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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42875

FusionGeneSummary for ZFYVE28_POLN

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFYVE28_POLN
Fusion gene ID: 42875
HgeneTgene
Gene symbol

ZFYVE28

POLN

Gene ID

57732

353497

Gene namezinc finger FYVE-type containing 28DNA polymerase nu
SynonymsLST2|LYST2POL4P
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionlateral signaling target protein 2 homologhLst2zinc finger FYVE domain-containing protein 28zinc finger, FYVE domain containing 28DNA polymerase nuDNA polymerase NDNA polymerase POL4Ppolymerase (DNA directed) nupolymerase (DNA) nu
Modification date2018052320180523
UniProtAcc

Q9HCC9

Q7Z5Q5

Ensembl transtripts involved in fusion geneENST00000290974, ENST00000511071, 
ENST00000515312, ENST00000515169, 
ENST00000509171, ENST00000503000, 
ENST00000508471, ENST00000505421, 
ENST00000382865, ENST00000511885, 
ENST00000515357, 
Fusion gene scores* DoF score4 X 2 X 4=3212 X 7 X 9=756
# samples 412
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/756*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFYVE28 [Title/Abstract] AND POLN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePOLN

GO:0019985

translesion synthesis

20102227


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-HF-A5NB-01AZFYVE28chr4

2355660

-POLNchr4

2074756

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000290974ENST00000382865ZFYVE28chr4

2355660

-POLNchr4

2074756

-
Frame-shiftENST00000290974ENST00000511885ZFYVE28chr4

2355660

-POLNchr4

2074756

-
5CDS-intronENST00000290974ENST00000515357ZFYVE28chr4

2355660

-POLNchr4

2074756

-
Frame-shiftENST00000511071ENST00000382865ZFYVE28chr4

2355660

-POLNchr4

2074756

-
Frame-shiftENST00000511071ENST00000511885ZFYVE28chr4

2355660

-POLNchr4

2074756

-
5CDS-intronENST00000511071ENST00000515357ZFYVE28chr4

2355660

-POLNchr4

2074756

-
5UTR-3CDSENST00000515312ENST00000382865ZFYVE28chr4

2355660

-POLNchr4

2074756

-
5UTR-3CDSENST00000515312ENST00000511885ZFYVE28chr4

2355660

-POLNchr4

2074756

-
5UTR-intronENST00000515312ENST00000515357ZFYVE28chr4

2355660

-POLNchr4

2074756

-
5UTR-3CDSENST00000515169ENST00000382865ZFYVE28chr4

2355660

-POLNchr4

2074756

-
5UTR-3CDSENST00000515169ENST00000511885ZFYVE28chr4

2355660

-POLNchr4

2074756

-
5UTR-intronENST00000515169ENST00000515357ZFYVE28chr4

2355660

-POLNchr4

2074756

-
intron-3CDSENST00000509171ENST00000382865ZFYVE28chr4

2355660

-POLNchr4

2074756

-
intron-3CDSENST00000509171ENST00000511885ZFYVE28chr4

2355660

-POLNchr4

2074756

-
intron-intronENST00000509171ENST00000515357ZFYVE28chr4

2355660

-POLNchr4

2074756

-
Frame-shiftENST00000503000ENST00000382865ZFYVE28chr4

2355660

-POLNchr4

2074756

-
Frame-shiftENST00000503000ENST00000511885ZFYVE28chr4

2355660

-POLNchr4

2074756

-
5CDS-intronENST00000503000ENST00000515357ZFYVE28chr4

2355660

-POLNchr4

2074756

-
intron-3CDSENST00000508471ENST00000382865ZFYVE28chr4

2355660

-POLNchr4

2074756

-
intron-3CDSENST00000508471ENST00000511885ZFYVE28chr4

2355660

-POLNchr4

2074756

-
intron-intronENST00000508471ENST00000515357ZFYVE28chr4

2355660

-POLNchr4

2074756

-
intron-3CDSENST00000505421ENST00000382865ZFYVE28chr4

2355660

-POLNchr4

2074756

-
intron-3CDSENST00000505421ENST00000511885ZFYVE28chr4

2355660

-POLNchr4

2074756

-
intron-intronENST00000505421ENST00000515357ZFYVE28chr4

2355660

-POLNchr4

2074756

-

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FusionProtFeatures for ZFYVE28_POLN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFYVE28

Q9HCC9

POLN

Q7Z5Q5

DNA polymerase with very low fidelity that catalyzesconsiderable misincorporation by inserting dTTP opposite a Gtemplate, and dGTP opposite a T template (PubMed:16787914,PubMed:17118716). Is the least accurate of the DNA polymerase Afamily (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can performaccurate translesion DNA synthesis (TLS) past a 5S-thymine glycol.Can perform efficient strand displacement past a nick or a gap andgives rise to an amount of product similar to that on non-damagedtemplate. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dTregardless of template sequence (PubMed:25775266). May play a rolein TLS during interstrand cross-link (ICL) repair(PubMed:19908865). May be involved in TLS when genomic replicationis blocked by extremely large major groove DNA lesions. Mayfunction in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linkingagents (PubMed:20102227). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates inFANCD2-mediated repair. Forms a complex with HELQ helicase thatparticipates in homologous recombination (HR) repair and isessential for cellular protection against DNA cross-links(PubMed:19995904). {ECO:0000269|PubMed:16787914,ECO:0000269|PubMed:17118716, ECO:0000269|PubMed:19908865,ECO:0000269|PubMed:19995904, ECO:0000269|PubMed:20102227,ECO:0000269|PubMed:25775266}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZFYVE28_POLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZFYVE28_POLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZFYVE28EGF, RAB5A, RAB4A, RAB7A, EGFR, PRNPPOLNATR, FANCD2, POLDIP2, FANCA, FANCG, PCNA, FANCI, RAD51, HELQ, RAD18, BRCA1, BARD1, PALB2, BRCA2, BRIP1, RBBP8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZFYVE28_POLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZFYVE28_POLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource