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Fusion gene ID: 42766 |
FusionGeneSummary for ZFAND6_TRIM13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFAND6_TRIM13 | Fusion gene ID: 42766 | Hgene | Tgene | Gene symbol | ZFAND6 | TRIM13 | Gene ID | 54469 | 10206 |
| Gene name | zinc finger AN1-type containing 6 | tripartite motif containing 13 | |
| Synonyms | AWP1|ZA20D3|ZFAND5B | CAR|DLEU5|LEU5|RFP2|RNF77 | |
| Cytomap | 15q25.1 | 13q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AN1-type zinc finger protein 6protein associated with PRK1zinc finger, A20 domain containing 3zinc finger, AN1-type domain 6 | E3 ubiquitin-protein ligase TRIM13B-cell chronic lymphocytic leukemia tumor suppressor Leu5CLL-associated RING fingerRING finger protein 77RING-type E3 ubiquitin transferase TRIM13leukemia-associated protein 5putative tumor suppressor RFP2ret finge | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q6FIF0 | O60858 | |
| Ensembl transtripts involved in fusion gene | ENST00000261749, ENST00000561060, ENST00000559157, ENST00000558494, ENST00000559835, ENST00000559775, ENST00000558688, ENST00000558087, | ENST00000478111, ENST00000420995, ENST00000378182, ENST00000356017, ENST00000457662, ENST00000298772, | |
| Fusion gene scores | * DoF score | 5 X 3 X 2=30 | 3 X 3 X 3=27 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/30*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZFAND6 [Title/Abstract] AND TRIM13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TRIM13 | GO:0010942 | positive regulation of cell death | 21333377 |
| Tgene | TRIM13 | GO:0016239 | positive regulation of macroautophagy | 22178386 |
| Tgene | TRIM13 | GO:0030433 | ubiquitin-dependent ERAD pathway | 17314412 |
| Tgene | TRIM13 | GO:0032897 | negative regulation of viral transcription | 18248090 |
| Tgene | TRIM13 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 23077300 |
| Tgene | TRIM13 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 17314412 |
| Tgene | TRIM13 | GO:0045087 | innate immune response | 18248090 |
| Tgene | TRIM13 | GO:0051865 | protein autoubiquitination | 17314412 |
| Tgene | TRIM13 | GO:1902187 | negative regulation of viral release from host cell | 18248090 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-D3-A2J6-06A | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3UTR | ENST00000261749 | ENST00000478111 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| 5UTR-intron | ENST00000261749 | ENST00000420995 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| 5UTR-intron | ENST00000261749 | ENST00000378182 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| 5UTR-intron | ENST00000261749 | ENST00000356017 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| 5UTR-intron | ENST00000261749 | ENST00000457662 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| 5UTR-intron | ENST00000261749 | ENST00000298772 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-3UTR | ENST00000561060 | ENST00000478111 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000561060 | ENST00000420995 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000561060 | ENST00000378182 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000561060 | ENST00000356017 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000561060 | ENST00000457662 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000561060 | ENST00000298772 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-3UTR | ENST00000559157 | ENST00000478111 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000559157 | ENST00000420995 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000559157 | ENST00000378182 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000559157 | ENST00000356017 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000559157 | ENST00000457662 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000559157 | ENST00000298772 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-3UTR | ENST00000558494 | ENST00000478111 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558494 | ENST00000420995 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558494 | ENST00000378182 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558494 | ENST00000356017 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558494 | ENST00000457662 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558494 | ENST00000298772 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-3UTR | ENST00000559835 | ENST00000478111 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000559835 | ENST00000420995 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000559835 | ENST00000378182 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000559835 | ENST00000356017 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000559835 | ENST00000457662 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000559835 | ENST00000298772 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| 5UTR-3UTR | ENST00000559775 | ENST00000478111 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| 5UTR-intron | ENST00000559775 | ENST00000420995 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| 5UTR-intron | ENST00000559775 | ENST00000378182 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| 5UTR-intron | ENST00000559775 | ENST00000356017 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| 5UTR-intron | ENST00000559775 | ENST00000457662 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| 5UTR-intron | ENST00000559775 | ENST00000298772 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-3UTR | ENST00000558688 | ENST00000478111 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558688 | ENST00000420995 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558688 | ENST00000378182 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558688 | ENST00000356017 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558688 | ENST00000457662 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558688 | ENST00000298772 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-3UTR | ENST00000558087 | ENST00000478111 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558087 | ENST00000420995 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558087 | ENST00000378182 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558087 | ENST00000356017 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558087 | ENST00000457662 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
| intron-intron | ENST00000558087 | ENST00000298772 | ZFAND6 | chr15 | 80390920 | + | TRIM13 | chr13 | 50594350 | + |
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FusionProtFeatures for ZFAND6_TRIM13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZFAND6 | TRIM13 |
| Involved in regulation of TNF-alpha induced NF-kappa-Bactivation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreasesassociation of TRAF2 with RIPK1. Required for PTS1 targetsequence-dependent protein import into peroxisomes and PEX5stability; may cooperate with PEX6. In vitro involved in PEX5export from the cytosol to peroxisomes (By similarity).{ECO:0000250, ECO:0000269|PubMed:19285159,ECO:0000269|PubMed:21810480}. | Endoplasmic reticulum (ER) membrane anchored E3 ligaseinvolved in the retrotranslocation and turnover of membrane andsecretory proteins from the ER through a set of processes namedER-associated degradation (ERAD). This process acts on misfoldedproteins as well as in the regulated degradation of correctlyfolded proteins. Enhances ionizing radiation-induced p53/TP53stability and apoptosis via ubiquitinating MDM2 and AKT1 anddecreasing AKT1 kinase activity through MDM2 and AKT1 proteasomaldegradation. Regulates ER stress-induced autophagy, and may act asa tumor suppressor (PubMed:22178386). Plays also a role in innateimmune response by stimulating NF-kappa-B activity in the TLR2signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linkedpolyubiquitination chain resulting in NF-kappa-B activation(PubMed:28087809). Participates as well in T-cell receptor-mediated NF-kappa-B activation (PubMed:25088585). In the presenceof TNF, modulates the IKK complex by regulating IKBKG/NEMOubiquitination leading to the repression of NF-kappa-B(PubMed:25152375). {ECO:0000269|PubMed:17314412,ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386,ECO:0000269|PubMed:25088585, ECO:0000269|PubMed:25152375,ECO:0000269|PubMed:28087809}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZFAND6_TRIM13 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZFAND6_TRIM13 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZFAND6 | TRAF2, UBC, CDC34, USP3, WIPI2, PPP2R1A, TRAF5, CDV3, CIRBP, GSS, HNRNPA3, NONO, TXLNG, BIRC2 | TRIM13 | MDM2, AKT1, CACNA1C, ROBO2, ARHGDIA, SQSTM1, ZFYVE1, VCP, CALM1, ATP2A2, DDOST, UBE2D2, TRIM13, IKBKG, GMCL1, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, TRAF6, CTDNEP1, COMMD10, ELOVL2, TEX28, LRRN2, KIAA1467, KIR3DL2, NPLOC4, CKAP4, PTPRN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZFAND6_TRIM13 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFAND6_TRIM13 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ZFAND6 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Hgene | ZFAND6 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
| Hgene | ZFAND6 | C0520757 | Delayed Emergence from Anesthesia | 1 | CTD_human |
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