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Fusion gene ID: 42876 |
FusionGeneSummary for ZFYVE28_TACC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFYVE28_TACC3 | Fusion gene ID: 42876 | Hgene | Tgene | Gene symbol | ZFYVE28 | TACC3 | Gene ID | 57732 | 10460 |
| Gene name | zinc finger FYVE-type containing 28 | transforming acidic coiled-coil containing protein 3 | |
| Synonyms | LST2|LYST2 | ERIC-1|ERIC1 | |
| Cytomap | 4p16.3 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lateral signaling target protein 2 homologhLst2zinc finger FYVE domain-containing protein 28zinc finger, FYVE domain containing 28 | transforming acidic coiled-coil-containing protein 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9HCC9 | Q9Y6A5 | |
| Ensembl transtripts involved in fusion gene | ENST00000290974, ENST00000511071, ENST00000515312, ENST00000515169, ENST00000509171, ENST00000503000, ENST00000508471, ENST00000505421, | ENST00000313288, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 6 X 10 X 13=780 |
| # samples | 4 | 42 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(42/780*10)=-0.893084796083488 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZFYVE28 [Title/Abstract] AND TACC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-DK-A3IS-01A | ZFYVE28 | chr4 | 2420012 | - | TACC3 | chr4 | 1741429 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000290974 | ENST00000313288 | ZFYVE28 | chr4 | 2420012 | - | TACC3 | chr4 | 1741429 | + |
| In-frame | ENST00000511071 | ENST00000313288 | ZFYVE28 | chr4 | 2420012 | - | TACC3 | chr4 | 1741429 | + |
| intron-3CDS | ENST00000515312 | ENST00000313288 | ZFYVE28 | chr4 | 2420012 | - | TACC3 | chr4 | 1741429 | + |
| intron-3CDS | ENST00000515169 | ENST00000313288 | ZFYVE28 | chr4 | 2420012 | - | TACC3 | chr4 | 1741429 | + |
| In-frame | ENST00000509171 | ENST00000313288 | ZFYVE28 | chr4 | 2420012 | - | TACC3 | chr4 | 1741429 | + |
| In-frame | ENST00000503000 | ENST00000313288 | ZFYVE28 | chr4 | 2420012 | - | TACC3 | chr4 | 1741429 | + |
| intron-3CDS | ENST00000508471 | ENST00000313288 | ZFYVE28 | chr4 | 2420012 | - | TACC3 | chr4 | 1741429 | + |
| intron-3CDS | ENST00000505421 | ENST00000313288 | ZFYVE28 | chr4 | 2420012 | - | TACC3 | chr4 | 1741429 | + |
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FusionProtFeatures for ZFYVE28_TACC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZFYVE28 | TACC3 |
| Plays a role in the microtubule-dependent coupling ofthe nucleus and the centrosome. Involved in the processes thatregulate centrosome-mediated interkinetic nuclear migration (INM)of neural progenitors (By similarity). Acts as component of theTACC3/ch-TOG/clathrin complex proposed to contribute tostabilization of kinetochore fibers of the mitotic spindle byacting as inter-microtubule bridge. The TACC3/ch-TOG/clathrincomplex is required for the maintenance of kinetochore fibertension (PubMed:21297582, PubMed:23532825). May be involved in thecontrol of cell growth and differentiation. May contribute tocancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11,ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582,ECO:0000269|PubMed:23532825}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZFYVE28 | chr4:2420012 | chr4:1741429 | ENST00000290974 | - | 1 | 13 | 817_879 | 13 | 888 | Zinc finger | FYVE-type |
| Hgene | >ZFYVE28 | chr4:2420012 | chr4:1741429 | ENST00000503000 | - | 1 | 7 | 817_879 | 13 | 288 | Zinc finger | FYVE-type |
| Hgene | >ZFYVE28 | chr4:2420012 | chr4:1741429 | ENST00000509171 | - | 1 | 5 | 817_879 | 13 | 173 | Zinc finger | FYVE-type |
| Hgene | >ZFYVE28 | chr4:2420012 | chr4:1741429 | ENST00000511071 | - | 1 | 12 | 817_879 | 13 | 858 | Zinc finger | FYVE-type |
| Hgene | >ZFYVE28 | chr4:2420012 | chr4:1741429 | ENST00000515169 | - | 1 | 7 | 817_879 | -164 | 164 | Zinc finger | FYVE-type |
| Hgene | >ZFYVE28 | chr4:2420012 | chr4:1741429 | ENST00000515312 | - | 1 | 13 | 817_879 | -188 | 818 | Zinc finger | FYVE-type |
| Tgene | TACC3 | chr4:2420012 | chr4:1741429 | ENST00000313288 | + | 9 | 16 | 637_837 | 647 | 839 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | TACC3 | chr4:2420012 | chr4:1741429 | ENST00000313288 | + | 9 | 16 | 155_160 | 647 | 839 | Compositional bias | Note=Poly-Ser |
| Tgene | TACC3 | chr4:2420012 | chr4:1741429 | ENST00000313288 | + | 9 | 16 | 522_577 | 647 | 839 | Region | Necessary but not sufficient for spindle localization |
| Tgene | TACC3 | chr4:2420012 | chr4:1741429 | ENST00000313288 | + | 9 | 16 | 594_838 | 647 | 839 | Region | Necessary but not sufficient for spindle localization |
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FusionGeneSequence for ZFYVE28_TACC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZFYVE28_ENST00000290974_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_205aa MMNRFRKWLYKPKVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSD LFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTV >In-frame_ZFYVE28_ENST00000511071_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_205aa MMNRFRKWLYKPKVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSD LFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTV >In-frame_ZFYVE28_ENST00000509171_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_205aa MMNRFRKWLYKPKVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSD LFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTV >In-frame_ZFYVE28_ENST00000503000_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_205aa MMNRFRKWLYKPKVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSD LFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZFYVE28_ENST00000290974_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_615nt ATGATGAACAGGTTCCGAAAGTGGCTCTACAAACCCAAGGTAAAGGCGACACAGGAGGAGAACCGGGAGCTGAGGAGCAGGTGTGAGGAG CTCCACGGGAAGAACCTGGAACTGGGGAAGATCATGGACAGGTTCGAAGAGGTTGTGTACCAGGCCATGGAGGAAGTTCAGAAGCAGAAG GAACTTTCCAAAGCTGAAATCCAGAAAGTTCTAAAAGAAAAAGACCAACTTACCACAGATCTGAACTCCATGGAGAAGTCCTTCTCCGAC CTCTTCAAGCGTTTTGAGAAACAGAAAGAGGTGATCGAGGGCTACCGCAAGAACGAAGAGTCACTGAAGAAGTGCGTGGAGGATTACCTG GCAAGGATCACCCAGGAGGGCCAGAGGTACCAAGCCCTGAAGGCCCACGCGGAGGAGAAGCTGCAGCTGGCAAACGAGGAGATCGCCCAG GTCCGGAGCAAGGCCCAGGCGGAAGCGTTGGCCCTCCAGGCCAGCCTGAGGAAGGAGCAGATGCGCATCCAGTCGCTGGAGAAGACAGTG >In-frame_ZFYVE28_ENST00000511071_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_615nt ATGATGAACAGGTTCCGAAAGTGGCTCTACAAACCCAAGGTAAAGGCGACACAGGAGGAGAACCGGGAGCTGAGGAGCAGGTGTGAGGAG CTCCACGGGAAGAACCTGGAACTGGGGAAGATCATGGACAGGTTCGAAGAGGTTGTGTACCAGGCCATGGAGGAAGTTCAGAAGCAGAAG GAACTTTCCAAAGCTGAAATCCAGAAAGTTCTAAAAGAAAAAGACCAACTTACCACAGATCTGAACTCCATGGAGAAGTCCTTCTCCGAC CTCTTCAAGCGTTTTGAGAAACAGAAAGAGGTGATCGAGGGCTACCGCAAGAACGAAGAGTCACTGAAGAAGTGCGTGGAGGATTACCTG GCAAGGATCACCCAGGAGGGCCAGAGGTACCAAGCCCTGAAGGCCCACGCGGAGGAGAAGCTGCAGCTGGCAAACGAGGAGATCGCCCAG GTCCGGAGCAAGGCCCAGGCGGAAGCGTTGGCCCTCCAGGCCAGCCTGAGGAAGGAGCAGATGCGCATCCAGTCGCTGGAGAAGACAGTG >In-frame_ZFYVE28_ENST00000509171_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_615nt ATGATGAACAGGTTCCGAAAGTGGCTCTACAAACCCAAGGTAAAGGCGACACAGGAGGAGAACCGGGAGCTGAGGAGCAGGTGTGAGGAG CTCCACGGGAAGAACCTGGAACTGGGGAAGATCATGGACAGGTTCGAAGAGGTTGTGTACCAGGCCATGGAGGAAGTTCAGAAGCAGAAG GAACTTTCCAAAGCTGAAATCCAGAAAGTTCTAAAAGAAAAAGACCAACTTACCACAGATCTGAACTCCATGGAGAAGTCCTTCTCCGAC CTCTTCAAGCGTTTTGAGAAACAGAAAGAGGTGATCGAGGGCTACCGCAAGAACGAAGAGTCACTGAAGAAGTGCGTGGAGGATTACCTG GCAAGGATCACCCAGGAGGGCCAGAGGTACCAAGCCCTGAAGGCCCACGCGGAGGAGAAGCTGCAGCTGGCAAACGAGGAGATCGCCCAG GTCCGGAGCAAGGCCCAGGCGGAAGCGTTGGCCCTCCAGGCCAGCCTGAGGAAGGAGCAGATGCGCATCCAGTCGCTGGAGAAGACAGTG >In-frame_ZFYVE28_ENST00000503000_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_615nt ATGATGAACAGGTTCCGAAAGTGGCTCTACAAACCCAAGGTAAAGGCGACACAGGAGGAGAACCGGGAGCTGAGGAGCAGGTGTGAGGAG CTCCACGGGAAGAACCTGGAACTGGGGAAGATCATGGACAGGTTCGAAGAGGTTGTGTACCAGGCCATGGAGGAAGTTCAGAAGCAGAAG GAACTTTCCAAAGCTGAAATCCAGAAAGTTCTAAAAGAAAAAGACCAACTTACCACAGATCTGAACTCCATGGAGAAGTCCTTCTCCGAC CTCTTCAAGCGTTTTGAGAAACAGAAAGAGGTGATCGAGGGCTACCGCAAGAACGAAGAGTCACTGAAGAAGTGCGTGGAGGATTACCTG GCAAGGATCACCCAGGAGGGCCAGAGGTACCAAGCCCTGAAGGCCCACGCGGAGGAGAAGCTGCAGCTGGCAAACGAGGAGATCGCCCAG GTCCGGAGCAAGGCCCAGGCGGAAGCGTTGGCCCTCCAGGCCAGCCTGAGGAAGGAGCAGATGCGCATCCAGTCGCTGGAGAAGACAGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZFYVE28_ENST00000290974_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_1113nt GTGCGGCGCGGGGCGGCCGTGACCAGCGGAGCGCTGGGTGTCAGTGAGCAGCGAGGAGCCGCGCGCCCCCGTGCCCGCGTCTGTCCGTGC GCCCGAGCGCCCACTCCCGGGTCTGAGGTCTGCCCGGCGCGCCGCTTGCAGAGCATACTCAGGGCCGCGCACCTGCCCCGCGCACCTGCC CGCCGCCCGCTCGGCGCTCCGGGCTTCGCTAGCCAGCCTCCCTGCGACAGCGCGGGGGCTCCGGCCGTGCCTCCGCGTCCGCCCCGCGCC TCAGCCGGGCCCGGGCGCAGCGCTGCGGAGGGCGAGGGCCGCCCGGAGTCCGGCCAGGGCCGGCGCGGCGATGATGAACAGGTTCCGAAA GTGGCTCTACAAACCCAAGGTAAAGGCGACACAGGAGGAGAACCGGGAGCTGAGGAGCAGGTGTGAGGAGCTCCACGGGAAGAACCTGGA ACTGGGGAAGATCATGGACAGGTTCGAAGAGGTTGTGTACCAGGCCATGGAGGAAGTTCAGAAGCAGAAGGAACTTTCCAAAGCTGAAAT CCAGAAAGTTCTAAAAGAAAAAGACCAACTTACCACAGATCTGAACTCCATGGAGAAGTCCTTCTCCGACCTCTTCAAGCGTTTTGAGAA ACAGAAAGAGGTGATCGAGGGCTACCGCAAGAACGAAGAGTCACTGAAGAAGTGCGTGGAGGATTACCTGGCAAGGATCACCCAGGAGGG CCAGAGGTACCAAGCCCTGAAGGCCCACGCGGAGGAGAAGCTGCAGCTGGCAAACGAGGAGATCGCCCAGGTCCGGAGCAAGGCCCAGGC GGAAGCGTTGGCCCTCCAGGCCAGCCTGAGGAAGGAGCAGATGCGCATCCAGTCGCTGGAGAAGACAGTGGAGCAGAAGACTAAAGAGAA CGAGGAGCTGACCAGGATCTGCGACGACCTCATCTCCAAGATGGAGAAGATCTGACCTCCACGGAGCCGCTGTCCCCGCCCCCCTGCTCC CGTCTGTCTGTCCTGTCTGATTCTCTTAGGTGTCATGTTCTTTTTTCTGTCTTGTCTTCAACTTTTTTAAAAACTAGATTGCTTTGAAAA >In-frame_ZFYVE28_ENST00000511071_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_1086nt GGAGCGCTGGGTGTCAGTGAGCAGCGAGGAGCCGCGCGCCCCCGTGCCCGCGTCTGTCCGTGCGCCCGAGCGCCCACTCCCGGGTCTGAG GTCTGCCCGGCGCGCCGCTTGCAGAGCATACTCAGGGCCGCGCACCTGCCCCGCGCACCTGCCCGCCGCCCGCTCGGCGCTCCGGGCTTC GCTAGCCAGCCTCCCTGCGACAGCGCGGGGGCTCCGGCCGTGCCTCCGCGTCCGCCCCGCGCCTCAGCCGGGCCCGGGCGCAGCGCTGCG GAGGGCGAGGGCCGCCCGGAGTCCGGCCAGGGCCGGCGCGGCGATGATGAACAGGTTCCGAAAGTGGCTCTACAAACCCAAGGTAAAGGC GACACAGGAGGAGAACCGGGAGCTGAGGAGCAGGTGTGAGGAGCTCCACGGGAAGAACCTGGAACTGGGGAAGATCATGGACAGGTTCGA AGAGGTTGTGTACCAGGCCATGGAGGAAGTTCAGAAGCAGAAGGAACTTTCCAAAGCTGAAATCCAGAAAGTTCTAAAAGAAAAAGACCA ACTTACCACAGATCTGAACTCCATGGAGAAGTCCTTCTCCGACCTCTTCAAGCGTTTTGAGAAACAGAAAGAGGTGATCGAGGGCTACCG CAAGAACGAAGAGTCACTGAAGAAGTGCGTGGAGGATTACCTGGCAAGGATCACCCAGGAGGGCCAGAGGTACCAAGCCCTGAAGGCCCA CGCGGAGGAGAAGCTGCAGCTGGCAAACGAGGAGATCGCCCAGGTCCGGAGCAAGGCCCAGGCGGAAGCGTTGGCCCTCCAGGCCAGCCT GAGGAAGGAGCAGATGCGCATCCAGTCGCTGGAGAAGACAGTGGAGCAGAAGACTAAAGAGAACGAGGAGCTGACCAGGATCTGCGACGA CCTCATCTCCAAGATGGAGAAGATCTGACCTCCACGGAGCCGCTGTCCCCGCCCCCCTGCTCCCGTCTGTCTGTCCTGTCTGATTCTCTT AGGTGTCATGTTCTTTTTTCTGTCTTGTCTTCAACTTTTTTAAAAACTAGATTGCTTTGAAAACATGACTCAATAAAAGTTTCCTTTCAA >In-frame_ZFYVE28_ENST00000509171_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_1101nt GCGGCCGTGACCAGCGGAGCGCTGGGTGTCAGTGAGCAGCGAGGAGCCGCGCGCCCCCGTGCCCGCGTCTGTCCGTGCGCCCGAGCGCCC ACTCCCGGGTCTGAGGTCTGCCCGGCGCGCCGCTTGCAGAGCATACTCAGGGCCGCGCACCTGCCCCGCGCACCTGCCCGCCGCCCGCTC GGCGCTCCGGGCTTCGCTAGCCAGCCTCCCTGCGACAGCGCGGGGGCTCCGGCCGTGCCTCCGCGTCCGCCCCGCGCCTCAGCCGGGCCC GGGCGCAGCGCTGCGGAGGGCGAGGGCCGCCCGGAGTCCGGCCAGGGCCGGCGCGGCGATGATGAACAGGTTCCGAAAGTGGCTCTACAA ACCCAAGGTAAAGGCGACACAGGAGGAGAACCGGGAGCTGAGGAGCAGGTGTGAGGAGCTCCACGGGAAGAACCTGGAACTGGGGAAGAT CATGGACAGGTTCGAAGAGGTTGTGTACCAGGCCATGGAGGAAGTTCAGAAGCAGAAGGAACTTTCCAAAGCTGAAATCCAGAAAGTTCT AAAAGAAAAAGACCAACTTACCACAGATCTGAACTCCATGGAGAAGTCCTTCTCCGACCTCTTCAAGCGTTTTGAGAAACAGAAAGAGGT GATCGAGGGCTACCGCAAGAACGAAGAGTCACTGAAGAAGTGCGTGGAGGATTACCTGGCAAGGATCACCCAGGAGGGCCAGAGGTACCA AGCCCTGAAGGCCCACGCGGAGGAGAAGCTGCAGCTGGCAAACGAGGAGATCGCCCAGGTCCGGAGCAAGGCCCAGGCGGAAGCGTTGGC CCTCCAGGCCAGCCTGAGGAAGGAGCAGATGCGCATCCAGTCGCTGGAGAAGACAGTGGAGCAGAAGACTAAAGAGAACGAGGAGCTGAC CAGGATCTGCGACGACCTCATCTCCAAGATGGAGAAGATCTGACCTCCACGGAGCCGCTGTCCCCGCCCCCCTGCTCCCGTCTGTCTGTC CTGTCTGATTCTCTTAGGTGTCATGTTCTTTTTTCTGTCTTGTCTTCAACTTTTTTAAAAACTAGATTGCTTTGAAAACATGACTCAATA >In-frame_ZFYVE28_ENST00000503000_chr4_2420012_-_TACC3_ENST00000313288_chr4_1741429_+_1059nt GGAGCCGCGCGCCCCCGTGCCCGCGTCTGTCCGTGCGCCCGAGCGCCCACTCCCGGGTCTGAGGTCTGCCCGGCGCGCCGCTTGCAGAGC ATACTCAGGGCCGCGCACCTGCCCCGCGCACCTGCCCGCCGCCCGCTCGGCGCTCCGGGCTTCGCTAGCCAGCCTCCCTGCGACAGCGCG GGGGCTCCGGCCGTGCCTCCGCGTCCGCCCCGCGCCTCAGCCGGGCCCGGGCGCAGCGCTGCGGAGGGCGAGGGCCGCCCGGAGTCCGGC CAGGGCCGGCGCGGCGATGATGAACAGGTTCCGAAAGTGGCTCTACAAACCCAAGGTAAAGGCGACACAGGAGGAGAACCGGGAGCTGAG GAGCAGGTGTGAGGAGCTCCACGGGAAGAACCTGGAACTGGGGAAGATCATGGACAGGTTCGAAGAGGTTGTGTACCAGGCCATGGAGGA AGTTCAGAAGCAGAAGGAACTTTCCAAAGCTGAAATCCAGAAAGTTCTAAAAGAAAAAGACCAACTTACCACAGATCTGAACTCCATGGA GAAGTCCTTCTCCGACCTCTTCAAGCGTTTTGAGAAACAGAAAGAGGTGATCGAGGGCTACCGCAAGAACGAAGAGTCACTGAAGAAGTG CGTGGAGGATTACCTGGCAAGGATCACCCAGGAGGGCCAGAGGTACCAAGCCCTGAAGGCCCACGCGGAGGAGAAGCTGCAGCTGGCAAA CGAGGAGATCGCCCAGGTCCGGAGCAAGGCCCAGGCGGAAGCGTTGGCCCTCCAGGCCAGCCTGAGGAAGGAGCAGATGCGCATCCAGTC GCTGGAGAAGACAGTGGAGCAGAAGACTAAAGAGAACGAGGAGCTGACCAGGATCTGCGACGACCTCATCTCCAAGATGGAGAAGATCTG ACCTCCACGGAGCCGCTGTCCCCGCCCCCCTGCTCCCGTCTGTCTGTCCTGTCTGATTCTCTTAGGTGTCATGTTCTTTTTTCTGTCTTG |
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FusionGenePPI for ZFYVE28_TACC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZFYVE28 | EGF, RAB5A, RAB4A, RAB7A, EGFR, PRNP | TACC3 | AKAP9, TTF2, NDEL1, MBD2, CKAP5, KAT2A, KAT2B, RAE1, AHCYL1, SRXN1, SEC23A, RAD23B, CPLX1, UBA2, RAD23A, RAB14, SSSCA1, PAICS, SEC24A, AURKA, ARNT2, VPS37C, TBC1D22B, KIZ, ASPSCR1, CIB3, SNX20, FZR1, SNAP29, PLEKHO2, C17orf59, MRE11A, NTRK1, ADAR, CALD1, CUX1, KIF11, PCDH7, VASP, SLBP, NFS1, XPR1, DHRS2, ZER1, SLAIN2, ARX, BOD1L1, ORC3, ENAH, METTL14, RNF123, PDF, PANK2, RNF135, KIAA1804, PRMT9, DEPDC7, RNF168, WDR90, C2orf69, PRR14L, FRYL, FAM111B, MIA3, CRISP2, CORO6, SPERT, EVL, HSPA8, MVK, HSPBP1, OIP5, GTF2E2, ZFC3H1, CDC27 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZFYVE28_TACC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFYVE28_TACC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TACC3 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | TACC3 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
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