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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42897

FusionGeneSummary for ZHX3_SPTBN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZHX3_SPTBN1
Fusion gene ID: 42897
HgeneTgene
Gene symbol

ZHX3

SPTBN1

Gene ID

23051

6711

Gene namezinc fingers and homeoboxes 3spectrin beta, non-erythrocytic 1
SynonymsTIX1ELF|HEL102|SPTB2|betaSpII
Cytomap

20q12

2p16.2

Type of geneprotein-codingprotein-coding
Descriptionzinc fingers and homeoboxes protein 3triple homeobox 1triple homeobox protein 1zinc finger and homeodomain protein 3spectrin beta chain, non-erythrocytic 1beta-G spectrinbeta-II spectrinbeta-fodrinbeta-spectrin 2beta-spectrin IIbeta-spectrin non-erythrocytic 1embryonic liver beta-fodrinepididymis luminal protein 102fodrin beta chainspectrin beta chain, brain
Modification date2018052320180522
UniProtAcc

Q9H4I2

Q01082

Ensembl transtripts involved in fusion geneENST00000309060, ENST00000540170, 
ENST00000559234, ENST00000557816, 
ENST00000558993, ENST00000544979, 
ENST00000560361, ENST00000432768, 
ENST00000561291, 		ENST00000356805, 
ENST00000333896, 
Fusion gene scores* DoF score6 X 5 X 5=15013 X 13 X 6=1014
# samples 715
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1014*10)=-2.75702324650746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZHX3 [Title/Abstract] AND SPTBN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZHX3

GO:0045892

negative regulation of transcription, DNA-templated

12659632


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ717700ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
ChiTaRS3.1BQ717652ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000309060ENST00000356805ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-3UTRENST00000309060ENST00000333896ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-intronENST00000540170ENST00000356805ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-3UTRENST00000540170ENST00000333896ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-intronENST00000559234ENST00000356805ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-3UTRENST00000559234ENST00000333896ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-intronENST00000557816ENST00000356805ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-3UTRENST00000557816ENST00000333896ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-intronENST00000558993ENST00000356805ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-3UTRENST00000558993ENST00000333896ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-intronENST00000544979ENST00000356805ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-3UTRENST00000544979ENST00000333896ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-intronENST00000560361ENST00000356805ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-3UTRENST00000560361ENST00000333896ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-intronENST00000432768ENST00000356805ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-3UTRENST00000432768ENST00000333896ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-intronENST00000561291ENST00000356805ZHX3chr20

39945290

-SPTBN1chr2

54889301

+
intron-3UTRENST00000561291ENST00000333896ZHX3chr20

39945290

-SPTBN1chr2

54889301

+

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FusionProtFeatures for ZHX3_SPTBN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZHX3

Q9H4I2

SPTBN1

Q01082

Acts as a transcriptional repressor. Involved in theearly stages of mesenchymal stem cell (MSC) osteogenicdifferentiation. Is a regulator of podocyte gene expression duringprimary glomerula disease. Binds to promoter DNA.{ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. Fodrin, which seems to be involved in secretion,interacts with calmodulin in a calcium-dependent manner and isthus candidate for the calcium-dependent movement of thecytoskeleton at the membrane.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZHX3_SPTBN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZHX3_SPTBN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZHX3_SPTBN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSPTBN1Q01082DB01373CalciumSpectrin beta chain, non-erythrocytic 1small moleculeapproved|nutraceutical

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RelatedDiseases for ZHX3_SPTBN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSPTBN1C0043094Weight Gain1CTD_human