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Fusion gene ID: 42826 |
FusionGeneSummary for ZFP41_LGR5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFP41_LGR5 | Fusion gene ID: 42826 | Hgene | Tgene | Gene symbol | ZFP41 | LGR5 | Gene ID | 286128 | 8549 |
| Gene name | ZFP41 zinc finger protein | leucine rich repeat containing G protein-coupled receptor 5 | |
| Synonyms | ZNF753|zfp-41 | FEX|GPR49|GPR67|GRP49|HG38 | |
| Cytomap | 8q24.3 | 12q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 41 homolog | leucine-rich repeat-containing G-protein coupled receptor 5G-protein coupled receptor 49G-protein coupled receptor 67G-protein coupled receptor HG38orphan G protein-coupled receptor HG38 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q8N8Y5 | O75473 | |
| Ensembl transtripts involved in fusion gene | ENST00000520584, ENST00000330701, ENST00000522233, ENST00000522452, | ENST00000266674, ENST00000536515, ENST00000540815, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 4 X 4=112 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/112*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZFP41 [Title/Abstract] AND LGR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LGR5 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 21693646|22815884 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A1KZ-01A | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000520584 | ENST00000266674 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| 5UTR-intron | ENST00000520584 | ENST00000536515 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| 5UTR-intron | ENST00000520584 | ENST00000540815 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| 5UTR-3CDS | ENST00000330701 | ENST00000266674 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| 5UTR-intron | ENST00000330701 | ENST00000536515 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| 5UTR-intron | ENST00000330701 | ENST00000540815 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| 3UTR-3CDS | ENST00000522233 | ENST00000266674 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| 3UTR-intron | ENST00000522233 | ENST00000536515 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| 3UTR-intron | ENST00000522233 | ENST00000540815 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| 5UTR-3CDS | ENST00000522452 | ENST00000266674 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| 5UTR-intron | ENST00000522452 | ENST00000536515 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
| 5UTR-intron | ENST00000522452 | ENST00000540815 | ZFP41 | chr8 | 144329312 | + | LGR5 | chr12 | 71946853 | + |
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FusionProtFeatures for ZFP41_LGR5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZFP41 | LGR5 |
| A putative DNA-binding regulatory protein associatedwith meiosis in spermatogenesis. {ECO:0000250}. | Receptor for R-spondins that potentiates the canonicalWnt signaling pathway and acts as a stem cell marker of theintestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates withphosphorylated LRP6 and frizzled receptors that are activated byextracellular Wnt receptors, triggering the canonical Wntsignaling pathway to increase expression of target genes. Incontrast to classical G-protein coupled receptors, does notactivate heterotrimeric G-proteins to transduce the signal.Involved in the development and/or maintenance of the adultintestinal stem cells during postembryonic development.{ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895,ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884,ECO:0000269|PubMed:23809763}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZFP41_LGR5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZFP41_LGR5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZFP41 | ZC3H4, MRTO4, PYGB, PYGL, LRP2, LRP1B, LRP1, LIMA1, SAFB, SAFB2, NOTCH2, RAI14, NELL2, GYS1, SORL1, AKAP1, LRP4, NDUFA2, GRN, UBE2O, C18orf25, PRRC2C, FRAS1, LDLR, MPRIP, LTBP1, FBN2, FBN1, KBTBD7, KBTBD6, SETD7, PPP1R10, CRELD2, SF1, GYG1, FBLN1, CNRIP1, RAD18, AGRN, LTBP4, ARIH1, NOTCH3, ARIH2, FBLN5, TRIM25 | LGR5 | NTRK1, ZNRF3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZFP41_LGR5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFP41_LGR5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LGR5 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | LGR5 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
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