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Fusion gene ID: 42844 |
FusionGeneSummary for ZFPM2_SLC27A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFPM2_SLC27A2 | Fusion gene ID: 42844 | Hgene | Tgene | Gene symbol | ZFPM2 | SLC27A2 | Gene ID | 23414 | 11001 |
| Gene name | zinc finger protein, FOG family member 2 | solute carrier family 27 member 2 | |
| Synonyms | DIH3|FOG2|SRXY9|ZC2HC11B|ZNF89B|hFOG-2 | ACSVL1|FACVL1|FATP2|HsT17226|VLACS|VLCS|hFACVL1 | |
| Cytomap | 8q23.1 | 15q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein ZFPM2FOG-2Friend of GATA2friend of GATA 2friend of GATA protein 2transcription factor GATA4, modulator ofzinc finger protein 89Bzinc finger protein, multitype 2 | very long-chain acyl-CoA synthetaseFATP-2THCA-CoA ligasefatty acid transport protein 2fatty-acid-coenzyme A ligase, very long-chain 1long-chain-fatty-acid--CoA ligasesolute carrier family 27 (fatty acid transporter), member 2very long-chain fatty-a | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q8WW38 | O14975 | |
| Ensembl transtripts involved in fusion gene | ENST00000407775, ENST00000520492, ENST00000517361, ENST00000522296, ENST00000378472, | ENST00000267842, ENST00000380902, ENST00000544960, | |
| Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 4 X 2 X 4=32 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZFPM2 [Title/Abstract] AND SLC27A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZFPM2 | GO:0045892 | negative regulation of transcription, DNA-templated | 20206639 |
| Hgene | ZFPM2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10438528 |
| Tgene | SLC27A2 | GO:0001561 | fatty acid alpha-oxidation | 10198260 |
| Tgene | SLC27A2 | GO:0001676 | long-chain fatty acid metabolic process | 22022213 |
| Tgene | SLC27A2 | GO:0006635 | fatty acid beta-oxidation | 10198260 |
| Tgene | SLC27A2 | GO:0006699 | bile acid biosynthetic process | 11980911 |
| Tgene | SLC27A2 | GO:0044539 | long-chain fatty acid import | 22022213 |
| Tgene | SLC27A2 | GO:0097089 | methyl-branched fatty acid metabolic process | 10198260 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A8BX-01A | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000407775 | ENST00000267842 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| In-frame | ENST00000407775 | ENST00000380902 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| 5CDS-5UTR | ENST00000407775 | ENST00000544960 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-3CDS | ENST00000520492 | ENST00000267842 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-3CDS | ENST00000520492 | ENST00000380902 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-5UTR | ENST00000520492 | ENST00000544960 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-3CDS | ENST00000517361 | ENST00000267842 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-3CDS | ENST00000517361 | ENST00000380902 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-5UTR | ENST00000517361 | ENST00000544960 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-3CDS | ENST00000522296 | ENST00000267842 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-3CDS | ENST00000522296 | ENST00000380902 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-5UTR | ENST00000522296 | ENST00000544960 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-3CDS | ENST00000378472 | ENST00000267842 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-3CDS | ENST00000378472 | ENST00000380902 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
| intron-5UTR | ENST00000378472 | ENST00000544960 | ZFPM2 | chr8 | 106331209 | + | SLC27A2 | chr15 | 50489697 | + |
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FusionProtFeatures for ZFPM2_SLC27A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZFPM2 | SLC27A2 |
| Transcription regulator that plays a central role inheart morphogenesis and development of coronary vessels fromepicardium, by regulating genes that are essential duringcardiogenesis. Essential cofactor that acts via the formation of aheterodimer with transcription factors of the GATA family GATA4,GATA5 and GATA6. Such heterodimer can both activate or represstranscriptional activity, depending on the cell and promotercontext. Also required in gonadal differentiation, possibly beregulating expression of SRY. Probably acts a corepressor of NR2F2(By similarity). {ECO:0000250, ECO:0000269|PubMed:10438528}. | Acyl-CoA synthetase probably involved in bile acidmetabolism. Proposed to activate C27 precursors of bile acids totheir CoA thioesters derivatives before side chain cleavage viaperoxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27precursor of cholic acid deriving from the de novo synthesis fromcholesterol. Does not utilize C24 bile acids as substrates. Invitro, also activates long- and branched-chain fatty acids and mayhave additional roles in fatty acid metabolism. May be involved intranslocation of long-chain fatty acids (LFCA) across membranes(By similarity). {ECO:0000250, ECO:0000269|PubMed:11980911}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 222_233 | 159 | 621 | Nucleotide binding | AMP |
| Tgene | >SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 222_233 | 159 | 568 | Nucleotide binding | AMP |
| Tgene | >SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 283_620 | 159 | 621 | Topological domain | Cytoplasmic |
| Tgene | >SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 283_620 | 159 | 568 | Topological domain | Cytoplasmic |
| Tgene | >SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 262_282 | 159 | 621 | Transmembrane | Helical |
| Tgene | >SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 262_282 | 159 | 568 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZFPM2 | chr8:106331209 | chr15:50489697 | ENST00000407775 | + | 1 | 8 | 736_740 | 13 | 1152 | Motif | Nuclear localization signal |
| Hgene | >ZFPM2 | chr8:106331209 | chr15:50489697 | ENST00000407775 | + | 1 | 8 | 1113_1146 | 13 | 1152 | Zinc finger | CCHC FOG-type 5 |
| Hgene | >ZFPM2 | chr8:106331209 | chr15:50489697 | ENST00000407775 | + | 1 | 8 | 244_277 | 13 | 1152 | Zinc finger | CCHC FOG-type 1 |
| Hgene | >ZFPM2 | chr8:106331209 | chr15:50489697 | ENST00000407775 | + | 1 | 8 | 296_320 | 13 | 1152 | Zinc finger | C2H2-type 1 |
| Hgene | >ZFPM2 | chr8:106331209 | chr15:50489697 | ENST00000407775 | + | 1 | 8 | 335_357 | 13 | 1152 | Zinc finger | C2H2-type 2 |
| Hgene | >ZFPM2 | chr8:106331209 | chr15:50489697 | ENST00000407775 | + | 1 | 8 | 363_385 | 13 | 1152 | Zinc finger | C2H2-type 3 |
| Hgene | >ZFPM2 | chr8:106331209 | chr15:50489697 | ENST00000407775 | + | 1 | 8 | 542_575 | 13 | 1152 | Zinc finger | CCHC FOG-type 2 |
| Hgene | >ZFPM2 | chr8:106331209 | chr15:50489697 | ENST00000407775 | + | 1 | 8 | 681_714 | 13 | 1152 | Zinc finger | CCHC FOG-type 3 |
| Hgene | >ZFPM2 | chr8:106331209 | chr15:50489697 | ENST00000407775 | + | 1 | 8 | 848_881 | 13 | 1152 | Zinc finger | CCHC FOG-type 4 |
| Tgene | SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 128_261 | 159 | 621 | Topological domain | Lumenal |
| Tgene | SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 1_4 | 159 | 621 | Topological domain | Lumenal |
| Tgene | SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 28_106 | 159 | 621 | Topological domain | Cytoplasmic |
| Tgene | SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 128_261 | 159 | 568 | Topological domain | Lumenal |
| Tgene | SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 1_4 | 159 | 568 | Topological domain | Lumenal |
| Tgene | SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 28_106 | 159 | 568 | Topological domain | Cytoplasmic |
| Tgene | SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 107_127 | 159 | 621 | Transmembrane | Helical |
| Tgene | SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 5_27 | 159 | 621 | Transmembrane | Helical |
| Tgene | SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 107_127 | 159 | 568 | Transmembrane | Helical |
| Tgene | SLC27A2 | chr8:106331209 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 5_27 | 159 | 568 | Transmembrane | Helical |
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FusionGeneSequence for ZFPM2_SLC27A2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZFPM2_ENST00000407775_chr8_106331209_+_SLC27A2_ENST00000267842_chr15_50489697_+_475aa MSRRKQSKPRQIKQLQAAVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAM ITHQRIWYGTGLTFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKP NDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVR VPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDF VQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLD >In-frame_ZFPM2_ENST00000407775_chr8_106331209_+_SLC27A2_ENST00000380902_chr15_50489697_+_422aa MSRRKQSKPRQIKQLQAAVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGATLALR TKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVG AVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMV DHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZFPM2_ENST00000407775_chr8_106331209_+_SLC27A2_ENST00000267842_chr15_50489697_+_1425nt ATGTCCCGGCGAAAGCAAAGCAAACCCCGGCAGATCAAACAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGATGAT GTGTCCATCTATTATGTGAGCAGAACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACCTATC CCAGAGTCATGGAGGTCTGAAGTCACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTCTTCCAAAAGCAGCCATG ATCACTCATCAGCGCATATGGTATGGAACTGGCCTCACTTTTGTAAGCGGATTGAAGGCAGATGATGTCATCTATATCACTCTGCCCTTT TACCACAGTGCTGCACTACTGATTGGCATTCACGGATGTATTGTGGCTGGTGCTACTCTTGCCTTGCGGACTAAATTTTCAGCCAGCCAG TTTTGGGATGACTGCAGAAAATACAACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTATTTATGCAACTCACCACAGAAACCA AATGACCGTGATCATAAAGTGAGACTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACAATTTGTCAAGAGATTTGGGGACATA TGCATCTATGAGTTCTATGCTGCCACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGTTGGTGCTGTTGGAAGAGTAAACTAC CTACAGAAAAAAATCATAACTTATGACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCGTGATGAAAATGGATATTGCGTCAGA GTTCCCAAAGGTGAAGTTGGACTTCTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTATGCTGGAGCAAAGGCTCAGACAGAG AAGAAAAAACTGAGAGATGTCTTTAAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAATGGTTGACCATGAAAATTTCATCTAT TTCCACGACAGAGTTGGAGATACATTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGCTGATACAGTTGGACTGGTTGATTTT GTCCAAGAAGTAAATGTTTATGGAGTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTCCATCAAAATGAAAGAAAACCATGAA TTTGATGGAAAGAAACTCTTTCAGCACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTTTCTAAGAATACAGGACACCATTGAG ATCACTGGAACTTTTAAACACCGCAAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCATCAAAGATGCCTTGTATTTCTTGGAT >In-frame_ZFPM2_ENST00000407775_chr8_106331209_+_SLC27A2_ENST00000380902_chr15_50489697_+_1266nt ATGTCCCGGCGAAAGCAAAGCAAACCCCGGCAGATCAAACAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGATGAT GTGTCCATCTATTATGTGAGCAGAACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACCTATC CCAGAGTCATGGAGGTCTGAAGTCACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTGCTACTCTTGCCTTGCGG ACTAAATTTTCAGCCAGCCAGTTTTGGGATGACTGCAGAAAATACAACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTATTTA TGCAACTCACCACAGAAACCAAATGACCGTGATCATAAAGTGAGACTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACAATTT GTCAAGAGATTTGGGGACATATGCATCTATGAGTTCTATGCTGCCACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGTTGGT GCTGTTGGAAGAGTAAACTACCTACAGAAAAAAATCATAACTTATGACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCGTGAT GAAAATGGATATTGCGTCAGAGTTCCCAAAGGTGAAGTTGGACTTCTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTATGCT GGAGCAAAGGCTCAGACAGAGAAGAAAAAACTGAGAGATGTCTTTAAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAATGGTT GACCATGAAAATTTCATCTATTTCCACGACAGAGTTGGAGATACATTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGCTGAT ACAGTTGGACTGGTTGATTTTGTCCAAGAAGTAAATGTTTATGGAGTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTCCATC AAAATGAAAGAAAACCATGAATTTGATGGAAAGAAACTCTTTCAGCACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTTTCTA AGAATACAGGACACCATTGAGATCACTGGAACTTTTAAACACCGCAAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCATCAAA GATGCCTTGTATTTCTTGGATGACACAGCAAAAATGTATGTGCCTATGACTGAGGACATCTATAATGCCATAAGTGCTAAAACCCTGAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZFPM2_ENST00000407775_chr8_106331209_+_SLC27A2_ENST00000267842_chr15_50489697_+_1974nt CTCTCCCCCTCCCCTCCTCACTGTCACACTCTCTGTGCCCCCGTCTCTCTTCTCTCATTTGCTTGCTCATCTCCGAACGTGAATCCGCGG CTCCCGGAGGAGCCCAGCGCCCGGAGCACCTGGAGTCCGGCCGGCGGCGGGCCGAGCCTGGCCAGCGGCGGCGGCGGCGGCGGCGGCGGC GGGAGCCGAGGGAGCGGCAGCCGCGACCGCGGGCACCGCGGGAGCCCCAGCGGCAGCAGCCGCCGCCGAGATGTCCCGGCGAAAGCAAAG CAAACCCCGGCAGATCAAACAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGATGATGTGTCCATCTATTATGTGAG CAGAACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACCTATCCCAGAGTCATGGAGGTCTGA AGTCACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTCTTCCAAAAGCAGCCATGATCACTCATCAGCGCATATG GTATGGAACTGGCCTCACTTTTGTAAGCGGATTGAAGGCAGATGATGTCATCTATATCACTCTGCCCTTTTACCACAGTGCTGCACTACT GATTGGCATTCACGGATGTATTGTGGCTGGTGCTACTCTTGCCTTGCGGACTAAATTTTCAGCCAGCCAGTTTTGGGATGACTGCAGAAA ATACAACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTATTTATGCAACTCACCACAGAAACCAAATGACCGTGATCATAAAGT GAGACTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACAATTTGTCAAGAGATTTGGGGACATATGCATCTATGAGTTCTATGC TGCCACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGTTGGTGCTGTTGGAAGAGTAAACTACCTACAGAAAAAAATCATAAC TTATGACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCGTGATGAAAATGGATATTGCGTCAGAGTTCCCAAAGGTGAAGTTGG ACTTCTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTATGCTGGAGCAAAGGCTCAGACAGAGAAGAAAAAACTGAGAGATGT CTTTAAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAATGGTTGACCATGAAAATTTCATCTATTTCCACGACAGAGTTGGAGA TACATTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGCTGATACAGTTGGACTGGTTGATTTTGTCCAAGAAGTAAATGTTTA TGGAGTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTCCATCAAAATGAAAGAAAACCATGAATTTGATGGAAAGAAACTCTT TCAGCACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTTTCTAAGAATACAGGACACCATTGAGATCACTGGAACTTTTAAACA CCGCAAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCATCAAAGATGCCTTGTATTTCTTGGATGACACAGCAAAAATGTATGT GCCTATGACTGAGGACATCTATAATGCCATAAGTGCTAAAACCCTGAAACTCTGAATATTCCCAGGAGGATAACTCAACATTTCCAGAAA GAAACTGAATGGACAGCCACTTGATATAATCCAACTTTAATTTGATTGAAGATTGTGAGGAAATTTTGTAGGAAATTTGCATACCCGTAA AGGGAGACTTTTTTAAATAACAGTTGAGTCTTTGCAAGTAAAAAGATTTAGAGATTATTATTTTTCAGTGTGCACCTACTGTTTGTATTT >In-frame_ZFPM2_ENST00000407775_chr8_106331209_+_SLC27A2_ENST00000380902_chr15_50489697_+_1798nt CTCTCCCCCTCCCCTCCTCACTGTCACACTCTCTGTGCCCCCGTCTCTCTTCTCTCATTTGCTTGCTCATCTCCGAACGTGAATCCGCGG CTCCCGGAGGAGCCCAGCGCCCGGAGCACCTGGAGTCCGGCCGGCGGCGGGCCGAGCCTGGCCAGCGGCGGCGGCGGCGGCGGCGGCGGC GGGAGCCGAGGGAGCGGCAGCCGCGACCGCGGGCACCGCGGGAGCCCCAGCGGCAGCAGCCGCCGCCGAGATGTCCCGGCGAAAGCAAAG CAAACCCCGGCAGATCAAACAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGATGATGTGTCCATCTATTATGTGAG CAGAACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACCTATCCCAGAGTCATGGAGGTCTGA AGTCACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTGCTACTCTTGCCTTGCGGACTAAATTTTCAGCCAGCCA GTTTTGGGATGACTGCAGAAAATACAACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTATTTATGCAACTCACCACAGAAACC AAATGACCGTGATCATAAAGTGAGACTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACAATTTGTCAAGAGATTTGGGGACAT ATGCATCTATGAGTTCTATGCTGCCACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGTTGGTGCTGTTGGAAGAGTAAACTA CCTACAGAAAAAAATCATAACTTATGACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCGTGATGAAAATGGATATTGCGTCAG AGTTCCCAAAGGTGAAGTTGGACTTCTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTATGCTGGAGCAAAGGCTCAGACAGA GAAGAAAAAACTGAGAGATGTCTTTAAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAATGGTTGACCATGAAAATTTCATCTA TTTCCACGACAGAGTTGGAGATACATTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGCTGATACAGTTGGACTGGTTGATTT TGTCCAAGAAGTAAATGTTTATGGAGTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTCCATCAAAATGAAAGAAAACCATGA ATTTGATGGAAAGAAACTCTTTCAGCACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTTTCTAAGAATACAGGACACCATTGA GATCACTGGAACTTTTAAACACCGCAAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCATCAAAGATGCCTTGTATTTCTTGGA TGACACAGCAAAAATGTATGTGCCTATGACTGAGGACATCTATAATGCCATAAGTGCTAAAACCCTGAAACTCTGAATATTCCCAGGAGG ATAACTCAACATTTCCAGAAAGAAACTGAATGGACAGCCACTTGATATAATCCAACTTTAATTTGATTGAAGATTGTGAGGAAATTTTGT AGGAAATTTGCATACCCGTAAAGGGAGACTTTTTTAAATAACAGTTGAGTCTTTGCAAGTAAAAAGATTTAGAGATTATTATTTTTCAGT |
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FusionGenePPI for ZFPM2_SLC27A2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZFPM2 | GATA1, GATA4, CTBP2, MTA1, MTA2, HDAC1, HDAC2, RBBP7, RBBP4, MTA3, ITSN1, UBQLN4, STAT3, IL32, DUSP23 | SLC27A2 | NCSTN, SDHA, PEX5, ABCD1, PEX14, CALR, YWHAQ, TSPAN5, HPS1, EID3, HAUS7, SLC39A4, SMPD1, LPCAT1, PRKCSH, FAM63B, PNPLA3, FAM177A1, CCNB1, KPNB1, SLC33A1, CTDSPL2, FAM134A, SPC24, RANBP6, PPP6R2, SCGB2A2, ARMC6, BCL2L2, EXOC8, CNPPD1, DFNA5, UNC45A, ATP6V0D1, FAM73B, EIF2B2, MRPL34, HEATR1, BZW2, ROPN1, UBC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ZFPM2 | chr8:106331209 | chr15:50489697 | ENST00000407775 | + | 1 | 8 | 829_835 | 13 | 1152 | CTBP2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZFPM2_SLC27A2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFPM2_SLC27A2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ZFPM2 | C0039685 | Tetralogy of Fallot | 2 | CTD_human;HPO;ORPHANET;UNIPROT |
| Hgene | ZFPM2 | C4015129 | 46,XY SEX REVERSAL 9 | 2 | UNIPROT |
| Hgene | ZFPM2 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
| Hgene | ZFPM2 | C1857586 | CONOTRUNCAL HEART MALFORMATIONS (disorder) | 1 | UNIPROT |
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