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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42765

FusionGeneSummary for ZFAND6_PSMB1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFAND6_PSMB1
Fusion gene ID: 42765
HgeneTgene
Gene symbol

ZFAND6

PSMB1

Gene ID

54469

5689

Gene namezinc finger AN1-type containing 6proteasome subunit beta 1
SynonymsAWP1|ZA20D3|ZFAND5BHC5|PMSB1|PSC5
Cytomap

15q25.1

6q27

Type of geneprotein-codingprotein-coding
DescriptionAN1-type zinc finger protein 6protein associated with PRK1zinc finger, A20 domain containing 3zinc finger, AN1-type domain 6proteasome subunit beta type-1macropain subunit C5multicatalytic endopeptidase complex subunit C5proteasome (prosome, macropain) subunit, beta type, 1proteasome beta 1 subunitproteasome component C5proteasome gamma chainproteasome subunit HC5testi
Modification date2018052220180523
UniProtAcc

Q6FIF0

P20618

Ensembl transtripts involved in fusion geneENST00000261749, ENST00000561060, 
ENST00000559157, ENST00000558494, 
ENST00000559835, ENST00000559775, 
ENST00000558688, ENST00000558087, 
ENST00000262193, ENST00000462957, 
Fusion gene scores* DoF score5 X 3 X 2=308 X 6 X 4=192
# samples 48
** MAII scorelog2(4/30*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFAND6 [Title/Abstract] AND PSMB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB122525ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000261749ENST00000262193ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
5UTR-5UTRENST00000261749ENST00000462957ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
5UTR-3CDSENST00000561060ENST00000262193ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
5UTR-5UTRENST00000561060ENST00000462957ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
5UTR-3CDSENST00000559157ENST00000262193ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
5UTR-5UTRENST00000559157ENST00000462957ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
5UTR-3CDSENST00000558494ENST00000262193ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
5UTR-5UTRENST00000558494ENST00000462957ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
intron-3CDSENST00000559835ENST00000262193ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
intron-5UTRENST00000559835ENST00000462957ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
intron-3CDSENST00000559775ENST00000262193ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
intron-5UTRENST00000559775ENST00000462957ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
intron-3CDSENST00000558688ENST00000262193ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
intron-5UTRENST00000558688ENST00000462957ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
intron-3CDSENST00000558087ENST00000262193ZFAND6chr15

80352151

+PSMB1chr6

170858204

-
intron-5UTRENST00000558087ENST00000462957ZFAND6chr15

80352151

+PSMB1chr6

170858204

-

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FusionProtFeatures for ZFAND6_PSMB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFAND6

Q6FIF0

PSMB1

P20618

Involved in regulation of TNF-alpha induced NF-kappa-Bactivation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreasesassociation of TRAF2 with RIPK1. Required for PTS1 targetsequence-dependent protein import into peroxisomes and PEX5stability; may cooperate with PEX6. In vitro involved in PEX5export from the cytosol to peroxisomes (By similarity).{ECO:0000250, ECO:0000269|PubMed:19285159,ECO:0000269|PubMed:21810480}. Component of the 20S core proteasome complex involved inthe proteolytic degradation of most intracellular proteins. Thiscomplex plays numerous essential roles within the cell byassociating with different regulatory particles. Associated withtwo 19S regulatory particles, forms the 26S proteasome and thusparticipates in the ATP-dependent degradation of ubiquitinatedproteins. The 26S proteasome plays a key role in the maintenanceof protein homeostasis by removing misfolded or damaged proteinsthat could impair cellular functions, and by removing proteinswhose functions are no longer required. Associated with the PA200or PA28, the 20S proteasome mediates ubiquitin-independent proteindegradation. This type of proteolysis is required in severalpathways including spermatogenesis (20S-PA200 complex) orgeneration of a subset of MHC class I-presented antigenic peptides(20S-PA28 complex). {ECO:0000269|PubMed:15244466,ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZFAND6_PSMB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZFAND6_PSMB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZFAND6TRAF2, UBC, CDC34, USP3, WIPI2, PPP2R1A, TRAF5, CDV3, CIRBP, GSS, HNRNPA3, NONO, TXLNG, BIRC2PSMB1EXOSC6, DCP2, VHL, DSTYK, RIOK3, CASP4, PASK, FANCG, PLK1, SLX1B, UBC, MYC, INSIG2, PSMA2, PCK1, BCL3, RAD23A, SHFM1, PSMB3, PSMB7, PSMB5, POMP, SERPINE1, PSMA4, SERPINB2, PSEN1, PSMB8, PSMA7, FKBP8, UCHL5, PSMB2, PSMA1, PSMA3, PSMA5, PSMA6, PSMB4, PSMB6, PSMC4, PSMD11, PSMD12, PSMD13, PSMD1, PSMD2, PSMD3, PSMD8, PSMD6, PSMC3, PSMC1, PSMD4, PSMC5, PSMC6, PSMC2, PSMD7, PSMD14, PSME1, PSME3, PSME2, PSMD5, PSMA8, PSMB10, UFM1, RBM8A, CCT5, UBE2A, UBE4B, SF3A1, NOTCH2, RPL5, RPL10A, UBE2V1, SNX3, RPL24, RPS23, RPL7A, FBXO28, SRSF2, SUGT1, RPS15A, EPAS1, FN1, VCAM1, IQCB1, ITGA4, CFTR, PARK2, BAG3, HECW2, AP3M1, HNRNPA2B1, SEC13, DDB2, RPP30, RPP38, SMEK1, PSME4, PYCRL, PSMG3, CDKN1B, HAUS2, KIFC3, KRT13, KRT15, TRIM27, TRAF1, MAPRE3, AMFR, SYVN1, PSMB9, UNK, ADRM1, ASNA1, CLIC4, HSD17B10, MRPS9, PEX19, PGK1, MED4, MCM2, MID1, ENPP1, FBXO7, PSMG2, PSMF1, PSMG1, MAPRE2, MAPRE1, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZFAND6_PSMB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePSMB1P20618DB00188BortezomibProteasome subunit beta type-1small moleculeapproved|investigational
TgenePSMB1P20618DB08889CarfilzomibProteasome subunit beta type-1small moleculeapproved|investigational

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RelatedDiseases for ZFAND6_PSMB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZFAND6C0037274Dermatologic disorders1CTD_human
HgeneZFAND6C0311375Arsenic Poisoning1CTD_human
HgeneZFAND6C0520757Delayed Emergence from Anesthesia1CTD_human
TgenePSMB1C0029408Degenerative polyarthritis1CTD_human
TgenePSMB1C0031117Peripheral Neuropathy1CTD_human
TgenePSMB1C0948089Acute Coronary Syndrome1CTD_human