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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42864

FusionGeneSummary for ZFYVE1_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFYVE1_MBP
Fusion gene ID: 42864
HgeneTgene
Gene symbol

ZFYVE1

MBP

Gene ID

53349

5553

Gene namezinc finger FYVE-type containing 1proteoglycan 2, pro eosinophil major basic protein
SynonymsDFCP1|PPP1R172|SR3|TAFF1|ZNFN2A1BMPG|MBP|MBP1|proMBP
Cytomap

14q24.2

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger FYVE domain-containing protein 1double FYVE-containing protein 1phosphoinositide-binding protein SR3protein phosphatase 1, regulatory subunit 172tandem FYVE fingers-1 proteinzinc finger protein, subfamily 2A, member 1zinc finger, FYVE dobone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018052220180519
UniProtAcc

Q9HBF4

P02686

Ensembl transtripts involved in fusion geneENST00000553891, ENST00000318876, 
ENST00000556143, ENST00000394207, 
ENST00000555072, ENST00000554145, 
ENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 
Fusion gene scores* DoF score3 X 3 X 2=1826 X 20 X 3=1560
# samples 327
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFYVE1 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZFYVE1

GO:0009267

cellular response to starvation

25578879

HgeneZFYVE1

GO:0010923

negative regulation of phosphatase activity

19389623

HgeneZFYVE1

GO:0016236

macroautophagy

25578879


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA272659ZFYVE1chr14

73437248

-MBPchr18

74729041

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000553891ENST00000382582ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000553891ENST00000355994ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000397875ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000397866ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000397865ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000527041ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000359645ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000528160ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000397869ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000553891ENST00000354542ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000526111ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000580402ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000579129ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000578193ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000397863ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000553891ENST00000397860ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000553891ENST00000487778ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000318876ENST00000382582ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000318876ENST00000355994ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000397875ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000397866ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000397865ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000527041ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000359645ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000528160ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000397869ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000318876ENST00000354542ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000526111ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000580402ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000579129ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000578193ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000397863ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000318876ENST00000397860ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000318876ENST00000487778ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000556143ENST00000382582ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000556143ENST00000355994ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000397875ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000397866ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000397865ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000527041ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000359645ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000528160ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000397869ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000556143ENST00000354542ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000526111ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000580402ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000579129ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000578193ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000397863ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000556143ENST00000397860ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000556143ENST00000487778ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000394207ENST00000382582ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000394207ENST00000355994ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000397875ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000397866ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000397865ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000527041ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000359645ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000528160ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000397869ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000394207ENST00000354542ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000526111ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000580402ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000579129ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000578193ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000397863ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000394207ENST00000397860ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000394207ENST00000487778ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000555072ENST00000382582ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000555072ENST00000355994ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000397875ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000397866ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000397865ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000527041ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000359645ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000528160ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000397869ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000555072ENST00000354542ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000526111ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000580402ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000579129ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000578193ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000397863ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000555072ENST00000397860ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000555072ENST00000487778ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000554145ENST00000382582ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000554145ENST00000355994ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000397875ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000397866ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000397865ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000527041ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000359645ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000528160ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000397869ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000554145ENST00000354542ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000526111ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000580402ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000579129ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000578193ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000397863ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-intronENST00000554145ENST00000397860ZFYVE1chr14

73437248

-MBPchr18

74729041

-
intron-5UTRENST00000554145ENST00000487778ZFYVE1chr14

73437248

-MBPchr18

74729041

-

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FusionProtFeatures for ZFYVE1_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFYVE1

Q9HBF4

MBP

P02686


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZFYVE1_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZFYVE1_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZFYVE1_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZFYVE1_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human