![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 4291 |
FusionGeneSummary for BOLA2_AP1B1 |
![]() |
Fusion gene information | Fusion gene name: BOLA2_AP1B1 | Fusion gene ID: 4291 | Hgene | Tgene | Gene symbol | BOLA2 | AP1B1 | Gene ID | 654483 | 162 |
Gene name | bolA family member 2B | adaptor related protein complex 1 subunit beta 1 | |
Synonyms | BOLA2 | ADTB1|AP105A|BAM22|CLAPB2 | |
Cytomap | 16p11.2 | 22q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | AP-1 complex subunit beta-1ADTB1, CLAPB2Golgi adaptor HA1/AP1 adaptin beta subunitadapter-related protein complex 1 subunit beta-1adaptor protein complex AP-1 subunit beta-1adaptor related protein complex 1 beta 1 subunitbeta-1-adaptinbeta-adaptin | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9H3K6 | Q10567 | |
Ensembl transtripts involved in fusion gene | ENST00000330978, | ENST00000356015, ENST00000432560, ENST00000357586, ENST00000405198, ENST00000317368, ENST00000402502, ENST00000415447, ENST00000472057, | |
Fusion gene scores | * DoF score | 24 X 31 X 3=2232 | 2 X 2 X 2=8 |
# samples | 31 | 2 | |
** MAII score | log2(31/2232*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: BOLA2 [Title/Abstract] AND AP1B1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
Hgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI394032 | BOLA2 | chr16 | 29859133 | - | AP1B1 | chr22 | 29754725 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000330978 | ENST00000356015 | BOLA2 | chr16 | 29859133 | - | AP1B1 | chr22 | 29754725 | + |
intron-3CDS | ENST00000330978 | ENST00000432560 | BOLA2 | chr16 | 29859133 | - | AP1B1 | chr22 | 29754725 | + |
intron-3CDS | ENST00000330978 | ENST00000357586 | BOLA2 | chr16 | 29859133 | - | AP1B1 | chr22 | 29754725 | + |
intron-3CDS | ENST00000330978 | ENST00000405198 | BOLA2 | chr16 | 29859133 | - | AP1B1 | chr22 | 29754725 | + |
intron-3CDS | ENST00000330978 | ENST00000317368 | BOLA2 | chr16 | 29859133 | - | AP1B1 | chr22 | 29754725 | + |
intron-3CDS | ENST00000330978 | ENST00000402502 | BOLA2 | chr16 | 29859133 | - | AP1B1 | chr22 | 29754725 | + |
intron-3CDS | ENST00000330978 | ENST00000415447 | BOLA2 | chr16 | 29859133 | - | AP1B1 | chr22 | 29754725 | + |
intron-intron | ENST00000330978 | ENST00000472057 | BOLA2 | chr16 | 29859133 | - | AP1B1 | chr22 | 29754725 | + |
Top |
FusionProtFeatures for BOLA2_AP1B1 |
![]() |
Hgene | Tgene |
BOLA2 | AP1B1 |
Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}. | Subunit of clathrin-associated adaptor protein complex 1that plays a role in protein sorting in the late-Golgi/trans-Golginetwork (TGN) and/or endosomes. The AP complexes mediate both therecruitment of clathrin to membranes and the recognition ofsorting signals within the cytosolic tails of transmembrane cargomolecules. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for BOLA2_AP1B1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for BOLA2_AP1B1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for BOLA2_AP1B1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for BOLA2_AP1B1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |