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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42766

FusionGeneSummary for ZFAND6_TRIM13

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFAND6_TRIM13
Fusion gene ID: 42766
HgeneTgene
Gene symbol

ZFAND6

TRIM13

Gene ID

54469

10206

Gene namezinc finger AN1-type containing 6tripartite motif containing 13
SynonymsAWP1|ZA20D3|ZFAND5BCAR|DLEU5|LEU5|RFP2|RNF77
Cytomap

15q25.1

13q14.2

Type of geneprotein-codingprotein-coding
DescriptionAN1-type zinc finger protein 6protein associated with PRK1zinc finger, A20 domain containing 3zinc finger, AN1-type domain 6E3 ubiquitin-protein ligase TRIM13B-cell chronic lymphocytic leukemia tumor suppressor Leu5CLL-associated RING fingerRING finger protein 77RING-type E3 ubiquitin transferase TRIM13leukemia-associated protein 5putative tumor suppressor RFP2ret finge
Modification date2018052220180522
UniProtAcc

Q6FIF0

O60858

Ensembl transtripts involved in fusion geneENST00000261749, ENST00000561060, 
ENST00000559157, ENST00000558494, 
ENST00000559835, ENST00000559775, 
ENST00000558688, ENST00000558087, 
ENST00000478111, ENST00000420995, 
ENST00000378182, ENST00000356017, 
ENST00000457662, ENST00000298772, 
Fusion gene scores* DoF score5 X 3 X 2=303 X 3 X 3=27
# samples 43
** MAII scorelog2(4/30*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZFAND6 [Title/Abstract] AND TRIM13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM13

GO:0010942

positive regulation of cell death

21333377

TgeneTRIM13

GO:0016239

positive regulation of macroautophagy

22178386

TgeneTRIM13

GO:0030433

ubiquitin-dependent ERAD pathway

17314412

TgeneTRIM13

GO:0032897

negative regulation of viral transcription

18248090

TgeneTRIM13

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

23077300

TgeneTRIM13

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

17314412

TgeneTRIM13

GO:0045087

innate immune response

18248090

TgeneTRIM13

GO:0051865

protein autoubiquitination

17314412

TgeneTRIM13

GO:1902187

negative regulation of viral release from host cell

18248090


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D3-A2J6-06AZFAND6chr15

80390920

+TRIM13chr13

50594350

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000261749ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000261749ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000261749ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000261749ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000261749ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000261749ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000561060ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000561060ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000561060ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000561060ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000561060ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000561060ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000559157ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559157ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559157ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559157ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559157ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559157ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000558494ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558494ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558494ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558494ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558494ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558494ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000559835ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559835ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559835ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559835ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559835ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559835ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-3UTRENST00000559775ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000559775ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000559775ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000559775ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000559775ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000559775ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000558688ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558688ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558688ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558688ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558688ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558688ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000558087ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558087ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558087ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558087ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558087ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558087ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+

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FusionProtFeatures for ZFAND6_TRIM13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFAND6

Q6FIF0

TRIM13

O60858

Involved in regulation of TNF-alpha induced NF-kappa-Bactivation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreasesassociation of TRAF2 with RIPK1. Required for PTS1 targetsequence-dependent protein import into peroxisomes and PEX5stability; may cooperate with PEX6. In vitro involved in PEX5export from the cytosol to peroxisomes (By similarity).{ECO:0000250, ECO:0000269|PubMed:19285159,ECO:0000269|PubMed:21810480}. Endoplasmic reticulum (ER) membrane anchored E3 ligaseinvolved in the retrotranslocation and turnover of membrane andsecretory proteins from the ER through a set of processes namedER-associated degradation (ERAD). This process acts on misfoldedproteins as well as in the regulated degradation of correctlyfolded proteins. Enhances ionizing radiation-induced p53/TP53stability and apoptosis via ubiquitinating MDM2 and AKT1 anddecreasing AKT1 kinase activity through MDM2 and AKT1 proteasomaldegradation. Regulates ER stress-induced autophagy, and may act asa tumor suppressor (PubMed:22178386). Plays also a role in innateimmune response by stimulating NF-kappa-B activity in the TLR2signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linkedpolyubiquitination chain resulting in NF-kappa-B activation(PubMed:28087809). Participates as well in T-cell receptor-mediated NF-kappa-B activation (PubMed:25088585). In the presenceof TNF, modulates the IKK complex by regulating IKBKG/NEMOubiquitination leading to the repression of NF-kappa-B(PubMed:25152375). {ECO:0000269|PubMed:17314412,ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386,ECO:0000269|PubMed:25088585, ECO:0000269|PubMed:25152375,ECO:0000269|PubMed:28087809}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZFAND6_TRIM13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZFAND6_TRIM13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZFAND6TRAF2, UBC, CDC34, USP3, WIPI2, PPP2R1A, TRAF5, CDV3, CIRBP, GSS, HNRNPA3, NONO, TXLNG, BIRC2TRIM13MDM2, AKT1, CACNA1C, ROBO2, ARHGDIA, SQSTM1, ZFYVE1, VCP, CALM1, ATP2A2, DDOST, UBE2D2, TRIM13, IKBKG, GMCL1, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, TRAF6, CTDNEP1, COMMD10, ELOVL2, TEX28, LRRN2, KIAA1467, KIR3DL2, NPLOC4, CKAP4, PTPRN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZFAND6_TRIM13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZFAND6_TRIM13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZFAND6C0037274Dermatologic disorders1CTD_human
HgeneZFAND6C0311375Arsenic Poisoning1CTD_human
HgeneZFAND6C0520757Delayed Emergence from Anesthesia1CTD_human