FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42776

FusionGeneSummary for ZFAT_GSTO2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFAT_GSTO2
Fusion gene ID: 42776
HgeneTgene
Gene symbol

ZFAT

GSTO2

Gene ID

57623

119391

Gene namezinc finger and AT-hook domain containingglutathione S-transferase omega 2
SynonymsAITD3|ZFAT1|ZNF406GSTO 2-2|bA127L20.1
Cytomap

8q24.22

10q25.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein ZFATzinc finger gene in autoimmune thyroid diseasezinc finger protein 406zinc-finger gene in AITD susceptibility regionglutathione S-transferase omega-2GSTO-2MMA(V) reductasebA127L20.1 (novel glutathione-S-transferase)glutathione S-transferase omega 2-2glutathione-S-transferase-like proteinglutathione-dependent dehydroascorbate reductasemonomethylarsonic acid reduc
Modification date2018052320180523
UniProtAcc

Q9P243

Q9H4Y5

Ensembl transtripts involved in fusion geneENST00000520356, ENST00000520727, 
ENST00000429442, ENST00000377838, 
ENST00000520214, ENST00000523399, 
ENST00000517307, 		ENST00000450629, 
ENST00000338595, ENST00000401888, 
ENST00000477078, ENST00000369707, 
ENST00000429569, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 1=4
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/4*10)=2.32192809488736
Context

PubMed: ZFAT [Title/Abstract] AND GSTO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGSTO2

GO:0006805

xenobiotic metabolic process

15970797

TgeneGSTO2

GO:0019852

L-ascorbic acid metabolic process

15970797

TgeneGSTO2

GO:0055114

oxidation-reduction process

15970797

TgeneGSTO2

GO:0071243

cellular response to arsenic-containing substance

15970797


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ369613ZFATchr8

135627551

+GSTO2chr10

106046903

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000520356ENST00000450629ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520356ENST00000338595ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520356ENST00000401888ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520356ENST00000477078ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520356ENST00000369707ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520356ENST00000429569ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520727ENST00000450629ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520727ENST00000338595ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520727ENST00000401888ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520727ENST00000477078ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520727ENST00000369707ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520727ENST00000429569ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000429442ENST00000450629ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000429442ENST00000338595ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000429442ENST00000401888ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000429442ENST00000477078ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000429442ENST00000369707ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000429442ENST00000429569ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000377838ENST00000450629ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000377838ENST00000338595ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000377838ENST00000401888ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000377838ENST00000477078ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000377838ENST00000369707ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000377838ENST00000429569ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520214ENST00000450629ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520214ENST00000338595ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520214ENST00000401888ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520214ENST00000477078ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520214ENST00000369707ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000520214ENST00000429569ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000523399ENST00000450629ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000523399ENST00000338595ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000523399ENST00000401888ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000523399ENST00000477078ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000523399ENST00000369707ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000523399ENST00000429569ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000517307ENST00000450629ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000517307ENST00000338595ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000517307ENST00000401888ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000517307ENST00000477078ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000517307ENST00000369707ZFATchr8

135627551

+GSTO2chr10

106046903

-
intron-intronENST00000517307ENST00000429569ZFATchr8

135627551

+GSTO2chr10

106046903

-

Top

FusionProtFeatures for ZFAT_GSTO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFAT

Q9P243

GSTO2

Q9H4Y5

Exhibits glutathione-dependent thiol transferaseactivity. Has high dehydroascorbate reductase activity and maycontribute to the recycling of ascorbic acid. Participates in thebiotransformation of inorganic arsenic and reducesmonomethylarsonic acid (MMA). {ECO:0000269|PubMed:15970797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZFAT_GSTO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZFAT_GSTO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZFAT_GSTO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGSTO2Q9H4Y5DB00143GlutathioneGlutathione S-transferase omega-2small moleculeapproved|investigational|nutraceutical

Top

RelatedDiseases for ZFAT_GSTO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGSTO2C0005695Bladder Neoplasm1CTD_human