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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42818

FusionGeneSummary for ZFP36L2_SLAIN2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFP36L2_SLAIN2
Fusion gene ID: 42818
HgeneTgene
Gene symbol

ZFP36L2

SLAIN2

Gene ID

678

57606

Gene nameZFP36 ring finger protein like 2SLAIN motif family member 2
SynonymsBRF2|ERF-2|ERF2|RNF162C|TIS11DKIAA1458
Cytomap

2p21

4p11

Type of geneprotein-codingprotein-coding
DescriptionmRNA decay activator protein ZFP36L2EGF-response factor 2TPA-induced sequence 11dZFP36-like 2butyrate response factor 2zinc finger protein 36, C3H type-like 1zinc finger protein 36, C3H type-like 2zinc finger protein 36, C3H1 type-like 2zinc fingeSLAIN motif-containing protein 2
Modification date2018052320180519
UniProtAcc

P47974

Q9P270

Ensembl transtripts involved in fusion geneENST00000282388, ENST00000264313, 
ENST00000506375, ENST00000512093, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 1=9
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZFP36L2 [Title/Abstract] AND SLAIN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZFP36L2

GO:0009611

response to wounding

27182009

HgeneZFP36L2

GO:0044344

cellular response to fibroblast growth factor stimulus

20166898

HgeneZFP36L2

GO:0070371

ERK1 and ERK2 cascade

25106868

HgeneZFP36L2

GO:0071356

cellular response to tumor necrosis factor

20166898

HgeneZFP36L2

GO:0071364

cellular response to epidermal growth factor stimulus

20166898

HgeneZFP36L2

GO:0071385

cellular response to glucocorticoid stimulus

20166898

HgeneZFP36L2

GO:0071560

cellular response to transforming growth factor beta stimulus

20166898

HgeneZFP36L2

GO:0097011

cellular response to granulocyte macrophage colony-stimulating factor stimulus

20166898


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW080228ZFP36L2chr2

43449782

+SLAIN2chr4

48425613

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000282388ENST00000264313ZFP36L2chr2

43449782

+SLAIN2chr4

48425613

-
intron-intronENST00000282388ENST00000506375ZFP36L2chr2

43449782

+SLAIN2chr4

48425613

-
intron-3UTRENST00000282388ENST00000512093ZFP36L2chr2

43449782

+SLAIN2chr4

48425613

-

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FusionProtFeatures for ZFP36L2_SLAIN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFP36L2

P47974

SLAIN2

Q9P270

Zinc-finger RNA-binding protein that destabilizesseveral cytoplasmic AU-rich element (ARE)-containing mRNAtranscripts by promoting their poly(A) tail removal ordeadenylation, and hence provide a mechanism for attenuatingprotein synthesis (PubMed:25106868, PubMed:14981510). Acts as a3'-untranslated region (UTR) ARE mRNA-binding adapter protein tocommunicate signaling events to the mRNA decay machinery(PubMed:25106868). Functions by recruiting the CCR4-NOTdeadenylase complex and probably other components of thecytoplasmic RNA decay machinery to the bound ARE-containing mRNAs,and hence promotes ARE-mediated mRNA deadenylation and decayprocesses (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs(PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL)receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner(PubMed:25106868). Positively regulates early adipogenesis bypromoting ARE-mediated mRNA decay of immediate early genes (IEGs).Plays a role in mature peripheral neuron integrity by promotingARE-containing mRNA decay of the transcriptional repressor RESTmRNA. Plays a role in ovulation and oocyte meiotic maturation bypromoting ARE-mediated mRNA decay of the luteinizing hormonereceptor LHCGR mRNA. Acts as a negative regulator of erythroidcell differentiation: promotes glucocorticoid-induced self-renewalof erythroid cells by binding mRNAs that are induced or highlyexpressed during terminal erythroid differentiation and promotestheir degradation, preventing erythroid cell differentiation. Inassociation with ZFP36L1 maintains quiescence on developing Blymphocytes by promoting ARE-mediated decay of several mRNAsencoding cell cycle regulators that help B cells progress throughthe cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cellformation. Together with ZFP36L1 is also necessary for thymocytedevelopment and prevention of T-cell acute lymphoblastic leukemia(T-ALL) transformation by promoting ARE-mediated mRNA decay of theoncogenic transcription factor NOTCH1 mRNA.{ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510,ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868}. Binds to the plus end of microtubules and regulatesmicrotubule dynamics and microtubule organization. Promotescytoplasmic microtubule nucleation and elongation. Required fornormal structure of the microtubule cytoskeleton duringinterphase. {ECO:0000269|PubMed:21646404}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZFP36L2_SLAIN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZFP36L2_SLAIN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZFP36L2_SLAIN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZFP36L2_SLAIN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZFP36L2C0033578Prostatic Neoplasms1CTD_human