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Fusion gene ID: 42896 |
FusionGeneSummary for ZHX3_SMG9 |
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Fusion gene information | Fusion gene name: ZHX3_SMG9 | Fusion gene ID: 42896 | Hgene | Tgene | Gene symbol | ZHX3 | SMG9 | Gene ID | 23051 | 56006 |
Gene name | zinc fingers and homeoboxes 3 | SMG9, nonsense mediated mRNA decay factor | |
Synonyms | TIX1 | C19orf61|F17127_1|HBMS | |
Cytomap | 20q12 | 19q13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc fingers and homeoboxes protein 3triple homeobox 1triple homeobox protein 1zinc finger and homeodomain protein 3 | protein SMG9protein smg-9 homolog | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9H4I2 | Q9H0W8 | |
Ensembl transtripts involved in fusion gene | ENST00000309060, ENST00000540170, ENST00000559234, ENST00000557816, ENST00000558993, ENST00000544979, ENST00000560361, ENST00000432768, ENST00000561291, | ENST00000270066, ENST00000601170, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 3 X 2 X 3=18 |
# samples | 7 | 3 | |
** MAII score | log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZHX3 [Title/Abstract] AND SMG9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZHX3 | GO:0045892 | negative regulation of transcription, DNA-templated | 12659632 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | MESO | TCGA-TS-A7P7-01A | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000309060 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000309060 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000540170 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000540170 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000559234 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000559234 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000557816 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000557816 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000558993 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000558993 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000544979 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000544979 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
5UTR-3CDS | ENST00000560361 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
5UTR-3CDS | ENST00000560361 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000432768 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
intron-3CDS | ENST00000432768 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
5UTR-3CDS | ENST00000561291 | ENST00000270066 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
5UTR-3CDS | ENST00000561291 | ENST00000601170 | ZHX3 | chr20 | 39896103 | - | SMG9 | chr19 | 44242369 | - |
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FusionProtFeatures for ZHX3_SMG9 |
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Hgene | Tgene |
ZHX3 | SMG9 |
Acts as a transcriptional repressor. Involved in theearly stages of mesenchymal stem cell (MSC) osteogenicdifferentiation. Is a regulator of podocyte gene expression duringprimary glomerula disease. Binds to promoter DNA.{ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. | Involved in nonsense-mediated decay (NMD) of mRNAscontaining premature stop codons (PubMed:19417104). Is recruitedby release factors to stalled ribosomes together with SMG1 andSMG8 (forming the SMG1C protein kinase complex) and, in the SMG1Ccomplex, is required for the efficient association between SMG1and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eyedevelopment (By similarity). {ECO:0000250|UniProtKB:Q9DB90,ECO:0000269|PubMed:19417104}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZHX3_SMG9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZHX3_SMG9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZHX3 | ZHX1, ZHX2, ZHX3, TFAP4, ATXN1, NLK, PDIA6, SH2D2A, EWSR1, WDYHV1 | SMG9 | SMG1, SMG8, UPF1, RBM8A, RUVBL1, TRIM23, KRT31, TRAF2, CNTROB, STIL, DDX11, PRPSAP1, VPRBP, EPHA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZHX3_SMG9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZHX3_SMG9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |