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Fusion gene ID: 42838 |
FusionGeneSummary for ZFPM1_KLF6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFPM1_KLF6 | Fusion gene ID: 42838 | Hgene | Tgene | Gene symbol | ZFPM1 | KLF6 | Gene ID | 161882 | 1316 |
| Gene name | zinc finger protein, FOG family member 1 | Kruppel like factor 6 | |
| Synonyms | FOG|FOG1|ZC2HC11A|ZNF408|ZNF89A | BCD1|CBA1|COPEB|CPBP|GBF|PAC1|ST12|ZF9 | |
| Cytomap | 16q24.2 | 10p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein ZFPM1FOG-1friend of GATA 1friend of GATA protein 1zinc finger protein 89Azinc finger protein, multitype 1 | Krueppel-like factor 6B-cell-derived protein 1GC-rich binding factorGC-rich sites-binding factor GBFKruppel-like zinc finger protein Zf9core promoter element-binding proteinproto-oncogene BCD1protooncogene B-cell derived 1suppression of tumorigeni | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IX07 | Q99612 | |
| Ensembl transtripts involved in fusion gene | ENST00000319555, ENST00000569086, | ENST00000497571, ENST00000542957, ENST00000173785, ENST00000469435, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 1=25 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZFPM1 [Title/Abstract] AND KLF6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZFPM1 | GO:0010724 | regulation of definitive erythrocyte differentiation | 15920471 |
| Hgene | ZFPM1 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process | 21646796 |
| Hgene | ZFPM1 | GO:0045403 | negative regulation of interleukin-4 biosynthetic process | 21646796 |
| Tgene | KLF6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18755691 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CT004488 | ZFPM1 | chr16 | 88580928 | + | KLF6 | chr10 | 3824407 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000319555 | ENST00000497571 | ZFPM1 | chr16 | 88580928 | + | KLF6 | chr10 | 3824407 | - |
| In-frame | ENST00000319555 | ENST00000542957 | ZFPM1 | chr16 | 88580928 | + | KLF6 | chr10 | 3824407 | - |
| 5CDS-intron | ENST00000319555 | ENST00000173785 | ZFPM1 | chr16 | 88580928 | + | KLF6 | chr10 | 3824407 | - |
| 5CDS-intron | ENST00000319555 | ENST00000469435 | ZFPM1 | chr16 | 88580928 | + | KLF6 | chr10 | 3824407 | - |
| 3UTR-3CDS | ENST00000569086 | ENST00000497571 | ZFPM1 | chr16 | 88580928 | + | KLF6 | chr10 | 3824407 | - |
| 3UTR-3CDS | ENST00000569086 | ENST00000542957 | ZFPM1 | chr16 | 88580928 | + | KLF6 | chr10 | 3824407 | - |
| 3UTR-intron | ENST00000569086 | ENST00000173785 | ZFPM1 | chr16 | 88580928 | + | KLF6 | chr10 | 3824407 | - |
| 3UTR-intron | ENST00000569086 | ENST00000469435 | ZFPM1 | chr16 | 88580928 | + | KLF6 | chr10 | 3824407 | - |
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FusionProtFeatures for ZFPM1_KLF6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZFPM1 | KLF6 |
| Transcription regulator that plays an essential role inerythroid and megakaryocytic cell differentiation. Essentialcofactor that acts via the formation of a heterodimer withtranscription factors of the GATA family GATA1, GATA2 and GATA3.Such heterodimer can both activate or repress transcriptionalactivity, depending on the cell and promoter context. Theheterodimer formed with GATA proteins is essential to activateexpression of genes such as NFE2, ITGA2B, alpha- and beta-globin,while it represses expression of KLF1. May be involved inregulation of some genes in gonads. May also be involved incardiac development, in a non-redundant way with ZFPM2/FOG2 (Bysimilarity). {ECO:0000250}. | Transcriptional activator (By similarity). Binds a GCbox motif. Could play a role in B-cell growth and development.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >KLF6 | chr16:88580928 | chr10:3824407 | ENST00000469435 | - | 0 | 2 | 200_224 | 34 | 282 | Zinc finger | C2H2-type 1 |
| Tgene | >KLF6 | chr16:88580928 | chr10:3824407 | ENST00000469435 | - | 0 | 2 | 230_254 | 34 | 282 | Zinc finger | C2H2-type 2 |
| Tgene | >KLF6 | chr16:88580928 | chr10:3824407 | ENST00000469435 | - | 0 | 2 | 260_282 | 34 | 282 | Zinc finger | C2H2-type 3 |
| Tgene | >KLF6 | chr16:88580928 | chr10:3824407 | ENST00000497571 | - | 0 | 4 | 200_224 | 34 | 284 | Zinc finger | C2H2-type 1 |
| Tgene | >KLF6 | chr16:88580928 | chr10:3824407 | ENST00000497571 | - | 0 | 4 | 230_254 | 34 | 284 | Zinc finger | C2H2-type 2 |
| Tgene | >KLF6 | chr16:88580928 | chr10:3824407 | ENST00000497571 | - | 0 | 4 | 260_282 | 34 | 284 | Zinc finger | C2H2-type 3 |
| Tgene | >KLF6 | chr16:88580928 | chr10:3824407 | ENST00000542957 | - | 0 | 3 | 200_224 | 34 | 238 | Zinc finger | C2H2-type 1 |
| Tgene | >KLF6 | chr16:88580928 | chr10:3824407 | ENST00000542957 | - | 0 | 3 | 230_254 | 34 | 238 | Zinc finger | C2H2-type 2 |
| Tgene | >KLF6 | chr16:88580928 | chr10:3824407 | ENST00000542957 | - | 0 | 3 | 260_282 | 34 | 238 | Zinc finger | C2H2-type 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZFPM1 | chr16:88580928 | chr10:3824407 | ENST00000319555 | + | 4 | 10 | 235_268 | 134 | 1007 | Zinc finger | CCHC FOG-type 1 |
| Hgene | >ZFPM1 | chr16:88580928 | chr10:3824407 | ENST00000319555 | + | 4 | 10 | 290_314 | 134 | 1007 | Zinc finger | C2H2-type 1 |
| Hgene | >ZFPM1 | chr16:88580928 | chr10:3824407 | ENST00000319555 | + | 4 | 10 | 320_342 | 134 | 1007 | Zinc finger | C2H2-type 2 |
| Hgene | >ZFPM1 | chr16:88580928 | chr10:3824407 | ENST00000319555 | + | 4 | 10 | 348_371 | 134 | 1007 | Zinc finger | C2H2-type 3 |
| Hgene | >ZFPM1 | chr16:88580928 | chr10:3824407 | ENST00000319555 | + | 4 | 10 | 571_604 | 134 | 1007 | Zinc finger | CCHC FOG-type 2 |
| Hgene | >ZFPM1 | chr16:88580928 | chr10:3824407 | ENST00000319555 | + | 4 | 10 | 677_710 | 134 | 1007 | Zinc finger | CCHC FOG-type 3 |
| Hgene | >ZFPM1 | chr16:88580928 | chr10:3824407 | ENST00000319555 | + | 4 | 10 | 811_844 | 134 | 1007 | Zinc finger | CCHC FOG-type 4 |
| Hgene | >ZFPM1 | chr16:88580928 | chr10:3824407 | ENST00000319555 | + | 4 | 10 | 854_877 | 134 | 1007 | Zinc finger | C2H2-type 4 |
| Hgene | >ZFPM1 | chr16:88580928 | chr10:3824407 | ENST00000319555 | + | 4 | 10 | 968_1001 | 134 | 1007 | Zinc finger | CCHC FOG-type 5 |
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FusionGeneSequence for ZFPM1_KLF6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZFPM1_ENST00000319555_chr16_88580928_+_KLF6_ENST00000497571_chr10_3824407_-_384aa MSRRKQSNPRQIKRSLGDMEAREEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPTSPGGPKELEGQEPEPRPTEEEPGSPWSGPD ELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPTCLELERYLQSEPCTVSASEIKFDSQEDLWTKIILAREKKEESELK ISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSREPSQLWGCVPGELP SPGKVRSGTSGKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPF >In-frame_ZFPM1_ENST00000319555_chr16_88580928_+_KLF6_ENST00000542957_chr10_3824407_-_338aa MSRRKQSNPRQIKRSLGDMEAREEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPTSPGGPKELEGQEPEPRPTEEEPGSPWSGPD ELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPTCLELERYLQSEPCTVSASEIKFDSQEDLWTKIILAREKKEESELK ISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSREPSQLWGCVPGELP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZFPM1_ENST00000319555_chr16_88580928_+_KLF6_ENST00000497571_chr10_3824407_-_1152nt ATGTCCAGGCGGAAACAGAGCAACCCCCGGCAGATCAAGCGTTCCCTCGGAGACATGGAGGCCAGAGAGGAGGTGCAGTTGGTGGGTGCC AGCCACATGGAGCAAAAGGCCACGGCACCTGAAGCCCCGAGCCCTCCCAGCGCAGATGTTAACTCACCCCCACCGCTGCCGCCCCCCACA TCCCCAGGAGGCCCCAAGGAGCTGGAAGGACAGGAACCAGAACCCAGGCCCACGGAGGAAGAGCCGGGCAGTCCCTGGAGCGGGCCAGAC GAGCTGGAGCCGGTGGTGCAGGATGGGCAGAGGCGCATACGGGCCCGACTCAGCCTCGCCACGGGCCTGTCCTGGGGCCCGTTCCATGGG AGTGTCCAGACCAGAGCCTCATCCCCCAGGCAGGCGGAGCCGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTT TCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCTGTGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAG ATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCCGAGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGC GAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGCCAAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTG AGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGAACTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCC TCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCCAGGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCAC CGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAAAAGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTAC AGATGCTCATGGGAAGGGTGTGAGTGGCGTTTTGCAAGAAGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTT >In-frame_ZFPM1_ENST00000319555_chr16_88580928_+_KLF6_ENST00000542957_chr10_3824407_-_1014nt ATGTCCAGGCGGAAACAGAGCAACCCCCGGCAGATCAAGCGTTCCCTCGGAGACATGGAGGCCAGAGAGGAGGTGCAGTTGGTGGGTGCC AGCCACATGGAGCAAAAGGCCACGGCACCTGAAGCCCCGAGCCCTCCCAGCGCAGATGTTAACTCACCCCCACCGCTGCCGCCCCCCACA TCCCCAGGAGGCCCCAAGGAGCTGGAAGGACAGGAACCAGAACCCAGGCCCACGGAGGAAGAGCCGGGCAGTCCCTGGAGCGGGCCAGAC GAGCTGGAGCCGGTGGTGCAGGATGGGCAGAGGCGCATACGGGCCCGACTCAGCCTCGCCACGGGCCTGTCCTGGGGCCCGTTCCATGGG AGTGTCCAGACCAGAGCCTCATCCCCCAGGCAGGCGGAGCCGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTT TCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCTGTGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAG ATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCCGAGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGC GAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGCCAAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTG AGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGAACTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCC TCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCCAGGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCAC CGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAAAAGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGTGTTTTTCCAGGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZFPM1_ENST00000319555_chr16_88580928_+_KLF6_ENST00000497571_chr10_3824407_-_5017nt CGCCGCTCGCCGCCCGCGGGTTCCATTGAGAAAAGCCGAGCGGCCGCGGCGGCGGCGGCGAGTGCGCGGGAGCGGAGGAGCCGGCACCCG CCCGTCGGGCAGTCCGCGCGCCCGCAACGCAGGACCGTGGCCTCTCGGGCCTCCGCGGCAGCTCCAGCGGCTCCGGGGCTGGGCGCGCGG GCTGGGGGCGCGGGCCGGGGCGGCCGCGGAGACCGGGGGCCGGGGGCATGAGCGGCCCCGCGGCCCCGCCGCGCCCCCGCCGCCCGCCGC CGCCCGCCCGGGGCTAGAGGCGGCCGCCGGGAGGGCGCGCGGCGCCGGAGACATGTCCAGGCGGAAACAGAGCAACCCCCGGCAGATCAA GCGTTCCCTCGGAGACATGGAGGCCAGAGAGGAGGTGCAGTTGGTGGGTGCCAGCCACATGGAGCAAAAGGCCACGGCACCTGAAGCCCC GAGCCCTCCCAGCGCAGATGTTAACTCACCCCCACCGCTGCCGCCCCCCACATCCCCAGGAGGCCCCAAGGAGCTGGAAGGACAGGAACC AGAACCCAGGCCCACGGAGGAAGAGCCGGGCAGTCCCTGGAGCGGGCCAGACGAGCTGGAGCCGGTGGTGCAGGATGGGCAGAGGCGCAT ACGGGCCCGACTCAGCCTCGCCACGGGCCTGTCCTGGGGCCCGTTCCATGGGAGTGTCCAGACCAGAGCCTCATCCCCCAGGCAGGCGGA GCCGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCT GTGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCC GAGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGC CAAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGA ACTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCC AGGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAA AAGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGTTTTGCAAG AAGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGTGTTTTTCCAGGTCTGA CCACCTGGCCCTGCACATGAAGAGGCACCTCTGAGGGAGCAGAGAGGTGGATCCTGTAGGCTAAAAGGCTTCCAGGCTGAGAGCCGGCCG TGGAAGGAGGGATGCGTGTTCCAGCCAAAGCATGCCGTTCTGCACCCTACCCAGTTGCCTCCAGGGCCTCTCCTTGGAAGGTCTTTTGAG GGCTAAAAAGGTCCTGTAAGAAGCGGCATAGCACCCGTGGTGCATGGTATGTGGGTGACCCTGGACTCGCCACTGGTACCCGCCCTTCCG AGCGGCGCCTAAGCCTTTGCCGTGAGCATGCACACTGAGAATGCTAATGGTTGGGTTGATTGTATGTTGAGGATCTATTACTGACCGTAT GATGAGGCCAACTTTTTTTCCTTGTGGTTAGCAAGACTGCAAGAGATGGAAAAAAAGTAGTTTGAATGTTTTGTGTGTAAGGAGTATACC ATGAGATGAGATGACCACCAATCATTTCCTTGGGGGGAGGGGGTGTCTGCACCTTAGAAAAAAAAAGAAAAATCAAAAAAACAAAAAAAC AAAAACAAAAAAAGAAGGAAAATCTTGGAGGGTGGGCGTGGGAACTCAGGACCCCAGAGTGGCGAGTGGTGTGGGGAGGGAGAGCCTCTC TCCCCCTTTTCTGTGTGAGAGGAACTCTTAGTGTCTGGTGCAGCTATTAAATGTGCAATGTGTCAAGTAGCTTGTTTTACACGCTACAAC ATAGCTCATTTGTAACCCATTGTATAAGCTGTGTATTTACAAATATAACACAACAATTTAACTTTTCCTTAGAATACAAAAAGTCATGCA TGGTCTGGGGAACTATATGCTTTTCCATTTTTAAGTCAGGACTGCAATACTGATTCCAGTTAATGAGCAGCTAAGATCCAATCTGTCTAA TACAGTGACCCCCTAGCCATCCGGGCCTGGCAATATACAATTTTTTTTCCCCTCCAAGTTTGTAACACTCCCCTTCCAGAAAGGCATTGT GCAACACAGGATTATTTTTAAATGATTCTGAATTTGAATTAACTTTTTGGAGAATTCTGTGATGCCCTTAGAAGAAATTGGACACGTATT GAGTGTCACAAAGCTGGGGCTGGGAATTGCTGGTCTAATGTTTCATTAGACTTAAGAACCTAAAATTTTTCTCAGTTGGGTGGATAAAAC CACTAACGCTTAGAAACTGTTTTCTCATGCAGCTATGTTTCTCTTATTTATGCCTTGAGGACTAATTTCTGGTTTTCTAGCTGTTAATGC ACTGTTGACCTTCATAATGGTGCCTTACGCAAGCGATCCCTTCTGTGGGGGTCTCATACAGGGGTGTGGGCGATGCATGCTTTATTAAGG CTCTTGTTTCACCTGGCAGTGTACTGTATCAACGTATAATACAGAAAAAAAATCTCTTTAAGGTCCTCCTTCACAAAGACATAGAGTGAA ACTCCCTTTACATGTCAGTATTTGTTCAACACTTTAGGCAACTTGACTGTCAGTGTTAAAATGGAAAACAGGAAAATGGAAAAATCTGAC CAATTCTGCCACCTTGAGACTTTCATATAGACCTTGCACAACAATTGTATAGATCACACACCGGCTGTATTTAATATGTAACATTTTCAC ACATATTAAAGATACAGAAGTATTAAAAAACCCCCAATGTTAATGTATTTGCTTAAAAGGCACAAGTTTCACATATCTGTCTAGCTATCT GTTGGTAATACAGAAAGTATACTACTTTTTTAAAAAAGTGGGCAGAATTCTTGTGTATGTATATTTGTGTGTACAGTATGTGTATGTGTG TATATATATATATTATATATATAGATAATATATAAATATTTTTTTTAAGGAGAAACTAGAATGTTTAGCTAGAAAATTCCACAGCCTGTG AAGAAATATTTCAAAATGGCCATAAAGGAGGTAAAAATGAAAACCATAACCTAACTTTTATAGAGGCTTTATCTTTAATTTAACGATGTG CGGAGGACTTTCTTGCTTGAATCTGTTCCGGGCTGTCTGCTCTGTCCATCAAATGGGCAGGTCTGGAATGGGGCACCTTCGGCCGTTCAG AAGTGGCCTGAACAGAATGCTGGAACCCAGGCTGGACTCGGACACACTAAGGTTTTGATTTTGAATTTCAGCCTTATTAGAAGATCTAAC CTAAGAGTAAGCTAACCACAGGGATTCTTTTGTAGAACACTTTTTATGCAGATGAAGCTATTTTTTCCAGCAAGTAGATTCTTCCAGTTT TTCCAAGGAGTAATTTCCCCGAATTGGCATACCACGGCGTGGACAGCTGATATTTCACCCAGCTGCTGGCTTGTGGGTGTGGCTCTTTGC TTTATATATATATACACACATGTGAGTCTGGCTGGGCTGGTATTTTGTTTGATCTTCCTGGAAATGAGCAGTGACTAACGCTCACATAAC TGGTTTTTTTTTTATCTGGGCTGATGAATACATTTACCTAAGAAACTCATTTCGTTTTACTTAAGAGGGGAAGTGCAGTTTTCTTTTGGC AGTTCAGAATCCAAGCACTTGATTTGCTGGGTTTGGAAAACTCCTTTTTTGGCCTTCTATGTGCTTAGCCATAACAATTCCATTAAGCAA GAAGGTAAGCAAAAGACAAAAAAAAAAAAAGGAAAAAAAAAAACTTGCACTGGCTTGTCTCACTTACGAAACATGTCGGAGCTGTTTGCC TGGGTGGGGCTGGGTACCGTACCTGTCAATGCCTGTGATTTTCATAATTAGCACGTACATAAAGAAGTACATTCTGTTCAGGTGATAACT GAGCCTCAATCAAGCAGAAACTTTTTGCTTGAAATTAAAAAAAAATTTCTATTAGTGAAATTTCTTTTTTTTTTTTTTTTGGAAGCACCC TGTTATCTAAAGAATCTTTGTAAGATTTTTGTAAAATTTTGTTTTACAAGATTTTATTTGAAATTGTTTTTTGCAAGATTGTTATATTTC TGTATGAATGTATTTTTTATTGGAATAACATAAAAGAATTCTTATCAGCATCTTGAGTCTGGTTGTTTTTTTTGGGGGAAGGGGGTTGTT GGAACAGATTCCTCCTGCATTCATCACCCTGGCTTCCTCCTGGGGGCAAATCTTCATTGAGCAACCCTGAGAACAACTCACCGACCTCAG CCCCTTCCTCTTTCCACAGCCTGTCCTGGGAGCTGGAGAGGATGTCAGCGAGCCTGACATTGCCCTCCCTGAATGCATCAAATACTCTTC TCCAAGGACTGACAAAAACAACCCCCCGGCTGTGGGCACAGTAGGGAACCATGCCGGTTTGATCTTCCATTGCTCAAGCCAGGGAATGCA TTGCAGAGGCACCTGCACAACGACAAACTTGAGTGTTTCCCTGCCACTTCTGTGCCTCCACAGCCTGCTCCAGTTCCGCAGCTAGAGCTG GGCCTACCTTCCCCAGCCAGCCCTGCCACACACCTGGCTGAGGCATGTCTGGGAGGGGTGGAGGAGGCAGAGGGACTCCAGGCCAGAGGG >In-frame_ZFPM1_ENST00000319555_chr16_88580928_+_KLF6_ENST00000542957_chr10_3824407_-_4892nt CGCCGCTCGCCGCCCGCGGGTTCCATTGAGAAAAGCCGAGCGGCCGCGGCGGCGGCGGCGAGTGCGCGGGAGCGGAGGAGCCGGCACCCG CCCGTCGGGCAGTCCGCGCGCCCGCAACGCAGGACCGTGGCCTCTCGGGCCTCCGCGGCAGCTCCAGCGGCTCCGGGGCTGGGCGCGCGG GCTGGGGGCGCGGGCCGGGGCGGCCGCGGAGACCGGGGGCCGGGGGCATGAGCGGCCCCGCGGCCCCGCCGCGCCCCCGCCGCCCGCCGC CGCCCGCCCGGGGCTAGAGGCGGCCGCCGGGAGGGCGCGCGGCGCCGGAGACATGTCCAGGCGGAAACAGAGCAACCCCCGGCAGATCAA GCGTTCCCTCGGAGACATGGAGGCCAGAGAGGAGGTGCAGTTGGTGGGTGCCAGCCACATGGAGCAAAAGGCCACGGCACCTGAAGCCCC GAGCCCTCCCAGCGCAGATGTTAACTCACCCCCACCGCTGCCGCCCCCCACATCCCCAGGAGGCCCCAAGGAGCTGGAAGGACAGGAACC AGAACCCAGGCCCACGGAGGAAGAGCCGGGCAGTCCCTGGAGCGGGCCAGACGAGCTGGAGCCGGTGGTGCAGGATGGGCAGAGGCGCAT ACGGGCCCGACTCAGCCTCGCCACGGGCCTGTCCTGGGGCCCGTTCCATGGGAGTGTCCAGACCAGAGCCTCATCCCCCAGGCAGGCGGA GCCGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCT GTGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCC GAGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGC CAAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGA ACTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCC AGGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAA AAGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGTGTTTTTCCAGGTCTGACCACCTGGCCCTGCACATGAAGAGGCACCTCTGA GGGAGCAGAGAGGTGGATCCTGTAGGCTAAAAGGCTTCCAGGCTGAGAGCCGGCCGTGGAAGGAGGGATGCGTGTTCCAGCCAAAGCATG CCGTTCTGCACCCTACCCAGTTGCCTCCAGGGCCTCTCCTTGGAAGGTCTTTTGAGGGCTAAAAAGGTCCTGTAAGAAGCGGCATAGCAC CCGTGGTGCATGGTATGTGGGTGACCCTGGACTCGCCACTGGTACCCGCCCTTCCGAGCGGCGCCTAAGCCTTTGCCGTGAGCATGCACA CTGAGAATGCTAATGGTTGGGTTGATTGTATGTTGAGGATCTATTACTGACCGTATGATGAGGCCAACTTTTTTTCCTTGTGGTTAGCAA GACTGCAAGAGATGGAAAAAAAGTAGTTTGAATGTTTTGTGTGTAAGGAGTATACCATGAGATGAGATGACCACCAATCATTTCCTTGGG GGGAGGGGGTGTCTGCACCTTAGAAAAAAAAAGAAAAATCAAAAAAACAAAAAAACAAAAACAAAAAAAGAAGGAAAATCTTGGAGGGTG GGCGTGGGAACTCAGGACCCCAGAGTGGCGAGTGGTGTGGGGAGGGAGAGCCTCTCTCCCCCTTTTCTGTGTGAGAGGAACTCTTAGTGT CTGGTGCAGCTATTAAATGTGCAATGTGTCAAGTAGCTTGTTTTACACGCTACAACATAGCTCATTTGTAACCCATTGTATAAGCTGTGT ATTTACAAATATAACACAACAATTTAACTTTTCCTTAGAATACAAAAAGTCATGCATGGTCTGGGGAACTATATGCTTTTCCATTTTTAA GTCAGGACTGCAATACTGATTCCAGTTAATGAGCAGCTAAGATCCAATCTGTCTAATACAGTGACCCCCTAGCCATCCGGGCCTGGCAAT ATACAATTTTTTTTCCCCTCCAAGTTTGTAACACTCCCCTTCCAGAAAGGCATTGTGCAACACAGGATTATTTTTAAATGATTCTGAATT TGAATTAACTTTTTGGAGAATTCTGTGATGCCCTTAGAAGAAATTGGACACGTATTGAGTGTCACAAAGCTGGGGCTGGGAATTGCTGGT CTAATGTTTCATTAGACTTAAGAACCTAAAATTTTTCTCAGTTGGGTGGATAAAACCACTAACGCTTAGAAACTGTTTTCTCATGCAGCT ATGTTTCTCTTATTTATGCCTTGAGGACTAATTTCTGGTTTTCTAGCTGTTAATGCACTGTTGACCTTCATAATGGTGCCTTACGCAAGC GATCCCTTCTGTGGGGGTCTCATACAGGGGTGTGGGCGATGCATGCTTTATTAAGGCTCTTGTTTCACCTGGCAGTGTACTGTATCAACG TATAATACAGAAAAAAAATCTCTTTAAGGTCCTCCTTCACAAAGACATAGAGTGAAACTCCCTTTACATGTCAGTATTTGTTCAACACTT TAGGCAACTTGACTGTCAGTGTTAAAATGGAAAACAGGAAAATGGAAAAATCTGACCAATTCTGCCACCTTGAGACTTTCATATAGACCT TGCACAACAATTGTATAGATCACACACCGGCTGTATTTAATATGTAACATTTTCACACATATTAAAGATACAGAAGTATTAAAAAACCCC CAATGTTAATGTATTTGCTTAAAAGGCACAAGTTTCACATATCTGTCTAGCTATCTGTTGGTAATACAGAAAGTATACTACTTTTTTAAA AAAGTGGGCAGAATTCTTGTGTATGTATATTTGTGTGTACAGTATGTGTATGTGTGTATATATATATATTATATATATAGATAATATATA AATATTTTTTTTAAGGAGAAACTAGAATGTTTAGCTAGAAAATTCCACAGCCTGTGAAGAAATATTTCAAAATGGCCATAAAGGAGGTAA AAATGAAAACCATAACCTAACTTTTATAGAGGCTTTATCTTTAATTTAACGATGTGCGGAGGACTTTCTTGCTTGAATCTGTTCCGGGCT GTCTGCTCTGTCCATCAAATGGGCAGGTCTGGAATGGGGCACCTTCGGCCGTTCAGAAGTGGCCTGAACAGAATGCTGGAACCCAGGCTG GACTCGGACACACTAAGGTTTTGATTTTGAATTTCAGCCTTATTAGAAGATCTAACCTAAGAGTAAGCTAACCACAGGGATTCTTTTGTA GAACACTTTTTATGCAGATGAAGCTATTTTTTCCAGCAAGTAGATTCTTCCAGTTTTTCCAAGGAGTAATTTCCCCGAATTGGCATACCA CGGCGTGGACAGCTGATATTTCACCCAGCTGCTGGCTTGTGGGTGTGGCTCTTTGCTTTATATATATATACACACATGTGAGTCTGGCTG GGCTGGTATTTTGTTTGATCTTCCTGGAAATGAGCAGTGACTAACGCTCACATAACTGGTTTTTTTTTTATCTGGGCTGATGAATACATT TACCTAAGAAACTCATTTCGTTTTACTTAAGAGGGGAAGTGCAGTTTTCTTTTGGCAGTTCAGAATCCAAGCACTTGATTTGCTGGGTTT GGAAAACTCCTTTTTTGGCCTTCTATGTGCTTAGCCATAACAATTCCATTAAGCAAGAAGGTAAGCAAAAGACAAAAAAAAAAAAAGGAA AAAAAAAAACTTGCACTGGCTTGTCTCACTTACGAAACATGTCGGAGCTGTTTGCCTGGGTGGGGCTGGGTACCGTACCTGTCAATGCCT GTGATTTTCATAATTAGCACGTACATAAAGAAGTACATTCTGTTCAGGTGATAACTGAGCCTCAATCAAGCAGAAACTTTTTGCTTGAAA TTAAAAAAAAATTTCTATTAGTGAAATTTCTTTTTTTTTTTTTTTTGGAAGCACCCTGTTATCTAAAGAATCTTTGTAAGATTTTTGTAA AATTTTGTTTTACAAGATTTTATTTGAAATTGTTTTTTGCAAGATTGTTATATTTCTGTATGAATGTATTTTTTATTGGAATAACATAAA AGAATTCTTATCAGCATCTTGAGTCTGGTTGTTTTTTTTGGGGGAAGGGGGTTGTTGGAACAGATTCCTCCTGCATTCATCACCCTGGCT TCCTCCTGGGGGCAAATCTTCATTGAGCAACCCTGAGAACAACTCACCGACCTCAGCCCCTTCCTCTTTCCACAGCCTGTCCTGGGAGCT GGAGAGGATGTCAGCGAGCCTGACATTGCCCTCCCTGAATGCATCAAATACTCTTCTCCAAGGACTGACAAAAACAACCCCCCGGCTGTG GGCACAGTAGGGAACCATGCCGGTTTGATCTTCCATTGCTCAAGCCAGGGAATGCATTGCAGAGGCACCTGCACAACGACAAACTTGAGT GTTTCCCTGCCACTTCTGTGCCTCCACAGCCTGCTCCAGTTCCGCAGCTAGAGCTGGGCCTACCTTCCCCAGCCAGCCCTGCCACACACC TGGCTGAGGCATGTCTGGGAGGGGTGGAGGAGGCAGAGGGACTCCAGGCCAGAGGGCTGTTCTCACAACCTCAGCCCACTCTCAGTCAAG |
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FusionGenePPI for ZFPM1_KLF6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZFPM1 | GATA2, GATA1, RBBP4, MTA1, TRIM21, GSK3B, CTBP2, ERP44, DEFA6 | KLF6 | EHMT2, APOM, GTF3C1, PNO1, POLA2, KLF4, SP1, NR0B2, E2F1, HDAC3, NUFIP1, TAF9, FBL, NOP56, LCOR, APP, RUNX1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ZFPM1 | chr16:88580928 | chr10:3824407 | ENST00000319555 | + | 4 | 10 | 794_800 | 134 | 1007 | CTBP2 |
| Hgene | ZFPM1 | chr16:88580928 | chr10:3824407 | ENST00000319555 | + | 4 | 10 | 330_341 | 134 | 1007 | TACC3 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZFPM1_KLF6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFPM1_KLF6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KLF6 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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