACTCTGTGAGTGGGATTTGTTTTGTGGGCTACAAGAACTACCGATACCGTGCGGGCTTCGTGCTGGCCCCAATCGGCCTGGTGCTCA
TCGTGGGAGGCTACTTCCTCATCCGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAGGCTGCCA
GCAAGATCAACGAGACCATGCTGCGCCTGGGCATTTTTGGCTTCCTGGCCTTTGGCTTTGTGCTCATTACCTTCAGCTGCCACTTCTACG
ACTTCTTCAACCAGGCTGAGTGGGAGCGCAGCTTCCGGGACTATGTGCTATGTCAGGCCAATGTGACCATCGGGCTGCCCACCAAGCAGC
CCATCCCTGACTGTGAGATCAAGAATCGCCCGAGCCTTCTGGTGGAGAAGATCAACCTGTTTGCCATGTTTGGAACTGGCATCGCCATGA
GCACCTGGGTCTGGACCAAGGCCACGCTGCTCATCTGGAGGCGTACCTGGTGCAGGTTGACTGGGCAGAGTGACGATGAGCCAAAGCGGA
TCAAGAAGAGCAAGATGATTGCCAAGGCCTTCTCTAAGCGGCACGAGCTCCTGCAGAACCCAGGCCAGGAGCTGTCCTTCAGCATGCACA
CTGTGTCCCACGACGGGCCCGTGGCGGGCTTGGCCTTTGACCTCAATGAGCCCTCAGCTGATGTCTCCTCTGCCTGGGCCCAGCATGTCA
CCAAGATGGTGGCTCGGAGAGGAGCCATACTGCCCCAGGATATTTCTGTCACCCCTGTGGCAACTCCAGTGCCCCCAGAGGAACAAGCCA
ACCTGTGGCTGGTTGAGGCAGAGATCTCCCCAGAGCTGCAGAAGCGCCTGGGCCGGAAGAAGAAGAGGAGGAAGAGGAAGAAGGAGGTGT
GCCCGCTGGCGCCGCCCCCTGAGCTTCACCCCCCTGCCCCTGCCCCCAGTACCATTCCTCGACTGCCTCAGCTGCCCCGGCAGAAATGCC
TGGTGGCTGCAGGTGCCTGGGGAGCTGGGGACTCTTGCCGACAGGGAGCGTGGACCCTGGTCTCCAACCCATTCTGCCCAGAGCCCAGTC
CCCCTCAGGATCCATTTCTGCCCAGTGCACCGGCCCCCGTGGCATGGGCTCATGGCCGCCGACAGGGCCTGGGGCCTATTCACTCCCGCA
CCAACCTGATGGACACAGAACTCATGGATGCAGACTCGGACTTCTGAGCCTGCAGAGCAGGACCTGGGACAGGAAAGAGAGGAACCAATA
CCTTCAAGGCTCTTCTTCCTCACCGAGCATGCTTCCCTAGGATCCCGTCTTCCAGAGAACCTGTGGGCTGACTGCCCTCCGAAGAGAGTT
CTGGATGTCTGGCTCAAAGCAGCAGGACTGTGGGAAAGAGCCTAACATCTCCATGGGGAGGCCTCACCCCAGGGACAGGGCCCTGGAGCT
CAGGGTCCTTGTTTCTGCCCTGCCAGCTGCAGCCTGGTTGGCAGCATCTGCTCCATCGGGGCAGGGGGTATGCAGAGCTTGTGGTGGGGC
AGGAACGGTGGAGGCAGAGGTGACAGTTCCCAGAGTGGGCTTTGGTGGCCAGGGAGGCAGCCTAGCCTATGTCTGGCAGATGAGGGCTGG
CTGCCGTTTTCTGGGCTGATGGGTGCCCTTTCCTGGCAGTCTCAGTCCAAAAGTGTTGACTGTGTCATTAGTCCTTTGTCTAAGTAGGGC
CAGGGCACCGTATTCCTCTCCCAGGTGTTTGTGGGGCTGGAAGGACCTGCTCCCACAGGGGCCATGTCCTCTCTTAATAGGTGGCACTAC
CCCAAACCCATCTTTTGTTCTCCTATATCCTCCTTCTTCTGTTCCATTTCAGTTCAGTTTCAGCGGTGCCAACCTCTTTGCGTTTCCTTT
TTGTTGATGAGGACCCAGAGCTGCTGCACACACTCACCTCTAACCCCCTCCCCTCGCTGCTGGGCCCCATCTCCACAGGAGAGACTGGTT
CAGCTCTAGGGCCTCAGTCTGGAGTGGGATAGGAGCAGTGAGTGACAAAGCCTCTGAAAGATGCATCATCTCTTCCTCACACCCATTTAG
TGGGGGATGGGTCCTCTAGACTTGAGGGGCTACCCTGGGAAGCTGCCGTAGCTTCAGCCAGGCAAGAAAGCTTCCTTCAACCTGCATAGC
CGGTGGGTGAGGAGATTCCCACCTTCCATAGCCTCCAAACATGTTCCCAAGGCCCCACTTTCAAGAATCAGACAGCAGGAAGCCATAGAT


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FusionGenePPI for ZKSCAN5_SMO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZKSCAN5ZBTB9, ZSCAN1, TNNT1, THOC5, THOC3, SUV39H1, ZSCAN20, ZNF232, TRIM25SMOPTCH1, PTCH2, BCL6, NEDD4, CHEK1, ATM, KIT, FAM189B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012538_569110788BBS5 and BBS7
TgeneSMOchr7:99110214chr7:128843225ENST00000249373+012581_593110788DLG5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZKSCAN5_SMO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSMOQ99835DB01047FluocinonideSmoothened homologsmall moleculeapproved|investigational
TgeneSMOQ99835DB08828VismodegibSmoothened homologsmall moleculeapproved|investigational
TgeneSMOQ99835DB09143SonidegibSmoothened homologsmall moleculeapproved|investigational
TgeneSMOQ99835DB06786HalcinonideSmoothened homologsmall moleculeapproved|investigational|withdrawn

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RelatedDiseases for ZKSCAN5_SMO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSMOC0007117Basal cell carcinoma2CTD_human;HPO
TgeneSMOC0002448Ameloblastoma1CTD_human
TgeneSMOC0006118Brain Neoplasms1CTD_human
TgeneSMOC0022360Jaw Abnormalities1CTD_human
TgeneSMOC0023487Acute Promyelocytic Leukemia1CTD_human
TgeneSMOC0024954Maxillary Neoplasms1CTD_human
TgeneSMOC0025286Meningioma1CTD_human
TgeneSMOC0037286Skin Neoplasms1CTD_human
TgeneSMOC0206663Neuroectodermal Tumor, Primitive1CTD_human
TgeneSMOC0795915Winter Shortland Temple syndrome1ORPHANET;UNIPROT