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Fusion gene ID: 42840 |
FusionGeneSummary for ZFPM2_BOLA2 |
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Fusion gene information | Fusion gene name: ZFPM2_BOLA2 | Fusion gene ID: 42840 | Hgene | Tgene | Gene symbol | ZFPM2 | BOLA2 | Gene ID | 23414 | 654483 |
Gene name | zinc finger protein, FOG family member 2 | bolA family member 2B | |
Synonyms | DIH3|FOG2|SRXY9|ZC2HC11B|ZNF89B|hFOG-2 | BOLA2 | |
Cytomap | 8q23.1 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein ZFPM2FOG-2Friend of GATA2friend of GATA 2friend of GATA protein 2transcription factor GATA4, modulator ofzinc finger protein 89Bzinc finger protein, multitype 2 | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q8WW38 | Q9H3K6 | |
Ensembl transtripts involved in fusion gene | ENST00000407775, ENST00000520492, ENST00000517361, ENST00000522296, ENST00000378472, | ENST00000330978, | |
Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 19 X 26 X 1=494 |
# samples | 8 | 28 | |
** MAII score | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/494*10)=-0.819084214639711 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZFPM2 [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZFPM2 | GO:0045892 | negative regulation of transcription, DNA-templated | 20206639 |
Hgene | ZFPM2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10438528 |
Tgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
Tgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF876330 | ZFPM2 | chr8 | 106382731 | + | BOLA2 | chr16 | 29934041 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000407775 | ENST00000330978 | ZFPM2 | chr8 | 106382731 | + | BOLA2 | chr16 | 29934041 | - |
intron-intron | ENST00000520492 | ENST00000330978 | ZFPM2 | chr8 | 106382731 | + | BOLA2 | chr16 | 29934041 | - |
intron-intron | ENST00000517361 | ENST00000330978 | ZFPM2 | chr8 | 106382731 | + | BOLA2 | chr16 | 29934041 | - |
intron-intron | ENST00000522296 | ENST00000330978 | ZFPM2 | chr8 | 106382731 | + | BOLA2 | chr16 | 29934041 | - |
intron-intron | ENST00000378472 | ENST00000330978 | ZFPM2 | chr8 | 106382731 | + | BOLA2 | chr16 | 29934041 | - |
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FusionProtFeatures for ZFPM2_BOLA2 |
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Hgene | Tgene |
ZFPM2 | BOLA2 |
Transcription regulator that plays a central role inheart morphogenesis and development of coronary vessels fromepicardium, by regulating genes that are essential duringcardiogenesis. Essential cofactor that acts via the formation of aheterodimer with transcription factors of the GATA family GATA4,GATA5 and GATA6. Such heterodimer can both activate or represstranscriptional activity, depending on the cell and promotercontext. Also required in gonadal differentiation, possibly beregulating expression of SRY. Probably acts a corepressor of NR2F2(By similarity). {ECO:0000250, ECO:0000269|PubMed:10438528}. | Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZFPM2_BOLA2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZFPM2_BOLA2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZFPM2_BOLA2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFPM2_BOLA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZFPM2 | C0039685 | Tetralogy of Fallot | 2 | CTD_human;HPO;ORPHANET;UNIPROT |
Hgene | ZFPM2 | C4015129 | 46,XY SEX REVERSAL 9 | 2 | UNIPROT |
Hgene | ZFPM2 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
Hgene | ZFPM2 | C1857586 | CONOTRUNCAL HEART MALFORMATIONS (disorder) | 1 | UNIPROT |