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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42896

FusionGeneSummary for ZHX3_SMG9

check button Fusion gene summary
Fusion gene informationFusion gene name: ZHX3_SMG9
Fusion gene ID: 42896
HgeneTgene
Gene symbol

ZHX3

SMG9

Gene ID

23051

56006

Gene namezinc fingers and homeoboxes 3SMG9, nonsense mediated mRNA decay factor
SynonymsTIX1C19orf61|F17127_1|HBMS
Cytomap

20q12

19q13.31

Type of geneprotein-codingprotein-coding
Descriptionzinc fingers and homeoboxes protein 3triple homeobox 1triple homeobox protein 1zinc finger and homeodomain protein 3protein SMG9protein smg-9 homolog
Modification date2018052320180519
UniProtAcc

Q9H4I2

Q9H0W8

Ensembl transtripts involved in fusion geneENST00000309060, ENST00000540170, 
ENST00000559234, ENST00000557816, 
ENST00000558993, ENST00000544979, 
ENST00000560361, ENST00000432768, 
ENST00000561291, 
ENST00000270066, 
ENST00000601170, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 2 X 3=18
# samples 73
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZHX3 [Title/Abstract] AND SMG9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZHX3

GO:0045892

negative regulation of transcription, DNA-templated

12659632


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDMESOTCGA-TS-A7P7-01AZHX3chr20

39896103

-SMG9chr19

44242369

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000309060ENST00000270066ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000309060ENST00000601170ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000540170ENST00000270066ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000540170ENST00000601170ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000559234ENST00000270066ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000559234ENST00000601170ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000557816ENST00000270066ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000557816ENST00000601170ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000558993ENST00000270066ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000558993ENST00000601170ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000544979ENST00000270066ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000544979ENST00000601170ZHX3chr20

39896103

-SMG9chr19

44242369

-
5UTR-3CDSENST00000560361ENST00000270066ZHX3chr20

39896103

-SMG9chr19

44242369

-
5UTR-3CDSENST00000560361ENST00000601170ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000432768ENST00000270066ZHX3chr20

39896103

-SMG9chr19

44242369

-
intron-3CDSENST00000432768ENST00000601170ZHX3chr20

39896103

-SMG9chr19

44242369

-
5UTR-3CDSENST00000561291ENST00000270066ZHX3chr20

39896103

-SMG9chr19

44242369

-
5UTR-3CDSENST00000561291ENST00000601170ZHX3chr20

39896103

-SMG9chr19

44242369

-

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FusionProtFeatures for ZHX3_SMG9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZHX3

Q9H4I2

SMG9

Q9H0W8

Acts as a transcriptional repressor. Involved in theearly stages of mesenchymal stem cell (MSC) osteogenicdifferentiation. Is a regulator of podocyte gene expression duringprimary glomerula disease. Binds to promoter DNA.{ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. Involved in nonsense-mediated decay (NMD) of mRNAscontaining premature stop codons (PubMed:19417104). Is recruitedby release factors to stalled ribosomes together with SMG1 andSMG8 (forming the SMG1C protein kinase complex) and, in the SMG1Ccomplex, is required for the efficient association between SMG1and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eyedevelopment (By similarity). {ECO:0000250|UniProtKB:Q9DB90,ECO:0000269|PubMed:19417104}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZHX3_SMG9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZHX3_SMG9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZHX3ZHX1, ZHX2, ZHX3, TFAP4, ATXN1, NLK, PDIA6, SH2D2A, EWSR1, WDYHV1SMG9SMG1, SMG8, UPF1, RBM8A, RUVBL1, TRIM23, KRT31, TRAF2, CNTROB, STIL, DDX11, PRPSAP1, VPRBP, EPHA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZHX3_SMG9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZHX3_SMG9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource