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Fusion gene ID: 42820 |
FusionGeneSummary for ZFP36_YY1AP1 |
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Fusion gene information | Fusion gene name: ZFP36_YY1AP1 | Fusion gene ID: 42820 | Hgene | Tgene | Gene symbol | ZFP36 | YY1AP1 | Gene ID | 7538 | 55249 |
Gene name | ZFP36 ring finger protein | YY1 associated protein 1 | |
Synonyms | G0S24|GOS24|NUP475|RNF162A|TIS11|TTP|zfp-36 | GRNG|HCCA1|HCCA2|YY1AP | |
Cytomap | 19q13.2 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | mRNA decay activator protein ZFP36G0/G1 switch regulatory protein 24growth factor-inducible nuclear protein NUP475tristetraprolintristetraprolinezinc finger protein 36 homologzinc finger protein 36, C3H type, homologzinc finger protein, C3H type, 3 | YY1-associated protein 1hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-associated protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P26651 | Q9H869 | |
Ensembl transtripts involved in fusion gene | ENST00000597629, ENST00000248673, ENST00000594045, | ENST00000311573, ENST00000368340, ENST00000347088, ENST00000361831, ENST00000355499, ENST00000404643, ENST00000407221, ENST00000359205, ENST00000295566, ENST00000368330, ENST00000368339, ENST00000535662, ENST00000405763, ENST00000438245, ENST00000476093, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 5 X 1=25 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/25*10)=1.26303440583379 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZFP36 [Title/Abstract] AND YY1AP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZFP36 | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 23644599 |
Hgene | ZFP36 | GO:0006402 | mRNA catabolic process | 10330172|10751406|11782475|20221403 |
Hgene | ZFP36 | GO:0009611 | response to wounding | 27182009 |
Hgene | ZFP36 | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay | 11279239 |
Hgene | ZFP36 | GO:0032680 | regulation of tumor necrosis factor production | 15014438 |
Hgene | ZFP36 | GO:0042594 | response to starvation | 15014438 |
Hgene | ZFP36 | GO:0043488 | regulation of mRNA stability | 9703499|11719186|15687258|20702587 |
Hgene | ZFP36 | GO:0044344 | cellular response to fibroblast growth factor stimulus | 20166898 |
Hgene | ZFP36 | GO:0045647 | negative regulation of erythrocyte differentiation | 20702587 |
Hgene | ZFP36 | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 10330172 |
Hgene | ZFP36 | GO:0061158 | 3'-UTR-mediated mRNA destabilization | 9703499|11719186|15687258|20221403|27193233 |
Hgene | ZFP36 | GO:0070935 | 3'-UTR-mediated mRNA stabilization | 15014438 |
Hgene | ZFP36 | GO:0071222 | cellular response to lipopolysaccharide | 14766228 |
Hgene | ZFP36 | GO:0071356 | cellular response to tumor necrosis factor | 20166898 |
Hgene | ZFP36 | GO:0071364 | cellular response to epidermal growth factor stimulus | 20166898 |
Hgene | ZFP36 | GO:0071385 | cellular response to glucocorticoid stimulus | 20166898 |
Hgene | ZFP36 | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus | 20166898 |
Hgene | ZFP36 | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 12748283 |
Hgene | ZFP36 | GO:1901835 | positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA | 16364915 |
Tgene | YY1AP1 | GO:0051726 | regulation of cell cycle | 17541814 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF930057 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000597629 | ENST00000311573 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000597629 | ENST00000368340 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000597629 | ENST00000347088 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000597629 | ENST00000361831 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000597629 | ENST00000355499 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000597629 | ENST00000404643 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000597629 | ENST00000407221 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000597629 | ENST00000359205 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000597629 | ENST00000295566 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000597629 | ENST00000368330 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000597629 | ENST00000368339 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000597629 | ENST00000535662 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-intron | ENST00000597629 | ENST00000405763 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-intron | ENST00000597629 | ENST00000438245 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-intron | ENST00000597629 | ENST00000476093 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000311573 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000368340 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000347088 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000361831 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000355499 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000404643 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000407221 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000359205 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000295566 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000368330 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000368339 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-3CDS | ENST00000248673 | ENST00000535662 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-intron | ENST00000248673 | ENST00000405763 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-intron | ENST00000248673 | ENST00000438245 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
3UTR-intron | ENST00000248673 | ENST00000476093 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000311573 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000368340 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000347088 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000361831 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000355499 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000404643 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000407221 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000359205 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000295566 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000368330 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000368339 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-3CDS | ENST00000594045 | ENST00000535662 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-intron | ENST00000594045 | ENST00000405763 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-intron | ENST00000594045 | ENST00000438245 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
intron-intron | ENST00000594045 | ENST00000476093 | ZFP36 | chr19 | 39899819 | + | YY1AP1 | chr1 | 155629754 | - |
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FusionProtFeatures for ZFP36_YY1AP1 |
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Hgene | Tgene |
ZFP36 | YY1AP1 |
Zinc-finger RNA-binding protein that destabilizesseveral cytoplasmic AU-rich element (ARE)-containing mRNAtranscripts by promoting their poly(A) tail removal ordeadenylation, and hence provide a mechanism for attenuatingprotein synthesis (PubMed:9703499, PubMed:10330172,PubMed:10751406, PubMed:11279239, PubMed:12115244,PubMed:12748283, PubMed:15187101, PubMed:15634918,PubMed:17030620, PubMed:16702957, PubMed:20702587,PubMed:20221403, PubMed:21775632, PubMed:27193233,PubMed:23644599, PubMed:25815583). Acts as an 3'-untranslatedregion (UTR) ARE mRNA-binding adapter protein to communicatesignaling events to the mRNA decay machinery (PubMed:15687258,PubMed:23644599). Recruits deadenylase CNOT7 (and probably theCCR4-NOT complex) via association with CNOT1, and hence promotesARE-mediated mRNA deadenylation (PubMed:23644599). Functions alsoby recruiting components of the cytoplasmic RNA decay machinery tothe bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283,PubMed:15687258, PubMed:16364915). Self regulates by destabilizingits own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerousmRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406,PubMed:12115244, PubMed:15187101, PubMed:15634918,PubMed:17030620, PubMed:16702957, PubMed:19188452,PubMed:20702587, PubMed:20221403, PubMed:21775632,PubMed:25815583). Plays a role in anti-inflammatory responses;suppresses tumor necrosis factor (TNF)-alpha production bystimulating ARE-mediated TNF-alpha mRNA decay and several otherinflammatory ARE-containing mRNAs in interferon (IFN)- and/orlipopolysaccharide (LPS)-induced macrophages (By similarity).Plays also a role in the regulation of dendritic cell maturationat the post-transcriptional level, and hence operates as part of anegative feedback loop to limit the inflammatory response(PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelialcells to hypoxia (PubMed:21775632). Positively regulates earlyadipogenesis of preadipocytes by promoting ARE-mediated mRNA decayof immediate early genes (IEGs) (By similarity). Negativelyregulates hematopoietic/erythroid cell differentiation bypromoting ARE-mediated mRNA decay of the transcription factorSTAT5B mRNA (PubMed:20702587). Plays a role in maintainingskeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1mRNA (By similarity). Associates also with and regulates theexpression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs(PubMed:18367721). Participates in association with argonaute RISCcatalytic components in the ARE-mediated mRNA decay mechanism;assists microRNA (miRNA) targeting ARE-containing mRNAs(PubMed:15766526). May also play a role in the regulation ofcytoplasmic mRNA decapping; enhances decapping of ARE-containingRNAs, in vitro (PubMed:16364915). Involved in the delivery oftarget ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). Inaddition to its cytosolic mRNA-decay function, affects nuclearpre-mRNA processing (By similarity). Negatively regulates nuclearpoly(A)-binding protein PABPN1-stimulated polyadenylation activityon ARE-containing pre-mRNA during LPS-stimulated macrophages (Bysimilarity). Also involved in the regulation of stress granule(SG) and P-body (PB) formation and fusion (By similarity). Plays arole in the regulation of keratinocyte proliferation,differentiation and apoptosis (PubMed:27182009). Plays a role as atumor suppressor by inhibiting cell proliferation in breast cancercells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893,ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406,ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186,ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283,ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918,ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526,ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957,ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404,ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452,ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587,ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599,ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077,ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233,ECO:0000269|PubMed:9703499}. (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR)promoter. {ECO:0000269|PubMed:14679154}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZFP36_YY1AP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZFP36_YY1AP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZFP36_YY1AP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFP36_YY1AP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZFP36 | C0006625 | Cachexia | 2 | CTD_human |
Hgene | ZFP36 | C0002170 | Alopecia | 1 | CTD_human |
Hgene | ZFP36 | C0003864 | Arthritis | 1 | CTD_human |
Hgene | ZFP36 | C0011603 | Dermatitis | 1 | CTD_human |
Hgene | ZFP36 | C0020507 | Hyperplasia | 1 | CTD_human |
Hgene | ZFP36 | C0021368 | Inflammation | 1 | CTD_human |
Hgene | ZFP36 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ZFP36 | C0151744 | Myocardial Ischemia | 1 | CTD_human |